Chapter 28
Cell-Matrix Interactions
![Overview of Cell-Matrix Interactions](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13347.jpg)
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins…
![Integrins](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13348.jpg)
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a…
![Intracellular Signaling Affects Focal Adhesions](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13350.jpg)
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely…
![Anchoring Junctions](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13351.jpg)
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present…
![Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes](https://cloudfront.jove.com/files/thumbs/51646_t.png)
T lymphocyte adhesion is required for multiple T cell functions, including migration to sites of inflammation and formation of immunological synapses…
![Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor](https://cloudfront.jove.com/files/thumbs/59476_t.png)
Molecular tension transmitted by integrin-ligand bonds is the fundamental mechanical signal in the integrin pathway that plays significant roles in…