Brigitte Guérin Department of Nuclear Medicine and Radiobiology Université de Sherbrooke Biography Publications Institution JoVE Articles Brigitte Guérin has not added a biography. If you are Brigitte Guérin and would like to personalize this page please email our Author Liaison for assistance. Publications Evaluation of a Novel GRPR Antagonist for Prostate Cancer PET Imaging: [Cu]-DOTHA-PEG-RM26 Nuclear Medicine and Biology. Jan, 2018 | Pubmed ID: 29154145 Improved Estrogen Receptor Assessment by PET Using the Novel RadiotracerF-4FMFES in Estrogen Receptor-Positive Breast Cancer Patients: An Ongoing Phase II Clinical Trial Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Feb, 2018 | Pubmed ID: 28798032 Targeting IL-5Rα with Antibody-conjugates Reveals a Strategy for Imaging and Therapy for Invasive Bladder Cancer Oncoimmunology. 2017 | Pubmed ID: 29123949 Synthesis and Spectral Properties of Estrogen- and Androgen-BODIPY Conjugates Steroids. Jul, 2017 | Pubmed ID: 28483507 Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent Organic Letters. Apr, 2017 | Pubmed ID: 28368122 PACE4 is an Important Driver of ZR-75-1 Estrogen Receptor-positive Breast Cancer Proliferation and Tumor Progression European Journal of Cell Biology. Mar, 2017 | Pubmed ID: 28347547 Dietary Fatty Acid Metabolism of Brown Adipose Tissue in Cold-acclimated Men Nature Communications. Jan, 2017 | Pubmed ID: 28134339 Impact of Dianionic and Dicationic Linkers on Tumor Uptake and Biodistribution of [(64) Cu]Cu/NOTA Peptide-based Gastrin-releasing Peptide Receptors Antagonists Journal of Labelled Compounds & Radiopharmaceuticals. Apr, 2017 | Pubmed ID: 28129446 Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans Cell Metabolism. Feb, 2017 | Pubmed ID: 28089568 BODIPY-17α-ethynylestradiol Conjugates: Synthesis, Fluorescence Properties and Receptor Binding Affinities Bioorganic & Medicinal Chemistry Letters. Feb, 2017 | Pubmed ID: 28049591 Synthesis of Gly-ψ[(Z)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin Peptidomimetic ACS Chemical Neuroscience. Jan, 2017 | Pubmed ID: 27762555 Clinical Trial with Sodium (99m)Tc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2017 | Pubmed ID: 27738005 Increased Radiosensitivity of Colorectal Tumors with Intra-tumoral Injection of Low Dose of Gold Nanoparticles International Journal of Nanomedicine. 2016 | Pubmed ID: 27789945 Targeting the Neuropeptide Y1 Receptor for Cancer Imaging by Positron Emission Tomography Using Novel Truncated Peptides Molecular Pharmaceutics. Nov, 2016 | Pubmed ID: 27669056 Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects Diabetes. Nov, 2015 | Pubmed ID: 26224886 Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Oct, 2015 | Pubmed ID: 26205300 Multi-Leu PACE4 Inhibitor Retention Within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity BioMed Research International. 