Colin Farquharson Developmental Biology, The Roslin Institute and R(D)SVS University of Edinburgh Biography Publications Institution JoVE Articles Colin Farquharson has not added a biography. If you are Colin Farquharson and would like to personalize this page please email our Author Liaison for assistance. Publications Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation Frontiers in Physiology. 2017 | Pubmed ID: 29089903 Animal Models to Explore the Effects of Glucocorticoids on Skeletal Growth and Structure The Journal of Endocrinology. Oct, 2017 | Pubmed ID: 29051192 PLA2 and ENPP6 May Act in Concert to Generate Phosphocholine from the Matrix Vesicle Membrane During Skeletal Mineralization FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2017 | Pubmed ID: 28864658 A Distinctive Patchy Osteomalacia Characterises Phospho1-deficient Mice Journal of Anatomy. Aug, 2017 | Pubmed ID: 28737011 Hypomorphic Conditional Deletion of E11/Podoplanin Reveals a Role in Osteocyte Dendrite Elongation Journal of Cellular Physiology. Nov, 2017 | Pubmed ID: 28488815 Skeletal Energy Homeostasis: a Paradigm of Endocrine Discovery The Journal of Endocrinology. Jul, 2017 | Pubmed ID: 28455432 End Stage Renal Disease-induced Hypercalcemia May Promote Aortic Valve Calcification Via Annexin VI Enrichment of Valve Interstitial Cell Derived-matrix Vesicles Journal of Cellular Physiology. Nov, 2017 | Pubmed ID: 28369848 Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues International Journal of Molecular Sciences. Dec, 2016 | Pubmed ID: 28035954 Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi T1 Double-Knockout Mice Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2016 | Pubmed ID: 26773408 E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models Journal of Cellular Physiology. Jun, 2016 | Pubmed ID: 26639105 The Functional Co-operativity of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 During Initiation of Skeletal Mineralization Biochemistry and Biophysics Reports. Dec, 2015 | Pubmed ID: 26457330 Increased Linear Bone Growth by GH in the Absence of SOCS2 is Independent of IGF-1 Journal of Cellular Physiology. Nov, 2015 | Pubmed ID: 25833299 Piroxicam Treatment Augments Bone Abnormalities in Interleukin-10 Knockout Mice Inflammatory Bowel Diseases. Feb, 2015 | Pubmed ID: 25569742 An Investigation of the Mineral in Ductile and Brittle Cortical Mouse Bone Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. May, 2015 | Pubmed ID: 25418329 Deficiency of the Bone Mineralization Inhibitor NPP1 Protects Against Obesity and Diabetes Disease Models & Mechanisms. Oct, 2014 | Pubmed ID: 25368121 BMP-9 Regulates the Osteoblastic Differentiation and Calcification of Vascular Smooth Muscle Cells Through an ALK1 Mediated Pathway Journal of Cellular and Molecular Medicine. Oct, 2014 | Pubmed ID: 25297851 Reference Point Indentation is Not Indicative of Whole Mouse Bone Measures of Stress Intensity Fracture Toughness Bone. Oct, 2014 | Pubmed ID: 25280470 Design, Synthesis and Evaluation of Benzoisothiazolones As Selective Inhibitors of PHOSPHO1 Bioorganic & Medicinal Chemistry Letters. Sep, 2014 | Pubmed ID: 25124115 Ablation of Osteopontin Improves the Skeletal Phenotype of Phospho1(-/-) Mice Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Nov, 2014 | Pubmed ID: 24825455 Upregulation of IGF2 Expression During Vascular Calcification Journal of Molecular Endocrinology. Apr, 2014 | Pubmed ID: 24482492 Identification of Novel Regulators of Osteoblast Matrix Mineralization by Time Series Transcriptional Profiling Journal of Bone and Mineral Metabolism. May, 2014 | Pubmed ID: 23925391 Total Protein Analysis As a Reliable Loading Control for Quantitative Fluorescent Western Blotting PloS One. 2013 | Pubmed ID: 24023619 A Protective Role for FGF-23 in Local Defence Against Disrupted Arterial Wall Integrity? Molecular and Cellular Endocrinology. Jun, 2013 | Pubmed ID: 23523568 Suppression of Mammalian Bone Growth by Membrane Transport Inhibitors Journal of Cellular Biochemistry. Mar, 2013 | Pubmed ID: 23059814 Pharmacological Inhibition of PHOSPHO1 Suppresses Vascular Smooth Muscle Cell Calcification Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jan, 2013 | Pubmed ID: 22887744 Inflammation and Linear Bone Growth: the Inhibitory Role of SOCS2 on GH/IGF-1 Signaling Pediatric Nephrology (Berlin, Germany). Apr, 2013 | Pubmed ID: 22886280 Mechanisms and Clinical Consequences of Vascular Calcification Frontiers in Endocrinology. 