David Alexander Department of Microbiology & Environmental Toxicology University of California Santa Cruz - UCSC Biography Publications Institution JoVE Articles David Alexander has not added a biography. If you are David Alexander and would like to personalize this page please email our Author Liaison for assistance. Publications MupB, a New High-Level Mupirocin Resistance Mechanism in Staphylococcus Aureus Antimicrobial Agents and Chemotherapy. Jan, 2012 | Pubmed ID: 22252810 Quantifying Plasmid Copy Number to Investigate Plasmid Dosage Effects Associated with Directed Protein Evolution Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22144351 Postoperative Improvement in Health-related Quality of Life: a National Comparison of Surgical Treatment for Focal (one- to Two-level) Lumbar Spinal Stenosis Compared with Total Joint Arthroplasty for Osteoarthritis The Spine Journal : Official Journal of the North American Spine Society. Nov, 2011 | Pubmed ID: 22122836 Extensive Genomic Variation Within Clonal Complexes of Neisseria Meningitidis Genome Biology and Evolution. 2011 | Pubmed ID: 22084315 The Universal Language of Health Compendium of Continuing Education in Dentistry (Jamesburg, N.J. : 1995). Oct, 2011 | Pubmed ID: 22073804 Stability Selection for Genome-wide Association Genetic Epidemiology. Nov, 2011 | Pubmed ID: 22009793 Whole-genome Sequence of Streptococcus Pseudopneumoniae Isolate IS7493 Journal of Bacteriology. Nov, 2011 | Pubmed ID: 21994930 Synthesis and Characterization of Tritylthioethanamine Derivatives with Potent KSP Inhibitory Activity Bioorganic & Medicinal Chemistry. Sep, 2011 | Pubmed ID: 21855351 Multidrug-resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child Emerging Infectious Diseases. Aug, 2011 | Pubmed ID: 21801626 Enhancements to the ADMIXTURE Algorithm for Individual Ancestry Estimation BMC Bioinformatics. 2011 | Pubmed ID: 21682921 Roles of DNA Polymerase I in Leading and Lagging-strand Replication Defined by a High-resolution Mutation Footprint of ColE1 Plasmid Replication Nucleic Acids Research. Sep, 2011 | Pubmed ID: 21622658 The Costs of Conflict: Meeting the Mental Health Needs of Serving Personnel and Service Veterans International Review of Psychiatry (Abingdon, England). Apr, 2011 | Pubmed ID: 21521090 Dispersal of Mycobacterium Tuberculosis Via the Canadian Fur Trade Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011 | Pubmed ID: 21464295 Lack of Promoting Effect of Titanium Dioxide Particles on Ultraviolet B-initiated Skin Carcinogenesis in Rats Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2011 | Pubmed ID: 21414375 The Mind Continues to Matter: Psychologic and Physical Recovery 5 Years After Musculoskeletal Trauma Journal of Orthopaedic Trauma. Apr, 2011 | Pubmed ID: 21399473 A Quasi-Newton Acceleration for High-dimensional Optimization Algorithms Statistics and Computing. Jan, 2011 | Pubmed ID: 21359052 New Delhi Metallo-beta-lactamase, Ontario, Canada Emerging Infectious Diseases. Feb, 2011 | Pubmed ID: 21291614 Neuraminidase-inhibitor Resistance Testing for Pandemic Influenza A (H1N1) 2009 in Ontario, Canada Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Mar, 2011 | Pubmed ID: 21251873 Region of Difference 2 Contributes to Virulence of Mycobacterium Tuberculosis Infection and Immunity. Jan, 2011 | Pubmed ID: 20974821 Modeling Tissue Growth Within Nonwoven Scaffolds Pores Tissue Engineering. Part C, Methods. Feb, 2011 | Pubmed ID: 20687775 Transmission of Influenza A Pandemic (H1N1) 2009 Virus in a Long-term Care Facility in Ontario, Canada Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America. Dec, 2010 | Pubmed ID: 21029007 Involvement of the Reck Tumor Suppressor Protein in Maternal and Embryonic Vascular Remodeling in Mice BMC Developmental Biology. 