Frederick A. Villamena The Davis Heart and Lung Research Institute The Ohio State University Biography Publications Institution JoVE Articles Frederick A. Villamena has not added a biography. If you are Frederick A. Villamena and would like to personalize this page please email our Author Liaison for assistance. Publications Guest Inclusion in Cucurbiturils Studied by ESR and DFT: The Case of Nitroxide Radicals and Spin Adducts of DMPO and MNP The Journal of Physical Chemistry. A. Aug, 2012 | Pubmed ID: 22830598 Reactive Nitrogen Species Reactivities with Nitrones: Theoretical and Experimental Studies Chemical Research in Toxicology. Jul, 2012 | Pubmed ID: 22775566 Potential Implication of the Chemical Properties and Bioactivity of Nitrone Spin Traps for Therapeutics Future Medicinal Chemistry. Jun, 2012 | Pubmed ID: 22709256 Theoretical and Experimental Studies of the Spin Trapping of Inorganic Radicals by 5,5-Dimethyl-1-pyrroline N-Oxide (DMPO). 3. Sulfur Dioxide, Sulfite, and Sulfate Radical Anions The Journal of Physical Chemistry. A. Jul, 2012 | Pubmed ID: 22668066 Inhibition of ROS-induced Apoptosis in Endothelial Cells by Nitrone Spin Traps Via Induction of Phase II Enzymes and Suppression of Mitochondria-dependent Pro-apoptotic Signaling Biochemical Pharmacology. Aug, 2012 | Pubmed ID: 22580046 Synthesis of Tris-hydroxymethyl-based Nitrone Derivatives with Highly Reactive Nitronyl Carbon The Journal of Organic Chemistry. Jan, 2012 | Pubmed ID: 22188016 Reactivities of Superoxide and Hydroperoxyl Radicals with Disubstituted Cyclic Nitrones: a DFT Study The Journal of Physical Chemistry. A. Jan, 2012 | Pubmed ID: 22085265 Physicochemical and Toxicological Properties of Commercial Carbon Blacks Modified by Reaction with Ozone Environmental Science & Technology. Dec, 2011 | Pubmed ID: 22054302 Synthesis of Trityl Radical-conjugated Disulfide Biradicals for Measurement of Thiol Concentration The Journal of Organic Chemistry. May, 2011 | Pubmed ID: 21488696 Fast Reactivity of a Cyclic Nitrone-Calix[4]pyrrole Conjugate with Superoxide Radical Anion: Theoretical and Experimental Studies (†) Journal of the American Chemical Society. Nov, 2010 | Pubmed ID: 21070040 Synthesis of (14)N- and (15)N-labeled Trityl-nitroxide Biradicals with Strong Spin-Spin Interaction and Improved Sensitivity to Redox Status and Oxygen The Journal of Organic Chemistry. Oct, 2010 | Pubmed ID: 21028905 Amphiphilic Amide Nitrones: a New Class of Protective Agents Acting As Modifiers of Mitochondrial Metabolism Journal of Medicinal Chemistry. Jul, 2010 | Pubmed ID: 20527971 Trityl-nitroxide Biradicals As Unique Molecular Probes for the Simultaneous Measurement of Redox Status and Oxygenation Chemical Communications (Cambridge, England). Jan, 2010 | Pubmed ID: 20062884 Superoxide Radical Anion Adduct of 5,5-dimethyl-1-pyrroline N-oxide. 6. Redox Properties The Journal of Physical Chemistry. A. Jan, 2010 | Pubmed ID: 19968309 Perchlorotrityl Radical-fluorophore Conjugates As Dual Fluorescence and EPR Probes for Superoxide Radical Anion Bioorganic & Medicinal Chemistry. Jan, 2010 | Pubmed ID: 19963389 Spin Trapping and Cytoprotective Properties of Fluorinated Amphiphilic Carrier Conjugates of Cyclic Versus Linear Nitrones Chemical Research in Toxicology. Sep, 2009 | Pubmed ID: 19678661 Lipophilic Beta-cyclodextrin Cyclic-nitrone Conjugate: Synthesis and Spin Trapping Studies The Journal of Organic Chemistry. Aug, 2009 | Pubmed ID: 19530689 Superoxide Radical Anion Adduct of 5,5-dimethyl-1-pyrroline N-oxide. 