Dihua Yu

Publications

• Brain Metastasis: Unique Challenges and Open Opportunities
  Biochimica Et Biophysica Acta. Jan, 2017  |   Pubmed ID: 27939792
• Advances in Decoding Breast Cancer Brain Metastasis
  Cancer Metastasis Reviews. Dec, 2016  |   Pubmed ID: 27873078
• Deubiquitination and Stabilization of PD-L1 by CSN5
  Cancer Cell. Dec, 2016  |   Pubmed ID: 27866850
• Glycosylation and Stabilization of Programmed Death Ligand-1 Suppresses T-cell Activity
  Nature Communications. Aug, 2016  |   Pubmed ID: 27572267
• Downregulation of GLUT4 Contributes to Effective Intervention of Estrogen Receptor-negative/HER2-overexpressing Early Stage Breast Disease Progression by Lapatinib
  American Journal of Cancer Research. 2016  |   Pubmed ID: 27293993
• Upregulation of Lactate Dehydrogenase a by 14-3-3ζ Leads to Increased Glycolysis Critical for Breast Cancer Initiation and Progression
  Oncotarget. Jun, 2016  |   Pubmed ID: 27150057
• Selective Expression of Constitutively Active Pro-apoptotic Protein BikDD Gene in Primary Mammary Tumors Inhibits Tumor Growth and Reduces Tumor Initiating Cells
  American Journal of Cancer Research. 2015  |   Pubmed ID: 26885451
• Fluoxetine Induces Cytotoxic Endoplasmic Reticulum Stress and Autophagy in Triple Negative Breast Cancer
  World Journal of Clinical Oncology. Dec, 2015  |   Pubmed ID: 26677444
• Microenvironment-induced PTEN Loss by Exosomal MicroRNA Primes Brain Metastasis Outgrowth
  Nature. Nov, 2015  |   Pubmed ID: 26479035
• Src Inhibition Blocks C-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
  Cancer Research. Sep, 2015  |   Pubmed ID: 26383165
• Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases
  Stem Cells (Dayton, Ohio). Oct, 2015  |   Pubmed ID: 26260958
• PI3K-independent MTOR Activation Promotes Lapatinib Resistance and IAP Expression That Can Be Effectively Reversed by MTOR and Hsp90 Inhibition
  Cancer Biology & Therapy. 2015  |   Pubmed ID: 25692408
• 14-3-3ζ Turns TGF-β's Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from P53 to Gli2
  Cancer Cell. Feb, 2015  |   Pubmed ID: 25670079
• Heregulin-HER3-HER2 Signaling Promotes Matrix Metalloproteinase-dependent Blood-brain-barrier Transendothelial Migration of Human Breast Cancer Cell Lines
  Oncotarget. Feb, 2015  |   Pubmed ID: 25668816
• HER Family Kinase Domain Mutations Promote Tumor Progression and Can Predict Response to Treatment in Human Breast Cancer
  Molecular Oncology. Mar, 2015  |   Pubmed ID: 25435280
• S6K1 Promotes Invasiveness of Breast Cancer Cells in a Model of Metastasis of Triple-negative Breast Cancer
  American Journal of Translational Research. 2014  |   Pubmed ID: 25075253
• MDM2-mediated Degradation of SIRT6 Phosphorylated by AKT1 Promotes Tumorigenesis and Trastuzumab Resistance in Breast Cancer
  Science Signaling. Jul, 2014  |   Pubmed ID: 25074979
• Cooperativity of Oncogenic K-ras and Downregulated P16/INK4A in Human Pancreatic Tumorigenesis
  PloS One. 2014  |   Pubmed ID: 25029561
• Definition of PKC-α, CDK6, and MET As Therapeutic Targets in Triple-negative Breast Cancer
  Cancer Research. Sep, 2014  |   Pubmed ID: 24970481
• Biomarker-guided Sequential Targeted Therapies to Overcome Therapy Resistance in Rapidly Evolving Highly Aggressive Mammary Tumors
  Cell Research. May, 2014  |   Pubmed ID: 24675532
• Enhanced PI3K P110α Signaling Confers Acquired Lapatinib Resistance That Can Be Effectively Reversed by a P110α-selective PI3K Inhibitor
