Elizabeth Jaffee Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center The Johns Hopkins University School of Medicine Biography Publications Institution JoVE Articles Elizabeth Jaffee has not added a biography. If you are Elizabeth Jaffee and would like to personalize this page please email our Author Liaison for assistance. Publications A Feasibility Study of Cyclophosphamide, Trastuzumab, and an Allogeneic GM-CSF-Secreting Breast Tumor Vaccine for HER2+ Metastatic Breast Cancer Cancer Immunology Research. Aug, 2014 | Pubmed ID: 25116755 PAK1 Mediates Pancreatic Cancer Cell Migration and Resistance to MET Inhibition The Journal of Pathology. Jul, 2014 | Pubmed ID: 25074413 Immunobiology of Radiotherapy: New Paradigms Radiation Research. Aug, 2014 | Pubmed ID: 25036983 A Safety and Feasibility Study of an Allogeneic Colon Cancer Cell Vaccine Administered with a Granulocyte-Macrophage Colony Stimulating Factor-Producing Bystander Cell Line in Patients with Metastatic Colorectal Cancer Annals of Surgical Oncology. Jun, 2014 | Pubmed ID: 24943235 Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation Cancer Immunology Research. Jul, 2014 | Pubmed ID: 24942756 Development of Thyroglobulin Antibodies After GVAX Immunotherapy is Associated with Prolonged Survival International Journal of Cancer. Journal International Du Cancer. May, 2014 | Pubmed ID: 24832153 Oncogenic Kras Activates a Hematopoietic-to-epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia Cancer Cell. May, 2014 | Pubmed ID: 24823639 Can We Predict Mutant Neoepitopes in Human Cancers for Patient-specific Vaccine Therapy? Cancer Immunology Research. Jun, 2014 | Pubmed ID: 24795140 Apoptosis-regulated Low-avidity Cancer-specific CD8(+) T Cells Can Be Rescued to Eliminate HER2/neu-expressing Tumors by Costimulatory Agonists in Tolerized Mice Cancer Immunology Research. Apr, 2014 | Pubmed ID: 24764578 A Listeria Vaccine and Depletion of T-regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice Gastroenterology. Jun, 2014 | Pubmed ID: 24607504 Fusion Protein of Mutant B7-DC and Fc Enhances the Antitumor Immune Effect of GM-CSF-secreting Whole-cell Vaccine Journal of Immunotherapy (Hagerstown, Md. : 1997). Apr, 2014 | Pubmed ID: 24598447 Vaccine Therapy for Pancreatic Cancer Oncoimmunology. Dec, 2013 | Pubmed ID: 24498551 Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances Cancer Immunology Research. Jul, 2013 | Pubmed ID: 24409447 Mapping Patterns of Local Recurrence After Pancreaticoduodenectomy for Pancreatic Adenocarcinoma: a New Approach to Adjuvant Radiation Field Design International Journal of Radiation Oncology, Biology, Physics. Dec, 2013 | Pubmed ID: 24267969 Peptidases Released by Necrotic Cells Control CD8+ T Cell Cross-priming The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24216478 Harnessing Immune Responses in the Tumor Microenvironment: All Signals Needed Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 24097857 Low Total Lymphocyte Count is Associated with Poor Survival in Patients with Resected Pancreatic Adenocarcinoma Receiving a GM-CSF Secreting Pancreatic Tumor Vaccine Annals of Surgical Oncology. Dec, 2013 | Pubmed ID: 24046118 Evaluation of Ipilimumab in Combination with Allogeneic Pancreatic Tumor Cells Transfected with a GM-CSF Gene in Previously Treated Pancreatic Cancer Journal of Immunotherapy (Hagerstown, Md. : 1997). Sep, 2013 | Pubmed ID: 23924790 Next-generation Cancer Vaccine Approaches: Integrating Lessons Learned from Current Successes with Promising Biotechnologic Advances Journal of the National Comprehensive Cancer Network : JNCCN. Jul, 2013 | Pubmed ID: 23847215 Women in Oncology: Progress, Challenges, and Keys to Success American Society of Clinical Oncology Educational Book / ASCO. American Society of Clinical Oncology. Meeting. 