2010 | Pubmed ID: 20691046 Hematopoietic Stem Cell Quiescence Promotes Error-prone DNA Repair and Mutagenesis Cell Stem Cell. Aug, 2010 | Pubmed ID: 20619762 The Ontario Universal Typing of Tuberculosis (OUT-TB) Surveillance Program--what It Means to You Canadian Respiratory Journal : Journal of the Canadian Thoracic Society. May-Jun, 2010 | Pubmed ID: 20617215 Cancer Prevention by Bovine Lactoferrin: from Animal Studies to Human Trial Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine. Jun, 2010 | Pubmed ID: 20407806 Involvement of Macrophage Inflammatory Protein 1alpha (MIP1alpha) in Promotion of Rat Lung and Mammary Carcinogenic Activity of Nanoscale Titanium Dioxide Particles Administered by Intra-pulmonary Spraying Carcinogenesis. May, 2010 | Pubmed ID: 20185418 Model Tests of Gliding with Different Hindwing Configurations in the Four-winged Dromaeosaurid Microraptor Gui Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133792 Mature Acinar Cells Are Refractory to Carcinoma Development by Targeted Activation of Ras Oncogene in Adult Rats Cancer Science. Feb, 2010 | Pubmed ID: 19917056 Construction of a Multi-functional Helper-dependent Adenovirus Based System for Cancer Gene Therapy Asian Pacific Journal of Cancer Prevention : APJCP. 2009 | Pubmed ID: 20104994 Mapping of Contextual Modulation in the Population Response of Primary Visual Cortex Cognitive Neurodynamics. Nov, 2009 | Pubmed ID: 19898958 Effect of Orally Administered Bovine Lactoferrin on the Growth of Adenomatous Colorectal Polyps in a Randomized, Placebo-controlled Clinical Trial Cancer Prevention Research (Philadelphia, Pa.). Nov, 2009 | Pubmed ID: 19861543 An Animal Model of Preclinical Diagnosis of Pancreatic Ductal Adenocarcinomas Biochemical and Biophysical Research Communications. Dec, 2009 | Pubmed ID: 19818733 Fast Model-based Estimation of Ancestry in Unrelated Individuals Genome Research. Sep, 2009 | Pubmed ID: 19648217 Spatio-temporal EEG Waves in First Episode Schizophrenia Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. Sep, 2009 | Pubmed ID: 19646922 First Responders After Disasters: a Review of Stress Reactions, At-risk, Vulnerability, and Resilience Factors Prehospital and Disaster Medicine. Mar-Apr, 2009 | Pubmed ID: 19591301 Molecular Characterization of Drug-resistant Mycobacterium Tuberculosis Isolates from Ontario, Canada The Journal of Antimicrobial Chemotherapy. Aug, 2009 | Pubmed ID: 19520719 Mycobacterium Tuberculosis in Ontario, Canada: Insights from IS6110 Restriction Fragment Length Polymorphism and Mycobacterial Interspersed Repetitive-unit-variable-number Tandem-repeat Genotyping Journal of Clinical Microbiology. Aug, 2009 | Pubmed ID: 19494075 Synthesis and SAR of 4-substituted-2-aminopyrimidines As Novel C-Jun N-terminal Kinase (JNK) Inhibitors Bioorganic & Medicinal Chemistry Letters. Apr, 2009 | Pubmed ID: 19327989 BCG Vaccines: Their Mechanisms of Attenuation and Impact on Safety and Protective Efficacy Human Vaccines. Feb, 2009 | Pubmed ID: 19164935 Kidnapping and Hostage-taking: a Review of Effects, Coping and Resilience Journal of the Royal Society of Medicine. Jan, 2009 | Pubmed ID: 19147852 Genomic Comparison of PE and PPE Genes in the Mycobacterium Avium Complex Journal of Clinical Microbiology. Apr, 2009 | Pubmed ID: 19144814 Additional Evidence for Antagonistic Pleiotropic Effects of APOE Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jan, 2009 | Pubmed ID: 19118812 Insertion and Deletion Events That Define the Pathogen Mycobacterium Avium Subsp. Paratuberculosis Journal of Bacteriology. Feb, 2009 | Pubmed ID: 19028885 Anticarcinogenesis Pathways Activated by Bovine Lactoferrin in the Murine Small Intestine Biochimie. Jan, 2009 | Pubmed ID: 18634843 Proinflammatory Markers in Prediction of Posttraumatic Psychological Symptoms: a Prospective Cohort Study Mediators of Inflammation. 