2015 | Pubmed ID: 26114115 PACE4 Inhibitors and Their Peptidomimetic Analogs Block Prostate Cancer Tumor Progression Through Quiescence Induction, Increased Apoptosis and Impaired Neovascularisation Oncotarget. Feb, 2015 | Pubmed ID: 25682874 Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes Diabetes. Jul, 2015 | Pubmed ID: 25677914 Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans Diabetes. Jul, 2015 | Pubmed ID: 25503741 Contributions of White and Brown Adipose Tissues and Skeletal Muscles to Acute Cold-induced Metabolic Responses in Healthy Men The Journal of Physiology. Feb, 2015 | Pubmed ID: 25384777 PACE4-based Molecular Targeting of Prostate Cancer Using an Engineered ⁶⁴Cu-radiolabeled Peptide Inhibitor Neoplasia (New York, N.Y.). Aug, 2014 | Pubmed ID: 25220591 Development of Bifunctional Chelates Bearing Hydroxamate Arms for Highly Efficient (64)Cu Radiolabeling Organic Letters. Sep, 2014 | Pubmed ID: 25133292 Improved Cardiac Function and Dietary Fatty Acid Metabolism After Modest Weight Loss in Subjects with Impaired Glucose Tolerance American Journal of Physiology. Endocrinology and Metabolism. Jun, 2014 | Pubmed ID: 24760989 Increased Brown Adipose Tissue Oxidative Capacity in Cold-acclimated Humans The Journal of Clinical Endocrinology and Metabolism. Mar, 2014 | Pubmed ID: 24423363 Copper Transport and Regulation in Schizosaccharomyces Pombe Biochemical Society Transactions. Dec, 2013 | Pubmed ID: 24256274 Systematic Replacement of Amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the Impact on the Delta Opioid Receptor Activity Bioorganic & Medicinal Chemistry Letters. Oct, 2013 | Pubmed ID: 23988352 (68)Ga/DOTA- and (64)Cu/NOTA-phthalocyanine Conjugates As Fluorescent/PET Bimodal Imaging Probes Bioconjugate Chemistry. Sep, 2013 | Pubmed ID: 23978056 2-Fluoropyridine Prosthetic Compounds for the 18F Labeling of Bombesin Analogues Bioorganic & Medicinal Chemistry Letters. Jul, 2013 | Pubmed ID: 23683595 Preparation and Evaluation at the Delta Opioid Receptor of a Series of Linear Leu-enkephalin Analogues Obtained by Systematic Replacement of the Amides ACS Chemical Neuroscience. Aug, 2013 | Pubmed ID: 23650868 Phthalocyanine-peptide Conjugates: Receptor-targeting Bifunctional Agents for Imaging and Photodynamic Therapy Journal of Medicinal Chemistry. Feb, 2013 | Pubmed ID: 23356907 Increased Myocardial Uptake of Dietary Fatty Acids Linked to Cardiac Dysfunction in Glucose-intolerant Humans Diabetes. Nov, 2012 | Pubmed ID: 23093657 Sulfonyl Fluoride-based Prosthetic Compounds As Potential 18F Labelling Agents Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2012 | Pubmed ID: 22807282 EP 80317, a Selective CD36 Ligand, Shows Cardioprotective Effects Against Post-ischaemic Myocardial Damage in Mice Cardiovascular Research. Oct, 2012 | Pubmed ID: 22787133 Novel Radiolabeled Peptides for Breast and Prostate Tumor PET Imaging: (64)Cu/and (68)Ga/NOTA-PEG-[D-Tyr(6),βAla(11),Thi(13),Nle(14)]BBN(6-14) Bioconjugate Chemistry. Aug, 2012 | Pubmed ID: 22770480 Comparative Study of 64Cu/NOTA-[D-Tyr6,βAla11,Thi13,Nle14]BBN(6-14) Monomer and Dimers for Prostate Cancer PET Imaging EJNMMI Research. 2012 | Pubmed ID: 22333272 Brown Adipose Tissue Oxidative Metabolism Contributes to Energy Expenditure During Acute Cold Exposure in Humans The Journal of Clinical Investigation. Feb, 2012 | Pubmed ID: 22269323 PET Imaging Using 64Cu-labeled Sulfophthalocyanines: Synthesis and Biodistribution Bioorganic & Medicinal Chemistry Letters. Dec, 2011 | Pubmed ID: 22050887 Mfc1 is a Novel Forespore Membrane Copper Transporter in Meiotic and Sporulating Cells The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21828039 Evaluation of 64Cu-labeled Bifunctional Chelate-bombesin Conjugates Bioconjugate Chemistry. Aug, 2011 | Pubmed ID: 21761921 Phthalocyanine-peptide Conjugates Via Palladium-catalyzed