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In JoVE (2)
Other Publications (3)
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Articles by Adem Can in JoVE
اختبار ماوس القسري السباحة
Adem Can1, David T. Dao2, Michal Arad1, Chantelle E. Terrillion3, Sean C. Piantadosi1, Todd D. Gould1,3,4
1Department of Psychiatry, University of Maryland School of Medicine, 2Tulane University School of Medicine, 3Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 4The Program in Neuroscience, University of Maryland
التحقق من صحة الاختبار القسري السباحة كنهج تجريبية لتقييم فعالية مضادات الاكتئاب المحتملة في القوارض. توضع حيوانات التجارب في خزان للمياه والهروب السلوك المتصل التنقل هو كميا. ووصف إجراءات مشتركة لإصدار الماوس من هذا الاختبار.
اختبار الذيل تعليق
Adem Can*1, David T. Dao*1,2, Chantelle E. Terrillion3, Sean C. Piantadosi1, Shambhu Bhat1, Todd D. Gould1,3,4
1Department of Psychiatry, University of Maryland School of Medicine, 2Tulane University School of Medicine, 3The Program in Neuroscience, University of Maryland, 4Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine
التحقق من صحة اختبار الذيل التعليق كإجراء تجريبي لتقييم نجاعة العلاج بالعقاقير المضادة للاكتئاب من في الفئران. وعلقت الفئران التي ذيولها لمدة ست دقائق ، ويتم تقييم الهروب السلوكيات ذات الصلة. نحن تصف الإجراءات المستخدمة في إجراء اختبار تعليق الذيل.
Other articles by Adem Can on PubMed
Hormones and Behavior. Dec, 2007 | Pubmed ID: 17826778
After an initial increase, repeated exposure to a particular stimulus or familiarity with an event results in lower immediate early gene expression levels in relevant brain structures. We predicted that similar effects would occur in Japanese quail after repeated sexual experience within brain areas involved in sexual behavior, namely, the medial preoptic nucleus (POM), the bed nucleus of stria terminalis (BST), and the nucleus taeniae of the amygdala (TnA), an avian homolog of medial amygdala. High experience subjects copulated with a female once on each of 16 consecutive days, whereas low experience subjects were allowed to copulate either once or twice. Control subjects were never exposed to a female. High experience subjects were faster to initiate sexual interaction, performed more cloacal contacts, and completed each cloacal contact faster than low experience subjects. Low experience subjects showed an increase in egr-1 (ZENK) expression, an immediate early gene product used as marker of neural activation in birds, in the areas of interest. In contrast, in high experience animals, egr-1 expression in the POM, BST, and the periaqueductal gray (PAG) was not different than the level of expression in unmated controls. These results show that experience modulates the level of immediate early gene expression in the case of sexual behavior. Our results also indicate that immediate early gene expression in specific brain areas is not necessarily related to behavioral output but depends on the behavioral history of the subjects.
Behavior Genetics. Mar, 2012 | Pubmed ID: 21989731
There is considerable evidence for the existence of comorbidity between alcohol-use disorders and depression in humans. One strategy to elucidate hereditary factors affecting the comorbidity of these disorders is to use genetic animal models, such as mouse lines selectively bred for voluntary ethanol consumption. We hypothesized that mice from lines that were bred for high-alcohol preference would manifest increased depression-like phenotypes compared to low-alcohol preferring mice. Mice that were bi-directionally selected and bred on the basis of their High- (HAP) or Low-Alcohol Preference (LAP) were tested in the open-field (OFT), dark-light box (DLB), forced swim (FST), and learned helplessness tests (LH). The study was conducted in two independently derived replicates. In the OFT, both HAP2 and HAP3 mice showed higher levels of general locomotion compared to LAP mice. However, only HAP2 mice spent more time in the center compared to LAP2 mice. In the DLB, there was a slightly higher anxiety-like phenotype in HAP mice. In both FST and LH, we observed higher depression-like behaviors in HAP mice compared to LAP mice, but this was limited to the Replicate 2 mice. Overall, we identified affect-related behavioral changes in mouse lines bred for high-alcohol preference. Notably, the Replicate 3 lines that showed fewer depression-like behaviors also manifest smaller differences in alcohol intake. These data suggest that there may be overlap between genes that predispose to excessive alcohol intake and those underlying affect-related behaviors in the mouse.
The American Journal of Psychiatry. Jan, 2012 | Pubmed ID: 22223017