David T. Scadden Center for Regenerative Medicine Massachusetts General Hospital Biography Publications Institution JoVE Articles David T. Scadden has not added a biography. If you are David T. Scadden and would like to personalize this page please email our Author Liaison for assistance. Publications Health Consequences of Thymus Removal in Adults. Reply The New England Journal of Medicine. Nov, 2023 | Pubmed ID: 37913517 Clearing and Replacing Tissue-resident Myeloid Cells with an Anti-CD45 Antibody-drug Conjugate Blood Advances. Nov, 2023 | Pubmed ID: 37748049 Adult Prg4+ Progenitors Repair Long-term Articular Cartilage Wounds in Vivo JCI Insight. Sep, 2023 | Pubmed ID: 37681409 PPM1D Modulates Hematopoietic Cell Fitness and Response to DNA Damage and is a Therapeutic Target in Myeloid Malignancy Blood. Dec, 2023 | Pubmed ID: 37595362 Health Consequences of Thymus Removal in Adults The New England Journal of Medicine. Aug, 2023 | Pubmed ID: 37530823 The Bone Marrow Stroma in Human Myelodysplastic Syndrome Reveals Alterations That Regulate Disease Progression Blood Advances. Nov, 2023 | Pubmed ID: 37450380 Limited Plasticity of Monocyte Fate and Function Associated with Epigenetic Scripting at the Level of Progenitors Blood. Aug, 2023 | Pubmed ID: 37267513 Dissecting the Immune Suppressive Human Prostate Tumor Microenvironment Via Integrated Single-cell and Spatial Transcriptomic Analyses Nature Communications. Feb, 2023 | Pubmed ID: 36750562 Immune-responsive Biodegradable Scaffolds for Enhancing Neutrophil Regeneration Bioengineering & Translational Medicine. Jan, 2023 | Pubmed ID: 36684088 Isolation of Thymus Stromal Cells from Human and Murine Tissue Methods in Molecular Biology (Clifton, N.J.). 2023 | Pubmed ID: 36255703 Image-seq: Spatially Resolved Single-cell Sequencing Guided by in Situ and in Vivo Imaging Nature Methods. Dec, 2022 | Pubmed ID: 36424441 Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for Label-free Detection of Molecules Across Entire Cell Sections ELife. Nov, 2022 | Pubmed ID: 36382886 A Transcriptional Metastatic Signature Predicts Survival in Clear Cell Renal Cell Carcinoma Nature Communications. Sep, 2022 | Pubmed ID: 36180422 Sleep Exerts Lasting Effects on Hematopoietic Stem Cell Function and Diversity The Journal of Experimental Medicine. Nov, 2022 | Pubmed ID: 36129517 Recent Advances in "sickle and Niche" Research - Tribute to Dr. Paul S Frenette Stem Cell Reports. Jul, 2022 | Pubmed ID: 35830837 In Vivo Genome-wide CRISPR Screening in Murine Acute Myeloid Leukemia Uncovers Microenvironmental Dependencies Blood Advances. Sep, 2022 | Pubmed ID: 35793392 Bone Marrow Endothelial Dysfunction Promotes Myeloid Cell Expansion in Cardiovascular Disease Nature Cardiovascular Research. Jan, 2022 | Pubmed ID: 35747128 Author Correction: B Lymphocyte-derived Acetylcholine Limits Steady-state and Emergency Hematopoiesis Nature Immunology. Aug, 2022 | Pubmed ID: 35705799 B Lymphocyte-derived Acetylcholine Limits Steady-state and Emergency Hematopoiesis Nature Immunology. Apr, 2022 | Pubmed ID: 35352063 Proton Export Alkalinizes Intracellular PH and Reprograms Carbon Metabolism to Drive Normal and Malignant Cell Growth Blood. Jan, 2022 | Pubmed ID: 34610101 What is the Role of the Bone Marrow Microenvironment in AML? Best Practice & Research. Clinical Haematology. Dec, 2021 | Pubmed ID: 34865700 Low NCOR2 Levels in Multiple Myeloma Patients Drive Multidrug Resistance Via MYC Upregulation Blood Cancer Journal. Dec, 2021 | Pubmed ID: 34864816 Chromatin-state Barriers Enforce an Irreversible Mammalian Cell Fate Decision Cell Reports. Nov, 2021 | Pubmed ID: 34758323 Analysis of Leukemia Cell Metabolism Through Stable Isotope Tracing in Mice Bio-protocol. Oct, 2021 | Pubmed ID: 34722818 Human Prostate Cancer Bone Metastases Have an Actionable Immunosuppressive Microenvironment Cancer Cell. Nov, 2021 | Pubmed ID: 34719426 Author Correction: An Injectable Bone Marrow-like Scaffold Enhances T Cell Immunity After Hematopoietic Stem Cell Transplantation Nature Biotechnology. Nov, 2021 | Pubmed ID: 34663922 TiRNA Signaling Via Stress-regulated Vesicle Transfer in the Hematopoietic Niche Cell Stem Cell. Dec, 2021 | Pubmed ID: 34551362 In Memory of Paul Sylvain Frenette, a Pioneering Explorer of the Hematopoietic Stem Cell Niche Who Left Far Too Early Experimental Hematology. Aug, 2021 | Pubmed ID: 34403758 Metabolic Perturbations Sensitize Triple-negative Breast Cancers to Apoptosis Induced by BH3 Mimetics Science Signaling. Jun, 2021 | Pubmed ID: 34103421 Malic Enzyme 2 Connects the Krebs Cycle Intermediate Fumarate to Mitochondrial Biogenesis Cell Metabolism. May, 2021 | Pubmed ID: 33770508 Young