Klinikum Klagenfurt am Woerthersee 1 article published in JoVE Medicine Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy Thomas Reiberger1,2, Philipp Schwabl1,2, Michael Trauner1,2, Markus Peck-Radosavljevic2,3, Mattias Mandorfer1,2 1Division of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, 2Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, 3Department of Internal Medicine and Gastroenterology (IMuG), Klinikum Klagenfurt am Woerthersee Here, we present a protocol for measurement of hepatic venous pressure gradient (HVPG),the gold standard to diagnose clinically significant portal hypertension. Moreover, we describe how to perform a transjugular liver biopsy within the same session.