Darrell N. Kotton Center for Regenerative Medicine Boston University and Boston Medical Center Biography Publications Institution JoVE Articles Darrell N. Kotton has not added a biography. If you are Darrell N. Kotton and would like to personalize this page please email our Author Liaison for assistance. Publications Human Distal Airways Contain a Multipotent Secretory Cell That Can Regenerate Alveoli Nature. Apr, 2022 | Pubmed ID: 35355013 Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration Frontiers in Endocrinology. 2022 | Pubmed ID: 35211095 Patient-specific IPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease Cell Reports. Aug, 2021 | Pubmed ID: 34469722 Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 Proceedings of the National Academy of Sciences of the United States of America. 09, 2021 | Pubmed ID: 34413211 Differentiation of Human Pluripotent Stem Cells into Functional Airway Basal Stem Cells STAR Protocols. 09, 2021 | Pubmed ID: 34355203 Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine Frontiers in Endocrinology. 2021 | Pubmed ID: 33959101 Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell. 01, 2021 | Pubmed ID: 33098807 Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration Annual Review of Physiology. 02, 2021 | Pubmed ID: 33074772 Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Molecular Cell. 12, 2020 | Pubmed ID: 33259812 SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell. 12, 2020 | Pubmed ID: 32979316 Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells Cell Stem Cell. 10, 2020 | Pubmed ID: 32891189 The in Vivo Genetic Program of Murine Primordial Lung Epithelial Progenitors Nature Communications. 01, 2020 | Pubmed ID: 32005814 Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows During Differentiation of Human PSC-Derived Distal Lung Progenitors Cell Stem Cell. 04, 2020 | Pubmed ID: 32004478 Derivation of Self-renewing Lung Alveolar Epithelial Type II Cells from Human Pluripotent Stem Cells Nature Protocols. 12, 2019 | Pubmed ID: 31732721 Generation of a Purified IPSC-Derived Smooth Muscle-like Population For Cell Sheet Engineering Stem Cell Reports. 09, 2019 | Pubmed ID: 31422908 Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity Journal of Immunology (Baltimore, Md. : 1950). 04, 2019 | Pubmed ID: 30796179 Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium Stem Cell Reports. 05, 2018 | Pubmed ID: 29657097 Claudin-18: Unexpected Regulator of Lung Alveolar Epithelial Cell Proliferation The Journal of Clinical Investigation. 03, 2018 | Pubmed ID: 29400691 Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells Cell Stem Cell. 10, 2017 | Pubmed ID: 28965766 Pluripotent Stem Cell Differentiation Reveals Distinct Developmental Pathways Regulating Lung- Versus Thyroid-lineage Specification Development (Cambridge, England). 11, 2017 | Pubmed ID: 28947536 Vascular Smooth Muscle Cells Derived from Inbred Swine Induced Pluripotent Stem Cells for Vascular Tissue Engineering Biomaterials. Dec, 2017 | Pubmed ID: 28942128 Prospective Isolation of NKX2-1-expressing Human Lung Progenitors Derived from Pluripotent Stem Cells The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28463226 Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells Via Temporal Regulation of Wnt Signaling Cell Stem Cell. 06, 2017 | Pubmed ID: 28366587 Regenerative Therapy for Hypothyroidism: Mechanisms and Possibilities Molecular and Cellular Endocrinology. 