Haematopoietic Stem Cells Are Picky Eaters Cell Research. Apr, 2021 | Pubmed ID: 33633351 Imaging Dynamic MTORC1 Pathway Activity in Vivo Reveals Marked Shifts That Support Time-specific Inhibitor Therapy in AML Nature Communications. Jan, 2021 | Pubmed ID: 33431855 Progression Signature Underlies Clonal Evolution and Dissemination of Multiple Myeloma Blood. Apr, 2021 | Pubmed ID: 33150374 Efficacy and Safety of Anti-CD45-saporin As Conditioning Agent for RAG Deficiency The Journal of Allergy and Clinical Immunology. Jan, 2021 | Pubmed ID: 32387109 Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress Cell Reports. Sep, 2020 | Pubmed ID: 32877669 Cell Interactions in the Bone Marrow Microenvironment Affecting Myeloid Malignancies Blood Advances. Aug, 2020 | Pubmed ID: 32780848 Adult Blood Stem Cell Localization Reflects the Abundance of Reported Bone Marrow Niche Cell Types and Their Combinations Blood. Nov, 2020 | Pubmed ID: 32766876 Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance Cell Metabolism. Sep, 2020 | Pubmed ID: 32763164 C9orf72 Suppresses Systemic and Neural Inflammation Induced by Gut Bacteria Nature. Jun, 2020 | Pubmed ID: 32483373 Aldehyde Dehydrogenase 3a2 Protects AML Cells from Oxidative Death and the Synthetic Lethality of Ferroptosis Inducers Blood. Sep, 2020 | Pubmed ID: 32458004 Lipid Availability Determines Fate of Skeletal Progenitor Cells Via SOX9 Nature. Mar, 2020 | Pubmed ID: 32103177 A Biomaterial-based Vaccine Eliciting Durable Tumour-specific Responses Against Acute Myeloid Leukaemia Nature Biomedical Engineering. Jan, 2020 | Pubmed ID: 31937942 Metcalf Lecture Award: Applying Niche Biology to Engineer T-cell Regenerative Therapies Experimental Hematology. Dec, 2019 | Pubmed ID: 31765673 Exercise Reduces Inflammatory Cell Production and Cardiovascular Inflammation Via Instruction of Hematopoietic Progenitor Cells Nature Medicine. Nov, 2019 | Pubmed ID: 31700184 Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed Through Single-Cell Protein Expression Mapping Cell Stem Cell. Oct, 2019 | Pubmed ID: 31279774 A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia Cell. Jun, 2019 | Pubmed ID: 31130381 Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion Under Stress Cell Stem Cell. Jun, 2019 | Pubmed ID: 31006621 The Novel Dihydroorotate Dehydrogenase (DHODH) Inhibitor BAY 2402234 Triggers Differentiation and is Effective in the Treatment of Myeloid Malignancies Leukemia. Oct, 2019 | Pubmed ID: 30940908 Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics Cell Stem Cell. Apr, 2019 | Pubmed ID: 30880025 Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke Circulation Research. Apr, 2019 | Pubmed ID: 30782088 An Injectable Bone Marrow-like Scaffold Enhances T Cell Immunity After Hematopoietic Stem Cell Transplantation Nature Biotechnology. Mar, 2019 | Pubmed ID: 30742125 Selective Hematopoietic Stem Cell Ablation Using CD117-antibody-drug-conjugates Enables Safe and Effective Transplantation with Immunity Preservation Nature Communications. Feb, 2019 | Pubmed ID: 30728354 Cell Cycle Analysis of Hematopoietic Stem and Progenitor Cells by Multicolor Flow Cytometry Current Protocols in Cytometry. Jan, 2019 | Pubmed ID: 30335223 Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer Cancer Research. Sep, 2018 | Pubmed ID: 30065048 DropEst: Pipeline for Accurate Estimation of Molecular Counts in Droplet-based Single-cell RNA-seq Experiments Genome Biology. Jun, 2018 | Pubmed ID: 29921301 The NOTCH1/CD44 Axis Drives Pathogenesis in a T Cell Acute Lymphoblastic Leukemia Model The Journal of Clinical Investigation. Jul, 2018 | Pubmed ID: 29781813 Deficiency-induced Bone Marrow Niche Alterations Lead to the Initiation of Myeloproliferative Neoplasm Blood Advances. Mar, 2018 | Pubmed ID: 29514790 Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell Cell. Jan, 2018 | Pubmed ID: 29224778 Bone Marrow Drives Central Nervous System Regeneration After Radiation Injury The Journal of Clinical Investigation. Jan, 2018 | Pubmed ID: 29202481 Osteoblasts Remotely Supply Lung Tumors with Cancer-promoting SiglecF Neutrophils Science (New York, N.Y.). Dec, 2017 | Pubmed ID: 29191879 The Metabolic Regulator MTORC1 Controls Terminal Myeloid Differentiation Science Immunology. May, 2017 | Pubmed ID: 28763796 ZFP521 Regulates Murine Hematopoietic Stem Cell Function and Facilitates MLL-AF9 Leukemogenesis in Mouse and Human Cells Blood. Aug, 2017 | Pubmed ID: 28615219 Hematopoiesis: Reconciling Historic Controversies About the Niche Cell Stem Cell. May, 2017 | Pubmed ID: 28475884 Shipping Mouse Bone Marrow: Keep It in the Bone Experimental Hematology. May, 2017 | Pubmed ID: 28043821 Bone