Alan D.T. Barrett Department of Microbiology & Immunology The University of Texas Medical Branch Biography Publications Institution JoVE Articles Alan D.T. Barrett has not added a biography. If you are Alan D.T. Barrett and would like to personalize this page please email our Author Liaison for assistance. Publications Attenuated West Nile Virus Mutant NS1130-132QQA/175A/207A Exhibits Virus-induced Ultrastructural Changes and Accumulation of Protein in the Endoplasmic Reticulum Journal of Virology. Nov, 2014 | Pubmed ID: 25392222 A Lethal Murine Infection Model for Dengue Virus 3 in AG129 Mice Deficient in Type I and II Interferon Receptors Leads to Systemic Disease Journal of Virology. Nov, 2014 | Pubmed ID: 25392217 Evidence for Co-evolution of West Nile Virus and House Sparrows in North America PLoS Neglected Tropical Diseases. Oct, 2014 | Pubmed ID: 25357248 Functional Analysis of DENV-2 Envelope Protein Domain 3 Type-Specific and DENV Complex-Reactive Critical Epitope Residues The Journal of General Virology. Oct, 2014 | Pubmed ID: 25351518 Investigating the Efficacy of Monovalent and Tetravalent Dengue Vaccine Formulations Against DENV-4 Challenge in AG129 Mice Vaccine. Sep, 2014 | Pubmed ID: 25239488 Thermodynamic Mechanism for the Evasion of Antibody Neutralization in Flaviviruses Journal of the American Chemical Society. Jul, 2014 | Pubmed ID: 24950171 Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes Without Affecting Hyperphosphorylated Neurofibrillary Tangles The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2014 | Pubmed ID: 24647946 Economic Burden of West Nile Virus in the United States The American Journal of Tropical Medicine and Hygiene. Mar, 2014 | Pubmed ID: 24515938 Dynamics of the Emergence and Establishment of a Newly Dominant Genotype of Japanese Encephalitis Virus Throughout Asia Journal of Virology. Apr, 2014 | Pubmed ID: 24501419 Comparison of the Live Attenuated Yellow Fever Vaccine 17D-204 Strain to Its Virulent Parental Strain Asibi by Deep Sequencing The Journal of Infectious Diseases. Feb, 2014 | Pubmed ID: 24141982 Molecular Epidemiology and Evolution of West Nile Virus in North America International Journal of Environmental Research and Public Health. Oct, 2013 | Pubmed ID: 24135819 Phylogeography of Japanese Encephalitis Virus: Genotype is Associated with Climate PLoS Neglected Tropical Diseases. 2013 | Pubmed ID: 24009790 Continued Evolution of West Nile Virus, Houston, Texas, USA, 2002-2012 Emerging Infectious Diseases. 2013 | Pubmed ID: 23965756 A West Nile Virus NS4B-P38G Mutant Strain Induces Adaptive Immunity Via TLR7-MyD88-dependent and Independent Signaling Pathways Vaccine. Aug, 2013 | Pubmed ID: 23845800 Resurgence of West Nile Neurologic Disease in the United States in 2012: What Happened? What Needs to Be Done? Antiviral Research. Jul, 2013 | Pubmed ID: 23624155 Genetic Diversity of Japanese Encephalitis Virus Isolates Obtained from the Indonesian Archipelago Between 1974 and 1987 Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). Jul, 2013 | Pubmed ID: 23590316 Phylogeographic Reconstruction of African Yellow Fever Virus Isolates Indicates Recent Simultaneous Dispersal into East and West Africa PLoS Neglected Tropical Diseases. 