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In JoVE (1)
Other Publications (1)
Articles by Erika Atucha in JoVE
Rodent Stereotaxic Surgery and Animal Welfare Outcome Improvements for Behavioral Neuroscience
Raquel V. Fornari1, Romy Wichmann1, Piray Atsak1, Erika Atucha1, Areg Barsegyan1, Hassiba Beldjoud1, Fany Messanvi1, Catriene M.A. Thuring2, Benno Roozendaal1
1Department of Neuroscience, Section Anatomy, University Medical Center Groningen, University of Groningen, 2Animal Welfare Office, University of Groningen
Stereotaxic surgery on rodents allows for targeted administration of drugs or electrical stimulation and recordings in awake, behaving animals. In this video presentation we will demonstrate recent procedural refinements to this long-standing procedure that successfully improved survival rate and reduced post-surgical weight loss.
Other articles by Erika Atucha on PubMed
Structure-activity Relationship of Etomidate Derivatives at the GABA(A) Receptor: Comparison with Binding to 11beta-hydroxylase
Bioorganic & Medicinal Chemistry Letters. Aug, 2009 | Pubmed ID: 19497738
At the GABA(A) receptor, low concentrations of etomidate potentiate the inhibitory effect of GABA on specific binding of the closed channel ligand [(3)H]ethynylpropylbicycloorthobenzoate ([(3)H]EBOB). Here, we present SARs for etomidate and structurally related compounds inducing this effect. In the absence of GABA, similar SARs, but 14-20 times weaker potencies were observed. We discuss these SARs in comparison to the much higher potencies of these compounds as inhibitors of 11beta-hydroxylase.