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Articles by Eric B. Jelin in JoVE
JoVE Clinical and Translational Medicine
Monokoryonik ikiz plasenta Damar Haritalama Kılavuz Tel Destekli Kateterizasyon ve Renkli Boya Enjeksiyon
1Division of Pediatric and Fetal Surgery, Department of Surgery, University of California, San Francisco, 2Department of Pathology, University of Alberta, 3Department of Obstretics and Gynecology, University of California, San Francisco, 4Department of Radiology, University of California, San Francisco
Monokoryonik (MC) doğumdan sonra ikiz plasenta Damar haritalama ikizlerin dolaşım arasında vasküler bağlantıları detaylı bir gösteri için bir araç sağlar. Bu bağlantıları Dengesizlik, ikizden ikize transfüzyon sendromu da dahil olmak üzere MC eşleştirme komplikasyonlarının gelişiminde önemli bir rol oynadığı düşünülmektedir.
Other articles by Eric B. Jelin on PubMed
Management of Biliary Tract Disease During Pregnancy: a Decision Analysis
The appropriate management of biliary tract disease during pregnancy is uncertain. Although laparoscopic cholecystectomy can be performed safely during pregnancy, the timing and indications for this surgical intervention have not been firmly established.
Constitutively Active Endothelial Notch4 Causes Lung Arteriovenous Shunts in Mice
Lung arteriovenous (AV) shunts or malformations cause significant morbidity and mortality in several distinct clinical syndromes. For most patients with lung AV shunts, there is still no optimal treatment. The underlying molecular and cellular etiology for lung AV shunts remains elusive, and currently described animal models have insufficiently addressed this problem. Using a tetracycline-repressible system, we expressed constitutively active Notch4 (Notch4*) specifically in the endothelium of adult mice. More than 90% of mice developed lung hemorrhages and respiratory insufficiency and died by 6-7 wk after gene expression began. Vascular casting and fluorescent microsphere analysis showed evidence of lung AV shunts in affected mice. Cessation of Notch4* expression reversed these pathophysiological effects. Assessment of the vascular morphology revealed enlarged, tortuous vessels in the lungs that resembled arteriovenous malformations. By using whole lung organ culture, we demonstrated the effects of constitutively active Notch4 on the lung vasculature to be a primary lung phenomenon. Together, our results indicate the importance of Notch signaling in maintaining the lung vasculature and offer a new, reliable model with which to study the pathobiology of lung arteriovenous shunts and malformations.
Prenatal Steroids for Microcystic Congenital Cystic Adenomatoid Malformations
The purpose of this study is to evaluate the effect of prenatal steroid treatment in fetuses with sonographically diagnosed congenital cystic adenomatoid malformations (CCAMs).
Outcomes of Multigestational Pregnancies Affected by Congenital Diaphragmatic Hernia
The prognosis for multiple vs singleton pregnancies affected by congenital diaphragmatic hernia (CDH) is not known. To improve the counseling of families with multiple gestation pregnancies complicated by CDH, we examined outcomes of a consecutive series of CDH cases occurring in multiple gestation pregnancy referrals.
Magnamosis II: Magnetic Compression Anastomosis for Minimally Invasive Gastrojejunostomy and Jejunojejunostomy
Previously we demonstrated the safety and patency of a magnetic compression anastomosis (magnamosis). We present the further development of this technique, with specific focus on optimizing device design for minimally invasive magnamosis.
Dynamic Tracheal Occlusion Improves Lung Morphometrics and Function in the Fetal Lamb Model of Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) is associated with significant neonatal morbidity and mortality. Although prenatal complete tracheal occlusion (cTO) causes hypoplastic CDH lungs to enlarge, improved lung function has not been demonstrated. Furthermore, cTO interferes with the dynamic pressure change and fluid flow associated with fetal breathing.
Synchronous Ipsilateral Bochdalek and Morgagni Diaphragmatic Hernias: a Case Report
The etiology of congenital diaphragmatic hernia (CDH) is unknown. Phenotypic patterns of CDH defects provide clues about normal diaphragm development and the pathophysiology of CDH. We report a case of a patient who was diagnosed with CDH postnatally and was found on imaging to have simultaneous Bochdalek and Morgagni hernias on the right side. During the operative repair of these defects, an additional left-sided Morgagni-type defect was also found. To the best of our knowledge, this form of CDH has not been previously reported.
