Arthur L. Horwich Department of Genetics Yale School of Medicine Biography Publications Institution JoVE Articles Arthur L. Horwich has not added a biography. If you are Arthur L. Horwich and would like to personalize this page please email our Author Liaison for assistance. Publications Chaperonin-mediated Protein Folding The Journal of Biological Chemistry. Aug, 2013 | Pubmed ID: 23803606 Molecular Chaperone Hsp110 Rescues a Vesicle Transport Defect Produced by an ALS-associated Mutant SOD1 Protein in Squid Axoplasm Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23509252 Recessive Loss of Function of the Neuronal Ubiquitin Hydrolase UCHL1 Leads to Early-onset Progressive Neurodegeneration Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013 | Pubmed ID: 23359680 RNA-Seq Profiling of Spinal Cord Motor Neurons from a Presymptomatic SOD1 ALS Mouse PloS One. 2013 | Pubmed ID: 23301088 Structure and Allostery of the Chaperonin GroEL Journal of Molecular Biology. May, 2013 | Pubmed ID: 23183375 ATP-triggered Conformational Changes Delineate Substrate-binding and -folding Mechanics of the GroEL Chaperonin Cell. Mar, 2012 | Pubmed ID: 22445172 QnAs with Arthur L. Horwich. Interview by Prashant Nair Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22308493 Protein Folding in the Cell: an Inside Story Nature Medicine. Oct, 2011 | Pubmed ID: 21989012 Translational Diffusion of Macromolecular Assemblies Measured Using Transverse-relaxation-optimized Pulsed Field Gradient NMR Journal of the American Chemical Society. Oct, 2011 | Pubmed ID: 21919531 Localization of GroEL Determined by in Vivo Incorporation of a Fluorescent Amino Acid Bioorganic & Medicinal Chemistry Letters. Oct, 2011 | Pubmed ID: 21890355 Hydrogen-deuterium Exchange in Vivo to Measure Turnover of an ALS-associated Mutant SOD1 Protein in Spinal Cord of Mice Protein Science : a Publication of the Protein Society. Oct, 2011 | Pubmed ID: 21780215 Nuclear Magnetic Resonance Spectroscopy with the Stringent Substrate Rhodanese Bound to the Single-ring Variant SR1 of the E. Coli Chaperonin GroEL Protein Science : a Publication of the Protein Society. Aug, 2011 | Pubmed ID: 21633984 Double Mutant MBP Refolds at Same Rate in Free Solution As Inside the GroEL/GroES Chaperonin Chamber when Aggregation in Free Solution is Prevented FEBS Letters. Jun, 2011 | Pubmed ID: 21609718 ATP-triggered ADP Release from the Asymmetric Chaperonin GroEL/GroES/ADP7 is Not the Rate-limiting Step of the GroEL/GroES Reaction Cycle FEBS Letters. Mar, 2010 | Pubmed ID: 20083109 GroEL/GroES Cycling: ATP Binds to an Open Ring Before Substrate Protein Favoring Protein Binding and Production of the Native State Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19915138 Chaperonin-mediated Protein Folding: Using a Central Cavity to Kinetically Assist Polypeptide Chain Folding Quarterly Reviews of Biophysics. May, 2009 | Pubmed ID: 19638247 The GroEL/GroES Cis Cavity As a Passive Anti-aggregation Device FEBS Letters. Aug, 2009 | Pubmed ID: 19577567 Progressive Aggregation Despite Chaperone Associations of a Mutant SOD1-YFP in Transgenic Mice That Develop ALS Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19171884 An ALS-linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction when Expressed in Neurons of Caenorhabditis Elegans PLoS Genetics. Jan, 2009 | Pubmed ID: 19165329 A Small Molecule Inhibitor Selective for a Variant ATP-binding Site of the Chaperonin GroEL Bioorganic & Medicinal Chemistry Letters. Feb, 2009 | Pubmed ID: 19110421 Requirement for Binding Multiple ATPs to Convert a GroEL Ring to the Folding-active State Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19050077 Chaperonin Chamber Accelerates Protein Folding Through Passive Action of Preventing Aggregation Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 18987317 Multiple States of a Nucleotide-bound Group 2 Chaperonin Structure (London, England : 1993). Apr, 2008 | Pubmed ID: 18400175 Folding Trajectories of Human Dihydrofolate Reductase Inside the GroEL GroES Chaperonin Cavity and Free in Solution Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18093916 Topologies of a Substrate Protein Bound to the Chaperonin GroEL Molecular Cell. May, 2007 | Pubmed ID: 17499047 Two Families of Chaperonin: Physiology and Mechanism Annual Review of Cell and Developmental Biology. 