Alfred E. Chang Department of Surgery University of Michigan Biography Publications Institution JoVE Articles Alfred E. Chang has not added a biography. If you are Alfred E. Chang and would like to personalize this page please email our Author Liaison for assistance. Publications OK-432 Synergizes with IFN-γ to Confer Dendritic Cells with Enhanced Antitumor Immunity Immunology and Cell Biology. Dec, 2013 | Pubmed ID: 24296809 Cancer Immunotherapy: Current Status and Future Directions Surgical Oncology Clinics of North America. Oct, 2013 | Pubmed ID: 24012398 IL-17A Promotes Immune Cell Recruitment in Human Esophageal Cancers and the Infiltrating Dendritic Cells Represent a Positive Prognostic Marker for Patient Survival Journal of Immunotherapy (Hagerstown, Md. : 1997). Oct, 2013 | Pubmed ID: 23994890 Cytokine-induced Killer (CIK) Cells Bound with Anti-CD3/anti-CD133 Bispecific Antibodies Target CD133(high) Cancer Stem Cells in Vitro and in Vivo Clinical Immunology (Orlando, Fla.). Oct, 2013 | Pubmed ID: 23994769 Effects of Tumor Irradiation on Host T-regulatory Cells and Systemic Immunity in the Context of Adoptive T-cell Therapy in Mice Journal of Immunotherapy (Hagerstown, Md. : 1997). Feb, 2013 | Pubmed ID: 23377667 Targeting Cancer Stem Cells Via Dendritic-cell Vaccination Oncoimmunology. Nov, 2012 | Pubmed ID: 23243607 Interleukin-6 Inhibits Regulatory T Cells and Improves the Proliferation and Cytotoxic Activity of Cytokine-induced Killer Cells Journal of Immunotherapy (Hagerstown, Md. : 1997). May, 2012 | Pubmed ID: 22495391 Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity Cancer Research. Apr, 2012 | Pubmed ID: 22473314 Characterization of Bridging Integrator 1 (BIN1) As a Potential Tumor Suppressor and Prognostic Marker in Hepatocellular Carcinoma Molecular Medicine (Cambridge, Mass.). 2012 | Pubmed ID: 22281836 Is Duct Excision Still Necessary for All Cases of Suspicious Nipple Discharge? The Breast Journal. Mar-Apr, 2012 | Pubmed ID: 22211878 B Lymphocytes As Effector Cells in the Immunotherapy of Cancer Journal of Surgical Oncology. Mar, 2012 | Pubmed ID: 21898417 Is a Level III Dissection Necessary for a Positive Sentinel Lymph Node in Melanoma? Journal of Surgical Oncology. Mar, 2012 | Pubmed ID: 21882199 Validation of Statistical Predictive Models Meant to Select Melanoma Patients for Sentinel Lymph Node Biopsy Annals of Surgical Oncology. Jan, 2012 | Pubmed ID: 21822550 Defining the Critical Hurdles in Cancer Immunotherapy Journal of Translational Medicine. 2011 | Pubmed ID: 22168571 Long-term Cultured Human Neural Stem Cells Undergo Spontaneous Transformation to Tumor-initiating Cells International Journal of Biological Sciences. 2011 | Pubmed ID: 21814484 Adoptive Transfer of Tumor Reactive B Cells Confers Host T-cell Immunity and Tumor Regression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011 | Pubmed ID: 21690573 Surgical Options for Localized and Advanced Gastrointestinal Stromal Tumors Journal of Surgical Oncology. Dec, 2011 | Pubmed ID: 21381037 Intratumoral Expression of IL-17 and Its Prognostic Role in Gastric Adenocarcinoma Patients International Journal of Biological Sciences. 