2013 | Pubmed ID: 23516640 Vertebrate Attenuated West Nile Virus Mutants Have Differing Effects on Vector Competence in Culex Tarsalis Mosquitoes The Journal of General Virology. May, 2013 | Pubmed ID: 23303828 Dynamic Transmission of West Nile Virus Across the United States-Mexican Border Virology. Feb, 2013 | Pubmed ID: 23141421 Characterization of Epstein-Barr Virus Reactivation in a Modeled Spaceflight System Journal of Cellular Biochemistry. Mar, 2013 | Pubmed ID: 22991253 The Molecular Evolution of Lineage 2 West Nile Virus The Journal of General Virology. Nov, 2012 | Pubmed ID: 23136360 Editorial Commentary. Short-course Oral Corticosteroid Therapy is Not Effective in Early Dengue Infection Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Nov, 2012 | Pubmed ID: 22865873 Mutational Analysis of the West Nile Virus NS4B Protein Virology. Apr, 2012 | Pubmed ID: 22314017 Conservation of the DENV-2 Type-specific and DEN Complex-reactive Antigenic Sites Among DENV-2 Genotypes Virology. Jan, 2012 | Pubmed ID: 22153298 Alzheimers Disease: Review of Emerging Treatment Role for Intravenous Immunoglobulins Journal of Central Nervous System Disease. 2011 | Pubmed ID: 23861639 Reduced Avian Virulence and Viremia of West Nile Virus Isolates from Mexico and Texas The American Journal of Tropical Medicine and Hygiene. Oct, 2011 | Pubmed ID: 21976584 Multiple Amino Acid Changes at the First Glycosylation Motif in NS1 Protein of West Nile Virus Are Necessary for Complete Attenuation for Mouse Neuroinvasiveness Vaccine. Dec, 2011 | Pubmed ID: 21945257 Flavivirus-induced Antibody Cross-reactivity The Journal of General Virology. Dec, 2011 | Pubmed ID: 21900425 Envelope and Pre-membrane Protein Structural Amino Acid Mutations Mediate Diminished Avian Growth and Virulence of a Mexican West Nile Virus Isolate The Journal of General Virology. Dec, 2011 | Pubmed ID: 21865445 The Development of Dengue Vaccines. Introduction Vaccine. Sep, 2011 | Pubmed ID: 21708208 Evolution of New Genotype of West Nile Virus in North America Emerging Infectious Diseases. May, 2011 | Pubmed ID: 21529385 Phylogeography of West Nile Virus: from the Cradle of Evolution in Africa to Eurasia, Australia, and the Americas Journal of Virology. Mar, 2011 | Pubmed ID: 21159871 Genetic Characterization of Japanese Encephalitis Virus Genotype II Strains Isolated from 1951 to 1978 The Journal of General Virology. Mar, 2011 | Pubmed ID: 21123550 Mutations of an Antibody Binding Energy Hot Spot on Domain III of the Dengue 2 Envelope Glycoprotein Exploited for Neutralization Escape Virology. Nov, 2010 | Pubmed ID: 20832836 Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 20617142 Multiple Pathways to the Attenuation of West Nile Virus in South-east Texas in 2003 Virology. Sep, 2010 | Pubmed ID: 20580395 Role of BC Loop Residues in Structure, Function and Antigenicity of the West Nile Virus Envelope Protein Receptor-binding Domain III Virology. Jul, 2010 | Pubmed ID: 20447672 Characterization of a Dengue Type-specific Epitope on Dengue 3 Virus Envelope Protein Domain III The Journal of General Virology. Sep, 2010 | Pubmed ID: 20444995 Development and Characterization of Non-glycosylated E and NS1 Mutant Viruses As a Potential Candidate Vaccine for West Nile Virus Vaccine. Jan, 2010 | Pubmed ID: 19896447 Genetic Characterization of Early Isolates of Japanese Encephalitis Virus: Genotype II Has Been Circulating Since at Least 1951 The Journal of General Virology. Jan, 2010 | Pubmed ID: 19776238 Development Pathway for Biodefense Vaccines Vaccine. Nov, 2009 | Pubmed ID: 19837280 Introduction to This Supplement Vaccine. Nov, 2009 | Pubmed ID: 19837278 Structure of Yellow Fever Virus Envelope Protein Domain III Virology. Nov, 2009 | Pubmed ID: 19818466 Yellow Fever Vaccine - How Does It Work and Why Do Rare Cases of Serious Adverse Events Take Place? Current Opinion in Immunology. Jun, 2009 | Pubmed ID: 19520559 Characterization of Dengue Complex-reactive Epitopes on Dengue 3 Virus Envelope Protein Domain III Virology. Feb, 2009 | Pubmed ID: 19101005 NMR Assignments of the Sylvatic Dengue 1 Virus Envelope Protein Domain III Biomolecular NMR Assignments. Dec, 2008 | Pubmed ID: 19636893 Short Report: Comparison of Oral Infectious Dose of West Nile Virus Isolates Representing Three Distinct Genotypes in Culex Quinquefasciatus The American Journal of Tropical Medicine and Hygiene. Dec, 2008 | Pubmed ID: 19052310 Genetic Variation of St. Louis Encephalitis Virus The Journal of General Virology. Aug, 2008 | Pubmed ID: 18632961 The Enigma of Yellow Fever in East Africa Reviews in Medical Virology. Sep-Oct, 2008 | Pubmed ID: 18615782 International Laboratory Network for Yellow Fever Vaccine-associated Adverse Events Vaccine. Oct, 2008 | Pubmed ID: 18590790 Characterization of Dengue Virus Complex-specific Neutralizing Epitopes on Envelope Protein Domain III of Dengue 2 Virus Journal of Virology. Sep, 2008 | Pubmed ID: 18562544 Guidelines for Plaque-Reduction Neutralization Testing of Human Antibodies to Dengue Viruses Viral Immunology. Jun, 2008 | Pubmed ID: 18476771 Flavivirus DNA Vaccine with a Kick Nature Biotechnology. May, 2008 | Pubmed ID: 18464782 Long Range Communication in the Envelope Protein Domain III and Its Effect on the Resistance of West Nile Virus to Antibody-mediated Neutralization The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17986445 NMR Assignments of the Yellow Fever Virus Envelope Protein Domain III Biomolecular NMR Assignments. Jul, 2007 | Pubmed ID: 19636823 Characterization of an Antigenic Site That Contains a Dominant, Type-specific Neutralization Determinant on the Envelope Protein Domain III (ED3) of Dengue 2 Virus Virology. Sep, 2007 | Pubmed ID: 17719070 Complex Adenovirus-mediated Expression of West Nile Virus C, PreM, E, and NS1 Proteins Induces Both Humoral and Cellular Immune Responses Clinical and Vaccine Immunology : CVI. Sep, 2007 | Pubmed ID: 17634508 Out of Africa: a Molecular Perspective on the Introduction of Yellow Fever Virus into the Americas PLoS Pathogens. May, 2007 | Pubmed ID: 17511518 Scientific Consultation on Immunological Correlates of Protection Induced by Dengue Vaccines Report from a Meeting Held at the World Health Organization 17-18 November 2005 Vaccine. May, 2007 | Pubmed ID: 17428588 Solution Structure of the Envelope Protein Domain III of Dengue-4 Virus Virology. Jul, 2007 | Pubmed ID: 17395234 A Combination of Naturally Occurring Mutations in North American West Nile Virus Nonstructural Protein Genes and in the 3' Untranslated Region Alters Virus Phenotype Journal of Virology. Jun, 2007 | Pubmed ID: 17376926 17D Yellow Fever Vaccines: New Insights. A Report of a Workshop Held During the World Congress on Medicine and Health in the Tropics, Marseille, France, Monday 12 September 2005 Vaccine. Apr, 2007 | Pubmed ID: 17368349 Thioaptamer Decoy Targeting of AP-1 Proteins Influences Cytokine Expression and the Outcome of Arenavirus Infections The Journal of General Virology. Mar, 2007 | Pubmed ID: 17325372 Yellow Fever: a Disease That Has Yet to Be Conquered Annual Review of Entomology. 2007 | Pubmed ID: 16913829 Selection of Thioaptamers for Diagnostics and Therapeutics Annals of the New York Academy of Sciences. Oct, 2006 | Pubmed ID: 17145932 NMR Assignment of the Dengue 4 Virus Envelope Protein Domain III Journal of Biomolecular NMR. 2006 | Pubmed ID: 17131034 A Mutation in the Envelope Protein Fusion Loop Attenuates Mouse Neuroinvasiveness of the NY99 Strain of West Nile Virus Virology. Sep, 2006 | Pubmed ID: 16806383 Structure of the Envelope Protein Domain III of Omsk Hemorrhagic Fever Virus Virology. Jul, 2006 | Pubmed ID: 16647096 A Single Amino