Antonis E. Koromilas Lady Davis Institute for Medical Research Sir Mortimer B. Davis-Jewish General Hospital Biography Publications Institution JoVE Articles Antonis E. Koromilas has not added a biography. If you are Antonis E. Koromilas and would like to personalize this page please email our Author Liaison for assistance. Publications An Integrated Stress Response Via PKR Suppresses HER2+ Cancers and Improves Trastuzumab Therapy Nature Communications. 05, 2019 | Pubmed ID: 31086176 M(en)TORship Lessons on Life and Death by the Integrated Stress Response Biochimica Et Biophysica Acta. General Subjects. 03, 2019 | Pubmed ID: 30572003 Downregulation of PERK Activity and EIF2α Serine 51 Phosphorylation by MTOR Complex 1 Elicits Pro-oxidant and Pro-death Effects in Tuberous Sclerosis-deficient Cells Cell Death & Disease. Feb, 2018 | Pubmed ID: 29449538 Regulation of ULK1 Expression and Autophagy by STAT1 The Journal of Biological Chemistry. 02, 2017 | Pubmed ID: 28011640 STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor EIF4A Molecular Cancer Therapeutics. 12, 2016 | Pubmed ID: 27913706 Increased Phosphorylation of EIF2α in Chronic Myeloid Leukemia Cells Stimulates Secretion of Matrix Modifying Enzymes Oncotarget. Nov, 2016 | Pubmed ID: 27802179 The EIF2α Serine 51 Phosphorylation-ATF4 Arm Promotes HIPPO Signaling and Cell Death Under Oxidative Stress Oncotarget. 08, 2016 | Pubmed ID: 27409837 STAT1-mediated Translational Control in Tumor Suppression and Antitumor Therapies Molecular & Cellular Oncology. May, 2016 | Pubmed ID: 27314074 MTORC2 Balances AKT Activation and EIF2α Serine 51 Phosphorylation to Promote Survival Under Stress Molecular Cancer Research : MCR. Oct, 2015 | Pubmed ID: 26130148 Stat1 Stimulates Cap-independent MRNA Translation to Inhibit Cell Proliferation and Promote Survival in Response to Antitumor Drugs Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25870277 Roles of the Translation Initiation Factor EIF2α Serine 51 Phosphorylation in Cancer Formation and Treatment Biochimica Et Biophysica Acta. Jul, 2015 | Pubmed ID: 25497381 Translational Control During Endoplasmic Reticulum Stress Beyond Phosphorylation of the Translation Initiation Factor EIF2α The Journal of Biological Chemistry. May, 2014 | Pubmed ID: 24648524 Evidence for EIF2α Phosphorylation-independent Effects of GSK2656157, a Novel Catalytic Inhibitor of PERK with Clinical Implications Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 24401334 EIF2α Phosphorylation Bypasses Premature Senescence Caused by Oxidative Stress and Pro-oxidant Antitumor Therapies Aging. Dec, 2013 | Pubmed ID: 24334569 The Tumor Suppressor Function of STAT1 in Breast Cancer JAK-STAT. Apr, 2013 | Pubmed ID: 24058806 The PERK-eIF2α Phosphorylation Arm is a Pro-survival Pathway of BCR-ABL Signaling and Confers Resistance to Imatinib Treatment in Chronic Myeloid Leukemia Cells Cell Cycle (Georgetown, Tex.). Nov, 2012 | Pubmed ID: 23095523 Alternative Ferritin MRNA Translation Via Internal Initiation RNA (New York, N.Y.). Mar, 2012 | Pubmed ID: 22271759 Akt 确定通过公园 EIF2α 磷酸化途径抑制细胞命运。 Science Signaling. Sep, 2011 | Pubmed ID: 21954288 Negative Regulation of MTORC2 by Glycogen Synthase Kinase-3β: an Adaptive Process to Stress with an Anticancer Therapeutic Potential? Future Oncology (London, England). Jul, 2011 | Pubmed ID: 21732756 Development of Transgenic Mice Expressing a Conditionally Active Form of the EIF2α Kinase PKR Genesis (New York, N.Y. : 2000). Sep, 2011 | Pubmed ID: 21438126 Stat1 是 ErbB2 纽介导细胞转化和鼠标乳腺肿瘤形成的抑制。 Cell Cycle (Georgetown, Tex.). Mar, 2011 | Pubmed ID: 21311224 HDAC Pharmacological Inhibition Promotes Cell Death Through the EIF2α Kinases PKR and GCN2 Aging. Oct, 2010 | Pubmed ID: 21076179 EIF2{alpha} Kinase PKR Modulates the Hypoxic Response by Stat3-dependent Transcriptional Suppression of HIF-1{alpha} Cancer Research. Oct, 2010 | Pubmed ID: 20924113 Phosphorylation of EIF2α at Serine 51 is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency Molecular Biology of the Cell. Sep, 2010 | Pubmed ID: 20660158 STAT1 压抑 Skp2 基因转录,以促进在 Ras 转化细胞中的 P27Kip1 稳定。 