Cross-coupling Reactions The Journal of Organic Chemistry. Mar, 2011 | Pubmed ID: 21302913 Normal Postprandial Nonesterified Fatty Acid Uptake in Muscles Despite Increased Circulating Fatty Acids in Type 2 Diabetes Diabetes. Feb, 2011 | Pubmed ID: 21228312 Organ-specific Dietary Fatty Acid Uptake in Humans Using Positron Emission Tomography Coupled to Computed Tomography American Journal of Physiology. Endocrinology and Metabolism. Mar, 2011 | Pubmed ID: 21098737 Cyclotron Production of 99mTc: an Approach to the Medical Isotope Crisis Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Apr, 2010 | Pubmed ID: 20351346 [Lys(DOTA)4]BVD15, a Novel and Potent Neuropeptide Y Analog Designed for Y1 Receptor-targeted Breast Tumor Imaging Bioorganic & Medicinal Chemistry Letters. Feb, 2010 | Pubmed ID: 20042335 Total Solid-phase Synthesis of NOTA-functionalized Peptides for PET Imaging Organic Letters. Jan, 2010 | Pubmed ID: 20014826 New Enzyme-activated Solubility-switchable Contrast Agent for Magnetic Resonance Imaging: from Synthesis to in Vivo Imaging Journal of Medicinal Chemistry. Mar, 2009 | Pubmed ID: 19228016 Synthesis of Tertiary and Quaternary Stereogenic Centers: a Diastereoselective Tandem Reaction Sequence Combining Mukaiyama and Free Radical-based Allylation The Journal of Organic Chemistry. Feb, 2005 | Pubmed ID: 15675832 Enhanced Dermal and Retinal Vascular Permeability in Streptozotocin-induced Type 1 Diabetes in Wistar Rats: Blockade with a Selective Bradykinin B1 Receptor Antagonist Regulatory Peptides. Jan, 2005 | Pubmed ID: 15544863 Zinc Improves Gene Transfer Mediated by DNA/cationic Polymer Complexes The Journal of Gene Medicine. Sep-Oct, 2002 | Pubmed ID: 12221648 Intracellular Processing and Stability of DNA Complexed with Histidylated Polylysine Conjugates The Journal of Gene Medicine. May-Jun, 2002 | Pubmed ID: 12112644 Synthesis of 2,3-anti-3,4-anti and 2,3-anti-3,4-syn Propionate Motifs: a Diastereoselective Tandem Sequence of Mukaiyama and Free-radical-based Hydrogen Transfer Reactions Organic Letters. Mar, 2002 | Pubmed ID: 11893211 Synthesis of N-glycosides. An Alternative Approach Based on Diastereoselective Base Coupling and S(N)2 Cyclization Organic Letters. Jan, 2002 | Pubmed ID: 11796060 Poly[Lys-(AEDTP)]: a Cationic Polymer That Allows Dissociation of PDNA/cationic Polymer Complexes in a Reductive Medium and Enhances Polyfection Bioconjugate Chemistry. Jan-Feb, 2002 | Pubmed ID: 11792180 Évaluation initiale des anticorps-conjugués modifié avec Peptides viraux dérivés pour accroître l’Accumulation cellulaire et améliorer le ciblage tumoral Simon Beaudoin1, Michel Paquette1, Laurent Fafard-Couture1, Mylene A. Tremblay1, Roger Lecomte1,2,3, Brigitte Guérin1,2,3, Jeffrey V. Leyton1,2,3 1Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center (CIMS), Université de Sherbrooke, 3Sherbrooke Institute of Pharmacology JoVE 55440 Bioengineering
Évaluation initiale des anticorps-conjugués modifié avec Peptides viraux dérivés pour accroître l’Accumulation cellulaire et améliorer le ciblage tumoral Simon Beaudoin1, Michel Paquette1, Laurent Fafard-Couture1, Mylene A. Tremblay1, Roger Lecomte1,2,3, Brigitte Guérin1,2,3, Jeffrey V. Leyton1,2,3 1Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center (CIMS), Université de Sherbrooke, 3Sherbrooke Institute of Pharmacology JoVE 55440 Bioengineering