Marrow-derived Immature Myeloid Cells Are a Main Source of Circulating SuPAR Contributing to Proteinuric Kidney Disease Nature Medicine. Jan, 2017 | Pubmed ID: 27941791 Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia ACS Medicinal Chemistry Letters. Dec, 2016 | Pubmed ID: 27994748 Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells Cell. Nov, 2016 | Pubmed ID: 27863245 Leukaemogenic Effects of Ptpn11 Activating Mutations in the Stem Cell Microenvironment Nature. Nov, 2016 | Pubmed ID: 27783593 Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia Cell. Sep, 2016 | Pubmed ID: 27641501 PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation Via Deactivation of ACC2 Molecular Cell. Sep, 2016 | Pubmed ID: 27635760 Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators Cell Stem Cell. Oct, 2016 | Pubmed ID: 27524439 Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells Cell. Aug, 2016 | Pubmed ID: 27518564 Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow Stem Cell Reports. Aug, 2016 | Pubmed ID: 27453006 Non-genotoxic Conditioning for Hematopoietic Stem Cell Transplantation Using a Hematopoietic-cell-specific Internalizing Immunotoxin Nature Biotechnology. Jul, 2016 | Pubmed ID: 27272386 Hematopoietic Stem Cell Niche in Health and Disease Annual Review of Pathology. May, 2016 | Pubmed ID: 27193455 Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse Stem Cell Reports. Jun, 2016 | Pubmed ID: 27185283 Heterogeneity of the Bone Marrow Niche Current Opinion in Hematology. Jul, 2016 | Pubmed ID: 27177311 Blood and Bone The New England Journal of Medicine. May, 2016 | Pubmed ID: 27168440 Hematopoietic Stem Cell and Its Bone Marrow Niche Current Topics in Developmental Biology. 2016 | Pubmed ID: 27137653 Distinct Bone Marrow Blood Vessels Differentially Regulate Haematopoiesis Nature. Apr, 2016 | Pubmed ID: 27074509 Tle1 Tumor Suppressor Negatively Regulates Inflammation in Vivo and Modulates NF-κB Inflammatory Pathway Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016 | Pubmed ID: 26831087 Targeting the Warburg Effect for Leukemia Therapy: Magnitude Matters Molecular & Cellular Oncology. 2015 | Pubmed ID: 27308458 Not All Created Equal: Lineage Hard-Wiring in the Production of Blood Cell. Dec, 2015 | Pubmed ID: 26687347 A Hostel for the Hostile: the Bone Marrow Niche in Hematologic Neoplasms Haematologica. Nov, 2015 | Pubmed ID: 26521296 Transcriptome Comparison of Distinct Osteolineage Subsets in the Hematopoietic Stem Cell Niche Using a Triple Fluorescent Transgenic Mouse Model Genomics Data. Sep, 2015 | Pubmed ID: 26484277 Global Transcriptome Analysis of T-competent Progenitors in the Bone Marrow Genomics Data. Sep, 2015 | Pubmed ID: 26484235 Engineering Pulmonary Vasculature in Decellularized Rat and Human Lungs Nature Biotechnology. Oct, 2015 | Pubmed ID: 26368048 Harnessing the Apoptotic Programs in Cancer Stem-like Cells EMBO Reports. Sep, 2015 | Pubmed ID: 26253117 Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells Cell Stem Cell. May, 2015 | Pubmed ID: 25957903 Specific Bone Cells Produce DLL4 to Generate Thymus-seeding Progenitors from Bone Marrow The Journal of Experimental Medicine. May, 2015 | Pubmed ID: 25918341 Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention Stem Cells (Dayton, Ohio). Apr, 2015 | Pubmed ID: 25851125 Mesenchymal Cell Contributions to the Stem Cell Niche Cell Stem Cell. Mar, 2015 | Pubmed ID: 25748931 Bayesian Approach to Single-cell Differential Expression Analysis Nature Methods. May, 2014 | Pubmed ID: 24836921 Tic-TACs: Refreshing Hair Growth Cell. May, 2014 | Pubmed ID: 24813602 Nice Neighborhood: Emerging Concepts of the Stem Cell Niche Cell. Mar, 2014 | Pubmed ID: 24679525 Direct Measurement of Local Oxygen Concentration in the Bone Marrow of Live Animals Nature. Apr, 2014 | Pubmed ID: 24590072 Bone's Dark Side: Mutated Osteoblasts Implicated in Leukemia Cell Research. Apr, 2014 | Pubmed ID: 24589711 Stress Hematopoiesis is Regulated by the Krüppel-like Transcription Factor ZBP-89 Stem Cells (Dayton, Ohio). Mar, 2014 | Pubmed ID: 24549639 The Bone Marrow Niche for Haematopoietic Stem Cells Nature. Jan, 2014 | Pubmed ID: 24429631 Genome-wide Map of Nuclear Protein Degradation Shows NCoR1 Turnover As a Key to Mitochondrial Gene Regulation Cell. Dec, 2013 | Pubmed ID: 24315104 Blood Scent Cell. Nov, 2013 | Pubmed ID: 24267883 Correction: Tracking Single Cells in Live Animals Using a Photoconvertible Near-Infrared Cell Membrane Label PloS One. 2013 | Pubmed ID: 24250779 Modeling Human Hematopoietic Stem Cell Biology in the Mouse Seminars in Hematology. Apr, 2013 | Pubmed ID: 24216169 Sox4 is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia Cancer Cell. Nov, 2013 | Pubmed ID: 24183681 Differential Regulation of Myeloid Leukemias by the Bone Marrow Microenvironment Nature Medicine. Nov, 2013 | Pubmed ID: 24162813 Niche-based Screening Identifies Small-molecule Inhibitors of Leukemia Stem Cells Nature Chemical Biology. Dec, 2013 | Pubmed ID: 24161946 Prostaglandin-modulated Umbilical Cord Blood Hematopoietic Stem Cell Transplantation Blood. Oct, 2013 | Pubmed ID: 23996087 Tracking Single Cells in Live Animals Using a Photoconvertible Near-infrared Cell Membrane Label PloS One. 2013 | Pubmed ID: 23990881 Generation of Functionally Competent and Durable Engineered Blood Vessels from Human Induced Pluripotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23861493 In Vivo RNAi Screening Identifies a Leukemia-specific Dependence on Integrin Beta 3 Signaling Cancer Cell. Jul, 2013 | Pubmed ID: 23770013 Influenza, but Not HIV-specific CTL Epitopes, Elicits Delayed-type Hypersensitivity (DTH) Reactions in HIV-infected Patients European Journal of Immunology. Jun, 2013 | Pubmed ID: 23504637 Differential Stem- and Progenitor-cell Trafficking by Prostaglandin E2 Nature. Mar, 2013 | Pubmed ID: 23485965 BM Mesenchymal Stromal Cell-derived Exosomes Facilitate Multiple Myeloma Progression The Journal of Clinical Investigation. Apr, 2013 | Pubmed ID: 23454749 Xist RNA is a Potent Suppressor of Hematologic Cancer in Mice Cell. Feb, 2013 | Pubmed ID: 23415223 SIRT3 Reverses Aging-associated Degeneration Cell Reports. Feb, 2013 | Pubmed ID: 23375372 The Hematopoietic Stem Cell Niche--home for Friend and Foe? Cytometry. Part B, Clinical Cytometry. Jan-Feb, 2013 | Pubmed ID: 23281119 Myelopoiesis is Regulated by Osteocytes Through Gsα-dependent Signaling Blood. Feb, 2013 | Pubmed ID: 23160461 Advances in the Biology and Therapy of Chronic Myeloid Leukemia: Proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop Leukemia & Lymphoma. Jun, 2013 | Pubmed ID: 23121619 Fate Through Fat: Lipid Metabolism Determines Stem Cell Division Outcome Cell Metabolism. Oct, 2012 | Pubmed ID: 23040066 Complex Oncogene Dependence in MicroRNA-125a-induced Myeloproliferative Neoplasms Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23012470 MTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-loss-evoked Leukemogenesis Cell Stem Cell. Sep, 2012 | Pubmed ID: 22958934 The Stem Cell Niche: Tissue Physiology at a Single Cell Level The Journal of Clinical Investigation. Sep, 2012 | Pubmed ID: 22945635 Cancers Predispose Neutrophils to Release Extracellular DNA Traps That Contribute to Cancer-associated Thrombosis Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22826226 Rethinking Stroma: Lessons from the Blood Cell Stem Cell. Jun, 2012 | Pubmed ID: 22704500 The Secrets of the Bone Marrow Niche: Metabolic Priming for AML Nature Medicine. Jun, 2012 | Pubmed ID: 22673998 Deconstructing the Complexity of a Microenvironmental Niche Cell. Mar, 2012 | Pubmed ID: 22464318 A Randomized Controlled Trial of Highly Active Antiretroviral Therapy Versus Highly Active Antiretroviral Therapy and Chemotherapy in Therapy-naive Patients with HIV-associated Kaposi Sarcoma in South Africa Journal of Acquired Immune Deficiency Syndromes (1999). Jun, 2012 | Pubmed ID: 22395672 Endogenous Bone Marrow MSCs Are Dynamic, Fate-restricted Participants in Bone Maintenance and Regeneration Cell Stem Cell. Mar, 2012 | Pubmed ID: 22385654 The Hematopoietic Stem Cell Niche Frontiers in Bioscience : a Journal and Virtual Library. 2012 | Pubmed ID: 22201730 The Bone Marrow at the Crossroads of Blood and Immunity Nature Reviews. Immunology. Jan, 2012 | Pubmed ID: 22193770 NF-Y is Necessary for Hematopoietic Stem Cell Proliferation and Survival Blood. Feb, 2012 | Pubmed ID: 22072554 The Haematopoietic Stem Cell Niche at a Glance Journal of Cell Science. Nov, 2011 | Pubmed ID: 22083139 Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function Science Translational Medicine. Oct, 2011 | Pubmed ID: 21998408 AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias Cell. Sep, 2011 | Pubmed ID: 21884932 Differential Niche and Wnt Requirements During Acute Myeloid Leukemia Progression Blood. Sep, 2011 | Pubmed ID: 21765021 In Vivo Imaging of Treg Cells Providing Immune Privilege to the Haematopoietic Stem-cell Niche Nature. Jun, 2011 | Pubmed ID: 21654805 Crosstalk Between NOTCH and AKT Signaling During Murine Megakaryocyte Lineage Specification Blood. Aug, 2011 | Pubmed ID: 21653327 Guanine Nucleotide Exchange Factor Vav1 Regulates Perivascular Homing and Bone Marrow Retention of Hematopoietic Stem and Progenitor Cells Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606370 Inhibition of Bone Morphogenetic