Deborah L. French Pathology and Laboratory Medicine University of Pennsylvania Biography Publications Institution JoVE Articles Deborah L. FrenchProfessor Deborah French is a Research Professor in the Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania. She is Director of the Human Pluripotent Stem Cell Core in the Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia (CHOP).Dr. French received her undergraduate degree from Purdue University and her graduate degree from Rush University. She completed her post-doctoral training in the laboratory of Dr. Matthew Scharff at the Albert Einstein College of Medicine.In 2008, Dr. French established a core infrastructure at CHOP enabling investigators to work with pluripotent stem cells. She is a major collaborator of multi-investigator teams that are utilizing pluripotent stem cells for modeling human disease to study mechanism, development, and establish new therapeutic modalities. Publications Trisomy 21-associated Defects in Human Primitive Hematopoiesis Revealed Through Induced Pluripotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 Self-renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 High-throughput Screening Assay for Embryoid Body Differentiation of Human Embryonic Stem Cells Current Protocols in Stem Cell Biology. Mar, 2012 | Pubmed ID: 22415836 A High-throughput Multiplexed Screening Assay for Optimizing Serum-free Differentiation Protocols of Human Embryonic Stem Cells Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 Generation of Transgene-free Lung Disease-specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Development and Function of Myeloid-derived Suppressor Cells Generated from Mouse Embryonic and Hematopoietic Stem Cells Stem Cells (Dayton, Ohio). Mar, 2010 | Pubmed ID: 20073041 Molecular Diversity of Glanzmann Thrombasthenia in Southern India: New Insights into MRNA Splicing and Structure-function Correlations of AlphaIIbbeta3 Integrin (ITGA2B, ITGB3) Human Mutation. Apr, 2006 | Pubmed ID: 16463284 AlphaIIbbeta3 Biogenesis is Controlled by Engagement of AlphaIIb in the Calnexin Cycle Via the N15-linked Glycan Blood. Apr, 2006 | Pubmed ID: 16304048 Evidence for Megakaryocyte Engraftment Following Reduced-intensity Conditioning Experimental Hematology. Sep, 2004 | Pubmed ID: 15345290 Integrin Beta3 Regions Controlling Binding of Murine MAb 7E3: Implications for the Mechanism of Integrin AlphaIIbbeta3 Activation Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15277669 Stathmin Expression and Megakaryocyte Differentiation: a Potential Role in Polyploidy Experimental Hematology. May, 2003 | Pubmed ID: 12763137 Two Novel Mutations in the Alpha IIb Calcium-binding Domains Identify Hydrophobic Regions Essential for Alpha IIbbeta 3 Biogenesis Blood. Mar, 2003 | Pubmed ID: 12424194 Two New Beta3 Integrin Mutations in Indian Patients with Glanzmann Thrombasthenia: Localization of Mutations Affecting Cysteine Residues in Integrin Beta3 Thrombosis and Haemostasis. Sep, 2002 | Pubmed ID: 12353082 Monoclonal Antibodies by Somatic Cell Fusion ILAR Journal / National Research Council, Institute of Laboratory Animal Resources. Month, 1995 | Pubmed ID: 11528032 توليد تعديلات جينية محددة باستخدام CRISPR-CAS9 في الخلايا الجذعية البشرية متعددة القوى Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics جيل من صنع الإنسان من الخلايا الجذعية المحفزة الدموية المحيطية باستخدام Lentiviral STEMCCA المتجهات Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
توليد تعديلات جينية محددة باستخدام CRISPR-CAS9 في الخلايا الجذعية البشرية متعددة القوى Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics
جيل من صنع الإنسان من الخلايا الجذعية المحفزة الدموية المحيطية باستخدام Lentiviral STEMCCA المتجهات Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