Molecular Cancer Research : MCR. May, 2010 | Pubmed ID: 20407011 Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2alpha Phosphorylation Pathway Science Signaling. Dec, 2009 | Pubmed ID: 20029030 PKR is Not a Universal Target of Tumor Suppressor P53 in Response to Genotoxic Stress Cell Cycle (Georgetown, Tex.). Nov, 2009 | Pubmed ID: 19838063 Stat1 磷酸化确定通过调节 P27 Kip1 Ras 致癌性。 PloS One. 2008 | Pubmed ID: 18941537 The EIF2alpha Kinases Inhibit Vesicular Stomatitis Virus Replication Independently of EIF2alpha Phosphorylation Cell Cycle (Georgetown, Tex.). Aug, 2008 | Pubmed ID: 18677106 Modulation of the Eukaryotic Initiation Factor 2 Alpha-subunit Kinase PERK by Tyrosine Phosphorylation The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17998206 The EIF2alpha Kinases PERK and PKR Activate Glycogen Synthase Kinase 3 to Promote the Proteasomal Degradation of P53 The Journal of Biological Chemistry. Oct, 2007 | Pubmed ID: 17785458 A Novel Function of EIF2alpha Kinases As Inducers of the Phosphoinositide-3 Kinase Signaling Pathway Molecular Biology of the Cell. Sep, 2007 | Pubmed ID: 17596516 Expression of the Subgenomic Hepatitis C Virus Replicon Alters Iron Homeostasis in Huh7 Cells Journal of Hepatology. Jul, 2007 | Pubmed ID: 17399844 Interferons Induce Tyrosine Phosphorylation of the EIF2alpha Kinase PKR Through Activation of Jak1 and Tyk2 EMBO Reports. Mar, 2007 | Pubmed ID: 17290288 Initiation of Protein Synthesis by Hepatitis C Virus is Refractory to Reduced EIF2.GTP.Met-tRNA(i)(Met) Ternary Complex Availability Molecular Biology of the Cell. Nov, 2006 | Pubmed ID: 16928960 The Catalytic Activity of the Eukaryotic Initiation Factor-2alpha Kinase PKR is Required to Negatively Regulate Stat1 and Stat3 Via Activation of the T-cell Protein-tyrosine Phosphatase The Journal of Biological Chemistry. Apr, 2006 | Pubmed ID: 16431927 Tyrosine Phosphorylation Acts As a Molecular Switch to Full-scale Activation of the EIF2alpha RNA-dependent Protein Kinase Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16373505 Endoplasmic Reticulum Stress Accelerates P53 Degradation by the Cooperative Actions of Hdm2 and Glycogen Synthase Kinase 3beta Molecular and Cellular Biology. Nov, 2005 | Pubmed ID: 16227590 Iron Inactivates the RNA Polymerase NS5B and Suppresses Subgenomic Replication of Hepatitis C Virus The Journal of Biological Chemistry. Mar, 2005 | Pubmed ID: 15637067 Control of Tumor Suppressor P53 Function by Endoplasmic Reticulum Stress Cell Cycle (Georgetown, Tex.). May, 2004 | Pubmed ID: 15107622 Control of Alpha Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2 Alpha) Phosphorylation by the Human Papillomavirus Type 18 E6 Oncoprotein: Implications for EIF2 Alpha-dependent Gene Expression and Cell Death Molecular and Cellular Biology. Apr, 2004 | Pubmed ID: 15060162 Endoplasmic Reticulum Stress Induces P53 Cytoplasmic Localization and Prevents P53-dependent Apoptosis by a Pathway Involving Glycogen Synthase Kinase-3beta Genes & Development. Feb, 2004 | Pubmed ID: 14744935 PKR-dependent Mechanisms of Gene Expression from a Subgenomic Hepatitis C Virus Clone Journal of Virology. Nov, 2002 | Pubmed ID: 12368306 Functional Characterization of Pkr Gene Products Expressed in Cells from Mice with a Targeted Deletion of the N Terminus or C Terminus Domain of PKR The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12161430 超声成像对小鼠肺肿瘤进展的检测 Nour Ghaddar1,2, Shuo Wang1, Véronique Michaud1, Urszula Kazimierczak1,3, Nicolas Ah-son1, Antonis E. Koromilas1,4 1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, 2Division of Experimental Medicine, Faculty of Medicine, McGill University, 3Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 4Gerald Bronfman Department of Oncology, Faculty of Medicine, McGill University JoVE 60565 Cancer Research
超声成像对小鼠肺肿瘤进展的检测 Nour Ghaddar1,2, Shuo Wang1, Véronique Michaud1, Urszula Kazimierczak1,3, Nicolas Ah-son1, Antonis E. Koromilas1,4 1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, 2Division of Experimental Medicine, Faculty of Medicine, McGill University, 3Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 4Gerald Bronfman Department of Oncology, Faculty of Medicine, McGill University JoVE 60565 Cancer Research