Acid Substitution in the Central Portion of the West Nile Virus NS4B Protein Confers a Highly Attenuated Phenotype in Mice Virology. Jun, 2006 | Pubmed ID: 16624366 Genome Analysis and Phylogenetic Relationships Between East, Central and West African Isolates of Yellow Fever Virus The Journal of General Virology. Apr, 2006 | Pubmed ID: 16528039 Introductions of West Nile Virus Strains to Mexico Emerging Infectious Diseases. Feb, 2006 | Pubmed ID: 16494762 Characterization of a Viscerotropic Yellow Fever Vaccine Variant from a Patient in Brazil Vaccine. Apr, 2006 | Pubmed ID: 16464518 West Nile Virus Isolation in Human and Mosquitoes, Mexico Emerging Infectious Diseases. Sep, 2005 | Pubmed ID: 16229779 Phylogenetic Analysis of North American West Nile Virus Isolates, 2001-2004: Evidence for the Emergence of a Dominant Genotype Virology. Nov, 2005 | Pubmed ID: 16137736 Envelope Protein Glycosylation Status Influences Mouse Neuroinvasion Phenotype of Genetic Lineage 1 West Nile Virus Strains Journal of Virology. Jul, 2005 | Pubmed ID: 15956579 Phenotypic and Molecular Characterization of a Non-lethal, Hamster-viscerotropic Strain of Yellow Fever Virus Virus Research. Jun, 2005 | Pubmed ID: 15845256 Differential Expression of Domain III Neutralizing Epitopes on the Envelope Proteins of West Nile Virus Strains Virology. Apr, 2005 | Pubmed ID: 15823609 Recombination and Flavivirus Vaccines: a Commentary Vaccine. Apr, 2005 | Pubmed ID: 15811640 Size Heterogeneity in the 3' Noncoding Region of South American Isolates of Yellow Fever Virus Journal of Virology. Mar, 2005 | Pubmed ID: 15731274 An Animal Model for the Tickborne Flavivirus--Omsk Hemorrhagic Fever Virus The Journal of Infectious Diseases. Jan, 2005 | Pubmed ID: 15593010 Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico Emerging Infectious Diseases. Dec, 2004 | Pubmed ID: 15663867 Characterization of a West Nile Virus Isolate from a Human on the Gulf Coast of Texas Journal of Clinical Microbiology. Nov, 2004 | Pubmed ID: 15528747 Emergence of Attenuated West Nile Virus Variants in Texas, 2003 Virology. Dec, 2004 | Pubmed ID: 15527859 Yellow Fever Virus Infectivity for Bolivian Aedes Aegypti Mosquitoes Emerging Infectious Diseases. Sep, 2004 | Pubmed ID: 15498171 Genetic Divergence and Dispersal of Yellow Fever Virus, Brazil Emerging Infectious Diseases. Sep, 2004 | Pubmed ID: 15498159 Transmission Cycles, Host Range, Evolution and Emergence of Arboviral Disease Nature Reviews. Microbiology. Oct, 2004 | Pubmed ID: 15378043 Use of Recombinant E Protein Domain III-based Enzyme-linked Immunosorbent Assays for Differentiation of Tick-borne Encephalitis Serocomplex Flaviviruses from Mosquito-borne Flaviviruses Journal of Clinical Microbiology. Sep, 2004 | Pubmed ID: 15364996 West Nile Virus: Where Are We Now? The Lancet. Infectious Diseases. Sep, 2004 | Pubmed ID: 15336221 Genetic Relationships and Evolution of Genotypes of Yellow Fever Virus and Other Members of the Yellow Fever Virus Group Within the Flavivirus Genus Based on the 3' Noncoding Region Journal of Virology. Sep, 2004 | Pubmed ID: 15331698 Protection Against Japanese Encephalitis Virus Strains Representing Four Genotypes by Passive Transfer of Sera Raised Against ChimeriVax-JE Experimental Vaccine Vaccine. Sep, 2004 | Pubmed ID: 15315852 Current Status of the Arilvax; Yellow Fever Vaccine Expert Review of Vaccines. Aug, 2004 | Pubmed ID: 15270646 Solution Structure and Structural Dynamics of Envelope Protein Domain III of Mosquito- and Tick-borne Flaviviruses Biochemistry. Jul, 2004 | Pubmed ID: 15248774 1H, 13C and 15N Resonance Assignments for Domain III of the West