2011 | Pubmed ID: 21234303 From the Guest Editors: Introduction to Local Therapies in the Treatment of Liver Cancer Cancer Journal (Sudbury, Mass.). Mar-Apr, 2010 | Pubmed ID: 20404604 Rate of Freeze Alters the Immunologic Response After Cryoablation of Breast Cancer Annals of Surgical Oncology. Apr, 2010 | Pubmed ID: 20033323 Intratumoral Delivery of Encapsulated IL-12, IL-18 and TNF-alpha in a Model of Metastatic Breast Cancer Breast Cancer Research and Treatment. Jul, 2010 | Pubmed ID: 19802695 Is There a Benefit to Sentinel Lymph Node Biopsy in Patients with T4 Melanoma? Cancer. Dec, 2009 | Pubmed ID: 19827151 Prognostic Significance of a Positive Nonsentinel Lymph Node in Cutaneous Melanoma Annals of Surgical Oncology. Nov, 2009 | Pubmed ID: 19711133 In Vivo Sensitized and in Vitro Activated B Cells Mediate Tumor Regression in Cancer Adoptive Immunotherapy Journal of Immunology (Baltimore, Md. : 1950). Sep, 2009 | Pubmed ID: 19667089 Radiotherapy Combined with Intratumoral Dendritic Cell Vaccination Enhances the Therapeutic Efficacy of Adoptive T-cell Transfer Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2009 | Pubmed ID: 19483649 Gemcitabine-based Combination Chemotherapy Followed by Radiation with Capecitabine As Adjuvant Therapy for Resected Pancreas Cancer International Journal of Radiation Oncology, Biology, Physics. Dec, 2009 | Pubmed ID: 19409732 Antitumor Activity of T Cells Generated from Lymph Nodes Draining the SEA-expressing Murine B16 Melanoma and Secondarily Activated with Dendritic Cells International Journal of Biological Sciences. 2009 | Pubmed ID: 19173035 Determinants of Breast Conservation Rates: Reasons for Mastectomy at a Comprehensive Cancer Center The Breast Journal. Jan-Feb, 2009 | Pubmed ID: 19141132 Residual Disease After Re-excision Lumpectomy for Close Margins Journal of Surgical Oncology. Feb, 2009 | Pubmed ID: 19065638 Dendritic Cells Pulsed with Keyhole Limpet Hemocyanin and Cryopreserved Maintain Anti-tumor Activity in a Murine Melanoma Model Clinical Immunology (Orlando, Fla.). Dec, 2008 | Pubmed ID: 18845485 Intratumoral Dendritic Cells and Chemoradiation for the Treatment of Murine Squamous Cell Carcinoma Journal of Immunotherapy (Hagerstown, Md. : 1997). Nov-Dec, 2008 | Pubmed ID: 18832999 Axillary Staging Prior to Neoadjuvant Chemotherapy for Breast Cancer: Predictors of Recurrence Annals of Surgical Oncology. Nov, 2008 | Pubmed ID: 18784961 Do Micromorphometric Features of Metastatic Deposits Within Sentinel Nodes Predict Nonsentinel Lymph Node Involvement in Melanoma? Annals of Surgical Oncology. Sep, 2008 | Pubmed ID: 18626721 Tumor-induced Immune Suppression of in Vivo Effector T-cell Priming is Mediated by the B7-H1/PD-1 Axis and Transforming Growth Factor Beta Cancer Research. Jul, 2008 | Pubmed ID: 18593946 Phase Ib Trial Assessing Autologous, Tumor-pulsed Dendritic Cells As a Vaccine Administered with or Without IL-2 in Patients with Metastatic Melanoma Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2008 | Pubmed ID: 18528294 Interleukin-21 Augments the Efficacy of T-cell Therapy by Eliciting Concurrent Cellular and Humoral Responses Cancer Research. Jun, 2008 | Pubmed ID: 18519706 Mechanisms Involved in Radiation Enhancement of Intratumoral Dendritic Cell Therapy Journal of Immunotherapy (Hagerstown, Md. : 1997). May, 2008 | Pubmed ID: 18391761 Adjuvant Effect of Anti-4-1BB MAb Administration in Adoptive T Cell Therapy of Cancer International Journal of Biological Sciences. 