2012 | Pubmed ID: 22888324 Cartilage Development and Degeneration: a Wnt Wnt Situation Cell Biochemistry and Function. Dec, 2012 | Pubmed ID: 22714865 The Importance of the SIBLING Family of Proteins on Skeletal Mineralisation and Bone Remodelling The Journal of Endocrinology. Sep, 2012 | Pubmed ID: 22700194 Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation PloS One. 2012 | Pubmed ID: 22586496 Altered Bone Development and an Increase in FGF-23 Expression in Enpp1(-/-) Mice PloS One. 2012 | Pubmed ID: 22359666 SOCS2 is the Critical Regulator of GH Action in Murine Growth Plate Chondrogenesis Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. May, 2012 | Pubmed ID: 22228213 The Skeleton: No Bones About It The Journal of Endocrinology. Nov, 2011 | Pubmed ID: 21784772 Sodium Fluoride Induces Apoptosis and Alters Bcl-2 Family Protein Expression in MC3T3-E1 Osteoblastic Cells Biochemical and Biophysical Research Communications. Jul, 2011 | Pubmed ID: 21708129 Social Networking Between Cells of the Foetal Skeleton: the Importance of Thyroid Hormones The Journal of Endocrinology. Aug, 2011 | Pubmed ID: 21680616 The Appearance and Modulation of Osteocyte Marker Expression During Calcification of Vascular Smooth Muscle Cells PloS One. 2011 | Pubmed ID: 21611184 PHOSPHO1 is Essential for Mechanically Competent Mineralization and the Avoidance of Spontaneous Fractures Bone. May, 2011 | Pubmed ID: 21272676 Loss of Skeletal Mineralization by the Simultaneous Ablation of PHOSPHO1 and Alkaline Phosphatase Function: a Unified Model of the Mechanisms of Initiation of Skeletal Calcification Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Feb, 2011 | Pubmed ID: 20684022 Inhibition of PHOSPHO1 Activity Results in Impaired Skeletal Mineralization During Limb Development of the Chick Bone. Apr, 2010 | Pubmed ID: 20053388 Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-deficient Matrix Vesicles Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2010 | Pubmed ID: 19874193 Genetic Selection for Fast Growth Generates Bone Architecture Characterised by Enhanced Periosteal Expansion and Limited Consolidation of the Cortices but a Diminution in the Early Responses to Mechanical Loading Bone. Aug, 2009 | Pubmed ID: 19409517 Identification of a Novel Splice Variant of the Haloacid Dehalogenase: PHOSPHO1 Biochemical and Biophysical Research Communications. Jul, 2008 | Pubmed ID: 18471996 Phospholipase C-eta Enzymes As Putative Protein Kinase C and Ca2+ Signalling Components in Neuronal and Neuroendocrine Tissues Neuroendocrinology. 2007 | Pubmed ID: 17895620 IGF-I Signalling in Bone Growth: Inhibitory Actions of Dexamethasone and IL-1beta Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society. Oct, 2007 | Pubmed ID: 17590365 Functional Involvement of PHOSPHO1 in Matrix Vesicle-mediated Skeletal Mineralization Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2007 | Pubmed ID: 17227223 Effect of Spironolactone on C-reactive Protein Levels in Patients with Heart Disease International Journal of Cardiology. Apr, 2007 | Pubmed ID: 16899309 The Presence of PHOSPHO1 in Matrix Vesicles and Its Developmental Expression Prior to Skeletal Mineralization Bone. Nov, 2006 | Pubmed ID: 16837257 Elevated Expression of Hypoxia Inducible Factor-2alpha in Terminally Differentiating Growth Plate Chondrocytes Journal of Cellular Physiology. Feb, 2006 | Pubmed ID: 16155924 Probing the Substrate Specificities of Human PHOSPHO1 and PHOSPHO2 Biochimica Et