Articles by Balarininvasa R. Sajja in JoVE

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

JoVE 2459 12/09/2010

Michael Boska¹, Yutong Liu¹, Mariano Uberti¹, Balarininvasa R. Sajja¹, Shantanu Balkundi², JoEllyn McMillan², Howard E. Gendelman²

¹Department of Radiology, University of Nebraska Medical Center, ²Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center

Bioimaging methods used to assess cell biodistribution of nanoparticles are applicable for therapeutic and diagnostic monitoring of nanoformulated compounds. The methods described herein are sensitive and specific when assessed by histological coregistration. The methodologies provide a translational pathway from rodent to human applications.