Protein Signaling Attenuates Anemia Associated with Inflammation Blood. May, 2011 | Pubmed ID: 21393479 Biomimetic Platforms for Human Stem Cell Research Cell Stem Cell. Mar, 2011 | Pubmed ID: 21362565 In Vivo Imaging of Transplanted Hematopoietic Stem and Progenitor Cells in Mouse Calvarium Bone Marrow Nature Protocols. Jan, 2011 | Pubmed ID: 21212779 The Lkb1 Metabolic Sensor Maintains Haematopoietic Stem Cell Survival Nature. Dec, 2010 | Pubmed ID: 21124451 A MicroRNA Regulating Adult Hematopoietic Stem Cells Cell Cycle (Georgetown, Tex.). Sep, 2010 | Pubmed ID: 20855952 Mesenchymal and Haematopoietic Stem Cells Form a Unique Bone Marrow Niche Nature. Aug, 2010 | Pubmed ID: 20703299 Stem Cells and DNA Damage: Persist or Perish? Cell. Aug, 2010 | Pubmed ID: 20691895 Vitamin D Receptor Deletion Leads to Increased Hematopoietic Stem and Progenitor Cells Residing in the Spleen Blood. Nov, 2010 | Pubmed ID: 20664059 MicroRNA MiR-125a Controls Hematopoietic Stem Cell Number Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20616003 The HSC Niche Concept Has Turned 31. Has Our Knowledge Matured? Annals of the New York Academy of Sciences. Mar, 2010 | Pubmed ID: 20392212 Bone Progenitor Dysfunction Induces Myelodysplasia and Secondary Leukaemia Nature. Apr, 2010 | Pubmed ID: 20305640 Activin A Promotes Multiple Myeloma-induced Osteolysis and is a Promising Target for Myeloma Bone Disease Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20194748 CD133 Expression Defines a Tumor Initiating Cell Population in Primary Human Ovarian Cancer Stem Cells (Dayton, Ohio). Dec, 2009 | Pubmed ID: 19816957 VEGFR2+PDGFRbeta+ Circulating Precursor Cells Participate in Capillary Restoration After Hyperoxia Acute Lung Injury (HALI) Journal of Cellular and Molecular Medicine. Sep, 2009 | Pubmed ID: 19426150 The Leukemic Stem Cell Niche: Current Concepts and Therapeutic Opportunities Blood. Aug, 2009 | Pubmed ID: 19401558 P27Kip1 Constrains Proliferation of Neural Progenitor Cells in Adult Brain Under Homeostatic and Ischemic Conditions Stem Cells (Dayton, Ohio). Apr, 2009 | Pubmed ID: 19353520 Haematopoietic Stem Cells Depend on Galpha(s)-mediated Signalling to Engraft Bone Marrow Nature. May, 2009 | Pubmed ID: 19322176 Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. May, 2009 | Pubmed ID: 19257832 Forward RNAi Screens in Primary Human Hematopoietic Stem/progenitor Cells Blood. Apr, 2009 | Pubmed ID: 19188664 Live-animal Tracking of Individual Haematopoietic Stem/progenitor Cells in Their Niche Nature. Jan, 2009 | Pubmed ID: 19052546 Will Stem Cells Finally Deliver? Newsweek. Dec, 2008 | Pubmed ID: 19105310 Divided Within: Heterogeneity Within Adult Stem Cell Pools Cell. Dec, 2008 | Pubmed ID: 19070570 Osteoblastic Regulation of B Lymphopoiesis is Mediated by Gs{alpha}-dependent Signaling Pathways Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 18957542 GATA-2 Regulates Granulocyte-macrophage Progenitor Cell Function Blood. Dec, 2008 | Pubmed ID: 18840712 Nf2/merlin Regulates Hematopoietic Stem Cell Behavior by Altering Microenvironmental Architecture Cell Stem Cell. Aug, 2008 | Pubmed ID: 18682243 MicroRNA-mediated Control of Cell Fate in Megakaryocyte-erythrocyte Progenitors Developmental Cell. Jun, 2008 | Pubmed ID: 18539114 Evolving Concepts on the Microenvironmental Niche for Hematopoietic Stem Cells Current Opinion in Hematology. Jul, 2008 | Pubmed ID: 18536566 Hematopoietic Stem Cell Responsiveness to Exogenous Signals is Limited by Caspase-3 Cell Stem Cell. Jun, 2008 | Pubmed ID: 18522851 Differential H3K4 Methylation Identifies Developmentally Poised Hematopoietic Genes Developmental Cell. May, 2008 | Pubmed ID: 18477461 Tumor Necrosis Factor-alpha and Endothelial Cells Modulate Notch Signaling in the Bone Marrow Microenvironment During Inflammation Experimental Hematology. May, 2008 | Pubmed ID: 18439488 Stem-cell Ecology and Stem Cells in Motion Blood. Apr, 2008 | Pubmed ID: 18398055 Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and is Necessary to Preserve Self-renewal in Vivo Cell Stem Cell. Mar, 2008 | Pubmed ID: 18371452 Circadian Rhythms: Stem Cells Traffic in Time Nature. Mar, 2008 | Pubmed ID: 18368105 Mutations in the Neutral Sphingomyelinase Gene SMPD3 Implicate the Ceramide Pathway in Human Leukemias Blood. May, 2008 | Pubmed ID: 18299447 Prospects for Stem Cell-based Therapy Cell. Feb, 2008 | Pubmed ID: 18295571 Functional Analyses of the Cancer Stem Cell-like Properties of Human Endometrial Tumor Initiating Cells Cell Cycle (Georgetown, Tex.). Jan, 2008 | Pubmed ID: 18256549 Pharmacologic Targeting of a Stem/progenitor Population in Vivo is Associated with Enhanced Bone Regeneration in