UT Southwestern Medical Center 1 article published in JoVE Medicine Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production Ashley A. Rowe1, Yacine Issioui1, Blessing Johnny1, Katherine J. Wert1,2,3,4 1Department of Ophthalmology, UT Southwestern Medical Center, 2Department of Molecular Biology, UT Southwestern Medical Center, 3Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, 4Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center This manuscript describes a consistent way to quickly perform survival rodent orchiectomies and ovariectomies.