Articles by Angela C. deAlmeida in JoVE

Transverse Aortic Constriction in Mice

JoVE 1729 4/21/2010

Angela C. deAlmeida¹, Ralph J. van Oort¹, Xander H.T. Wehrens^1,2

¹Department of Molecular Physiology and Biophysics, Baylor College of Medicine (BCM), ²The Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine (BCM)

Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model to study mechanisms underlying cardiac hypertrophy and heart failure development. Here, we describe procedures to constrict the aorta to create a reproducible degree of cardiac hypertrophy in mice.