  Molecular Cancer Therapeutics. Jan, 2014  |   Pubmed ID: 24249715
• 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression Via MiR-221-mediated Cell Proliferation
  Cancer Research. Jan, 2014  |   Pubmed ID: 24197133
• Inhibition of Type I Insulin-like Growth Factor Receptor Signaling Attenuates the Development of Breast Cancer Brain Metastasis
  PloS One. 2013  |   Pubmed ID: 24039934
• Needle-based Fluorescence Endomicroscopy Via Structured Illumination with a Plastic, Achromatic Objective
  Journal of Biomedical Optics. Sep, 2013  |   Pubmed ID: 24002190
• SRC Family Kinases As Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases
  Cancer Research. Sep, 2013  |   Pubmed ID: 23913825
• Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-resistant Breast Cancer
  Cancer Research. Sep, 2012  |   Pubmed ID: 22773664
• Growth Factor Signaling in Metastasis: Current Understanding and Future Opportunities
  Cancer Metastasis Reviews. Dec, 2012  |   Pubmed ID: 22706845
• The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis
  Cell. May, 2012  |   Pubmed ID: 22632973
• Evidence That GTP-binding Domain but Not Catalytic Domain of Transglutaminase 2 is Essential for Epithelial-to-mesenchymal Transition in Mammary Epithelial Cells
  Breast Cancer Research : BCR. Jan, 2012  |   Pubmed ID: 22225906
• Targeting Src Family Kinases in Anti-cancer Therapies: Turning Promise into Triumph
  Trends in Pharmacological Sciences. Dec, 2011  |   Pubmed ID: 22153719
• Nucleolin Protein Interacts with Microprocessor Complex to Affect Biogenesis of MicroRNAs 15a and 16
  The Journal of Biological Chemistry. Dec, 2011  |   Pubmed ID: 22049078
• BikDD Eliminates Breast Cancer Initiating Cells and Synergizes with Lapatinib for Breast Cancer Treatment
  Cancer Cell. Sep, 2011  |   Pubmed ID: 21907925
• Phase I/II Study of Trastuzumab in Combination with Everolimus (RAD001) in Patients with HER2-overexpressing Metastatic Breast Cancer Who Progressed on Trastuzumab-based Therapy
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2011  |   Pubmed ID: 21730275
• Microenvironment Determinants of Brain Metastasis
  Cell & Bioscience. 2011  |   Pubmed ID: 21711688
• Evidence That Aberrant Expression of Tissue Transglutaminase Promotes Stem Cell Characteristics in Mammary Epithelial Cells
  PloS One. 2011  |   Pubmed ID: 21687668
• Pilot and Feasibility Study: Prospective Proteomic Profiling of Mammary Epithelial Cells from High-risk Women Provides Evidence of Activation of Pro-survival Pathways
  Breast Cancer Research and Treatment. Jun, 2011  |   Pubmed ID: 21647677
• Cancer Cell Migration: Integrated Roles of Matrix Mechanics and Transforming Potential
  PloS One. 2011  |   Pubmed ID: 21647371
• Combating Trastuzumab Resistance by Targeting SRC, a Common Node Downstream of Multiple Resistance Pathways
  Nature Medicine. Apr, 2011  |   Pubmed ID: 21399647
• P53 Regulates Epithelial-mesenchymal Transition and Stem Cell Properties Through Modulating MiRNAs
  Nature Cell Biology. Mar, 2011  |   Pubmed ID: 21336307
• Protein Microarray Analysis of Mammary Epithelial Cells from Obese and Nonobese Women at High Risk for Breast Cancer: Feasibility Data
  Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Mar, 2011  |   Pubmed ID: 21242333
• Cytokine Receptor CXCR4 Mediates Estrogen-independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer
