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Articles by Basheal Agrawal in JoVE
JoVE Clinical and Translational Medicine
Оценка раковых стволовых клеток миграции с помощью Compartmentalizing микрофлюидных устройств и изображений живых клеток
1Department of Biomedical Engineering, University of Wisconsin-Madison, 2Materials Science Program, University of Wisconsin-Madison, 3Department of Neurological Surgery, University of Wisconsin-Madison, 4Carbone Comprehensive Cancer Center and Center for Stem Cell and Regenerative Medicine, University of Wisconsin-Madison
Compartmentalizing микрофлюидных устройство для исследования раковых стволовых клеток миграции описано. Этот роман платформы создает жизнеспособную сотовой микросреды и позволяет микроскопическим визуализации живых передвижения клетки. Высокая подвижность раковых клеток выделяют для изучения молекулярных механизмов агрессивного проникновения, что может привести к более эффективному лечению будущем.
Other articles by Basheal Agrawal on PubMed
Polyostotic Fibrous Dysplasia of the Cervical Spine: Case Report and Review of the Literature
Multiple lytic lesions of the spine usually represent metastatic or infectious disease processes.
Superficial Vascular Anatomy of the Medial Prefrontal Cortex: an Anatomical Study
Superficial vascular anatomy of the medial prefrontal cortex, which is exposed after craniotomy for the anterior interhemispheric approach, has received little attention in the anatomy literature. This study focuses on the precise vascular anatomy of the medial part of the prefrontal cortex and provides more detailed information for surgery.
Microfluidics-based Devices: New Tools for Studying Cancer and Cancer Stem Cell Migration
Cell movement is highly sensitive to stimuli from the extracellular matrix and media. Receptors on the plasma membrane in cells can activate signal transduction pathways that change the mechanical behavior of a cell by reorganizing motion-related organelles. Cancer cells change their migration mechanisms in response to different environments more robustly than noncancer cells. Therefore, therapeutic approaches to immobilize cancer cells via inhibition of the related signal transduction pathways rely on a better understanding of cell migration mechanisms. In recent years, engineers have been working with biologists to apply microfluidics technology to study cell migration. As opposed to conventional cultures on dishes, microfluidics deals with the manipulation of fluids that are geometrically constrained to a submillimeter scale. Such small scales offer a number of advantages including cost effectiveness, low consumption of reagents, high sensitivity, high spatiotemporal resolution, and laminar flow. Therefore, microfluidics has a potential as a new platform to study cell migration. In this review, we summarized recent progress on the application of microfluidics in cancer and other cell migration researches. These studies have enhanced our understanding of cell migration and cancer invasion as well as their responses to subtle variations in their microenvironment. We hope that this review will serve as an interdisciplinary guidance for both biologists and engineers as they further develop the microfluidic toolbox toward applications in cancer research.
Wisconsin Spine Outcome Study-Pilot: Preliminary Data
Given the pragmatic difficulties in developing randomized controlled trials in patients with disorders of the spine, the Wisconsin Spine Outcome Group has adopted the use of a prospective registry design to perform comparative effectiveness research on treatments for degenerative lumbar disorders. The goal of the Wisconsin Spine Outcome Study-Pilot (WISPOS-P) was to establish a Web-based, Health Insurance Portability and Accountability Act-compliant registry and to implement a patient registration paradigm that demonstrates at least 80% compliance in collecting pre- and posttreatment data in patients with lumbar disorders, regardless of the treatment they receive. The primary outcome measures were the percentage of patients with lumbar spine disorders who completed a Web-based survey preappointment, and at 1 and 3 months postappointment; the percentage of patients receiving a physician-assigned diagnosis in the registry; and the success of electronic data transition from the Web-based interface to a locally controlled registry.
The Temporal Association of Sphenoid Sinus Mucosal Thickening on MR Imaging with Pituitary Apoplexy
Pituitary apoplexy is an infrequent but potentially devastating complication in patients with pituitary adenomas. Previous studies have cited an association between MR visualized sphenoid sinus mucosal thickening and apoplexy. However, uncertainties still remain on the significance and temporal association of this finding with pituitary apoplexy. We provide a clinical study that better delineates this temporal association and also provides histopathologic data for sinus thickening compared to control subjects. MATERIAL and
