Darrell N. Kotton Center for Regenerative Medicine Boston University and Boston Medical Center Biography Publications Institution JoVE Articles Darrell N. Kotton has not added a biography. If you are Darrell N. Kotton and would like to personalize this page please email our Author Liaison for assistance. Publications Human Distal Airways Contain a Multipotent Secretory Cell That Can Regenerate Alveoli Nature. Apr, 2022 | Pubmed ID: 35355013 Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration Frontiers in Endocrinology. 2022 | Pubmed ID: 35211095 Patient-specific IPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease Cell Reports. Aug, 2021 | Pubmed ID: 34469722 Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 Proceedings of the National Academy of Sciences of the United States of America. 09, 2021 | Pubmed ID: 34413211 Differentiation of Human Pluripotent Stem Cells into Functional Airway Basal Stem Cells STAR Protocols. 09, 2021 | Pubmed ID: 34355203 Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine Frontiers in Endocrinology. 2021 | Pubmed ID: 33959101 Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell. 01, 2021 | Pubmed ID: 33098807 Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration Annual Review of Physiology. 02, 2021 | Pubmed ID: 33074772 Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Molecular Cell. 12, 2020 | Pubmed ID: 33259812 SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell. 12, 2020 | Pubmed ID: 32979316 Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells Cell Stem Cell. 10, 2020 | Pubmed ID: 32891189 The in Vivo Genetic Program of Murine Primordial Lung Epithelial Progenitors Nature Communications. 01, 2020 | Pubmed ID: 32005814 Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows During Differentiation of Human PSC-Derived Distal Lung Progenitors Cell Stem Cell. 04, 2020 | Pubmed ID: 32004478 Derivation of Self-renewing Lung Alveolar Epithelial Type II Cells from Human Pluripotent Stem Cells Nature Protocols. 12, 2019 | Pubmed ID: 31732721 Generation of a Purified IPSC-Derived Smooth Muscle-like Population For Cell Sheet Engineering Stem Cell Reports. 09, 2019 | Pubmed ID: 31422908 Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity Journal of Immunology (Baltimore, Md. : 1950). 04, 2019 | Pubmed ID: 30796179 Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium Stem Cell Reports. 05, 2018 | Pubmed ID: 29657097 Claudin-18: Unexpected Regulator of Lung Alveolar Epithelial Cell Proliferation The Journal of Clinical Investigation. 03, 2018 | Pubmed ID: 29400691 Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells Cell Stem Cell. 10, 2017 | Pubmed ID: 28965766 Pluripotent Stem Cell Differentiation Reveals Distinct Developmental Pathways Regulating Lung- Versus Thyroid-lineage Specification Development (Cambridge, England). 11, 2017 | Pubmed ID: 28947536 Vascular Smooth Muscle Cells Derived from Inbred Swine Induced Pluripotent Stem Cells for Vascular Tissue Engineering Biomaterials. Dec, 2017 | Pubmed ID: 28942128 Prospective Isolation of NKX2-1-expressing Human Lung Progenitors Derived from Pluripotent Stem Cells The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28463226 Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells Via Temporal Regulation of Wnt Signaling Cell Stem Cell. 06, 2017 | Pubmed ID: 28366587 Regenerative Therapy for Hypothyroidism: Mechanisms and Possibilities Molecular and Cellular Endocrinology. 04, 2017 | Pubmed ID: 27876515 Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells Cell Stem Cell. Nov, 2015 | Pubmed ID: 26593959 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Embryonic and Induced Pluripotent Stem Cells for Lung Regeneration Annals of the American Thoracic Society. Mar, 2015 | Pubmed ID: 25830836 Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells Stem Cell Reports. Apr, 2015 | Pubmed ID: 25772471 Derivation of Endodermal Progenitors From Pluripotent Stem Cells Journal of Cellular Physiology. Feb, 2015 | Pubmed ID: 25160562 Lung Regeneration: Mechanisms, Applications and Emerging Stem Cell Populations Nature Medicine. Aug, 2014 | Pubmed ID: 25100528 KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development Cell Stem Cell. Jun, 2013 | Pubmed ID: 23746980 The Aryl Hydrocarbon Receptor Directs Hematopoietic Progenitor Cell Expansion and Differentiation Blood. Jul, 2013 | Pubmed ID: 23723449 Lentiviral Delivery of RNAi for in Vivo Lineage-specific Modulation of Gene Expression in Mouse Lung Macrophages Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23403494 诱导的胚胎干细胞用于揭示复杂遗传学长 QT 综合征家毒品行动。 