2007 | Pubmed ID: 18071585 Generation of a Tumor-specific Systemic Response After Intratumoral Injection of IL-12 and IL-18-loaded Polylactic Acid Microspheres Journal of Immunotherapy (Hagerstown, Md. : 1997). Nov-Dec, 2007 | Pubmed ID: 18049332 Synergistic Effect of Intratumoral IL-12 and TNF-alpha Microspheres: Systemic Anti-tumor Immunity is Mediated by Both CD8+ CTL and NK Cells Surgery. Nov, 2007 | Pubmed ID: 17981196 The Registry Case Finding Engine: an Automated Tool to Identify Cancer Cases from Unstructured, Free-text Pathology Reports and Clinical Notes Journal of the American College of Surgeons. Nov, 2007 | Pubmed ID: 17964445 Phase I Study of Oxaliplatin, Full-dose Gemcitabine, and Concurrent Radiation Therapy in Pancreatic Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2007 | Pubmed ID: 17925553 CCL19 and CXCL13 Synergistically Regulate Interaction Between B Cell Acute Lymphocytic Leukemia CD23+CD5+ B Cells and CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Sep, 2007 | Pubmed ID: 17709502 Sentinel Lymph Node Biopsy for Breast Cancer: How Many Nodes Are Enough? Journal of Surgical Oncology. Dec, 2007 | Pubmed ID: 17685432 Inguinal Node Dissection for Melanoma in the Era of Sentinel Lymph Node Biopsy Surgery. Jun, 2007 | Pubmed ID: 17560249 Sentinel Lymph Node Biopsy Performed After Neoadjuvant Chemotherapy is Accurate in Patients with Documented Node-positive Breast Cancer at Presentation Annals of Surgical Oncology. Oct, 2007 | Pubmed ID: 17514407 4-1BB Costimulation of Effector T Cells for Adoptive Immunotherapy of Cancer: Involvement of Bcl Gene Family Members Journal of Immunotherapy (Hagerstown, Md. : 1997). May-Jun, 2007 | Pubmed ID: 17457215 Radiation-induced Apoptosis Along with Local and Systemic Cytokine Elaboration is Associated with DC Plus Radiotherapy-mediated Renal Cell Tumor Regression Clinical Immunology (Orlando, Fla.). Jun, 2007 | Pubmed ID: 17449328 What is a Sentinel Node? Re-evaluating the 10% Rule for Sentinel Lymph Node Biopsy in Melanoma Journal of Surgical Oncology. Jun, 2007 | Pubmed ID: 17345610 Improving Surgical Outcomes for Cancer in the United States Journal of Surgical Oncology. Feb, 2007 | Pubmed ID: 17262738 The Impact of Factors Beyond Breslow Depth on Predicting Sentinel Lymph Node Positivity in Melanoma Cancer. Jan, 2007 | Pubmed ID: 17146784 CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23+CD5+ B Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2006 | Pubmed ID: 17082584 Changes in Surgical Management Resulting from Case Review at a Breast Cancer Multidisciplinary Tumor Board Cancer. Nov, 2006 | Pubmed ID: 16998942 Adoptive Immunotherapy of Breast Cancer with Lymph Node Cells Primed by Cryoablation of the Primary Tumor Cryobiology. Dec, 2006 | Pubmed ID: 16973145 Neoadjuvant Intratumoral Cytokine-loaded Microspheres Are Superior to Postoperative Autologous Cellular Vaccines in Generating Systemic Anti-tumor Immunity Journal of Surgical Oncology. Oct, 2006 | Pubmed ID: 16967445 Significance of Multiple Lymphatic Basin Drainage in Truncal Melanoma Patients Undergoing Sentinel Lymph Node Biopsy Annals of Surgical Oncology. Sep, 2006 | Pubmed ID: 16952026 Ex Vivo Culture with Interleukin (IL)-12 Improves