2007 | Pubmed ID: 17489689 Perturbed ATPase Activity and Not "close Confinement" of Substrate in the Cis Cavity Affects Rates of Folding by Tail-multiplied GroEL Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17372195 Disulfide Formation As a Probe of Folding in GroEL-GroES Reveals Correct Formation of Long-range Bonds and Editing of Incorrect Short-range Ones Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17283341 Global Aggregation of Newly Translated Proteins in an Escherichia Coli Strain Deficient of the Chaperonin GroEL Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17043235 Proton-proton Overhauser NMR Spectroscopy with Polypeptide Chains in Large Structures Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17032756 GroEL-GroES-mediated Protein Folding Chemical Reviews. May, 2006 | Pubmed ID: 16683761 Allosteric Signaling of ATP Hydrolysis in GroEL-GroES Complexes Nature Structural & Molecular Biology. Feb, 2006 | Pubmed ID: 16429154 Probing the Sequence of Conformationally Induced Polarity Changes in the Molecular Chaperonin GroEL with Fluorescence Spectroscopy The Journal of Physical Chemistry. B. Dec, 2005 | Pubmed ID: 16375456 Roles of the N-domains of the ClpA Unfoldase in Binding Substrate Proteins and in Stable Complex Formation with the ClpP Protease The Journal of Biological Chemistry. Dec, 2005 | Pubmed ID: 16207718 Direct NMR Observation of a Substrate Protein Bound to the Chaperonin GroEL Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16116078 Loops in the Central Channel of ClpA Chaperone Mediate Protein Binding, Unfolding, and Translocation Cell. Jul, 2005 | Pubmed ID: 15989953 No Evidence for a Forced-unfolding Mechanism During ATP/GroES Binding to Substrate-bound GroEL: No Observable Protection of Metastable Rubisco Intermediate or GroEL-bound Rubisco from Tritium Exchange FEBS Letters. Feb, 2005 | Pubmed ID: 15710410 Chaperoned Protein Disaggregation--the ClpB Ring Uses Its Central Channel Cell. Nov, 2004 | Pubmed ID: 15550237 Substrate Polypeptide Presents a Load on the Apical Domains of the Chaperonin GroEL Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15479763 A Mutant Chaperonin with Rearranged Inter-ring Electrostatic Contacts and Temperature-sensitive Dissociation Nature Structural & Molecular Biology. Nov, 2004 | Pubmed ID: 15475965 Exploring the Structural Dynamics of the E.coli Chaperonin GroEL Using Translation-libration-screw Crystallographic Refinement of Intermediate States Journal of Molecular Biology. Sep, 2004 | Pubmed ID: 15313620 Uniform and Residue-specific 15N-labeling of Proteins on a Highly Deuterated Background Journal of Biomolecular NMR. Jul, 2004 | Pubmed ID: 15213427 Chaperonin-mediated Protein Folding: Fate of Substrate Polypeptide Quarterly Reviews of Biophysics. May, 2003 | Pubmed ID: 14686103 Role of the Gamma-phosphate of ATP in Triggering Protein Folding by GroEL-GroES: Function, Structure and Energetics The EMBO Journal. Oct, 2003 | Pubmed ID: 14517228 Folding with and Without Encapsulation by Cis- and Trans-only GroEL-GroES Complexes The EMBO Journal. Jul, 2003 | Pubmed ID: 12839985 Solution NMR Techniques for Large Molecular and Supramolecular Structures Journal of the American Chemical Society. Oct, 2002 | Pubmed ID: 12371854 NMR Analysis of a 900K GroEL GroES Complex Nature. Jul, 2002 | Pubmed ID: 12110894 ClpS, a Substrate Modulator of the ClpAP Machine Molecular Cell. Mar, 2002 | Pubmed ID: 11931773 Production of RNA for Transcriptomic Analysis from Mouse Spinal Cord Motor Neuron Cell Bodies by Laser Capture Microdissection Urmi Bandyopadhyay1,2, Wayne A. Fenton1, Arthur L. Horwich1,2, Maria Nagy1,2 1Department of Genetics, Yale School of Medicine, 2Howard Hughes Medical Institute JoVE 51168 Neuroscience
Production of RNA for Transcriptomic Analysis from Mouse Spinal Cord Motor Neuron Cell Bodies by Laser Capture Microdissection Urmi Bandyopadhyay1,2, Wayne A. Fenton1, Arthur L. Horwich1,2, Maria Nagy1,2 1Department of Genetics, Yale School of Medicine, 2Howard Hughes Medical Institute JoVE 51168 Neuroscience
