Christopher J.H. Porter

Publications

• PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance After Subcutaneous Administration
  Molecular Pharmaceutics. Mar, 2015  |   Pubmed ID: 25644368
• Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties in Vivo
  ACS Nano. Feb, 2015  |   Pubmed ID: 25634484
• Optimal PEGylation Can Improve the Exposure of Interferon in the Lungs Following Pulmonary Administration
  Journal of Pharmaceutical Sciences. Jan, 2015  |   Pubmed ID: 25631360
• Methotrexate-conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumour-burdened Lymph Nodes After Intravenous and Subcutaneous Administration in Rats
  Molecular Pharmaceutics. Dec, 2014  |   Pubmed ID: 25485615
• Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug
  Pharmaceutical Research. Dec, 2014  |   Pubmed ID: 25446770
• Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase
  Pharmaceutical Research. Oct, 2014  |   Pubmed ID: 25288015
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels
  The AAPS Journal. Nov, 2014  |   Pubmed ID: 25274609
• An in Vitro Digestion Test That Reflects Rat Intestinal Conditions to Probe the Importance of Formulation Digestion Vs First Pass Metabolism in Danazol Bioavailability from Lipid Based Formulations
  Molecular Pharmaceutics. Nov, 2014  |   Pubmed ID: 25265395
• In Vitro-in Vivo Evaluation of Lipid Based Formulations of the CETP Inhibitors CP-529,414 (torcetrapib) and CP-532,623
  European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2014  |   Pubmed ID: 25152213
• Characterization of Two Distinct Modes of Drug Binding to Human Intestinal Fatty Acid Binding Protein
  ACS Chemical Biology. Nov, 2014  |   Pubmed ID: 25144524
• 'Stealth' Lipid-based Formulations: Poly(ethylene Glycol)-mediated Digestion Inhibition Improves Oral Bioavailability of a Model Poorly Water Soluble Drug
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2014  |   Pubmed ID: 25058571
• Digestion of Phospholipids After Secretion of Bile into the Duodenum Changes the Phase Behavior of Bile Components
  Molecular Pharmaceutics. Aug, 2014  |   Pubmed ID: 24987935
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 4: Proposing a New Lipid Formulation Performance Classification System
  Journal of Pharmaceutical Sciences. Aug, 2014  |   Pubmed ID: 24985238
• The Influence of Intestinal Lymphatic Transport on the Systemic Exposure and Brain Deposition of a Novel Highly Lipophilic Compound with Structural Similarity to Cholesterol
  The Journal of Pharmacy and Pharmacology. Oct, 2014  |   Pubmed ID: 24821499
• Nano-chemotherapeutics: Maximising Lymphatic Drug Exposure to Improve the Treatment of Lymph-metastatic Cancers
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2014  |   Pubmed ID: 24801249
• Lipid-based Formulations Solidified Via Adsorption Onto the Mesoporous Carrier Neusilin® US2: Effect of Drug Type and Formulation Composition on in Vitro Pharmaceutical Performance
  Journal of Pharmaceutical Sciences. Jun, 2014  |   Pubmed ID: 24740767
• Pulmonary Administration of a Doxorubicin-conjugated Dendrimer Enhances Drug Exposure to Lung Metastases and Improves Cancer Therapy
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2014  |   Pubmed ID: 24637466
• Pulmonary and Systemic Pharmacokinetics of Inhaled and Intravenous Colistin Methanesulfonate in Cystic Fibrosis Patients: Targeting Advantage of Inhalational Administration
  Antimicrobial Agents and Chemotherapy. May, 2014  |   Pubmed ID: 24550334
• Non-linear Increases in Danazol Exposure with Dose in Older Vs. Younger Beagle Dogs: the Potential Role of Differences in Bile Salt Concentration, Thermodynamic Activity, and Formulation Digestion
  Pharmaceutical Research. Jun, 2014  |   Pubmed ID: 24477676
