Articles by Andreas Guber in JoVE

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

JoVE 699 5/12/2008

Stefan Giselbrecht¹, Eric Gottwald¹, Roman Truckenmueller², Christina Trautmann³, Alexander Welle¹, Andreas Guber⁴, Volker Saile⁴, Thomas Gietzelt⁵, Karl-Friedrich Weibezahn¹

¹Institute for Biological Interfaces, Karlsruhe Research Centre, ²Institute for BioMedical Technology, University of Twente, ³Department of Materials Research, Institute for Heavy Ion Research, ⁴Institute of Microstructure Technology, Karlsruhe Research Centre, ⁵Institute for Micro Process Engineering, Karlsruhe Research Centre

We present two processes for the microfabrication of porous polymer chips for three-dimensional cell cultivation. The first one is hot embossing combined with a solvent vapour welding process. The second one uses a recently developed microthermoforming process combined with ion track technology leading to a significant simplification of manufacture.