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Articles by Cicely L. Williams in JoVE
JoVE Clinical and Translational Medicine
Брыжеечной артерии Сокращение и отдых Исследования с помощью автоматизированной миография провода
1Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, 2Department of Biology, North Carolina Central University, Durham, 3Department of Physiology & Pharmacology and Hypertension & Vascular Research Center, Wake Forest University School of Medicine
Автоматизированный метод миография для измерения силы в изолированных артерий брыжеечной описано. В нем занято Mulvany-Гальперн Авто Двойной Myograph провода 510A для определения ответов на фенилэфрин и внеклеточного кальция. Метод позволяет последовательно определения изометрической ответы на агонисты в мелких сосудах диаметром 60 - 300 мкм, независимо друг от друга.
Other articles by Cicely L. Williams on PubMed
Action of Thiazide on Renal Interstitial Calcium
Although thiazides increase urinary sodium excretion, they also decrease urinary calcium excretion. Recent studies in our laboratory have shown that increased dietary salt significantly reduces interstitial fluid calcium in Dahl salt-sensitive (DS) rats, and this was associated with a rise in blood pressure and increased urinary calcium excretion. Owing to the vasorelaxant actions of increased extracellular fluid calcium, we reasoned that the antihypertensive action of hydrochlorothiazide (HCTZ), a commonly used thiazide, may be the result of increased interstitial fluid calcium as a consequence of decreased urinary calcium excretion.
