Carl Nathan

Publications

• Reconstitution of a Mycobacterium Tuberculosis Proteostasis Network Highlights Essential Cofactor Interactions with Chaperone DnaK
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2016  |   Pubmed ID: 27872278
• Macrophages' Choice: Take It In or Keep It Out
  Immunity. Oct, 2016  |   Pubmed ID: 27760333
• Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors
  ChemMedChem. Oct, 2016  |   Pubmed ID: 27561172
• Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
  PLoS Pathogens. Jul, 2016  |   Pubmed ID: 27467575
• N-methylation of a Bactericidal Compound As a Resistance Mechanism in Mycobacterium Tuberculosis
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2016  |   Pubmed ID: 27432954
• Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium Tuberculosis
  Journal of Medicinal Chemistry. Jul, 2016  |   Pubmed ID: 27144688
• Human Studies at JEM: Immunology and Beyond
  The Journal of Experimental Medicine. Apr, 2016  |   Pubmed ID: 26976629
• Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library Against Nonreplicating Mycobacterium Tuberculosis
  ACS Infectious Diseases. Dec, 2015  |   Pubmed ID: 27623055
• Comparison of Transposon and Deletion Mutants in Mycobacterium Tuberculosis: The Case of Rv1248c, Encoding 2-hydroxy-3-oxoadipate Synthase
  Tuberculosis (Edinburgh, Scotland). Dec, 2015  |   Pubmed ID: 26547230
• IMMUNOLOGY. From Transient Infection to Chronic Disease
  Science (New York, N.Y.). Oct, 2015  |   Pubmed ID: 26450196
• E1 of α-ketoglutarate Dehydrogenase Defends Mycobacterium Tuberculosis Against Glutamate Anaplerosis and Nitroxidative Stress
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015  |   Pubmed ID: 26430237
• Cooperative Development of Antimicrobials: Looking Back to Look Ahead
  Nature Reviews. Microbiology. Oct, 2015  |   Pubmed ID: 26373373
• Rapid, Semiquantitative Assay To Discriminate Among Compounds with Activity Against Replicating or Nonreplicating Mycobacterium Tuberculosis
  Antimicrobial Agents and Chemotherapy. Oct, 2015  |   Pubmed ID: 26239979
• Identification of Rv3852 As an Agrimophol-Binding Protein in Mycobacterium Tuberculosis
  PloS One. 2015  |   Pubmed ID: 25978362
• A Multi-stress Model for High Throughput Screening Against Non-replicating Mycobacterium Tuberculosis
  Methods in Molecular Biology (Clifton, N.J.). 2015  |   Pubmed ID: 25779324
• TB Drug Development: Immunology at the Table
  Immunological Reviews. Mar, 2015  |   Pubmed ID: 25703568
• What Can Immunology Contribute to the Control of the World's Leading Cause of Death from Bacterial Infection?
  Immunological Reviews. Mar, 2015  |   Pubmed ID: 25703548
• Video Podcast: Tuberculosis
  Immunological Reviews. Mar, 2015  |   Pubmed ID: 25703547
• Stressed Mycobacteria Use the Chaperone ClpB to Sequester Irreversibly Oxidized Proteins Asymmetrically Within and Between Cells
  Cell Host & Microbe. Feb, 2015  |   Pubmed ID: 25620549
• Target-based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial PH Homeostasis in Mycobacterium Tuberculosis
  ACS Chemical Biology. Feb, 2015  |   Pubmed ID: 25457457
• Antibiotic Resistance--problems, Progress, and Prospects
  The New England Journal of Medicine. Nov, 2014  |   Pubmed ID: 25271470
• Isocitrate Lyase Mediates Broad Antibiotic Tolerance in Mycobacterium Tuberculosis
  Nature Communications. Jun, 2014  |   Pubmed ID: 24978671
• Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome
  ACS Medicinal Chemistry Letters. Apr, 2014  |   Pubmed ID: 24900849
• Synthetic Calanolides with Bactericidal Activity Against Replicating and Nonreplicating Mycobacterium Tuberculosis
  Journal of Medicinal Chemistry. May, 2014  |   Pubmed ID: 24694175
• Benzimidazole-based Compounds Kill Mycobacterium Tuberculosis
  European Journal of Medicinal Chemistry. Mar, 2014  |   Pubmed ID: 24556148
• Drug-resistant Tuberculosis: a New Shot on Goal
  Nature Medicine. Feb, 2014  |   Pubmed ID: 24504402
• Lipoamide Channel-binding Sulfonamides Selectively Inhibit Mycobacterial Lipoamide Dehydrogenase
  Biochemistry. Dec, 2013  |   Pubmed ID: 24251446
• Genetic Regulation of Vesiculogenesis and Immunomodulation in Mycobacterium Tuberculosis
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013  |   Pubmed ID: 24248369
• Nitrite Produced by Mycobacterium Tuberculosis in Human Macrophages in Physiologic Oxygen Impacts Bacterial ATP Consumption and Gene Expression
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013  |   Pubmed ID: 24145454
• Perspective: Graduation Time
  Nature. Oct, 2013  |   Pubmed ID: 24108080
• A Journey in Science: Promise, Purpose, Privilege
  Molecular Medicine (Cambridge, Mass.). Oct, 2013  |   Pubmed ID: 24089245
• Nitrite Impacts the Survival of Mycobacterium Tuberculosis in Response to Isoniazid and Hydrogen Peroxide
  MicrobiologyOpen. Dec, 2013  |   Pubmed ID: 24019302
• Whole Cell Screen for Inhibitors of PH Homeostasis in Mycobacterium Tuberculosis
  PloS One. 2013  |   Pubmed ID: 23935911
• N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets
  Journal of the American Chemical Society. Jul, 2013  |   Pubmed ID: 23782398
• Influence of Allosteric Regulators on Individual Steps in the Reaction Catalyzed by Mycobacterium Tuberculosis 2-hydroxy-3-oxoadipate Synthase
  The Journal of Biological Chemistry. Jul, 2013  |   Pubmed ID: 23760263
• SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2013  |   Pubmed ID: 23749635
• Beyond Oxidative Stress: an Immunologist's Guide to Reactive Oxygen Species
  Nature Reviews. Immunology. May, 2013  |   Pubmed ID: 23618831
• Efficacy of Nitazoxanide Against Clinical Isolates of Mycobacterium Tuberculosis
  Antimicrobial Agents and Chemotherapy. Jun, 2013  |   Pubmed ID: 23507275
• Nonsteroidal Anti-inflammatory Drug Sensitizes Mycobacterium Tuberculosis to Endogenous and Exogenous Antimicrobials
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 23012453
• Fresh Approaches to Anti-infective Therapies
  Science Translational Medicine. Jun, 2012  |   Pubmed ID: 22745440
• DSarm/Sarm1 is Required for Activation of an Injury-induced Axon Death Pathway
  Science (New York, N.Y.). Jul, 2012  |   Pubmed ID: 22678360
• Secretory Products of Macrophages: Twenty-five Years On
  The Journal of Clinical Investigation. Apr, 2012  |   Pubmed ID: 22570864
• Improved Control of Tuberculosis and Activation of Macrophages in Mice Lacking Protein Kinase R
  PloS One. 2012  |   Pubmed ID: 22359543
• Remembering Ralph Steinman
  The Journal of Experimental Medicine. Nov, 2011  |   Pubmed ID: 22216461
• Nitazoxanide Disrupts Membrane Potential and Intrabacterial PH Homeostasis of Mycobacterium Tuberculosis
  ACS Medicinal Chemistry Letters. 2011  |   Pubmed ID: 22096616
• Is INOS Beginning to Smoke?