Mice The Journal of Clinical Investigation. Feb, 2008 | Pubmed ID: 18219387 Deconstructing Stem Cell Self-renewal: Genetic Insights into Cell-cycle Regulation Nature Reviews. Genetics. Feb, 2008 | Pubmed ID: 18202695 Dose-reduced Busulfan, Cyclophosphamide, and Autologous Stem Cell Transplantation for Human Immunodeficiency Virus-associated Lymphoma: AIDS Malignancy Consortium Study 020 Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Jan, 2008 | Pubmed ID: 18158962 Differential in Vivo Potential of Endothelial Progenitor Cells from Human Umbilical Cord Blood and Adult Peripheral Blood to Form Functional Long-lasting Vessels Blood. Feb, 2008 | Pubmed ID: 17993613 Analysis of the Hematopoietic Stem Cell Niche Current Protocols in Stem Cell Biology. Nov, 2007 | Pubmed ID: 18785177 Limiting Factors in Murine Hematopoietic Stem Cell Assays Cell Stem Cell. Sep, 2007 | Pubmed ID: 18371361 Stem Cells Remember Their Grade Cell Stem Cell. Aug, 2007 | Pubmed ID: 18371344 The Weight of Cell Identity The Journal of Clinical Investigation. Dec, 2007 | Pubmed ID: 18060026 A Microenvironment-induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor Gamma Deficiency Cell. Jun, 2007 | Pubmed ID: 17574023 Kaposi's Sarcoma-associated Herpesvirus-specific Immune Reconstitution and Antiviral Effect of Combined HAART/chemotherapy in HIV Clade C-infected Individuals with Kaposi's Sarcoma AIDS (London, England). Jun, 2007 | Pubmed ID: 17545700 A Protocol for Phenotypic Detection and Enumeration of Circulating Endothelial Cells and Circulating Progenitor Cells in Human Blood Nature Protocols. 2007 | Pubmed ID: 17446880 The Stem Cell Niche in Health and Leukemic Disease Best Practice & Research. Clinical Haematology. Mar, 2007 | Pubmed ID: 17336251 Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-associated Herpesvirus and Epstein-Barr Virus Induce T-cell Responses with Similar Functional Properties and Memory Phenotypes Journal of Virology. May, 2007 | Pubmed ID: 17329344 Endothelial Cells Derived from Human Embryonic Stem Cells Form Durable Blood Vessels in Vivo Nature Biotechnology. Mar, 2007 | Pubmed ID: 17322871 Primitive Hematopoietic Cells Resist HIV-1 Infection Via P21 The Journal of Clinical Investigation. Feb, 2007 | Pubmed ID: 17273559 Therapeutic Targeting of a Stem Cell Niche Nature Biotechnology. Feb, 2007 | Pubmed ID: 17237769 AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients Cancer Cell. Jan, 2007 | Pubmed ID: 17222792 Stromal Cell-derived Factor-1/CXCR4 Signaling Modifies the Capillary-like Organization of Human Embryonic Stem Cell-derived Endothelium in Vitro Stem Cells (Dayton, Ohio). Feb, 2007 | Pubmed ID: 17038674 Case Records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old Man with Dyspnea, Fever, and Lymphadenopathy The New England Journal of Medicine. Sep, 2006 | Pubmed ID: 17005954 Tumor Stromal-derived Factor-1 Recruits Vascular Progenitors to Mitotic Neovasculature, Where Microenvironment Influences Their Differentiated Phenotypes Cancer Research. Sep, 2006 | Pubmed ID: 16982747 Stem-cell Ageing Modified by the Cyclin-dependent Kinase Inhibitor P16INK4a Nature. Sep, 2006 | Pubmed ID: 16957735 Embryonic Stem Cells Make Human T Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16894150 The Stem-cell Niche As an Entity of Action Nature. Jun, 2006 | Pubmed ID: 16810242 Osteoclasts Eat Stem Cells out of House and Home Nature Medicine. Jun, 2006 | Pubmed ID: 16761001 Stem Cells: Good, Bad and Reformable Nature. May, 2006 | Pubmed ID: 16724049 The Hematopoietic Stem Cell in Its Place Nature Immunology. Apr, 2006 | Pubmed ID: 16550195 Differential CD146 Expression on Circulating Versus Tissue Endothelial Cells in Rectal Cancer Patients: Implications for Circulating Endothelial and Progenitor Cells As Biomarkers for Antiangiogenic Therapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2006 | Pubmed ID: 16549839 CXCR4 and CCR5 Mediate Homing of Primitive Bone Marrow-derived Hematopoietic Cells to the Postnatal Thymus Experimental Hematology. Mar, 2006 | Pubmed ID: 16543065 Stem Cell Engraftment at the Endosteal Niche is Specified by the Calcium-sensing Receptor Nature. Feb, 2006 | Pubmed ID: 16382241 Evidence for Incorporation of Bone Marrow-derived Endothelial Cells into Perfused Blood Vessels in Tumors Blood. Apr, 2006 | Pubmed ID: 16339405 HOXB4-induced Self-renewal of Hematopoietic Stem Cells is Significantly Enhanced by P21 Deficiency Stem Cells (Dayton, Ohio). Mar, 2006 | Pubmed ID: 16210402 Differentiation and Characterization of T Cells Current Protocols in Immunology / Edited by John E. Coligan ... [et Al.]