Chapter 23
Signaling Networks of Kinase Receptors
![Receptor Tyrosine Kinases](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13207.jpg)
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular…
![Small GTPases - Ras and Rho](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13208.jpg)
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases…
![The JAK-STAT Signaling Pathway](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13210.jpg)
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as…
![PI3K/mTOR/AKT Signaling Pathway](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13211.jpg)
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to…
![Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia](https://cloudfront.jove.com/files/thumbs/50720_t.png)
Receptor tyrosine kinases have been implicated in the development and progression of many cancers, including both leukemia and solid tumors, and are…
![Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay](https://cloudfront.jove.com/files/thumbs/57646_t.png)
The Rho GTPase family belongs to the Ras superfamily and includes approximately 20 members in humans. Rho GTPases are important in the regulation of…