• Choice of Nonionic Surfactant Used to Formulate Type IIIA Self-emulsifying Drug Delivery Systems and the Physicochemical Properties of the Drug Have a Pronounced Influence on the Degree of Drug Supersaturation That Develops During in Vitro Digestion
  Journal of Pharmaceutical Sciences. Apr, 2014  |   Pubmed ID: 24470073
• Targeted Delivery of a Model Immunomodulator to the Lymphatic System: Comparison of Alkyl Ester Versus Triglyceride Mimetic Lipid Prodrug Strategies
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2014  |   Pubmed ID: 24398334
• Ionic Liquids Provide Unique Opportunities for Oral Drug Delivery: Structure Optimization and in Vivo Evidence of Utility
  Chemical Communications (Cambridge, England). Feb, 2014  |   Pubmed ID: 24394756
• The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats
  Molecular Pharmaceutics. Feb, 2014  |   Pubmed ID: 24350780
• Recent Advances in Lipid-based Formulation Technology
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 24158727
• Gastric Pre-processing is an Important Determinant of the Ability of Medium-chain Lipid Solution Formulations to Enhance Oral Bioavailability in Rats
  Journal of Pharmaceutical Sciences. Nov, 2013  |   Pubmed ID: 23983139
• PEGylated Polylysine Dendrimers Increase Lymphatic Exposure to Doxorubicin when Compared to PEGylated Liposomal and Solution Formulations of Doxorubicin
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2013  |   Pubmed ID: 23954628
• Population Pharmacokinetics of Colistin Methanesulfonate in Rats: Achieving Sustained Lung Concentrations of Colistin for Targeting Respiratory Infections
  Antimicrobial Agents and Chemotherapy. Oct, 2013  |   Pubmed ID: 23917323
• Lipid-based Formulations and Drug Supersaturation: Harnessing the Unique Benefits of the Lipid Digestion/absorption Pathway
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 23824582
• Lipid Absorption Triggers Drug Supersaturation at the Intestinal Unstirred Water Layer and Promotes Drug Absorption from Mixed Micelles
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 23793990
• Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 23771564
• Pulmonary Administration of PEGylated Polylysine Dendrimers: Absorption from the Lung Versus Retention Within the Lung is Highly Size-dependent
  Molecular Pharmaceutics. Aug, 2013  |   Pubmed ID: 23750747
• A Simple Quantitative Approach for the Determination of Long and Medium Chain Lipids in Bio-relevant Matrices by High Performance Liquid Chromatography with Refractive Index Detection
  AAPS PharmSciTech. Sep, 2013  |   Pubmed ID: 23733513
• The Potential for Drug Supersaturation During Intestinal Processing of Lipid-based Formulations May Be Enhanced for Basic Drugs
  Molecular Pharmaceutics. Jul, 2013  |   Pubmed ID: 23697606
• The Impact of Lymphatic Transport on the Systemic Disposition of Lipophilic Drugs
  Journal of Pharmaceutical Sciences. Jul, 2013  |   Pubmed ID: 23696002
• In Vitro Assessment of Drug-free and Fenofibrate-containing Lipid Formulations Using Dispersion and Digestion Testing Gives Detailed Insights into the Likely Fate of Formulations in the Intestine
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2013  |   Pubmed ID: 23684915
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the in Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-based Formulations
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 23661145
• Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis
  Molecular Pharmaceutics. Aug, 2013  |   Pubmed ID: 23631696
• PEGylation of Interferon α2 Improves Lymphatic Exposure After Subcutaneous and Intravenous Administration and Improves Antitumour Efficacy Against Lymphatic Breast Cancer Metastases
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2013  |   Pubmed ID: 23499718
• Intestinal Bile Secretion Promotes Drug Absorption from Lipid Colloidal Phases Via Induction of Supersaturation