Nile Virus Envelope Protein Journal of Biomolecular NMR. Jul, 2004 | Pubmed ID: 15213461 Solution Structure and Antibody Binding Studies of the Envelope Protein Domain III from the New York Strain of West Nile Virus The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15190071 Use of a Recombinant Envelope Protein Subunit Antigen for Specific Serological Diagnosis of West Nile Virus Infection Journal of Clinical Microbiology. Jun, 2004 | Pubmed ID: 15184463 Molecular Determinants of Antigenicity of Two Subtypes of the Tick-borne Flavivirus Omsk Haemorrhagic Fever Virus The Journal of General Virology. Jun, 2004 | Pubmed ID: 15166446 Experimental Infection of Rhesus Macaques with West Nile Virus: Level and Duration of Viremia and Kinetics of the Antibody Response After Infection The Journal of Infectious Diseases. Feb, 2004 | Pubmed ID: 14767821 West Nile Virus in Mexico: Evidence of Widespread Circulation Since July 2002 Emerging Infectious Diseases. Dec, 2003 | Pubmed ID: 14720402 Genetic Variation Among Temporally and Geographically Distinct West Nile Virus Isolates, United States, 2001, 2002 Emerging Infectious Diseases. Nov, 2003 | Pubmed ID: 14718086 Comparative Phylogenies of Yellow Fever Isolates from Peru and Brazil FEMS Immunology and Medical Microbiology. Nov, 2003 | Pubmed ID: 14625093 Analysis of the Complete Genome of the Tick-borne Flavivirus Omsk Hemorrhagic Fever Virus Virology. Aug, 2003 | Pubmed ID: 12951023 Crystallization and Preliminary X-ray Diffraction Analysis of Langat Virus Envelope Protein Domain III Acta Crystallographica. Section D, Biological Crystallography. Jun, 2003 | Pubmed ID: 12777770 Natural and Nosocomial Infection in a Patient with West Nile Encephalitis and Extrapyramidal Movement Disorders Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jun, 2003 | Pubmed ID: 12766856 Limited Evolution of West Nile Virus Has Occurred During Its Southwesterly Spread in the United States Virology. May, 2003 | Pubmed ID: 12758166 Origin and Evolution of Japanese Encephalitis Virus in Southeast Asia Journal of Virology. Mar, 2003 | Pubmed ID: 12584335 Molecular Characterization of a Hamster Viscerotropic Strain of Yellow Fever Virus Journal of Virology. Jan, 2003 | Pubmed ID: 12502861 The Epidemiology of Yellow Fever in Africa Microbes and Infection / Institut Pasteur. Nov, 2002 | Pubmed ID: 12475636 Identification of Neutralizing Epitopes Within Structural Domain III of the West Nile Virus Envelope Protein Journal of Virology. Dec, 2002 | Pubmed ID: 12438639 Arilvax (PowderJect) Current Opinion in Investigational Drugs (London, England : 2000). Jul, 2002 | Pubmed ID: 12186277 Mouse Neuroinvasive Phenotype of West Nile Virus Strains Varies Depending Upon Virus Genotype Virology. Apr, 2002 | Pubmed ID: 12036314 In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection Guorui Xie1, Melissa C. Whiteman2, Jason A. Wicker2, Alan D.T. Barrett1,2,3, Tian Wang1,2,3 1Department of Microbiology & Immunology, The University of Texas Medical Branch, 2Department of Pathology, The University of Texas Medical Branch, 3Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, The University of Texas Medical Branch JoVE 52121 Immunology and Infection
In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection Guorui Xie1, Melissa C. Whiteman2, Jason A. Wicker2, Alan D.T. Barrett1,2,3, Tian Wang1,2,3 1Department of Microbiology & Immunology, The University of Texas Medical Branch, 2Department of Pathology, The University of Texas Medical Branch, 3Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, The University of Texas Medical Branch JoVE 52121 Immunology and Infection