2008 | Pubmed ID: 19125188 Association of Inhalation Toxicologists (AIT) Working Party Recommendation for Standard Delivered Dose Calculation and Expression in Non-clinical Aerosol Inhalation Toxicology Studies with Pharmaceuticals Inhalation Toxicology. Oct, 2008 | Pubmed ID: 18802802 Novel Genome Polymorphisms in BCG Vaccine Strains and Impact on Efficacy BMC Genomics. 2008 | Pubmed ID: 18793412 Presentation and Management of Perirectal Sepsis Annals of the Royal College of Surgeons of England. Jul, 2008 | Pubmed ID: 18634720 Increased Absolute Magnitude of Gamma Synchrony in First-episode Psychosis Schizophrenia Research. Oct, 2008 | Pubmed ID: 18603413 Children, Resilience and Disasters: Recent Evidence That Should Influence a Model of Psychosocial Care Current Opinion in Psychiatry. Jul, 2008 | Pubmed ID: 18520737 Decreased Urinary Beta-defensin-1 Expression As a Biomarker of Response to Arsenic Toxicological Sciences : an Official Journal of the Society of Toxicology. Nov, 2008 | Pubmed ID: 18511430 Short-term and Long-term Outcomes of the Cleft Lift Procedure in the Management of Nonacute Pilonidal Disorders Diseases of the Colon and Rectum. Jul, 2008 | Pubmed ID: 18470564 Mycobacterium Avium Subsp. Paratuberculosis and M. Avium Subsp. Avium Are Independently Evolved Pathogenic Clones of a Much Broader Group of M. Avium Organisms Journal of Bacteriology. Apr, 2008 | Pubmed ID: 18245284 Event-related Wave Activity in the EEG Provides New Marker of ADHD Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. Jan, 2008 | Pubmed ID: 18054279 Rv1773 is a Transcriptional Repressor Deleted from BCG-Pasteur Tuberculosis (Edinburgh, Scotland). Sep, 2007 | Pubmed ID: 17669688 Ancient Argentavis Soars Again Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17640902 Paraplegia Caused by Invasive Spinal Aspergillosis Neurology. Jul, 2007 | Pubmed ID: 17620560 Misconception As a Barrier to Teaching About Disasters Prehospital and Disaster Medicine. Mar-Apr, 2007 | Pubmed ID: 17591180 Identification of the Lipooligosaccharide Biosynthetic Gene Cluster from Mycobacterium Marinum Molecular Microbiology. Mar, 2007 | Pubmed ID: 17302813 The Mind Does Matter: Psychological and Physical Recovery After Musculoskeletal Trauma The Journal of Trauma. Dec, 2006 | Pubmed ID: 17159684 Measurement of Health-related Quality of Life in the Early Follow-up of Colon and Rectal Cancer Diseases of the Colon and Rectum. Nov, 2006 | Pubmed ID: 17041750 A Qualitative Assessment of Dental Care Access and Utilization Among the Older Adult Population in the United States General Dentistry. Sep-Oct, 2006 | Pubmed ID: 17004574 The ESAT-6/CFP-10 Secretion System of Mycobacterium Marinum Modulates Phagosome Maturation Cellular Microbiology. Sep, 2006 | Pubmed ID: 16922861 Evaluation of in Situ Methods Used to Detect Mycobacterium Avium Subsp. Paratuberculosis in Samples from Patients with Crohn's Disease Journal of Clinical Microbiology. Aug, 2006 | Pubmed ID: 16891515 Plasmodium Falciparum AMA1 Binds a Rhoptry Neck Protein Homologous to TgRON4, a Component of the Moving Junction in Toxoplasma Gondii Eukaryotic Cell. Jul, 2006 | Pubmed ID: 16835460 Ductal Origin of Pancreatic Adenocarcinomas Induced by Conditional Activation of a Human Ha-ras Oncogene in Rat Pancreas Carcinogenesis. Dec, 2006 | Pubmed ID: 16774944 Radical Subtotal Pancreatic Resection, Including Splenectomy, is an Effective One-off Treatment for Infected Pancreatic Necrosis World Journal of Surgery. Jun, 2006 | Pubmed ID: 16736321 EEG Markers for Cognitive Decline in Elderly Subjects with Subjective Memory Complaints Journal of Integrative Neuroscience. Mar, 2006 | Pubmed ID: 16544366 Medicaid Reform: an Opportunity to Focus on the Real Challenges for Children Pediatrics. Mar, 2006 | Pubmed