  Molecular Pharmaceutics. May, 2013  |   Pubmed ID: 23480483
• A Mouse Model to Evaluate the Impact of Species, Sex, and Lipid Load on Lymphatic Drug Transport
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 23430484
• Strategies to Address Low Drug Solubility in Discovery and Development
  Pharmacological Reviews. Jan, 2013  |   Pubmed ID: 23383426
• Silica-lipid Hybrid (SLH) Formulations Enhance the Oral Bioavailability and Efficacy of Celecoxib: An in Vivo Evaluation
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2013  |   Pubmed ID: 23353808
• The Effect of Administered Dose of Lipid-based Formulations on the in Vitro and in Vivo Performance of Cinnarizine As a Model Poorly Water-soluble Drug
  Journal of Pharmaceutical Sciences. Feb, 2013  |   Pubmed ID: 23242691
• In Vitro Digestion Testing of Lipid-based Delivery Systems: Calcium Ions Combine with Fatty Acids Liberated from Triglyceride Rich Lipid Solutions to Form Soaps and Reduce the Solubilization Capacity of Colloidal Digestion Products
  International Journal of Pharmaceutics. Jan, 2013  |   Pubmed ID: 23178598
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations During in Vitro Digestion
  Molecular Pharmaceutics. Nov, 2012  |   Pubmed ID: 23030411
• Incomplete Desorption of Liquid Excipients Reduces the in Vitro and in Vivo Performance of Self-emulsifying Drug Delivery Systems Solidified by Adsorption Onto an Inorganic Mesoporous Carrier
  Molecular Pharmaceutics. Sep, 2012  |   Pubmed ID: 22870936
• Lipid Digestion As a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-emulsifying Drug Delivery Systems
  Molecular Pharmaceutics. Jul, 2012  |   Pubmed ID: 22656917
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 1: Method Parameterization and Comparison of in Vitro Digestion Profiles Across a Range of Representative Formulations
  Journal of Pharmaceutical Sciences. Sep, 2012  |   Pubmed ID: 22644939
• Intravenous Dosing Conditions May Affect Systemic Clearance for Highly Lipophilic Drugs: Implications for Lymphatic Transport and Absolute Bioavailability Studies
  Journal of Pharmaceutical Sciences. Sep, 2012  |   Pubmed ID: 22623170
• Association of Chemotherapeutic Drugs with Dendrimer Nanocarriers: An Assessment of the Merits of Covalent Conjugation Compared to Noncovalent Encapsulation
  Molecular Pharmaceutics. Jan, 2012  |   Pubmed ID: 22250750
• Doxorubicin-Conjugated PEGylated Dendrimers Show Similar Tumoricidal Activity but Lower Systemic Toxicity When Compared to PEGylated Liposome and Solution Formulations in Mouse and Rat Tumor Models
  Molecular Pharmaceutics. Jan, 2012  |   Pubmed ID: 22233281
• A Comparison of Changes to Doxorubicin Pharmacokinetics, Antitumor Activity, and Toxicity Mediated by PEGylated Dendrimer and PEGylated Liposome Drug Delivery Systems
  Nanomedicine : Nanotechnology, Biology, and Medicine. Jan, 2012  |   Pubmed ID: 21704192
• Correction to "targeted Drug Delivery to Lymphocytes: a Route to Site-specific Immunomodulation?"
  Molecular Pharmaceutics. Dec, 2011  |   Pubmed ID: 21995681
• Dendrimer Pharmacokinetics: the Effect of Size, Structure and Surface Characteristics on ADME Properties
  Nanomedicine (London, England). Aug, 2011  |   Pubmed ID: 21955077
• Differences in Colloidal Structure of PEGylated Nanomaterials Dictate the Likelihood of Accelerated Blood Clearance
  Journal of Pharmaceutical Sciences. Nov, 2011  |   Pubmed ID: 21721002
• Targeting the Lymphatics Using Dendritic Polymers (dendrimers)
  Advanced Drug Delivery Reviews. Sep, 2011  |   Pubmed ID: 21683746
• Acute Hypertriglyceridemia Promotes Intestinal Lymphatic Lipid and Drug Transport: a Positive Feedback Mechanism in Lipid and Drug Absorption
  Molecular Pharmaceutics. Aug, 2011  |   Pubmed ID: 21604764
• Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?