5. Thermodynamics and Kinetics of Unimolecular Decomposition The Journal of Physical Chemistry. A. Jun, 2009 | Pubmed ID: 19425559 The Radical Trap 5,5-dimethyl-1-pyrroline N-oxide Exerts Dose-dependent Protection Against Myocardial Ischemia-reperfusion Injury Through Preservation of Mitochondrial Electron Transport The Journal of Pharmacology and Experimental Therapeutics. May, 2009 | Pubmed ID: 19201989 Esterified Trityl Radicals As Intracellular Oxygen Probes Free Radical Biology & Medicine. Apr, 2009 | Pubmed ID: 19135524 Superoxide Radical Anion Adduct of 5,5-dimethyl-1-pyrroline N-oxide. 4. Conformational Effects on the EPR Hyperfine Splitting Constants The Journal of Physical Chemistry. A. Dec, 2008 | Pubmed ID: 19012384 Reactivity of Superoxide Radical Anion and Hydroperoxyl Radical with Alpha-phenyl-N-tert-butylnitrone (PBN) Derivatives The Journal of Physical Chemistry. A. Dec, 2008 | Pubmed ID: 18998656 Theoretical and Experimental Studies of Tyrosyl Hydroperoxide Formation in the Presence of H-bond Donors Chemical Research in Toxicology. Oct, 2008 | Pubmed ID: 18816073 Highly Stable Dendritic Trityl Radicals As Oxygen and PH Probe Chemical Communications (Cambridge, England). Sep, 2008 | Pubmed ID: 18802562 Improved Spin Trapping Properties by Beta-cyclodextrin-cyclic Nitrone Conjugate The Journal of Organic Chemistry. Sep, 2008 | Pubmed ID: 18707169 Synthesis and Spin-trapping Properties of a New Spirolactonyl Nitrone The Journal of Organic Chemistry. Apr, 2008 | Pubmed ID: 18331054 Superoxide Radical Anion Adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 3. Effect of Mildly Acidic PH on the Thermodynamics and Kinetics of Adduct Formation The Journal of Physical Chemistry. A. Mar, 2008 | Pubmed ID: 18303874 Synthesis and Characterization of Ester-derivatized Tetrathiatriarylmethyl Radicals As Intracellular Oxygen Probes The Journal of Organic Chemistry. Feb, 2008 | Pubmed ID: 18201099 Inactivation of Mitochondrial Respiratory Chain Complex I Leads Mitochondrial Nitric Oxide Synthase to Become Pro-oxidative Biochemical and Biophysical Research Communications. Mar, 2008 | Pubmed ID: 18191636 Reactivity of Superoxide Anion Radical with a Perchlorotriphenylmethyl (trityl) Radical The Journal of Physical Chemistry. B. Jan, 2008 | Pubmed ID: 18081340 Large-scale Synthesis of a Persistent Trityl Radical for Use in Biomedical EPR Applications and Imaging Bioorganic & Medicinal Chemistry Letters. Dec, 2007 | Pubmed ID: 17964156 Rate Constants of Hydroperoxyl Radical Addition to Cyclic Nitrones: a DFT Study The Journal of Physical Chemistry. A. Oct, 2007 | Pubmed ID: 17845014 Reactivity of Superoxide Radical Anion with Cyclic Nitrones: Role of Intramolecular H-bond and Electrostatic Effects Journal of the American Chemical Society. Jul, 2007 | Pubmed ID: 17564447 Synthesis and Characterization of a Perchlorotriphenylmethyl (trityl) Triester Radical: a Potential Sensor for Superoxide and Oxygen in Biological Systems Bioorganic & Medicinal Chemistry Letters. Jul, 2007 | Pubmed ID: 17499990 4-Aryl-1,3,2-oxathiazolylium-5-olates As PH-controlled NO-donors: the Next Generation of S-nitrosothiols Journal of the