  Cancer Research. Jan, 2011  |   Pubmed ID: 21123450
• 14-3-3ζ As a Prognostic Marker and Therapeutic Target for Cancer
  Expert Opinion on Therapeutic Targets. Dec, 2010  |   Pubmed ID: 21058923
• Activation of P21(CIP1/WAF1) in Mammary Epithelium Accelerates Mammary Tumorigenesis and Promotes Lung Metastasis
  Biochemical and Biophysical Research Communications. Dec, 2010  |   Pubmed ID: 21040707
• Tissue Transglutaminase Promotes Drug Resistance and Invasion by Inducing Mesenchymal Transition in Mammary Epithelial Cells
  PloS One. 2010  |   Pubmed ID: 20967228
• Cancer Cell Stiffness: Integrated Roles of Three-dimensional Matrix Stiffness and Transforming Potential
  Biophysical Journal. Oct, 2010  |   Pubmed ID: 20923638
• Activation of Murine Double Minute 2 by Akt in Mammary Epithelium Delays Mammary Involution and Accelerates Mammary Tumorigenesis
  Cancer Research. Oct, 2010  |   Pubmed ID: 20841468
• PTEN, PIK3CA, P-AKT, and P-p70S6K Status: Association with Trastuzumab Response and Survival in Patients with HER2-positive Metastatic Breast Cancer
  The American Journal of Pathology. Oct, 2010  |   Pubmed ID: 20813970
• PI(3)king Apart PTEN's Role in Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2010  |   Pubmed ID: 20622047
• Invasive Breast Cancer Development: "fatal Accident" from Malfunctions in Both "motor" and "brake"
  Cell Cycle (Georgetown, Tex.). Feb, 2010  |   Pubmed ID: 20090417
• Molecular Predictors of Response to Trastuzumab and Lapatinib in Breast Cancer
  Nature Reviews. Clinical Oncology. Feb, 2010  |   Pubmed ID: 20027191
• Upregulation of Neutrophil Gelatinase-associated Lipocalin by ErbB2 Through Nuclear Factor-kappaB Activation
  Cancer Research. Dec, 2009  |   Pubmed ID: 19951994
• 14-3-3zeta Cooperates with ErbB2 to Promote Ductal Carcinoma in Situ Progression to Invasive Breast Cancer by Inducing Epithelial-mesenchymal Transition
  Cancer Cell. Sep, 2009  |   Pubmed ID: 19732720
• Breast Cancer Metastasis: Challenges and Opportunities
  Cancer Research. Jun, 2009  |   Pubmed ID: 19470768
• ErbB2-mediated Src and Signal Transducer and Activator of Transcription 3 Activation Leads to Transcriptional Up-regulation of P21Cip1 and Chemoresistance in Breast Cancer Cells
  Molecular Cancer Research : MCR. Apr, 2009  |   Pubmed ID: 19372587
• 14-3-3zeta/tau Heterodimers Regulate Slingshot Activity in Migrating Keratinocytes
  Biochemical and Biophysical Research Communications. Jun, 2009  |   Pubmed ID: 19371722
• 14-3-3zeta Overexpression Defines High Risk for Breast Cancer Recurrence and Promotes Cancer Cell Survival
  Cancer Research. Apr, 2009  |   Pubmed ID: 19318578
• Oxygen Sensor Boosts Growth Factor Signaling
  Nature Medicine. Mar, 2009  |   Pubmed ID: 19265822
• Mitotic Deregulation by Survivin in ErbB2-overexpressing Breast Cancer Cells Contributes to Taxol Resistance
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2009  |   Pubmed ID: 19228734
• Ph.D. Training in Cancer Biology
  Cancer Research. Nov, 2008  |   Pubmed ID: 19010881
• 14-3-3 Zeta Down-regulates P53 in Mammary Epithelial Cells and Confers Luminal Filling
  Cancer Research. Mar, 2008  |   Pubmed ID: 18339856
• ERK Promotes Tumorigenesis by Inhibiting FOXO3a Via MDM2-mediated Degradation
  Nature Cell Biology. Feb, 2008  |   Pubmed ID: 18204439
• Loss of Trimethylation at Lysine 27 of Histone H3 is a Predictor of Poor Outcome in Breast, Ovarian, and Pancreatic Cancers