  Pharmaceutical Research. Sep, 2011  |   Pubmed ID: 21523511
• Nanostructured Liquid Crystalline Particles Provide Long Duration Sustained-release Effect for a Poorly Water Soluble Drug After Oral Administration
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2011  |   Pubmed ID: 21497623
• Characterisation and Tumour Targeting of PEGylated Polylysine Dendrimers Bearing Doxorubicin Via a PH Labile Linker
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2011  |   Pubmed ID: 21315119
• Preparation, Crystallization and Preliminary X-ray Diffraction Analysis of Two Intestinal Fatty-acid Binding Proteins in the Presence of 11-(dansylamino)undecanoic Acid
  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2011  |   Pubmed ID: 21301109
• Capping Methotrexate α-carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated Polylysine Dendrimers
  Molecular Pharmaceutics. Apr, 2011  |   Pubmed ID: 21171585
• Using Polymeric Precipitation Inhibitors to Improve the Absorption of Poorly Water-soluble Drugs: A Mechanistic Basis for Utility
  Journal of Drug Targeting. Dec, 2010  |   Pubmed ID: 20973755
• Targeted Drug Delivery to Lymphocytes: a Route to Site-specific Immunomodulation?
  Molecular Pharmaceutics. Dec, 2010  |   Pubmed ID: 20958081
• Phytantriol and Glyceryl Monooleate Cubic Liquid Crystalline Phases As Sustained-release Oral Drug Delivery Systems for Poorly Water-soluble Drugs II. In-vivo Evaluation
  The Journal of Pharmacy and Pharmacology. Jul, 2010  |   Pubmed ID: 20636873
• Phytantriol and Glyceryl Monooleate Cubic Liquid Crystalline Phases As Sustained-release Oral Drug Delivery Systems for Poorly Water Soluble Drugs I. Phase Behaviour in Physiologically-relevant Media
  The Journal of Pharmacy and Pharmacology. Jul, 2010  |   Pubmed ID: 20636872
• The Mechanism of Lymphatic Access of Two Cholesteryl Ester Transfer Protein Inhibitors (CP524,515 and CP532,623) and Evaluation of Their Impact on Lymph Lipoprotein Profiles
  Pharmaceutical Research. Sep, 2010  |   Pubmed ID: 20635194
• The Role of the Intestinal Lymphatics in the Absorption of Two Highly Lipophilic Cholesterol Ester Transfer Protein Inhibitors (CP524,515 and CP532,623)
  Pharmaceutical Research. May, 2010  |   Pubmed ID: 20221896
• Lymphatic Transport of Methylnortestosterone Undecanoate (MU) and the Bioavailability of Methylnortestosterone Are Highly Sensitive to the Mass of Coadministered Lipid After Oral Administration of MU
  The Journal of Pharmacology and Experimental Therapeutics. Nov, 2009  |   Pubmed ID: 19696095
• Probing the Fibrate Binding Specificity of Rat Liver Fatty Acid Binding Protein
  Journal of Medicinal Chemistry. Sep, 2009  |   Pubmed ID: 19663428
• Oral Bioavailability Assessment and Intestinal Lymphatic Transport of Org 45697 and Org 46035, Two Highly Lipophilic Novel Immunomodulator Analogues
  Current Drug Delivery. Aug, 2009  |   Pubmed ID: 19534711
• Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-l-lysine Dendrimers
  Molecular Pharmaceutics. Jul-Aug, 2009  |   Pubmed ID: 19453158
• Intestinal Lymphatic Transport Enhances the Post-prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-pass Metabolism
  Pharmaceutical Research. Jun, 2009  |   Pubmed ID: 19280324
• Characterization of Lipophilic Drug Binding to Rat Intestinal Fatty Acid Binding Protein
  Molecular and Cellular Biochemistry. Jun, 2009  |   Pubmed ID: 19160019
• An Evaluation of the Relative Roles of the Unstirred Water Layer and Receptor Sink in Limiting the In-vitro Intestinal Permeability of Drug Compounds of Varying Lipophilicity