ID: 16510681 Roles of Lsr2 in Colony Morphology and Biofilm Formation of Mycobacterium Smegmatis Journal of Bacteriology. Jan, 2006 | Pubmed ID: 16385053 Full Length and Delta Lactoferrin Display Differential Cell Localization Dynamics, but Do Not Act As Tumor Markers or Significantly Affect the Expression of Other Genes Medicinal Chemistry (ShÄriqah (United Arab Emirates)). Jan, 2005 | Pubmed ID: 16789886 The Psychological Aspects of Terrorism: from Denial to Hyperbole Journal of the Royal Society of Medicine. Dec, 2005 | Pubmed ID: 16319440 LosA, a Key Glycosyltransferase Involved in the Biosynthesis of a Novel Family of Glycosylated Acyltrehalose Lipooligosaccharides from Mycobacterium Marinum The Journal of Biological Chemistry. Dec, 2005 | Pubmed ID: 16257960 Identification of the Moving Junction Complex of Toxoplasma Gondii: a Collaboration Between Distinct Secretory Organelles PLoS Pathogens. Oct, 2005 | Pubmed ID: 16244709 Recovery After Musculoskeletal Trauma in Men and Women The Journal of Trauma. Jul, 2005 | Pubmed ID: 16096566 Genomic Polymorphisms for Mycobacterium Avium Subsp. Paratuberculosis Diagnostics Journal of Clinical Microbiology. Aug, 2005 | Pubmed ID: 16081899 The Impact of Early Life Stress on Psychophysiological, Personality and Behavioral Measures in 740 Non-clinical Subjects Journal of Integrative Neuroscience. Mar, 2005 | Pubmed ID: 16035139 Proteomic Analysis of Rhoptry Organelles Reveals Many Novel Constituents for Host-parasite Interactions in Toxoplasma Gondii The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16002398 Lipid-mediated Resistance of Gram-negative Bacteria Against Various Pore-forming Antimicrobial Peptides Journal of Endotoxin Research. 2005 | Pubmed ID: 15949145 Maximising SHO Training by Inclusion of Research Fellows into a Novel Hybrid Rota Annals of the Royal College of Surgeons of England. May, 2005 | Pubmed ID: 15901383 Enterovirus 70 Binds to Different Glycoconjugates Containing Alpha2,3-linked Sialic Acid on Different Cell Lines Journal of Virology. Jun, 2005 | Pubmed ID: 15890948 Reduced Expression of Antigenic Proteins MPB70 and MPB83 in Mycobacterium Bovis BCG Strains Due to a Start Codon Mutation in SigK Molecular Microbiology. Jun, 2005 | Pubmed ID: 15882422 Temperature Dependence of the Binding of Endotoxins to the Polycationic Peptides Polymyxin B and Its Nonapeptide Biophysical Journal. Mar, 2005 | Pubmed ID: 15596502 Effects of Acupuncture Treatment on Poststroke Motor Recovery and Physical Function: a Pilot Study Neurorehabilitation and Neural Repair. Dec, 2004 | Pubmed ID: 15537996 Extensive Genomic Polymorphism Within Mycobacterium Avium Journal of Bacteriology. Sep, 2004 | Pubmed ID: 15342607 Dose-dependent Response to Intramuscular Botulinum Toxin Type A for Upper-limb Spasticity in Patients After a Stroke Archives of Physical Medicine and Rehabilitation. Jul, 2004 | Pubmed ID: 15241751 Acquisition of Hrs, an Essential Component of Phagosomal Maturation, is Impaired by Mycobacteria Molecular and Cellular Biology. May, 2004 | Pubmed ID: 15121875 Language and Systems of Symbols Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15105476 Impact of Methoxymycolic Acid Production by Mycobacterium Bovis BCG Vaccines Infection and Immunity. May, 2004 | Pubmed ID: 15102790 Mutations in Two Matrix Metalloproteinase Genes, MMP-2 and MT1-MMP, Are Synthetic Lethal in Mice Oncogene. Jun, 2004 | Pubmed ID: 15064723 Heat Shock Protein 70 in the Rat Nasal Cavity: Localisation and Response to Hyperthermia Archives of Toxicology. Jun, 2004 | Pubmed ID: 15007540 Intrinsic Connections in Tree Shrew V1 Imply a Global to Local Mapping Vision Research. Apr, 2004 | Pubmed ID: 14992831 Binding to Decay-accelerating Factor is Not Required for Infection of Human Leukocyte Cell Lines by Enterovirus 70 