  Molecular Carcinogenesis. Sep, 2008  |   Pubmed ID: 18176935
• Novel Approaches for Chemosensitization of Breast Cancer Cells: the E1A Story
  Advances in Experimental Medicine and Biology. 2007  |   Pubmed ID: 17993239
• Molecular Mechanisms of ErbB2-mediated Breast Cancer Chemoresistance
  Advances in Experimental Medicine and Biology. 2007  |   Pubmed ID: 17993237
• Preclinical Testing of Clinically Applicable Strategies for Overcoming Trastuzumab Resistance Caused by PTEN Deficiency
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2007  |   Pubmed ID: 17908983
• Rad51 Overexpression Contributes to Chemoresistance in Human Soft Tissue Sarcoma Cells: a Role for P53/activator Protein 2 Transcriptional Regulation
  Molecular Cancer Therapeutics. May, 2007  |   Pubmed ID: 17513613
• High Prevalence of P53 Exon 4 Mutations in Soft Tissue Sarcoma
  Cancer. Jun, 2007  |   Pubmed ID: 17429838
• Tumor Progression and Metastasis from Genetic to Microenvironmental Determinants: a Workshop of the Tumor Progression and Metastasis NIH Study Section in Honor of Dr. Martin L. Padarathsingh, May 31, 2006, Georgetown, Washington, DC
  Cancer Biology & Therapy. Dec, 2006  |   Pubmed ID: 17224636
• Adenoviral-Vector Based SiRNA for Mutant K-ras As a Promising Tool for Lung Cancer Gene Therapy: A License to Kill
  Cancer Biology & Therapy. Dec, 2006  |   Pubmed ID: 17224631
• Wild-type P53 Inhibits Nuclear Factor-kappaB-induced Matrix Metalloproteinase-9 Promoter Activation: Implications for Soft Tissue Sarcoma Growth and Metastasis
  Molecular Cancer Research : MCR. Nov, 2006  |   Pubmed ID: 17077165
• Cytoplasmic Expression of P21CIP1/WAF1 is Correlated with IKKbeta Overexpression in Human Breast Cancers
  International Journal of Oncology. Nov, 2006  |   Pubmed ID: 17016640
• Vascular Endothelial Growth Factor Overexpression by Soft Tissue Sarcoma Cells: Implications for Tumor Growth, Metastasis, and Chemoresistance
  Cancer Research. Sep, 2006  |   Pubmed ID: 16951193
• Mechanisms of Disease: Understanding Resistance to HER2-targeted Therapy in Human Breast Cancer
  Nature Clinical Practice. Oncology. May, 2006  |   Pubmed ID: 16683005
• Selective Inhibition of ErbB2-overexpressing Breast Cancer in Vivo by a Novel TAT-based ErbB2-targeting Signal Transducers and Activators of Transcription 3-blocking Peptide
  Cancer Research. Apr, 2006  |   Pubmed ID: 16585203
• Synthetic Triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Growth Arrest in HER2-overexpressing Breast Cancer Cells
  Molecular Cancer Therapeutics. Feb, 2006  |   Pubmed ID: 16505105
• ErbB2 Increases Vascular Endothelial Growth Factor Protein Synthesis Via Activation of Mammalian Target of Rapamycin/p70S6K Leading to Increased Angiogenesis and Spontaneous Metastasis of Human Breast Cancer Cells
  Cancer Research. Feb, 2006  |   Pubmed ID: 16489002
• Prostate Tumor Cells Infected with a Recombinant Influenza Virus Expressing a Truncated NS1 Protein Activate Cytolytic CD8+ Cells to Recognize Noninfected Tumor Cells
  Journal of Virology. Jan, 2006  |   Pubmed ID: 16352563
• Mechanisms of Trastuzumab Resistance and Their Clinical Implications
  Annals of the New York Academy of Sciences. Nov, 2005  |   Pubmed ID: 16382045
• A Knotty Turnabout?: Akt1 As a Metastasis Suppressor
  Cancer Cell. Dec, 2005  |   Pubmed ID: 16338656
• ErbB2 Promotes Src Synthesis and Stability: Novel Mechanisms of Src Activation That Confer Breast Cancer Metastasis
