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In JoVE (1)
Other Publications (1)
Articles by Andrew Pistner in JoVE
Murine Echocardiography and Ultrasound Imaging
Andrew Pistner1, Stephen Belmonte2, Tonya Coulthard3, Burns C. Blaxall2,4
1Department of Pharmacology and Physiology, University of Rochester, 2Aab Cardiovascular Research Institute, University of Rochester, 3Visualsonics, 4Department of Medicine, University of Rochester
This video demonstrates use of a rail-mounted high-frequency ultrasound probe to perform echocardiography on an anesthetized mouse. The methods describe both conventional two-dimensional and M-mode measurements of cardiac function in addition to newer, more powerful tools such as color Doppler, strain analysis, as well as general and targeted contrast imaging.
Other articles by Andrew Pistner on PubMed
Circulation Research. Aug, 2010 | Pubmed ID: 20576935
Excess signaling through cardiac Gbetagamma subunits is an important component of heart failure (HF) pathophysiology. They recruit elevated levels of cytosolic G protein-coupled receptor kinase (GRK)2 to agonist-stimulated beta-adrenergic receptors (beta-ARs) in HF, leading to chronic beta-AR desensitization and downregulation; these events are all hallmarks of HF. Previous data suggested that inhibiting Gbetagamma signaling and its interaction with GRK2 could be of therapeutic value in HF.