. Nov, 2005 | Pubmed ID: 18432955 Plasmablastic Lymphoma in HIV-positive Patients: an Aggressive Epstein-Barr Virus-associated Extramedullary Plasmacytic Neoplasm The American Journal of Surgical Pathology. Dec, 2005 | Pubmed ID: 16327436 Surrogate Markers for Antiangiogenic Therapy and Dose-limiting Toxicities for Bevacizumab with Radiation and Chemotherapy: Continued Experience of a Phase I Trial in Rectal Cancer Patients Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2005 | Pubmed ID: 16258121 Differential Targeting and Shifts in the Immunodominance of Epstein-Barr Virus--specific CD8 and CD4 T Cell Responses During Acute and Persistent Infection The Journal of Infectious Diseases. Nov, 2005 | Pubmed ID: 16206065 Alpha E Beta 7 (CD103) Expression Identifies a Highly Active, Tonsil-resident Effector-memory CTL Population Journal of Immunology (Baltimore, Md. : 1950). Oct, 2005 | Pubmed ID: 16177076 Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood Cell. Jul, 2005 | Pubmed ID: 16051153 Impact of Kaposi Sarcoma-associated Herpesvirus (KSHV) Burden and HIV Coinfection on the Detection of T Cell Responses to KSHV ORF73 and ORF65 Proteins The Journal of Infectious Diseases. Aug, 2005 | Pubmed ID: 16028131 Restoration of Tubular Epithelial Cells During Repair of the Postischemic Kidney Occurs Independently of Bone Marrow-derived Stem Cells The Journal of Clinical Investigation. Jul, 2005 | Pubmed ID: 16007251 In Vivo Imaging of Specialized Bone Marrow Endothelial Microdomains for Tumour Engraftment Nature. Jun, 2005 | Pubmed ID: 15959517 Osteopontin is a Hematopoietic Stem Cell Niche Component That Negatively Regulates Stem Cell Pool Size The Journal of Experimental Medicine. Jun, 2005 | Pubmed ID: 15928197 Rituximab Does Not Improve Clinical Outcome in a Randomized Phase 3 Trial of CHOP with or Without Rituximab in Patients with HIV-associated Non-Hodgkin Lymphoma: AIDS-Malignancies Consortium Trial 010 Blood. Sep, 2005 | Pubmed ID: 15914552 Quantum Dots Spectrally Distinguish Multiple Species Within the Tumor Milieu in Vivo Nature Medicine. Jun, 2005 | Pubmed ID: 15880117 Haploinsufficiency of GATA-2 Perturbs Adult Hematopoietic Stem-cell Homeostasis Blood. Jul, 2005 | Pubmed ID: 15811962 Kinetic Expression of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) During Embryonic Stem Cell Differentiation Journal of Cellular Biochemistry. Jun, 2005 | Pubmed ID: 15786495 Generic Antiretroviral Efficacy in AIDS-associated Kaposi's Sarcoma in Sub-Saharan Africa AIDS (London, England). Mar, 2005 | Pubmed ID: 15750399 Anemia in HIV-infected Adults: Epidemiology, Pathogenesis, and Clinical Management Current Hematology Reports. Mar, 2005 | Pubmed ID: 15720957 Angiogenesis Inhibitor IM862 is Ineffective Against AIDS-Kaposi's Sarcoma in a Phase III Trial, but Demonstrates Sustained, Potent Effect of Highly Active Antiretroviral Therapy: from the AIDS Malignancy Consortium and IM862 Study Team Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2005 | Pubmed ID: 15598977 Flowing Cells Through Pulsed Electric Fields Efficiently Purges Stem Cell Preparations of Contaminating Myeloma Cells While Preserving Stem Cell Function Blood. Mar, 2005 | Pubmed ID: 15292069 Defective Immune Function of Primary Effusion Lymphoma Cells is Associated with Distinct KSHV Gene Expression Profiles Leukemia & Lymphoma. Jun, 2004 | Pubmed ID: 15360006 Cancer Stem Cells Refined Nature Immunology. Jul, 2004 | Pubmed ID: 15224098 Direct Vascular Delivery of Primitive Hematopoietic Cells to Bone Marrow Improves Localization but Not Engraftment Blood. Jun, 2004 | Pubmed ID: 15178586 In Vivo Self-renewing Divisions of Haematopoietic Stem Cells Are Increased in the Absence of the Early G1-phase Inhibitor, P18INK4C Nature Cell Biology. May, 2004 | Pubmed ID: 15122268 The Journal of Experimental Medicine. Apr, 2004 | Pubmed ID: 15067031 The Malignant Side of Successful Transplantation American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Feb, 2004 | Pubmed ID: 14974933 Direct Evidence That the VEGF-specific Antibody Bevacizumab Has Antivascular Effects in Human Rectal Cancer Nature Medicine. Feb, 2004 | Pubmed ID: 14745444 Ephrin Receptor, EphB4, Regulates ES Cell Differentiation of Primitive Mammalian Hemangioblasts, Blood, Cardiomyocytes, and Blood Vessels Blood. Jan, 2004 | Pubmed ID: 12958066 Stem Cells and Immune Reconstitution in AIDS Blood Reviews. Dec, 2003 | Pubmed ID: 14556777 Immune Reconstitution in HIV Infection and Its Relationship to Cancer Hematology/oncology Clinics of North America. Jun, 2003 | Pubmed ID: 12852652 P2Y-like Receptor, GPR105 (P2Y14), Identifies and Mediates Chemotaxis of Bone-marrow Hematopoietic Stem Cells Genes & Development. Jul, 2003 | Pubmed ID: 12842911 Myeloid Expression of Cytochrome P450 4F3 is Determined by a Lineage-specific Alternative Promoter The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12709424 Ex Vivo Targeting of P21Cip1/Waf1 Permits Relative Expansion of Human Hematopoietic Stem Cells Blood. Aug, 2003 | Pubmed ID: 12702511 AIDS-related Malignancies Annual Review of Medicine. 