  Cancer Research. Mar, 2005  |   Pubmed ID: 15753384
• A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2005  |   Pubmed ID: 15671549
• Expression of Receptor Tyrosine Kinases Epidermal Growth Factor Receptor and HER-2/neu in Synovial Sarcoma
  Cancer. Feb, 2005  |   Pubmed ID: 15641030
• Transcriptional Repression of Protein Kinase Calpha Via Sp1 by Wild Type P53 is Involved in Inhibition of Multidrug Resistance 1 P-glycoprotein Phosphorylation
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15563462
• Upregulation of CXCR4 is Essential for HER2-mediated Tumor Metastasis
  Cancer Cell. Nov, 2004  |   Pubmed ID: 15542430
• Activation of the Akt/mammalian Target of Rapamycin/4E-BP1 Pathway by ErbB2 Overexpression Predicts Tumor Progression in Breast Cancers
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2004  |   Pubmed ID: 15501954
• PTEN Activation Contributes to Tumor Inhibition by Trastuzumab, and Loss of PTEN Predicts Trastuzumab Resistance in Patients
  Cancer Cell. Aug, 2004  |   Pubmed ID: 15324695
• PI3K: Missense Mutation Motivates Malignancy
  Cancer Biology & Therapy. Aug, 2004  |   Pubmed ID: 15280668
• Lineage Infidelity of MDA-MB-435 Cells: Expression of Melanocyte Proteins in a Breast Cancer Cell Line
  Cancer Research. May, 2004  |   Pubmed ID: 15150101
• Liposomal Mediated Transfer of ErbB2 Antisense DNA: Coming of Age in the War Against Cancer
  Cancer Biology & Therapy. Feb, 2004  |   Pubmed ID: 14764991
• Silibinin: a Thorny Therapeutic for EGF-R Expressing Tumors?
  Cancer Biology & Therapy. Sep-Oct, 2003  |   Pubmed ID: 14614321
• Combined Trastuzumab and Paclitaxel Treatment Better Inhibits ErbB-2-mediated Angiogenesis in Breast Carcinoma Through a More Effective Inhibition of Akt Than Either Treatment Alone
  Cancer. Oct, 2003  |   Pubmed ID: 14508823
• ErbB2 Overexpression in Human Breast Carcinoma is Correlated with P21Cip1 Up-regulation and Tyrosine-15 Hyperphosphorylation of P34Cdc2: Poor Responsiveness to Chemotherapy with Cyclophoshamide Methotrexate, and 5-fluorouracil is Associated with Erb2 Overexpression and with P21Cip1 Overexpression
  Cancer. Sep, 2003  |   Pubmed ID: 12973835
• Enhanced Sensitization to Taxol-induced Apoptosis by Herceptin Pretreatment in ErbB2-overexpressing Breast Cancer Cells
  Cancer Research. Oct, 2002  |   Pubmed ID: 12384528
• Characterization of 11 Human Sarcoma Cell Strains: Evaluation of Cytogenetics, Tumorigenicity, Metastasis, and Production of Angiogenic Factors
  Cancer. Oct, 2002  |   Pubmed ID: 12237927
• ErbB2 Overexpression Correlates with Increased Expression of Vascular Endothelial Growth Factors A, C, and D in Human Breast Carcinoma
  Cancer. Jun, 2002  |   Pubmed ID: 12115372
• Phosphorylation on Tyrosine-15 of P34(Cdc2) by ErbB2 Inhibits P34(Cdc2) Activation and is Involved in Resistance to Taxol-induced Apoptosis
  Molecular Cell. May, 2002  |   Pubmed ID: 12049736
• Combined Anti-fetal Liver Kinase 1 Monoclonal Antibody and Continuous Low-dose Doxorubicin Inhibits Angiogenesis and Growth of Human Soft Tissue Sarcoma Xenografts by Induction of Endothelial Cell Apoptosis
  Cancer Research. Apr, 2002  |   Pubmed ID: 11929822
• Early Placenta Insulin-like Growth Factor (pro-EPIL) is Overexpressed and Secreted by C-erbB-2-positive Cells with High Invasion Potential
  Cancer Research. Feb, 2002  |   Pubmed ID: 11861376