  The Journal of Pharmacy and Pharmacology. Oct, 2008  |   Pubmed ID: 18812024
• Characterization of the Drug Binding Specificity of Rat Liver Fatty Acid Binding Protein
  Journal of Medicinal Chemistry. Jul, 2008  |   Pubmed ID: 18533710
• The Impact of Molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly L-lysine Dendrimers
  Molecular Pharmaceutics. May-Jun, 2008  |   Pubmed ID: 18393438
• Lipid-based Systems for the Enhanced Delivery of Poorly Water Soluble Drugs
  Advanced Drug Delivery Reviews. Mar, 2008  |   Pubmed ID: 18160174
• Enhancing Intestinal Drug Solubilisation Using Lipid-based Delivery Systems
  Advanced Drug Delivery Reviews. Mar, 2008  |   Pubmed ID: 18155801
• Lipid-based Delivery Systems and Intestinal Lymphatic Drug Transport: a Mechanistic Update
  Advanced Drug Delivery Reviews. Mar, 2008  |   Pubmed ID: 18155316
• Formulation of Lipid-based Delivery Systems for Oral Administration: Materials, Methods and Strategies
  Advanced Drug Delivery Reviews. Mar, 2008  |   Pubmed ID: 18068260
• Evaluation of the Impact of Surfactant Digestion on the Bioavailability of Danazol After Oral Administration of Lipidic Self-emulsifying Formulations to Dogs
  Journal of Pharmaceutical Sciences. Feb, 2008  |   Pubmed ID: 18064698
• Use of Plasma Proteins As Solubilizing Agents in in Vitro Permeability Experiments: Correction for Unbound Drug Concentration Using the Reciprocal Permeability Approach
  Journal of Pharmaceutical Sciences. Jan, 2008  |   Pubmed ID: 17585392
• Impact of Surface Derivatization of Poly-L-lysine Dendrimers with Anionic Arylsulfonate or Succinate Groups on Intravenous Pharmacokinetics and Disposition
  Molecular Pharmaceutics. Nov-Dec, 2007  |   Pubmed ID: 17953445
• Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Dec, 2007  |   Pubmed ID: 17875672
• Low Dose Lipid Formulations: Effects on Gastric Emptying and Biliary Secretion
  Pharmaceutical Research. Nov, 2007  |   Pubmed ID: 17657595
• A Lipid-based Liquid Crystalline Matrix That Provides Sustained Release and Enhanced Oral Bioavailability for a Model Poorly Water Soluble Drug in Rats
  International Journal of Pharmaceutics. Aug, 2007  |   Pubmed ID: 17467935
• Examination of the Role of Intestinal Fatty Acid-binding Protein in Drug Absorption Using a Parallel Artificial Membrane Permeability Assay
  Chemistry & Biology. Apr, 2007  |   Pubmed ID: 17462580
• Increasing the Proportional Content of Surfactant (Cremophor EL) Relative to Lipid in Self-emulsifying Lipid-based Formulations of Danazol Reduces Oral Bioavailability in Beagle Dogs
  Pharmaceutical Research. Apr, 2007  |   Pubmed ID: 17372700
• Lipids and Lipid-based Formulations: Optimizing the Oral Delivery of Lipophilic Drugs
  Nature Reviews. Drug Discovery. Mar, 2007  |   Pubmed ID: 17330072
• Impact of Cremophor-EL and Polysorbate-80 on Digoxin Permeability Across Rat Jejunum: Delineation of Thermodynamic and Transporter Related Events Using the Reciprocal Permeability Approach
  Journal of Pharmaceutical Sciences. Feb, 2007  |   Pubmed ID: 17051595
• Cationic Poly-L-lysine Dendrimers: Pharmacokinetics, Biodistribution, and Evidence for Metabolism and Bioresorption After Intravenous Administration to Rats
  Molecular Pharmaceutics. Sep-Oct, 2006  |   Pubmed ID: 17009860
• The Absorption of Darbepoetin Alfa Occurs Predominantly Via the Lymphatics Following Subcutaneous Administration to Sheep
  Pharmaceutical Research. Sep, 2006  |   Pubmed ID: 16951999
• Permeability Assessment of Poorly Water-soluble Compounds Under Solubilizing Conditions: the Reciprocal Permeability Approach
  Journal of Pharmaceutical Sciences. Oct, 2006  |   Pubmed ID: 16883557
