Aaron D. Gitler Department of Cell and Developmental Biology University of Pennsylvania School of Medicine Biography Publications Institution JoVE Articles Aaron D. Gitler has not added a biography. If you are Aaron D. Gitler and would like to personalize this page please email our Author Liaison for assistance. Publications The Modulation of Amyotrophic Lateral Sclerosis Risk by Ataxin-2 Intermediate Polyglutamine Expansions is a Specific Effect Neurobiology of Disease. Jan, 2012 | Pubmed ID: 21889984 Local RNA Translation at the Synapse and in Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2011 | Pubmed ID: 22072660 A Yeast Functional Screen Predicts New Candidate ALS Disease Genes Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22065782 Neuroscience. Another Reason to Exercise Science (New York, N.Y.). Nov, 2011 | Pubmed ID: 22053033 RNA-binding Proteins with Prion-like Domains in ALS and FTLD-U Prion. Jul, 2011 | Pubmed ID: 21847013 Model Organisms Reveal Insight into Human Neurodegenerative Disease: Ataxin-2 Intermediate-length Polyglutamine Expansions Are a Risk Factor for ALS Journal of Molecular Neuroscience : MN. Nov, 2011 | Pubmed ID: 21660502 Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS PLoS Biology. Apr, 2011 | Pubmed ID: 21541367 A Yeast Model for Polyalanine-expansion Aggregation and Toxicity Molecular Biology of the Cell. Jun, 2011 | Pubmed ID: 21508314 PolyQ Repeat Expansions in ATXN2 Associated with ALS Are CAA Interrupted Repeats PloS One. 2011 | Pubmed ID: 21479228 Ataxin-2 Intermediate-length Polyglutamine Expansions in European ALS Patients Human Molecular Genetics. May, 2011 | Pubmed ID: 21292779 TDP-43 Toxicity in Yeast Methods (San Diego, Calif.). Mar, 2011 | Pubmed ID: 21115123 Ataxin-2 Intermediate-length Polyglutamine Expansions Are Associated with Increased Risk for ALS Nature. Aug, 2010 | Pubmed ID: 20740007 GTPase Activity Plays a Key Role in the Pathobiology of LRRK2 PLoS Genetics. Apr, 2010 | Pubmed ID: 20386743 Prion-like Disorders: Blurring the Divide Between Transmissibility and Infectivity Journal of Cell Science. Apr, 2010 | Pubmed ID: 20356930 TDP-43 is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19465477 Disease Models and Mechanisms in the Classroom Disease Models & Mechanisms. Mar-Apr, 2009 | Pubmed ID: 19259378 Bridging High-throughput Genetic and Transcriptional Data Reveals Cellular Responses to Alpha-synuclein Toxicity Nature Genetics. Mar, 2009 | Pubmed ID: 19234470 Alpha-synuclein is Part of a Diverse and Highly Conserved Interaction Network That Includes PARK9 and Manganese Toxicity Nature Genetics. Mar, 2009 | Pubmed ID: 19182805 Evidence That Alpha-synuclein Does Not Inhibit Phospholipase D Biochemistry. Feb, 2009 | Pubmed ID: 19146388 Discovery and Characterization of Three Novel Synuclein Genes in Zebrafish Developmental Dynamics : an Official Publication of the American Association of Anatomists. Sep, 2008 | Pubmed ID: 18521955 A Yeast TDP-43 Proteinopathy Model: Exploring the Molecular Determinants of TDP-43 Aggregation and Cellular Toxicity Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18434538 The Parkinson's Disease Protein Alpha-synuclein Disrupts Cellular Rab Homeostasis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18162536 Beer and Bread to Brains and Beyond: Can Yeast Cells Teach Us About Neurodegenerative Disease? Neuro-Signals. 2008 | Pubmed ID: 18097160 A Suite of Gateway Cloning Vectors for High-throughput Genetic Analysis in Saccharomyces Cerevisiae Yeast (Chichester, England). Oct, 2007 | Pubmed ID: 17583893 Prime Time for Alpha-synuclein The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2007 | Pubmed ID: 17344380 Kermit 2/XGIPC, an IGF1 Receptor Interacting Protein, is Required for IGF Signaling in Xenopus Eye Development Development (Cambridge, England). Sep, 2006 | Pubmed ID: 16914488 Alpha-synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models Science (New York, N.Y.). Jul, 2006 | Pubmed ID: 16794039 Insertion of Cre into the Pax3 Locus Creates a New Allele of Splotch and Identifies Unexpected Pax3 Derivatives Developmental Biology. Apr, 2005 | Pubmed ID: 15882581 Semaphorin-plexin Signaling Guides Patterning of the Developing Vasculature Developmental Cell. Jul, 2004 | Pubmed ID: 15239959 PlexinD1 and Semaphorin Signaling Are Required in Endothelial Cells for Cardiovascular Development Developmental Cell. Jul, 2004 | Pubmed ID: 15239958 Tie2-Cre-induced Inactivation of a Conditional Mutant Nf1 Allele in Mouse Results in a Myeloproliferative Disorder That Models Juvenile Myelomonocytic Leukemia Pediatric Research. Apr, 2004 | Pubmed ID: 14739366 Molecular Markers of Cardiac Endocardial Cushion Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Dec, 2003 | Pubmed ID: 14648841 Cardiac Hypertrophy and Histone Deacetylase-dependent Transcriptional Repression Mediated by the Atypical Homeodomain Protein Hop The Journal of Clinical Investigation. Sep, 2003 | Pubmed ID: 12975471 Regulating Heart Development: the Role of Nf1 Cell Cycle (Georgetown, Tex.). Mar-Apr, 2003 | Pubmed ID: 12695655 Nf1 Has an Essential Role in Endothelial Cells Nature Genetics. Jan, 2003 | Pubmed ID: 12469121 Hop is an Unusual Homeobox Gene That Modulates Cardiac Development Cell. Sep, 2002 | Pubmed ID: 12297045 High-throughput Yeast Plasmid Overexpression Screen Michael S. Fleming1, Aaron D. Gitler2 1Neuroscience Graduate Group, University of Pennsylvania School of Medicine, 2Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine JoVE 2836 Biology
High-throughput Yeast Plasmid Overexpression Screen Michael S. Fleming1, Aaron D. Gitler2 1Neuroscience Graduate Group, University of Pennsylvania School of Medicine, 2Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine JoVE 2836 Biology