  Cell. Oct, 2011  |   Pubmed ID: 22000003
• In Vitro Differentiation of Human Macrophages with Enhanced Antimycobacterial Activity
  The Journal of Clinical Investigation. Oct, 2011  |   Pubmed ID: 21911939
• Mycobacterium Tuberculosis Gene Rv2136c is Dispensable for Acid Resistance and Virulence in Mice
  Tuberculosis (Edinburgh, Scotland). Sep, 2011  |   Pubmed ID: 21778115
• Identification of New Inhibitors of Protein Kinase R Guided by Statistical Modeling
  Bioorganic & Medicinal Chemistry Letters. Jul, 2011  |   Pubmed ID: 21632247
• Making Space for Anti-infective Drug Discovery
  Cell Host & Microbe. May, 2011  |   Pubmed ID: 21575903
• Central Carbon Metabolism in Mycobacterium Tuberculosis: an Unexpected Frontier
  Trends in Microbiology. Jul, 2011  |   Pubmed ID: 21561773
• Virulence of Mycobacterium Tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes
  Cell Host & Microbe. Jan, 2011  |   Pubmed ID: 21238944
• Identification of a Chemical That Inhibits the Mycobacterial UvrABC Complex in Nucleotide Excision Repair
  Biochemistry. Mar, 2011  |   Pubmed ID: 21235228
• Genome-wide Screen for Mycobacterium Tuberculosis Genes That Regulate Host Immunity
  PloS One. Dec, 2010  |   Pubmed ID: 21170273
• Metabolomics of Mycobacterium Tuberculosis Reveals Compartmentalized Co-catabolism of Carbon Substrates
  Chemistry & Biology. Oct, 2010  |   Pubmed ID: 21035735
• A Protecting Group-free Synthesis of Deazathiamine: a Step Toward Inhibitor Design
  Bioorganic & Medicinal Chemistry Letters. Nov, 2010  |   Pubmed ID: 20943392
• Induction of ER Stress in Macrophages of Tuberculosis Granulomas
  PloS One. Sep, 2010  |   Pubmed ID: 20856677
• Behavioral Deficits and Progressive Neuropathology in Progranulin-deficient Mice: a Mouse Model of Frontotemporal Dementia
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2010  |   Pubmed ID: 20667979
• Fellutamide B is a Potent Inhibitor of the Mycobacterium Tuberculosis Proteasome
  Archives of Biochemistry and Biophysics. Sep, 2010  |   Pubmed ID: 20558127
• Killing of Non-replicating Mycobacterium Tuberculosis by 8-hydroxyquinoline
  The Journal of Antimicrobial Chemotherapy. Jul, 2010  |   Pubmed ID: 20435781
• Activity-based Metabolomic Profiling of Enzymatic Function: Identification of Rv1248c As a Mycobacterial 2-hydroxy-3-oxoadipate Synthase
  Chemistry & Biology. Apr, 2010  |   Pubmed ID: 20416504
• SnapShot: Reactive Oxygen Intermediates (ROI)
  Cell. Mar, 2010  |   Pubmed ID: 20303882
• Nonresolving Inflammation
  Cell. Mar, 2010  |   Pubmed ID: 20303877
• Triazaspirodimethoxybenzoyls As Selective Inhibitors of Mycobacterial Lipoamide Dehydrogenase
  Biochemistry. Mar, 2010  |   Pubmed ID: 20078138
• Exaggerated Inflammation, Impaired Host Defense, and Neuropathology in Progranulin-deficient Mice
  The Journal of Experimental Medicine. Jan, 2010  |   Pubmed ID: 20026663
• N-iminoethyl-L-lysine Improves Memory and Reduces Amyloid Pathology in a Transgenic Mouse Model of Amyloid Deposition
  Neurochemistry International. Jan, 2010  |   Pubmed ID: 19914323
• Structural Insights on the Mycobacterium Tuberculosis Proteasomal ATPase Mpa
  Structure (London, England : 1993). Oct, 2009  |   Pubmed ID: 19836337
• Inhibitors Selective for Mycobacterial Versus Human Proteasomes
  Nature. Oct, 2009  |   Pubmed ID: 19759536
• Nitazoxanide Kills Replicating and Nonreplicating Mycobacterium Tuberculosis and Evades Resistance
  Journal of Medicinal Chemistry. Oct, 2009  |   Pubmed ID: 19736929
• Acid Resistance in Mycobacterium Tuberculosis
  Journal of Bacteriology. Aug, 2009  |   Pubmed ID: 19465648
• Taming Tuberculosis: a Challenge for Science and Society
  Cell Host & Microbe. Mar, 2009  |   Pubmed ID: 19286131
• Triterpenoid CDDO-methylamide Improves Memory and Decreases Amyloid Plaques in a Transgenic Mouse Model of Alzheimer's Disease
  Journal of Neurochemistry. Apr, 2009  |   Pubmed ID: 19200343