• An Acute and Coincident Increase in FABP Expression and Lymphatic Lipid and Drug Transport Occurs During Intestinal Infusion of Lipid-based Drug Formulations to Rats
  Pharmaceutical Research. Aug, 2006  |   Pubmed ID: 16858652
• Examination of the Impact of a Range of Pluronic Surfactants on the In-vitro Solubilisation Behaviour and Oral Bioavailability of Lipidic Formulations of Atovaquone
  The Journal of Pharmacy and Pharmacology. Jun, 2006  |   Pubmed ID: 16734982
• An Examination of the Interplay Between Enterocyte-based Metabolism and Lymphatic Drug Transport in the Rat
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2006  |   Pubmed ID: 16467133
• The Lymph Lipid Precursor Pool is a Key Determinant of Intestinal Lymphatic Drug Transport
  The Journal of Pharmacology and Experimental Therapeutics. Feb, 2006  |   Pubmed ID: 16249368
• Tissue Uptake of DDT is Independent of Chylomicron Metabolism
  Archives of Toxicology. Apr, 2006  |   Pubmed ID: 16180009
• Subcutaneous Drug Delivery and the Role of the Lymphatics
  Drug Discovery Today. Technologies. 2005  |   Pubmed ID: 24981760
• Bile Increases Intestinal Lymphatic Drug Transport in the Fasted Rat
  Pharmaceutical Research. Nov, 2005  |   Pubmed ID: 16132351
• An Improved Method for the Purification of Rat Liver-type Fatty Acid Binding Protein from Escherichia Coli
  Protein Expression and Purification. Nov, 2005  |   Pubmed ID: 15914028
• The Interaction of Lipophilic Drugs with Intestinal Fatty Acid-binding Protein
  The Journal of Biological Chemistry. May, 2005  |   Pubmed ID: 15722357
• Influence of the Intermediate Digestion Phases of Common Formulation Lipids on the Absorption of a Poorly Water-soluble Drug
  Journal of Pharmaceutical Sciences. Mar, 2005  |   Pubmed ID: 15619248
• Lymphatic Absorption is the Primary Contributor to the Systemic Availability of Epoetin Alfa Following Subcutaneous Administration to Sheep
  The Journal of Pharmacology and Experimental Therapeutics. Apr, 2005  |   Pubmed ID: 15579493
• A Novel Cubic Phase of Medium Chain Lipid Origin for the Delivery of Poorly Water Soluble Drugs
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2004  |   Pubmed ID: 15380632
• Susceptibility to Lipase-mediated Digestion Reduces the Oral Bioavailability of Danazol After Administration As a Medium-chain Lipid-based Microemulsion Formulation
  Pharmaceutical Research. Aug, 2004  |   Pubmed ID: 15359575
• Use of in Vitro Lipid Digestion Data to Explain the in Vivo Performance of Triglyceride-based Oral Lipid Formulations of Poorly Water-soluble Drugs: Studies with Halofantrine
  Journal of Pharmaceutical Sciences. May, 2004  |   Pubmed ID: 15067688
• Drug Solubilization Behavior During in Vitro Digestion of Suspension Formulations of Poorly Water-soluble Drugs in Triglyceride Lipids
  Pharmaceutical Research. Feb, 2004  |   Pubmed ID: 15032306
• Drug Solubilization Behavior During in Vitro Digestion of Simple Triglyceride Lipid Solution Formulations
  Pharmaceutical Research. Feb, 2004  |   Pubmed ID: 15032305
• Influence of Physicochemical Properties on the Patterns of Association of a Series of Aliphatic Esters of Halofantrine with Plasma Lipoproteins
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2004  |   Pubmed ID: 14980776
• Evaluation of the Impact of Altered Lipoprotein Binding Conditions on Halofantrine Induced QTc Interval Prolongation in an Anaesthetized Rabbit Model
  The Journal of Pharmacy and Pharmacology. Jan, 2004  |   Pubmed ID: 14980003
• Pharmacokinetics of Recombinant Human Leukemia Inhibitory Factor in Sheep