2013 | Pubmed ID: 23714569 Immunotherapy in Preneoplastic Disease: Targeting Early Procarcinogenic Inflammatory Changes That Lead to Immune Suppression and Tumor Tolerance Annals of the New York Academy of Sciences. May, 2013 | Pubmed ID: 23651188 Role of Immune Cells and Immune-based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma Gastroenterology. Jun, 2013 | Pubmed ID: 23622132 Development of a Cytokine-modified Allogeneic Whole Cell Pancreatic Cancer Vaccine Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23359154 Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2013 | Pubmed ID: 23340293 Effects of Genomic Changes in Hepatitis B Virus on Postoperative Recurrence and Survival in Patients with Hepatocellular Carcinoma Annals of Surgical Oncology. Apr, 2013 | Pubmed ID: 23104706 Evaluation of Predictive Variables in Locally Advanced Pancreatic Adenocarcinoma Patients Receiving Definitive Chemoradiation Practical Radiation Oncology. 2012 | Pubmed ID: 23585823 Vaccines for Pancreatic Cancer Cancer Journal (Sudbury, Mass.). Nov, 2012 | Pubmed ID: 23187853 Targeting the Right Regulatory T-cell Population for Tumor Immunotherapy Oncoimmunology. Oct, 2012 | Pubmed ID: 23170276 Rapid Characterization of Candidate Biomarkers for Pancreatic Cancer Using Cell Microarrays (CMAs) Journal of Proteome Research. Nov, 2012 | Pubmed ID: 22985314 Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-resistant Breast Cancer Cancer Research. Sep, 2012 | Pubmed ID: 22773664 Regulatory T-cell Modulation Using Cyclophosphamide in Vaccine Approaches: a Current Perspective Cancer Research. Jul, 2012 | Pubmed ID: 22761338 Annexin A2 is a New Antigenic Target for Pancreatic Cancer Immunotherapy Oncoimmunology. Jan, 2012 | Pubmed ID: 22720228 Whole Cell Vaccines--past Progress and Future Strategies Seminars in Oncology. Jun, 2012 | Pubmed ID: 22595050 Development of a Novel Preclinical Pancreatic Cancer Research Model: Bioluminescence Image-guided Focal Irradiation and Tumor Monitoring of Orthotopic Xenografts Translational Oncology. Apr, 2012 | Pubmed ID: 22496923 The Determinants of Tumour Immunogenicity Nature Reviews. Cancer. Apr, 2012 | Pubmed ID: 22378190 Trafficking of High Avidity HER-2/neu-specific T Cells into HER-2/neu-expressing Tumors After Depletion of Effector/memory-like Regulatory T Cells PloS One. 2012 | Pubmed ID: 22359647 A Live-attenuated Listeria Vaccine (ANZ-100) and a Live-attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2012 | Pubmed ID: 22147941 Defining the Critical Hurdles in Cancer Immunotherapy Journal of Translational Medicine. 2011 | Pubmed ID: 22168571 Increased Expression of DNA Repair Genes in Invasive Human Pancreatic Cancer Cells Pancreas. Jul, 2011 | Pubmed ID: 21633318 Tyrosine 23 Phosphorylation-dependent Cell-surface Localization of Annexin A2 is Required for Invasion and Metastases of Pancreatic Cancer PloS One. 2011 | Pubmed ID: 21572519 Review of the 25th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer Journal of Translational Medicine. 