The Journal of General Physiology. Jan, 2013 | Pubmed ID: 23277474 Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors Bio-protocol. Nov, 2012 | Pubmed ID: 27453901 The 2012 Nobel Prize in Physiology or Medicine: Democratizing Pluripotency for Lung Researchers American Journal of Respiratory and Critical Care Medicine. Dec, 2012 | Pubmed ID: 23204376 转录因子 Grainyhead 样 2 和 NK2-同源盒基因 1 形成一个监管的循环，坐标肺上皮细胞形态和分化。 The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22955271 建模瓣主动脉瓣狭窄征人类诱导多能干细胞。 Circulation. Oct, 2012 | Pubmed ID: 22914687 下一代再生： 希望和肺癌干细胞研究的炒作。 American Journal of Respiratory and Critical Care Medicine. Jun, 2012 | Pubmed ID: 22517787 纯净的肺、 甲状腺从胚胎干细胞的祖细胞的高效派生。 Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482505 从人类胚胎干细胞生成的胚祖行自我更新。 Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 维护和修理的肺内皮细胞并不涉及从骨髓内皮前体细胞的捐款。 American Journal of Respiratory Cell and Molecular Biology. Jul, 2012 | Pubmed ID: 22323363 马萨诸塞州总医院的案例记录。案例 2-2012 年。今年 63 岁女子与急进性呼吸衰竭和呼吸困难。 The New England Journal of Medicine. Jan, 2012 | Pubmed ID: 22256809 胚胎干和诱导多能干细胞的相同或不同吗？其潜在的治疗用途所涉的问题。 Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22186787 Nanog 的在维护期间邮政纳塔尔骨再生骨髓基质干细胞的作用。 Biochemical and Biophysical Research Communications. Jan, 2012 | Pubmed ID: 22142851 人类胚胎干细胞心肌细胞缓慢钾通道的生物物理特性牵连亚基化学计量比。 The Journal of Physiology. Dec, 2011 | Pubmed ID: 22025662 编程更改： 时代的药物学肺疾病的研究。 American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 21984571 从单元格文化转向生物： 体内成像实验再生医学中的小动物。 Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011 | Pubmed ID: 21952170 细胞在肺损伤与修复的可塑性： 从 NHLBI 讲习班，2010 年 4 月 19-20 日的报告。 Proceedings of the American Thoracic Society. Jun, 2011 | Pubmed ID: 21653526 鼠标 ES 和 IPS 细胞可以形成类似明确内的胚层尽管印迹基因存在着差异。 The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 FOXO1 调节成骨细胞分化。 Bone. May, 2011 | Pubmed ID: 21281751 使用单个可抽税慢病毒干细胞卡带的转基因无肺疾病特定人类诱导多能干干细胞的生成。 Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Lentivectors 接种后的 CD8 + T 细胞吸皮肤源性树突状细胞的作用。 Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20357252 通过慢病毒转导长寿肺肺泡巨噬细胞的小鼠肺气肿的改进。 The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20038801 切除的重编程转基因改善了使用单可抽税矢量生成的 IPS 细胞的分化潜能。 Stem Cells (Dayton, Ohio). Jan, 2010 | Pubmed ID: 19904830 肺泡蛋白沉积： 粒细胞-巨噬细胞集落刺激因子功能障碍台到床边故事。 Chest. Aug, 2009 | Pubmed ID: 19666756 骨折愈合的转录分析和诱导胚胎干细胞相关基因。 PloS One. 2009 | Pubmed ID: 19415118 诱导的多功能干细胞生成中使用单慢病毒干细胞卡带。 Stem Cells (Dayton, Ohio). Mar, 2009 | Pubmed ID: 19096035 1 受体及其 Antitrypsin 的操纵造血干细胞移植后的持续的表达。 American Journal of Respiratory Cell and Molecular Biology. Aug, 2008 | Pubmed ID: 18323534 干细胞生物学中的另一个槽口： 果蝇肠干细胞和细胞命运的规范。 BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2008 | Pubmed ID: 18200564 肺泡巨噬细胞延长的使用寿命。 American Journal of Respiratory Cell and Molecular Biology. Apr, 2008 | Pubmed ID: 18192503 双启动子慢病毒系统允许有毒蛋白诱导型的表达巨噬细胞。 Journal of Immunological Methods. Jan, 2008 | Pubmed ID: 17967462 肺癌干细胞。 Cell and Tissue Research. Jan, 2008 | Pubmed ID: 17805578 通过平移终止调制的哺乳动物基因表达外源控制。 Nature Medicine. Sep, 2006 | Pubmed ID: 16892063 失败的骨髓来重建肺上皮细胞。 American Journal of Respiratory Cell and Molecular Biology. Oct, 2005 | Pubmed ID: 15961722 效率的转导的高度纯化小鼠造血干细胞的慢病毒和 Oncoretroviral 向量的最小的体外操作条件下。 Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2005 | Pubmed ID: 15922964 与强大的造血功能重建活动的成人肝脏中的新型干细胞人口。 Blood. Sep, 2005 | Pubmed ID: 15870171 胚胎肺侧群细胞是造血和血管的前体。 American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15802552 肺癌干细胞： 新的范式。 Experimental Hematology. Apr, 2004 | Pubmed ID: 15050743 平移生理学： 原籍国和肺侧人口细胞表型。 American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2004 | Pubmed ID: 15047566 侧群细胞和 Bcrp1 在肺癌中的表达。 American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003 | Pubmed ID: 12626330 在肺血管内皮细胞的干细胞抗原-1 表达。 American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2003 | Pubmed ID: 12611818 生成人诱导的多能干细胞衍生的2型肺泡上皮细胞的3D球体和2D气液界面培养物 Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology 代人类诱导多能干细胞从外周血中使用STEMCCA慢病毒载体 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
生成人诱导的多能干细胞衍生的2型肺泡上皮细胞的3D球体和2D气液界面培养物 Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology
代人类诱导多能干细胞从外周血中使用STEMCCA慢病毒载体 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