CD8(+) T-cell Adoptive Immunotherapy for Murine Leukemia Independent of IL-18 or IFN-gamma but Requires Perforin Cancer Research. May, 2006 | Pubmed ID: 16651448 Does the Method of Biopsy Affect the Incidence of Sentinel Lymph Node Metastases? The Breast Journal. Jan-Feb, 2006 | Pubmed ID: 16409587 Clinicopathologic Features Associated with Having Four or More Metastatic Axillary Nodes in Breast Cancer Patients with a Positive Sentinel Lymph Node Annals of Surgical Oncology. Jan, 2006 | Pubmed ID: 16378156 Lymphatic Mapping and Sentinel Lymph Node Biopsy for Patients with Local Recurrence After Breast-conservation Therapy Annals of Surgical Oncology. Jan, 2006 | Pubmed ID: 16372155 Wide Excision Without Radiation for Desmoplastic Melanoma Cancer. Oct, 2005 | Pubmed ID: 16080180 Comprehensive Axillary Evaluation in Neoadjuvant Chemotherapy Patients with Ultrasonography and Sentinel Lymph Node Biopsy Annals of Surgical Oncology. Sep, 2005 | Pubmed ID: 16079956 Is Blue Dye Indicated for Sentinel Lymph Node Biopsy in Breast Cancer Patients with a Positive Lymphoscintigram? Annals of Surgical Oncology. Sep, 2005 | Pubmed ID: 16079955 Simultaneous Targeting of CD3 on T Cells and CD40 on B or Dendritic Cells Augments the Antitumor Reactivity of Tumor-primed Lymph Node Cells Journal of Immunology (Baltimore, Md. : 1950). Aug, 2005 | Pubmed ID: 16034078 Capecitabine and Radiation Therapy Preceded and Followed by Combination Chemotherapy in Advanced Pancreatic Cancer International Journal of Radiation Oncology, Biology, Physics. Dec, 2005 | Pubmed ID: 15993549 Predictors of Nonsentinel Lymph Node Positivity in Patients with a Positive Sentinel Node for Melanoma Journal of the American College of Surgeons. Jul, 2005 | Pubmed ID: 15978442 Immunologic Response to Cryoablation of Breast Cancer Breast Cancer Research and Treatment. Mar, 2005 | Pubmed ID: 15770533 Synergistic Effects of IL-12 and IL-18 in Skewing Tumor-reactive T-cell Responses Towards a Type 1 Pattern Cancer Research. Feb, 2005 | Pubmed ID: 15705908 Anti-CD137 Monoclonal Antibody Administration Augments the Antitumor Efficacy of Dendritic Cell-based Vaccines Cancer Research. Nov, 2004 | Pubmed ID: 15548712 An Academic Health Center Cost Analysis of Screening Mammography: Creating a Financially Viable Service Cancer. Sep, 2004 | Pubmed ID: 15329914 Mastectomy and Concomitant Sentinel Lymph Node Biopsy for Invasive Breast Cancer American Journal of Surgery. Jun, 2004 | Pubmed ID: 15191855 Efficacy of Sentinel Lymph Node Biopsy in Male Breast Cancer Journal of Surgical Oncology. May, 2004 | Pubmed ID: 15112248 Donor Cell Cycling, Trafficking, and Accumulation During Adoptive Immunotherapy for Murine Lung Metastases Cancer Research. Mar, 2004 | Pubmed ID: 15026361 Mitotic Rate and Younger Age Are Predictors of Sentinel Lymph Node Positivity: Lessons Learned from the Generation of a Probabilistic Model Annals of Surgical Oncology. Mar, 2004 | Pubmed ID: 14993019 Exaggerated Pigmented Granulomatous Reaction to the Artificial Joint Implant Mimics Metastatic Melanoma Diagnostic Cytopathology. Mar, 2004 | Pubmed ID: 14986302 Intratumoral IL-12 and TNF-alpha-loaded Microspheres Lead to Regression of Breast Cancer and Systemic Antitumor Immunity Annals of Surgical Oncology. Feb, 2004 | Pubmed ID: 14761917 