Biophysica Acta. Aug, 2005 | Pubmed ID: 16054448 Identification of a Novel Class of Mammalian Phosphoinositol-specific Phospholipase C Enzymes International Journal of Molecular Medicine. Jan, 2005 | Pubmed ID: 15583837 Tonic Levels of Angiotensin II Reduce Tonic Levels of Vascular Nitric Oxide Even in Salt-replete Man Journal of the Renin-angiotensin-aldosterone System : JRAAS. Jun, 2004 | Pubmed ID: 15295720 Human PHOSPHO1 Exhibits High Specific Phosphoethanolamine and Phosphocholine Phosphatase Activities The Biochemical Journal. Aug, 2004 | Pubmed ID: 15175005 PHOSPHO1-A Novel Phosphatase Specifically Expressed at Sites of Mineralisation in Bone and Cartilage Bone. Apr, 2004 | Pubmed ID: 15050893 Comparative Modelling of Human PHOSPHO1 Reveals a New Group of Phosphatases Within the Haloacid Dehalogenase Superfamily Protein Engineering. Dec, 2003 | Pubmed ID: 14983068 Aldosterone Induces Acute Endothelial Dysfunction in Vivo in Humans: Evidence for an Aldosterone-induced Vasculopathy Clinical Science (London, England : 1979). Oct, 2002 | Pubmed ID: 12241543 Differences in Metabolic Parameters and Gene Expression Related to Osteochondrosis/osteoarthrosis in Pigs Fed 25-hydroxyvitamin D3 Veterinary Research. Jul-Aug, 2002 | Pubmed ID: 12199365 Allopurinol Improves Endothelial Dysfunction in Chronic Heart Failure Circulation. Jul, 2002 | Pubmed ID: 12105162 Gradual Reactivation over Time of Vascular Tissue Angiotensin I to Angiotensin II Conversion During Chronic Lisinopril Therapy in Chronic Heart Failure Journal of the American College of Cardiology. Mar, 2002 | Pubmed ID: 11869839 Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification Cui Lin1, Dongxing Zhu2, Greg Markby1, Brendan M. Corcoran3, Colin Farquharson1, Vicky E. Macrae1 1Developmental Biology, The Roslin Institute and R(D)SVS, University of Edinburgh, 2Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, 3Clinical Sciences and R(D)SVS, University of Edinburgh JoVE 56126 Developmental Biology Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification Dean A. Houston*1, Katherine A. Staines*1, Vicky E. MacRae1, Colin Farquharson1 1Developmental Biology, The Roslin Institute and R(D)SVS, The University of Edinburgh JoVE 54978 Developmental Biology A Guide to Modern Quantitative Fluorescent Western Blotting with Troubleshooting Strategies Samantha L. Eaton1, Maica Llavero Hurtado1, Karla J. Oldknow2, Laura C. Graham1, Thomas W. Marchant1, Thomas H. Gillingwater3,4, Colin Farquharson2, Thomas M. Wishart1,4 1Division of Neurobiology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, 2Division of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, 3Centre for Integrative Physiology, University of Edinburgh, 4Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh JoVE 52099 Biology
Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification Cui Lin1, Dongxing Zhu2, Greg Markby1, Brendan M. Corcoran3, Colin Farquharson1, Vicky E. Macrae1 1Developmental Biology, The Roslin Institute and R(D)SVS, University of Edinburgh, 2Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, 3Clinical Sciences and R(D)SVS, University of Edinburgh JoVE 56126 Developmental Biology
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification Dean A. Houston*1, Katherine A. Staines*1, Vicky E. MacRae1, Colin Farquharson1 1Developmental Biology, The Roslin Institute and R(D)SVS, The University of Edinburgh JoVE 54978 Developmental Biology
A Guide to Modern Quantitative Fluorescent Western Blotting with Troubleshooting Strategies Samantha L. Eaton1, Maica Llavero Hurtado1, Karla J. Oldknow2, Laura C. Graham1, Thomas W. Marchant1, Thomas H. Gillingwater3,4, Colin Farquharson2, Thomas M. Wishart1,4 1Division of Neurobiology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, 2Division of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, 3Centre for Integrative Physiology, University of Edinburgh, 4Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh JoVE 52099 Biology