2011 | Pubmed ID: 21569425 Nondominant CD8 T Cells Are Active Players in the Vaccine-induced Antitumor Immune Response Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21346233 A Lethally Irradiated Allogeneic Granulocyte-macrophage Colony Stimulating Factor-secreting Tumor Vaccine for Pancreatic Adenocarcinoma. A Phase II Trial of Safety, Efficacy, and Immune Activation Annals of Surgery. Feb, 2011 | Pubmed ID: 21217520 CD8⺠Foxp3⺠Tumor Infiltrating Lymphocytes Accumulate in the Context of an Effective Anti-tumor Response International Journal of Cancer. Journal International Du Cancer. Aug, 2011 | Pubmed ID: 20857491 Tumor Antigen-targeted, Monoclonal Antibody-based Immunotherapy: Clinical Response, Cellular Immunity, and Immunoescape Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2010 | Pubmed ID: 20697078 Cellular Vaccine Approaches Cancer Journal (Sudbury, Mass.). Jul-Aug, 2010 | Pubmed ID: 20693840 Paclitaxel Enhances Early Dendritic Cell Maturation and Function Through TLR4 Signaling in Mice Cellular Immunology. 2010 | Pubmed ID: 20346445 Timed Sequential Treatment with Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-macrophage Colony-stimulating Factor-secreting Breast Tumor Vaccine: a Chemotherapy Dose-ranging Factorial Study of Safety and Immune Activation Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2009 | Pubmed ID: 19805669 SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2009 | Pubmed ID: 19584151 OX40 Costimulation Can Abrogate Foxp3+ Regulatory T Cell-mediated Suppression of Antitumor Immunity International Journal of Cancer. Journal International Du Cancer. Aug, 2009 | Pubmed ID: 19455675 Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer Cancer Research. Apr, 2009 | Pubmed ID: 19351817 Exomic Sequencing Identifies PALB2 As a Pancreatic Cancer Susceptibility Gene Science (New York, N.Y.). Apr, 2009 | Pubmed ID: 19264984 Use of Tumour-responsive T Cells As Cancer Treatment Lancet. Feb, 2009 | Pubmed ID: 19231634 Effective Depletion of Regulatory T Cells Allows the Recruitment of Mesothelin-specific CD8 T Cells to the Antitumor Immune Response Against a Mesothelin-expressing Mouse Pancreatic Adenocarcinoma Clinical and Translational Science. Dec, 2008 | Pubmed ID: 20357913 Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses Science (New York, N.Y.). Sep, 2008 | Pubmed ID: 18772397 Analysis of Fluorouracil-based Adjuvant Chemotherapy and Radiation After Pancreaticoduodenectomy for Ductal Adenocarcinoma of the Pancreas: Results of a Large, Prospectively Collected Database at the Johns Hopkins Hospital Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2008 | Pubmed ID: 18640931 Antibody Association with HER-2/neu-targeted Vaccine Enhances CD8 T Cell Responses in Mice Through Fc-mediated Activation of DCs The Journal of Clinical Investigation. May, 2008 | Pubmed ID: 18398507 Vaccine Impedes the Development of Reflux-induced Esophageal Cancer in a Surgical Rat Model: Efficacy of the Vaccine in a Post-Barrett's Esophagus Setting Digestive Diseases and Sciences. Nov, 2008 | Pubmed ID: 18343998 Allogeneic Granulocyte Macrophage Colony-stimulating Factor-secreting Tumor Immunotherapy Alone or in Sequence with Cyclophosphamide for Metastatic Pancreatic Cancer: a Pilot Study of Safety, Feasibility, and Immune Activation Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2008 | Pubmed ID: 18316569 Vaccine Impedes the Development of Reflux-induced Esophageal Cancer in a Surgical Rat Model: Efficacy of the Vaccine in a Pre-Barrett's Esophagus Setting Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract. Jan, 2008 | Pubmed ID: 17957441 Preclinical Evaluation of MORAb-009, a Chimeric Antibody Targeting Tumor-associated Mesothelin Cancer Immunity. 