Radiotherapy Potentiates the Therapeutic Efficacy of Intratumoral Dendritic Cell Administration Cancer Research. Dec, 2003 | Pubmed ID: 14679011 Clinicopathologic Features of Metastasis in Nonsentinel Lymph Nodes of Breast Carcinoma Patients Cancer. Dec, 2003 | Pubmed ID: 14635063 Sentinel Node Biopsy Prior to Neoadjuvant Chemotherapy American Journal of Surgery. Aug, 2003 | Pubmed ID: 12885598 Antitumor Reactivity of Anti-CD3/anti-CD28 Bead-activated Lymphoid Cells: Implications for Cell Therapy in a Murine Model Journal of Immunotherapy (Hagerstown, Md. : 1997). May-Jun, 2003 | Pubmed ID: 12806276 Polarization Effects of 4-1BB During CD28 Costimulation in Generating Tumor-reactive T Cells for Cancer Immunotherapy Cancer Research. May, 2003 | Pubmed ID: 12750278 Phase II Trial of Autologous Tumor Vaccination, Anti-CD3-activated Vaccine-primed Lymphocytes, and Interleukin-2 in Stage IV Renal Cell Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2003 | Pubmed ID: 12610189 Generation of Vaccine-primed Lymphocytes for the Treatment of Head and Neck Cancer Head & Neck. Mar, 2003 | Pubmed ID: 12599287 Comparison of Attenuation-corrected and Non-corrected FDG-PET Images for Axillary Nodal Staging in Newly Diagnosed Breast Cancer Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Mar, 2002 | Pubmed ID: 14537139 Applications of Gene Transfer to Cellular Immunotherapy Surgical Oncology Clinics of North America. Jul, 2002 | Pubmed ID: 12487059 Melanoma and Human Leukocyte Antigen Status: the Missing Link? Annals of Surgical Oncology. Oct, 2002 | Pubmed ID: 12374654 Hepatic Artery Chemotherapy for Colorectal Liver Metastases: Technical Considerations and Review of Clinical Trials Surgical Oncology. Nov, 2002 | Pubmed ID: 12356508 Therapeutic Effects of Tumor Reactive CD4+ Cells Generated from Tumor-primed Lymph Nodes Using Anti-CD3/anti-CD28 Monoclonal Antibodies Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2002 | Pubmed ID: 12142553 Mammographic Screening of TRAM Flap Breast Reconstructions for Detection of Nonpalpable Recurrent Cancer Radiology. Jul, 2002 | Pubmed ID: 12091685 Resection of Liver Tumors: Technical Aspects Surgical Oncology. May, 2002 | Pubmed ID: 12020669 A Phase I Trial of Tumor Lysate-pulsed Dendritic Cells in the Treatment of Advanced Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2002 | Pubmed ID: 11948109 Поколение новой дендритно-клеточной вакцины с использованием меланомы и плоскоклеточных раковых стволовых клеток Qiao Li1, Lin Lu1, Huimin Tao1, Carolyn Xue1, Seagal Teitz-Tennenbaum2, John H. Owen3, Jeffrey S Moyer3, Mark E.P. Prince3, Alfred E. Chang1, Max S. Wicha2 1Department of Surgery, University of Michigan, 2Department of Internal Medicine, University of Michigan, 3Department of Otolaryngology, University of Michigan JoVE 50561 Immunology and Infection
Поколение новой дендритно-клеточной вакцины с использованием меланомы и плоскоклеточных раковых стволовых клеток Qiao Li1, Lin Lu1, Huimin Tao1, Carolyn Xue1, Seagal Teitz-Tennenbaum2, John H. Owen3, Jeffrey S Moyer3, Mark E.P. Prince3, Alfred E. Chang1, Max S. Wicha2 1Department of Surgery, University of Michigan, 2Department of Internal Medicine, University of Michigan, 3Department of Otolaryngology, University of Michigan JoVE 50561 Immunology and Infection