04, 2017 | Pubmed ID: 27876515 Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells Cell Stem Cell. Nov, 2015 | Pubmed ID: 26593959 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Embryonic and Induced Pluripotent Stem Cells for Lung Regeneration Annals of the American Thoracic Society. Mar, 2015 | Pubmed ID: 25830836 Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells Stem Cell Reports. Apr, 2015 | Pubmed ID: 25772471 Derivation of Endodermal Progenitors From Pluripotent Stem Cells Journal of Cellular Physiology. Feb, 2015 | Pubmed ID: 25160562 Lung Regeneration: Mechanisms, Applications and Emerging Stem Cell Populations Nature Medicine. Aug, 2014 | Pubmed ID: 25100528 KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development Cell Stem Cell. Jun, 2013 | Pubmed ID: 23746980 The Aryl Hydrocarbon Receptor Directs Hematopoietic Progenitor Cell Expansion and Differentiation Blood. Jul, 2013 | Pubmed ID: 23723449 Lentiviral Delivery of RNAi for in Vivo Lineage-specific Modulation of Gene Expression in Mouse Lung Macrophages Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23403494 Inducidas Pluripotentes Células Madre Solía Revelan Acciones De Drogas En Una Familia De Síndrome QT Larga Con Genética Compleja The Journal of General Physiology. Jan, 2013 | Pubmed ID: 23277474 Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors Bio-protocol. Nov, 2012 | Pubmed ID: 27453901 The 2012 Nobel Prize in Physiology or Medicine: Democratizing Pluripotency for Lung Researchers American Journal of Respiratory and Critical Care Medicine. Dec, 2012 | Pubmed ID: 23204376 2 Grainyhead-como Factores De La Transcripción Y NK2-caja Homeo 1 Formar Un Bucle De Regulación Que Coordina La Diferenciación Y Morfogénesis De Células Epiteliales Del Pulmón The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22955271 Síndrome De Estenosis Aórtica Supravalvular Con Células Madre Pluripotentes Inducidas Humanas De Modelado Circulation. Oct, 2012 | Pubmed ID: 22914687 Regeneración De Próxima Generación: La Esperanza Y El Bombo De La Investigación De Células Madre De Pulmón American Journal of Respiratory and Critical Care Medicine. Jun, 2012 | Pubmed ID: 22517787 Derivación Eficaz Del Pulmón Purificado Y Progenitores De La Tiroides De Células Madre Embrionarias Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482505 Líneas De Progenitor Endodermal Renueva a Sí Misma Generadas a Partir De Células Madre Pluripotentes Humanas Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 Mantenimiento Y Reparación Del Endotelio Pulmonar No Implica Contribuciones De Células Precursoras Endoteliales Derivadas De La Médula American Journal of Respiratory Cell and Molecular Biology. Jul, 2012 | Pubmed ID: 22323363 Expedientes De Caso Del Massachusetts General Hospital. Caso 2-2012. Una Mujer De 63 Años Con Disnea E Insuficiencia Respiratoria Rápidamente Progresiva The New England Journal of Medicine. Jan, 2012 | Pubmed ID: 22256809 ¿Son Madre Embrionaria E Inducida Por Células Pluripotentes Del Mismas O Diferentes? Implicaciones Para Su Posible Uso Terapéutico Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22186787 Papel De Nanog En El Mantenimiento De Células Stromal Durante La Regeneración Del Hueso Natal Post De Médula Biochemical and Biophysical Research Communications. Jan, 2012 | Pubmed ID: 22142851 Propiedades Biofísicas De Los Canales De Potasio Lento En Cardiomiocitos De Células Madre Embrionarias Humanas Derivados Implican La Estequiometría De La Subunidad The Journal of Physiology. Dec, 2011 | Pubmed ID: 22025662 Cambio Programático: Investigación De Las Enfermedades Del Pulmón En La Era De Pluripotencialidad Inducida American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 21984571 Un Cambio De Cultivos Celulares a Criaturas: En Vivo Imágenes De Pequeños Animales En Medicina Regenerativa Experimental Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011 | Pubmed ID: 21952170 Plasticidad En Las Lesiones Pulmonares Y Reparación De La Célula: Informe De Un Taller NHLBI, 19-20 De Abril De 2010 Proceedings of the American Thoracic Society. Jun, 2011 | Pubmed ID: 21653526 ES De Ratón Y Células IPS Pueden Formar Endodermo Definitivo Similar a Pesar De Las Diferencias En Los Genes Impresos The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 FOXO1 Modula La Diferenciación De Los Osteoblastos Bone. May, 2011 | Pubmed ID: 21281751 Generación De Células Pluripotentes Inducidas Humanas De La Enfermedad-específica Pulmón Libre De Transgenes Usando Un Cassette De Célula Madre Lentivirales Los Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 El Papel De Células Dendríticas Piel