2007 | Pubmed ID: 18088084 Alteration of Cellular and Humoral Immunity by Mutant P53 Protein and Processed Mutant Peptide in Head and Neck Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007 | Pubmed ID: 18056201 Alphaviral Vector-transduced Dendritic Cells Are Successful Therapeutic Vaccines Against Neu-overexpressing Tumors in Wild-type Mice Vaccine. Sep, 2007 | Pubmed ID: 17675184 A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity Through an Immune-based Mechanism Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2007 | Pubmed ID: 17606729 Cancer Immunologists and Cancer Biologists: Why We Didn't Talk then but Need to Now Cancer Research. Apr, 2007 | Pubmed ID: 17413003 Cytogenetic Characterization and Gene Expression Profiling in the Rat Reflux-induced Esophageal Tumor Model The Journal of Thoracic and Cardiovascular Surgery. Mar, 2007 | Pubmed ID: 17320581 Ectopic Expression of Vascular Cell Adhesion Molecule-1 As a New Mechanism for Tumor Immune Evasion Cancer Research. Feb, 2007 | Pubmed ID: 17308126 Mechanisms of Immune Evasion by Tumors Advances in Immunology. 2006 | Pubmed ID: 16730261 Ductal Access for Prevention and Therapy of Mammary Tumors Cancer Research. Jan, 2006 | Pubmed ID: 16423990 OX40 Costimulation Synergizes with GM-CSF Whole-cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16393983 Genes to Vaccines for Immunotherapy: How the Molecular Biology Revolution Has Influenced Cancer Immunology Molecular Cancer Therapeutics. Nov, 2005 | Pubmed ID: 16275985 Cancer Vaccines in Combination with Multimodality Therapy Cancer Treatment and Research. 2005 | Pubmed ID: 16211873 Leveraging the Activity of Tumor Vaccines with Cytotoxic Chemotherapy Cancer Research. Sep, 2005 | Pubmed ID: 16166275 Fusion to Listeriolysin O and Delivery by Listeria Monocytogenes Enhances the Immunogenicity of HER-2/neu and Reveals Subdominant Epitopes in the FVB/N Mouse Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148111 Allergies and the Risk of Pancreatic Cancer: a Meta-analysis with Review of Epidemiology and Biological Mechanisms Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Aug, 2005 | Pubmed ID: 16103436 Immunotherapy for Pancreatic Cancer - Science Driving Clinical Progress Nature Reviews. Cancer. Jun, 2005 | Pubmed ID: 15905855 Recruitment of Latent Pools of High-avidity CD8(+) T Cells to the Antitumor Immune Response The Journal of Experimental Medicine. May, 2005 | Pubmed ID: 15883172 Diverse CD8+ T-cell Responses to Renal Cell Carcinoma Antigens in Patients Treated with an Autologous Granulocyte-macrophage Colony-stimulating Factor Gene-transduced Renal Tumor Cell Vaccine Cancer Research. Feb, 2005 | Pubmed ID: 15705910 Tumor-specific CD4+ T Cells from a Patient with Renal Cell Carcinoma Recognize Diverse Shared Antigens International Journal of Cancer. Journal International Du Cancer. Jul, 2005 | Pubmed ID: 15704175 Development of a Cytokine-modified Allogeneic Whole Cell Pancreatic Cancer Vaccine Methods in Molecular Medicine. 2005 | Pubmed ID: 15542914 Fatty Acid Synthase Inhibitors Are Chemopreventive for Mammary Cancer in Neu-N Transgenic Mice Oncogene. Jan, 2005 | Pubmed ID: 15489885 Augmenting the Potency of Breast Cancer Vaccines: Combined Modality Immunotherapy Breast Disease. 