• Mycobacterium Tuberculosis Expresses Methionine Sulphoxide Reductases A and B That Protect from Killing by Nitrite and Hypochlorite
  Molecular Microbiology. Feb, 2009  |   Pubmed ID: 19040639
• Acid-susceptible Mutants of Mycobacterium Tuberculosis Share Hypersusceptibility to Cell Wall and Oxidative Stress and to the Host Environment
  Journal of Bacteriology. Jan, 2009  |   Pubmed ID: 19011036
• Microbiology. An Antibiotic Mimics Immunity
  Science (New York, N.Y.). Nov, 2008  |   Pubmed ID: 19039126
• Distinct Specificities of Mycobacterium Tuberculosis and Mammalian Proteasomes for N-acetyl Tripeptide Substrates
  The Journal of Biological Chemistry. Dec, 2008  |   Pubmed ID: 18829465
• A Philosophy of Anti-infectives As a Guide in the Search for New Drugs for Tuberculosis
  Tuberculosis (Edinburgh, Scotland). Aug, 2008  |   Pubmed ID: 18762150
• Identification of a Copper-binding Metallothionein in Pathogenic Mycobacteria
  Nature Chemical Biology. Oct, 2008  |   Pubmed ID: 18724363
• A Membrane Protein Preserves Intrabacterial PH in Intraphagosomal Mycobacterium Tuberculosis
  Nature Medicine. Aug, 2008  |   Pubmed ID: 18641659
• Metchnikoff's Legacy in 2008
  Nature Immunology. Jul, 2008  |   Pubmed ID: 18563074
• Epidemic Inflammation: Pondering Obesity
  Molecular Medicine (Cambridge, Mass.). Jul-Aug, 2008  |   Pubmed ID: 18431463
• Selective Killing of Nonreplicating Mycobacteria
  Cell Host & Microbe. Mar, 2008  |   Pubmed ID: 18329613
• Pulmonary Nodules in an Infliximab-treated Rheumatoid Arthritis Patient: a Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special Surgery
  HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery. Feb, 2007  |   Pubmed ID: 18751782
• New Approaches to Filling the Gap in Tuberculosis Drug Discovery
  PLoS Medicine. Nov, 2007  |   Pubmed ID: 17988169
• MyD88-5 Links Mitochondria, Microtubules, and JNK3 in Neurons and Regulates Neuronal Survival
  The Journal of Experimental Medicine. Sep, 2007  |   Pubmed ID: 17724133
• Aligning Pharmaceutical Innovation with Medical Need
  Nature Medicine. Mar, 2007  |   Pubmed ID: 17342145
• Man is Not a Mouse: Reply
  Journal of Leukocyte Biology. Mar, 2007  |   Pubmed ID: 17332374
• Role of INOS in Human Host Defense
  Science (New York, N.Y.). Jun, 2006  |   Pubmed ID: 16809512
• Neutrophils and Immunity: Challenges and Opportunities
  Nature Reviews. Immunology. Mar, 2006  |   Pubmed ID: 16498448
• Cytosolic Phospholipase A2 Enzymes Are Not Required by Mouse Bone Marrow-derived Macrophages for the Control of Mycobacterium Tuberculosis in Vitro
  Infection and Immunity. Mar, 2006  |   Pubmed ID: 16495548
• Structure of the Mycobacterium Tuberculosis Proteasome and Mechanism of Inhibition by a Peptidyl Boronate
  Molecular Microbiology. Mar, 2006  |   Pubmed ID: 16468986
• Mycobacterium Tuberculosis PrcBA Genes Encode a Gated Proteasome with Broad Oligopeptide Specificity
  Molecular Microbiology. Mar, 2006  |   Pubmed ID: 16468985
• Abrupt Expression of TLR4 in TLR4-deficient Macrophages Imposes a Selective Disadvantage: Genetic Evidence for TLR4-dependent Responses to Endogenous, Nonmicrobial Stimuli
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006  |   Pubmed ID: 16394008
• Chemical Inhibitors of TNF Signal Transduction in Human Neutrophils Point to Distinct Steps in Cell Activation
  Journal of Leukocyte Biology. Jan, 2006  |   Pubmed ID: 16275893
• Protection from Alzheimer's-like Disease in the Mouse by Genetic Ablation of Inducible Nitric Oxide Synthase
  The Journal of Experimental Medicine. Nov, 2005  |   Pubmed ID: 16260491
• Outlook: the Profit Problem in Antibiotic R&D
  Nature Reviews. Drug Discovery. Nov, 2005  |   Pubmed ID: 16247440
• Progress and New Directions in Genetics of Tuberculosis: an NHLBI Working Group Report
  American Journal of Respiratory and Critical Care Medicine. Dec, 2005  |   Pubmed ID: 16192449
