Chapter 35
Cell Division
![Mitosis and Cytokinesis](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/13417.jpg)
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome…
![Duplication of Chromatin Structure](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12053.jpg)
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must…
![Condensins](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12055.jpg)
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of…
![The Mitotic Spindle](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12056.jpg)
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules.…
![Spindle Assembly](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12059.jpg)
Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the…
![Attachment of Sister Chromatids](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12060.jpg)
As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of…
![Separation of Sister Chromatids](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12062.jpg)
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister…
![The Spindle Assembly Checkpoint](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12063.jpg)
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint…
![Anaphase Promoting Complex](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12231.jpg)
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by…
![The Contractile Ring](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12066.jpg)
Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly…
![Live Cell Imaging of Chromosome Segregation During Mitosis](https://cloudfront.jove.com/files/thumbs/57389_t.png)
Chromosomes must be reliably and uniformly segregated into daughter cells during mitotic cell division. Fidelity of chromosomal segregation is…
![Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo](https://cloudfront.jove.com/files/thumbs/54218_t.png)
Mitosis is critical for organismal growth and differentiation. The process is highly dynamic and requires ordered events to accomplish proper…
![Imaging Centrosomes in Fly Testes](https://cloudfront.jove.com/files/thumbs/50938_t.png)
Imaging Centrosomes in Fly Testes
Free SampleFree access at this time
Centrosomes are conserved microtubule-based organelles whose structure and function change dramatically throughout the cell cycle and cell…