2004 | Pubmed ID: 15687703 Mesothelin-specific CD8(+) T Cell Responses Provide Evidence of in Vivo Cross-priming by Antigen-presenting Cells in Vaccinated Pancreatic Cancer Patients The Journal of Experimental Medicine. Aug, 2004 | Pubmed ID: 15289501 A Phase I Vaccine Safety and Chemotherapy Dose-finding Trial of an Allogeneic GM-CSF-secreting Breast Cancer Vaccine Given in a Specifically Timed Sequence with Immunomodulatory Doses of Cyclophosphamide and Doxorubicin Human Gene Therapy. Mar, 2004 | Pubmed ID: 15018740 Toward a Breast Cancer Vaccine: Work in Progress Oncology (Williston Park, N.Y.). Sep, 2003 | Pubmed ID: 14569849 Cancer Vaccines: an Old Idea Comes of Age Cancer Biology & Therapy. Jul-Aug, 2003 | Pubmed ID: 14508095 HER-2/neu-specific Monoclonal Antibodies Collaborate with HER-2/neu-targeted Granulocyte Macrophage Colony-stimulating Factor Secreting Whole Cell Vaccination to Augment CD8+ T Cell Effector Function and Tumor-free Survival in Her-2/neu-transgenic Mice Journal of Immunology (Baltimore, Md. : 1950). Aug, 2003 | Pubmed ID: 12902523 Spatial Distribution of Tumor Vaccine Improves Efficacy The Laryngoscope. Aug, 2003 | Pubmed ID: 12897566 Lentivirus-mediated Gene Transfer and Expression in Established Human Tumor Antigen-specific Cytotoxic T Cells and Primary Unstimulated T Cells Human Gene Therapy. Jul, 2003 | Pubmed ID: 12885348 Major Histocompatibility Complex Class II-restricted Presentation of a Cytosolic Antigen by Autophagy European Journal of Immunology. May, 2003 | Pubmed ID: 12731050 Identification and Characterization of the Immunodominant Rat HER-2/neu MHC Class I Epitope Presented by Spontaneous Mammary Tumors from HER-2/neu-transgenic Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2003 | Pubmed ID: 12682262 Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using CDNA Microarrays The American Journal of Pathology. Apr, 2003 | Pubmed ID: 12651607 Genetically Engineered Tumor Cell Vaccine in a Head and Neck Cancer Model The Laryngoscope. Mar, 2003 | Pubmed ID: 12616213 Apoptotic, but Not Necrotic, Tumor Cell Vaccines Induce a Potent Immune Response in Vivo International Journal of Cancer. Journal International Du Cancer. Jan, 2003 | Pubmed ID: 12455034 Cytokine Modified Tumor Vaccines Surgical Oncology Clinics of North America. Jul, 2002 | Pubmed ID: 12487062 To Live or Not to Live: That Depends on GAGE? Cancer Biology & Therapy. Jul-Aug, 2002 | Pubmed ID: 12432252 Pancreatic Cancer Current Problems in Cancer. Jul-Aug, 2002 | Pubmed ID: 12399802 Focus on Pancreas Cancer Cancer Cell. Jul, 2002 | Pubmed ID: 12150822 Cytokine Gene-modified Cell-based Cancer Vaccines Methods in Molecular Medicine. 2002 | Pubmed ID: 11987781 Aberrant CpG Island Methylation in Cancer Cell Lines Arises in the Primary Cancers from Which They Were Derived Oncogene. Mar, 2002 | Pubmed ID: 11960385 A Preclinical Murine Model of Hepatic Metastases Kevin C. Soares1, Kelly Foley2, Kelly Olino1, Ashley Leubner2, Skye C. Mayo1, Ajay Jain1, Elizabeth Jaffee2, Richard D. Schulick3, Kiyoshi Yoshimura1,2, Barish Edil1,2, Lei Zheng1,2 1Department of Surgery, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 3Department of Surgery, University of Colorado Anschutz Medical Campus JoVE 51677 Medicine
A Preclinical Murine Model of Hepatic Metastases Kevin C. Soares1, Kelly Foley2, Kelly Olino1, Ashley Leubner2, Skye C. Mayo1, Ajay Jain1, Elizabeth Jaffee2, Richard D. Schulick3, Kiyoshi Yoshimura1,2, Barish Edil1,2, Lei Zheng1,2 1Department of Surgery, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 3Department of Surgery, University of Colorado Anschutz Medical Campus JoVE 51677 Medicine