En Cebado De Células T CD8 + Tras La Vacunación Con Lentivectors Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20357252 Mejoramiento Del Enfisema En Ratones a Través De Transducción Lentivirales De Macrófagos Alveolares Pulmonares Duraderos The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20038801 Supresión De Reprogramación Transgenes Mejora El Potencial De Diferenciación De Células IPS Generadas Con Un Vector De Los Individual Stem Cells (Dayton, Ohio). Jan, 2010 | Pubmed ID: 19904830 La Proteinosis Alveolar Pulmonar: Una Historia Del Banco-a-cabecera De Disfunción De Factor Estimulante De Colonias Granulocito-macrófago Chest. Aug, 2009 | Pubmed ID: 19666756 Análisis Transcripcional De La Curación De La Fractura Y La Inducción De Genes Relacionados Con Células Madre Embrionarias PloS One. 2009 | Pubmed ID: 19415118 Generación De Células Madre Pluripotentes Inducidas Usando Un Cassette De Célula Madre Lentivirales Stem Cells (Dayton, Ohio). Mar, 2009 | Pubmed ID: 19096035 Expresión Sostenida De Alfa-1-antitripsina Después Del Trasplante De Células Hematopoyéticas Manipuladas American Journal of Respiratory Cell and Molecular Biology. Aug, 2008 | Pubmed ID: 18323534 Otra Muesca En Biología De Células Madre: Células Madre Intestinales De Drosophila Y La Especificación De Destino Celular BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2008 | Pubmed ID: 18200564 La Prolongada Vida útil De Los Macrófagos Alveolares American Journal of Respiratory Cell and Molecular Biology. Apr, 2008 | Pubmed ID: 18192503 Sistema Lentivirales Dual-promotor Permite La Expresión Inducible De Proteínas Nocivas En Macrófagos Journal of Immunological Methods. Jan, 2008 | Pubmed ID: 17967462 Células Madre De Pulmón Cell and Tissue Research. Jan, 2008 | Pubmed ID: 17805578 Control Exógeno De Genes Mamíferos Mediante Modulación De Terminación Traslacional Nature Medicine. Sep, 2006 | Pubmed ID: 16892063 Insuficiencia De Médula ósea Para Reconstituir El Epitelio Pulmonar American Journal of Respiratory Cell and Molecular Biology. Oct, 2005 | Pubmed ID: 15961722 Eficacia De Transducción Del Vástago Hematopoyético Murino Altamente Purificada De Las Células Por Lentivirales Y Oncoretroviral Vectores En Condiciones De Mínima Manipulación in Vitro Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2005 | Pubmed ID: 15922964 Una Población De Células Madre Novela En Hígado Adulto Con Potente Actividad De Reconstitución Hematopoyética Blood. Sep, 2005 | Pubmed ID: 15870171 Células De Pulmón Embrionario Lado Población Son Precursores Hematopoyéticos Y Vasculares American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15802552 Las Células Madre De Pulmón: Nuevos Paradigmas Experimental Hematology. Apr, 2004 | Pubmed ID: 15050743 Translational Physiology: Origin and Phenotype of Lung Side Population Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2004 | Pubmed ID: 15047566 Células De La Población De Lado Y Expresión De Bcrp1 En El Pulmón American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003 | Pubmed ID: 12626330 Expresión Del Antígeno-1 De Células Madre En El Endotelio Vascular Pulmonar American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2003 | Pubmed ID: 12611818 Generación de esferas 3D y cultivos de interfaz aire-líquido 2D de células epiteliales alveolares pluripotentes inducidas por humanos derivadas de células madre pluripotentes de tipo 2 Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology Generación de las células madre pluripotentes inducidas a partir de sangre periférica mediante el STEMCCA vector lentiviral Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
Generación de esferas 3D y cultivos de interfaz aire-líquido 2D de células epiteliales alveolares pluripotentes inducidas por humanos derivadas de células madre pluripotentes de tipo 2 Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology
Generación de las células madre pluripotentes inducidas a partir de sangre periférica mediante el STEMCCA vector lentiviral Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