  The Journal of Pharmacology and Experimental Therapeutics. Jun, 2004  |   Pubmed ID: 14872093
• Probing Drug Solubilization Patterns in the Gastrointestinal Tract After Administration of Lipid-based Delivery Systems: a Phase Diagram Approach
  Journal of Pharmaceutical Sciences. Feb, 2004  |   Pubmed ID: 14705191
• Intestinal Lymphatic Transport of Halofantrine Occurs After Oral Administration of a Unit-dose Lipid-based Formulation to Fasted Dogs
  Pharmaceutical Research. Sep, 2003  |   Pubmed ID: 14567642
• Examination of Oral Absorption and Lymphatic Transport of Halofantrine in a Triple-cannulated Canine Model After Administration in Self-microemulsifying Drug Delivery Systems (SMEDDS) Containing Structured Triglycerides
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Sep, 2003  |   Pubmed ID: 13678797
• Pharmacokinetic Model to Describe the Lymphatic Absorption of R-metHu-leptin After Subcutaneous Injection to Sheep
  Pharmaceutical Research. Aug, 2003  |   Pubmed ID: 12948012
• Application of Compartmental Modeling to an Examination of in Vitro Intestinal Permeability Data: Assessing the Impact of Tissue Uptake, P-glycoprotein, and CYP3A
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2003  |   Pubmed ID: 12920171
• Contribution of Lymphatically Transported Testosterone Undecanoate to the Systemic Exposure of Testosterone After Oral Administration of Two Andriol Formulations in Conscious Lymph Duct-cannulated Dogs
  The Journal of Pharmacology and Experimental Therapeutics. Sep, 2003  |   Pubmed ID: 12807999
• Using the Polymer Partitioning Method to Probe the Thermodynamic Activity of Poorly Water-soluble Drugs Solubilized in Model Lipid Digestion Products
  Journal of Pharmaceutical Sciences. Jun, 2003  |   Pubmed ID: 12761815
• Does Stereoselective Lymphatic Absorption Contribute to the Enantioselective Pharmacokinetics of Halofantrine In Vivo?
  Biopharmaceutics & Drug Disposition. May, 2003  |   Pubmed ID: 12698498
• A Kinetic Evaluation of the Absorption, Efflux, and Metabolism of Verapamil in the Autoperfused Rat Jejunum
  The Journal of Pharmacology and Experimental Therapeutics. Apr, 2003  |   Pubmed ID: 12649363
• Desbutylhalofantrine: Evaluation of QT Prolongation and Other Cardiovascular Effects After Intravenous Administration in Vivo
  Journal of Cardiovascular Pharmacology. Mar, 2003  |   Pubmed ID: 12605019
• Separation and Characterization of the Colloidal Phases Produced on Digestion of Common Formulation Lipids and Assessment of Their Impact on the Apparent Solubility of Selected Poorly Water-soluble Drugs
  Journal of Pharmaceutical Sciences. Mar, 2003  |   Pubmed ID: 12587125
• An in Vitro Examination of the Impact of Polyethylene Glycol 400, Pluronic P85, and Vitamin E D-alpha-tocopheryl Polyethylene Glycol 1000 Succinate on P-glycoprotein Efflux and Enterocyte-based Metabolism in Excised Rat Intestine
  AAPS PharmSci. 2002  |   Pubmed ID: 12646011
• Structured Triglyceride Vehicles for Oral Delivery of Halofantrine: Examination of Intestinal Lymphatic Transport and Bioavailability in Conscious Rats
  Pharmaceutical Research. Sep, 2002  |   Pubmed ID: 12403073
• A Physicochemical Basis for the Extensive Intestinal Lymphatic Transport of a Poorly Lipid Soluble Antimalarial, Halofantrine Hydrochloride, After Postprandial Administration to Dogs
  Journal of Pharmaceutical Sciences. Mar, 2002  |   Pubmed ID: 11920750
• Evaluation of the In-vitro Digestion Profiles of Long and Medium Chain Glycerides and the Phase Behaviour of Their Lipolytic Products
  The Journal of Pharmacy and Pharmacology. Jan, 2002  |   Pubmed ID: 11833493