Translate this page to:
In JoVE (1)
Other Publications (1)
This translation into Turkish was automatically generated.
English Version | Other Languages
Articles by Gabriel Parent in JoVE
Biyomekanik ve Mechanobiological Araştırmalar Rat Kuyruk Tendonlar hazırlanması
Amélie Bruneau, Nadia Champagne, Paule Cousineau-Pelletier, Gabriel Parent, Eve Langelier
Groupe PERSEUS, Faculté de Génie Département de génie mécanique, Université de Sherbrooke
Bu makalede, biyomekanik ve mechanobiological çalışmalar için sıçan kuyruğu tendonları hazırlamak için kullanılan deneysel prosedürleri açıklamaktadır. Biyoreaktör odasına durulama ve yükleme, çıkarma, kesit alanı ölçümü ile başlayan hazırlık olarak önemli adımlar çeşitli özellikleri göstermiştir.
Other articles by Gabriel Parent on PubMed
Annals of Biomedical Engineering. May, 2011 | Pubmed ID: 21287276
To stimulate healing and prevent tendinosis through optimized physical exercise, it is important to elucidate the tendon response to repetitive mechanical loading. However, the study of this response is challenging due to complex cell-matrix interactions. In an initial approximation, the authors examined tendon mechanical response only, and did not consider cellular activity. The authors investigated the hypothesis that mechanical degradation occurs relatively rapidly (< 24 h) even at very low stress levels. The authors subjected rat tail tendons to mechanical loadings oscillating between 0 and 1.5 MPa up to one of three fatigue levels: 4% strain, 8% strain, or rupture. Using non-destructive mechanical tests, changes in tendon strain and compliance over the entire fatigue testing period were evaluated. Using microscopy techniques, the structural evidence of mechanical degradation was examined. The changes in tendon strain and compliance progressed nonlinearly and accelerated before rupture which took place around the 15-h mark. Histological analyses revealed a higher degree of alteration in the collagen network at increased fatigue levels. At rupture, local zones of damage with low fibril density were evident. These results imply that a repair process must act rapidly at critical sites; otherwise, enzymatic degradation could cause further damage in the manner of a vicious cycle.