Journal of Virology. Mar, 2004 | Pubmed ID: 14990687 Normal Cells Control the Growth of Neighboring Transformed Cells Independent of Gap Junctional Communication and SRC Activity Cancer Research. Feb, 2004 | Pubmed ID: 14973064 PimF, a Mannosyltransferase of Mycobacteria, is Involved in the Biosynthesis of Phosphatidylinositol Mannosides and Lipoarabinomannan The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14960574 Orally Administered Bovine Lactoferrin Induces Caspase-1 and Interleukin-18 in the Mouse Intestinal Mucosa: a Possible Explanation for Inhibition of Carcinogenesis and Metastasis Cytokine. Jan, 2004 | Pubmed ID: 14687584 Terrorism, Disasters, and Security Prehospital and Disaster Medicine. Jul-Sep, 2003 | Pubmed ID: 15141853 Purchasing & Supply. Under Orders The Health Service Journal. Nov, 2003 | Pubmed ID: 14712841 Biochemical Terrorism: Too Awful to Contemplate, Too Serious to Ignore: Subjective Literature Review The British Journal of Psychiatry : the Journal of Mental Science. Dec, 2003 | Pubmed ID: 14645019 A Rifampin-hypersensitive Mutant Reveals Differences Between Strains of Mycobacterium Smegmatis and Presence of a Novel Transposon, IS1623 Antimicrobial Agents and Chemotherapy. Oct, 2003 | Pubmed ID: 14506032 Src Phosphorylates Cas on Tyrosine 253 to Promote Migration of Transformed Cells The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12972425 Botulinum Toxin (botox) Reduces Pain After Hemorrhoidectomy: Results of a Double-blind, Randomized Study Diseases of the Colon and Rectum. Aug, 2003 | Pubmed ID: 12907905 Transfer of Biologically Important Molecules Between Cells Through Gap Junction Channels Current Medicinal Chemistry. Oct, 2003 | Pubmed ID: 12871102 Mycobacterium Bovis BCG Vaccines Exhibit Defects in Alanine and Serine Catabolism Infection and Immunity. Feb, 2003 | Pubmed ID: 12540549 The Chandra Deep Field-North Survey and the Cosmic X-ray Background Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences. Sep, 2002 | Pubmed ID: 12804247 Comparison of a Nomogram and Physician-adjusted Dosage of Warfarin for Prophylaxis Against Deep-vein Thrombosis After Arthroplasty The Journal of Bone and Joint Surgery. American Volume. Nov, 2002 | Pubmed ID: 12429760 Survivors of the Piper Alpha Oil Platform Disaster: Long-term Follow-up Study The British Journal of Psychiatry : the Journal of Mental Science. Nov, 2002 | Pubmed ID: 12411271 5.2 Ethics, Equity and Global Responsibilities in Oral Health and Disease European Journal of Dental Education : Official Journal of the Association for Dental Education in Europe. 2002 | Pubmed ID: 12390275 Sialic Acid Functions in Enterovirus 70 Binding and Infection Journal of Virology. Nov, 2002 | Pubmed ID: 12388686 An Evaluation of Patient Satisfaction with an Information Leaflet for Trauma Survivors Journal of Traumatic Stress. Aug, 2002 | Pubmed ID: 12224805 Developmentally Regulated Trafficking of the Lysosomal Membrane Protein P67 in Trypanosoma Brucei Journal of Cell Science. Aug, 2002 | Pubmed ID: 12140257 Nature's Impartiality, Man's Inhumanity: Reflections on Terrorism and World Crisis in a Context of Historical Disaster Disasters. Mar, 2002 | Pubmed ID: 11929156 The Psychiatric Consequences of Trauma Hospital Medicine (London, England : 1998). Jan, 2002 | Pubmed ID: 11828809 Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli Chris Troll1, David Alexander1, Jennifer Allen1, Jacob Marquette1, Manel Camps1 1Department of Microbiology & Environmental Toxicology, University of California Santa Cruz - UCSC JoVE 2505 Biology
Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli Chris Troll1, David Alexander1, Jennifer Allen1, Jacob Marquette1, Manel Camps1 1Department of Microbiology & Environmental Toxicology, University of California Santa Cruz - UCSC JoVE 2505 Biology