Chapter 40
A Hierarchical Stem-Cell System: Blood Cell Formation
![Overview of the Vascular System](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12508.jpg)
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and…
![Mechanism of Angiogenesis](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12509.jpg)
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called…
![Hematopoiesis](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12511.jpg)
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This…
![Multipotency of Hematopoietic Stem Cells](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12512.jpg)
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained…
![Erythropoiesis](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12514.jpg)
Red blood cells (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished.…
![Differentiation of Common Myeloid Progenitor Cells](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/12515.jpg)
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are…
![Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development](https://cloudfront.jove.com/files/thumbs/4458_t.png)
Fate maps, constructed from lineage tracing all of the cells of an embryo, reveal which tissues descend from each cell of the embryo. Although fate…
![Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis](https://cloudfront.jove.com/files/thumbs/51894_t.png)
Erythropoiesis involves a dynamic process that begins with committed erythroid burst forming units (BFU-Es) followed by rapidly dividing erythroid…