2003 | Pubmed ID: 12525676 Multiple Measures of HIV Burden in Blood and Tissue Are Correlated with Each Other but Not with Clinical Parameters in Aviremic Subjects AIDS (London, England). Jan, 2003 | Pubmed ID: 12478069 Heterologous Cells Cooperate to Augment Stem Cell Migration, Homing, and Engraftment Blood. Jan, 2003 | Pubmed ID: 12393569 Lack of Antitumor Activity and Intolerance of Interleukin-4 in Patients with Advanced HIV Disease and Kaposi's Sarcoma Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Nov, 2002 | Pubmed ID: 12513914 The Contribution of Cytotoxic and Noncytotoxic Function by Donor T-cells That Support Engraftment After Allogeneic Bone Marrow Transplantation Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. 2002 | Pubmed ID: 12463477 Toward Cellular-based Therapies for HIV Infection Journal of Hematotherapy & Stem Cell Research. Oct, 2002 | Pubmed ID: 12427282 The Protease Inhibitor Ritonavir Inhibits the Functional Activity of the Multidrug Resistance Related-protein 1 (MRP-1) AIDS (London, England). Sep, 2002 | Pubmed ID: 12218384 Multicenter Trial of Low-dose Paclitaxel in Patients with Advanced AIDS-related Kaposi Sarcoma Cancer. Jul, 2002 | Pubmed ID: 12115328 Cell Cycle Entry of Hematopoietic Stem and Progenitor Cells Controlled by Distinct Cyclin-dependent Kinase Inhibitors International Journal of Hematology. Jun, 2002 | Pubmed ID: 12095144 Absence of Biologically Important Kaposi Sarcoma-associated Herpesvirus Gene Products and Virus-specific Cellular Immune Responses in Multiple Myeloma Blood. Jul, 2002 | Pubmed ID: 12091368 A Phase II Randomized Study of HIV-specific T-cell Gene Therapy in Subjects with Undetectable Plasma Viremia on Combination Antiretroviral Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2002 | Pubmed ID: 12027564 Thymocyte Emigration is Mediated by Active Movement Away from Stroma-derived Factors The Journal of Clinical Investigation. Apr, 2002 | Pubmed ID: 11956248 Receptor Tyrosine Kinase, EphB4 (HTK), Accelerates Differentiation of Select Human Hematopoietic Cells Blood. Apr, 2002 | Pubmed ID: 11929761 Notch1 Activation Increases Hematopoietic Stem Cell Self-renewal in Vivo and Favors Lymphoid over Myeloid Lineage Outcome Blood. Apr, 2002 | Pubmed ID: 11895769 Antitumor Activity of Oral 9-cis-retinoic Acid in HIV-associated Kaposi's Sarcoma AIDS (London, England). Feb, 2002 | Pubmed ID: 11834954 Human HTm4 is a Hematopoietic Cell Cycle Regulator The Journal of Clinical Investigation. Jan, 2002 | Pubmed ID: 11781350 Matrix Metalloproteinase Inhibitor COL-3 in the Treatment of AIDS-related Kaposi's Sarcoma: a Phase I AIDS Malignancy Consortium Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2002 | Pubmed ID: 11773164 Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single-Cell Sequencing Trine Kristiansen*1,2,3, Christina Mayerhofer*1,2,3, Karin Gustafsson1,2,3, David T. Scadden1,2,3 1Center for Regenerative Medicine, Massachusetts General Hospital, 2Harvard Stem Cell Institute, 3Department of Stem Cell and Regenerative Biology, Harvard University JoVE 66231 Immunology and Infection Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair Dongsu Park1, Joel A. Spencer2, Charles P. Lin2, David T. Scadden1 1Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute, 2Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School JoVE 51289 Medicine Homing of Hematopoietic Cells to the Bone Marrow Rushdia Z. Yusuf1, David T. Scadden1 1Center for Regenerative Medicine, MGH - Massachusetts General Hospital JoVE 1104 Biology
Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single-Cell Sequencing Trine Kristiansen*1,2,3, Christina Mayerhofer*1,2,3, Karin Gustafsson1,2,3, David T. Scadden1,2,3 1Center for Regenerative Medicine, Massachusetts General Hospital, 2Harvard Stem Cell Institute, 3Department of Stem Cell and Regenerative Biology, Harvard University JoVE 66231 Immunology and Infection
Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair Dongsu Park1, Joel A. Spencer2, Charles P. Lin2, David T. Scadden1 1Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute, 2Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School JoVE 51289 Medicine
Homing of Hematopoietic Cells to the Bone Marrow Rushdia Z. Yusuf1, David T. Scadden1 1Center for Regenerative Medicine, MGH - Massachusetts General Hospital JoVE 1104 Biology