• Crystal Structure and Functional Analysis of Lipoamide Dehydrogenase from Mycobacterium Tuberculosis
  The Journal of Biological Chemistry. Oct, 2005  |   Pubmed ID: 16093239
• Mycobacterium Tuberculosis Appears to Lack Alpha-ketoglutarate Dehydrogenase and Encodes Pyruvate Dehydrogenase in Widely Separated Genes
  Molecular Microbiology. Aug, 2005  |   Pubmed ID: 16045627
• Calcium-sensing Soluble Adenylyl Cyclase Mediates TNF Signal Transduction in Human Neutrophils
  The Journal of Experimental Medicine. Aug, 2005  |   Pubmed ID: 16043520
• Role for Nucleotide Excision Repair in Virulence of Mycobacterium Tuberculosis
  Infection and Immunity. Aug, 2005  |   Pubmed ID: 16040969
• Variant Tricarboxylic Acid Cycle in Mycobacterium Tuberculosis: Identification of Alpha-ketoglutarate Decarboxylase
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005  |   Pubmed ID: 16027371
• Mycobacterium Tuberculosis and the Host Response
  The Journal of Experimental Medicine. Jun, 2005  |   Pubmed ID: 15939785
• A Glutamate-alanine-leucine (EAL) Domain Protein of Salmonella Controls Bacterial Survival in Mice, Antioxidant Defence and Killing of Macrophages: Role of Cyclic DiGMP
  Molecular Microbiology. Jun, 2005  |   Pubmed ID: 15882417
• Characterization of a Mycobacterium Tuberculosis Proteasomal ATPase Homologue
  Molecular Microbiology. Jan, 2005  |   Pubmed ID: 15659170
• S-nitroso Proteome of Mycobacterium Tuberculosis: Enzymes of Intermediary Metabolism and Antioxidant Defense
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005  |   Pubmed ID: 15626759
• The Moving Frontier in Nitric Oxide-dependent Signaling
  Science's STKE : Signal Transduction Knowledge Environment. Nov, 2004  |   Pubmed ID: 15523044
• Antibiotics at the Crossroads
  Nature. Oct, 2004  |   Pubmed ID: 15496893
• Identification of Mycobacterium Tuberculosis Counterimmune (cim) Mutants in Immunodeficient Mice by Differential Screening
  Infection and Immunity. Sep, 2004  |   Pubmed ID: 15322028
• The Proteasome of Mycobacterium Tuberculosis is Required for Resistance to Nitric Oxide
  Science (New York, N.Y.). Dec, 2003  |   Pubmed ID: 14671303
• MyD88 Primes Macrophages for Full-scale Activation by Interferon-gamma Yet Mediates Few Responses to Mycobacterium Tuberculosis
  The Journal of Experimental Medicine. Oct, 2003  |   Pubmed ID: 14517275
• Transcriptional Adaptation of Mycobacterium Tuberculosis Within Macrophages: Insights into the Phagosomal Environment
  The Journal of Experimental Medicine. Sep, 2003  |   Pubmed ID: 12953091
• Immunology: Oxygen and the Inflammatory Cell
  Nature. Apr, 2003  |   Pubmed ID: 12700748
• Specificity of a Third Kind: Reactive Oxygen and Nitrogen Intermediates in Cell Signaling
  The Journal of Clinical Investigation. Mar, 2003  |   Pubmed ID: 12639979
• Critical Role of the Carboxyl Terminus of Proline-rich Tyrosine Kinase (Pyk2) in the Activation of Human Neutrophils by Tumor Necrosis Factor: Separation of Signals for the Respiratory Burst and Degranulation
  The Journal of Experimental Medicine. Jan, 2003  |   Pubmed ID: 12515814
• Conversion of Proepithelin to Epithelins: Roles of SLPI and Elastase in Host Defense and Wound Repair
  Cell. Dec, 2002  |   Pubmed ID: 12526812
• Points of Control in Inflammation
  Nature. Dec 19-26, 2002  |   Pubmed ID: 12490957
• Immunology. Catalytic Antibody Bridges Innate and Adaptive Immunity
  Science (New York, N.Y.). Dec, 2002  |   Pubmed ID: 12481124
• Inducible Nitric Oxide Synthase in the Tuberculous Human Lung
  American Journal of Respiratory and Critical Care Medicine. Jul, 2002  |   Pubmed ID: 12119220
• Nonredundant Antioxidant Defense by Multiple Two-cysteine Peroxiredoxins in Human Prostate Cancer Cells
  Molecular Medicine (Cambridge, Mass.). Feb, 2002  |   Pubmed ID: 12080185
• Peptide Methionine Sulfoxide Reductase: Structure, Mechanism of Action, and Biological Function
  Archives of Biochemistry and Biophysics. Jan, 2002  |   Pubmed ID: 11795868