American Chemical Society. May, 2007 | Pubmed ID: 17419627 Theoretical and Experimental Studies of the Spin Trapping of Inorganic Radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. Carbonate Radical Anion The Journal of Physical Chemistry. A. Jan, 2007 | Pubmed ID: 17214476 Theoretical and Experimental Studies of the Spin Trapping of Inorganic Radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. Carbon Dioxide Radical Anion The Journal of Physical Chemistry. A. Dec, 2006 | Pubmed ID: 17149843 Reactivity of Molecular Oxygen with Ethoxycarbonyl Derivatives of Tetrathiatriarylmethyl Radicals The Journal of Organic Chemistry. Sep, 2006 | Pubmed ID: 16958520 Evidence for Increased Exchange Interactions with 5d Compared to 4d Metal Ions. Experimental and Theoretical Insights into the Ferromagnetic Interactions of a Series of Trinuclear [{M(CN)8}3-/NiII] Compounds (M = MoV or WV) Journal of the American Chemical Society. Aug, 2006 | Pubmed ID: 16881650 Superoxide Radical Anion Adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The Thermodynamics of Decay and EPR Spectral Properties The Journal of Physical Chemistry. A. Jul, 2005 | Pubmed ID: 16833946 Superoxide Radical Anion Adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. The Thermodynamics of Formation and Its Acidity The Journal of Physical Chemistry. A. Jul, 2005 | Pubmed ID: 16833945 Comparative DFT Study of the Spin Trapping of Methyl, Mercapto, Hydroperoxy, Superoxide, and Nitric Oxide Radicals by Various Substituted Cyclic Nitrones The Journal of Physical Chemistry. A. Mar, 2005 | Pubmed ID: 16833491 Nitric Oxide Release from the Unimolecular Decomposition of the Superoxide Radical Anion Adduct of Cyclic Nitrones in Aqueous Medium Organic & Biomolecular Chemistry. Sep, 2005 | Pubmed ID: 16106305 Glutathione-mediated Formation of Oxygen Free Radicals by the Major Metabolite of Oltipraz Chemical Research in Toxicology. Jun, 2005 | Pubmed ID: 15962931 Cancer Chemopreventive Oltipraz Generates Superoxide Anion Radical Archives of Biochemistry and Biophysics. Mar, 2005 | Pubmed ID: 15680910 Spin Trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): Theoretical and Experimental Studies The Journal of Organic Chemistry. Nov, 2004 | Pubmed ID: 15527282 Detection of Reactive Oxygen and Nitrogen Species by EPR Spin Trapping Antioxidants & Redox Signaling. Jun, 2004 | Pubmed ID: 15130289 Theoretical Study of the Spin Trapping of Hydroxyl Radical by Cyclic Nitrones: a Density Functional Theory Approach Journal of the American Chemical Society. Feb, 2004 | Pubmed ID: 14871114 Detection of Nitric Oxide and Superoxide Radical Anion by Electron Paramagnetic Resonance Spectroscopy from Cells using Spin Traps Bhavani Gopalakrishnan1, Kevin M. Nash1, Murugesan Velayutham1, Frederick A. Villamena1,2 1The Davis Heart and Lung Research Institute, The Ohio State University, 2Department of Pharmacology, College of Medicine, The Ohio State University JoVE 2810 Biology
Detection of Nitric Oxide and Superoxide Radical Anion by Electron Paramagnetic Resonance Spectroscopy from Cells using Spin Traps Bhavani Gopalakrishnan1, Kevin M. Nash1, Murugesan Velayutham1, Frederick A. Villamena1,2 1The Davis Heart and Lung Research Institute, The Ohio State University, 2Department of Pharmacology, College of Medicine, The Ohio State University JoVE 2810 Biology
