Helmut Butzkueven Department of Neurology Royal Melbourne Hospital Biography Publications Institution JoVE Articles Helmut Butzkueven has not added a biography. If you are Helmut Butzkueven and would like to personalize this page please email our Author Liaison for assistance. Publications Defining Reliable Disability Outcomes in Multiple Sclerosis Brain : a Journal of Neurology. Nov, 2015 | Pubmed ID: 26359291 A New Era in the Treatment of Multiple Sclerosis The Medical Journal of Australia. Aug, 2015 | Pubmed ID: 26224184 The Effect of Oral Immunomodulatory Therapy on Treatment Uptake and Persistence in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jul, 2015 | Pubmed ID: 26199347 A Rare P2X7 Variant Arg307Gln with Absent Pore Formation Function Protects Against Neuroinflammation in Multiple Sclerosis Human Molecular Genetics. Jul, 2015 | Pubmed ID: 26188005 The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function PloS One. 2015 | Pubmed ID: 26068105 Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS PloS One. 2015 | Pubmed ID: 26046348 Switching from Natalizumab to Fingolimod: A Randomized, Placebo-controlled Study in RRMS Neurology. Jul, 2015 | Pubmed ID: 26024899 Parallel Changes in Structural and Functional Measures of Optic Nerve Myelination After Optic Neuritis PloS One. 2015 | Pubmed ID: 26020925 Predictors of Disability Worsening in Clinically Isolated Syndrome Annals of Clinical and Translational Neurology. May, 2015 | Pubmed ID: 26000321 Comparative Efficacy of Switching to Natalizumab in Active Multiple Sclerosis Annals of Clinical and Translational Neurology. Apr, 2015 | Pubmed ID: 25909083 Comparison of Switch to Fingolimod or Interferon Beta/glatiramer Acetate in Active Multiple Sclerosis JAMA Neurology. Apr, 2015 | Pubmed ID: 25665031 Galanin is an Autocrine Myelin and Oligodendrocyte Trophic Signal Induced by Leukemia Inhibitory Factor Glia. Jun, 2015 | Pubmed ID: 25639936 Altered Thalamic Functional Connectivity in Multiple Sclerosis European Journal of Radiology. Apr, 2015 | Pubmed ID: 25636387 Switch to Natalizumab Versus Fingolimod in Active Relapsing-remitting Multiple Sclerosis Annals of Neurology. Mar, 2015 | Pubmed ID: 25546031 Comparative Effectiveness of Glatiramer Acetate and Interferon Beta Formulations in Relapsing-remitting Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Aug, 2015 | Pubmed ID: 25480857 Continuing Fingolimod After Development of Macular Edema: A Case Report Neurology® Neuroimmunology & Neuroinflammation. Aug, 2014 | Pubmed ID: 25340066 Axonally Derived Matrilin-2 Induces Proinflammatory Responses That Exacerbate Autoimmune Neuroinflammation The Journal of Clinical Investigation. Nov, 2014 | Pubmed ID: 25329699 Seasonal Variation of Relapse Rate in Multiple Sclerosis is Latitude Dependent Annals of Neurology. Dec, 2014 | Pubmed ID: 25283272 Therapeutic Approaches to Disease Modifying Therapy for Multiple Sclerosis in Adults: an Australian and New Zealand Perspective: Part 3 Treatment Practicalities and Recommendations. MS Neurology Group of the Australian and New Zealand Association of Neurologists Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Nov, 2014 | Pubmed ID: 24993136 Therapeutic Approaches to Disease Modifying Therapy for Multiple Sclerosis in Adults: an Australian and New Zealand Perspective: Part 1 Historical and Established Therapies. MS Neurology Group of the Australian and New Zealand Association of Neurologists Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Nov, 2014 | Pubmed ID: 24993135 Therapeutic Approaches to Disease Modifying Therapy for Multiple Sclerosis in Adults: an Australian and New Zealand Perspective: Part 2 New and Emerging Therapies and Their Efficacy. MS Neurology Group of the Australian and New Zealand Association of Neurologists Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Nov, 2014 | Pubmed ID: 24986155 Cortical Thinning Correlates with Cognitive Change in Multiple Sclerosis but Not in Neuromyelitis Optica European Radiology. Sep, 2014 | Pubmed ID: 24906701 Risk of Relapse Phenotype Recurrence in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Oct, 2014 | Pubmed ID: 24777276 Ceruloplasmin Gene-deficient Mice with Experimental Autoimmune Encephalomyelitis Show Attenuated Early Disease Evolution Journal of Neuroscience Research. Jun, 2014 | Pubmed ID: 24615902 Fingolimod After Natalizumab and the Risk of Short-term Relapse Neurology. Apr, 2014 | Pubmed ID: 24610329 Efficacy and Safety of Natalizumab in Multiple Sclerosis: Interim Observational Programme Results Journal of Neurology, Neurosurgery, and Psychiatry. Feb, 2014 | Pubmed ID: 24532785 Predictors and Dynamics of Postpartum Relapses in Women with Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jan, 2014 | Pubmed ID: 24107309 Optic Nerve Diffusion Tensor Imaging After Acute Optic Neuritis Predicts Axonal and Visual Outcomes PloS One. 2013 | Pubmed ID: 24386285 Endogenously Regulated Dab2 Worsens Inflammatory Injury in Experimental Autoimmune Encephalomyelitis Acta Neuropathologica Communications. 2013 | Pubmed ID: 24252604 Sex As a Determinant of Relapse Incidence and Progressive Course of Multiple Sclerosis Brain : a Journal of Neurology. Dec, 2013 | Pubmed ID: 24142147 Analysis of Immune-related Loci Identifies 48 New Susceptibility Variants for Multiple Sclerosis Nature Genetics. Nov, 2013 | Pubmed ID: 24076602 Responsiveness of the Multiple Sclerosis International Quality of Life Questionnaire to Disability Change: a Longitudinal Study Health and Quality of Life Outcomes. 2013 | Pubmed ID: 23895207 Anti-aquaporin-4 Antibody Positivity in Neuromyelitis Optica is Associated with Lesion Activity European Neurology. 2013 | Pubmed ID: 23860467 Persistence on Therapy and Propensity Matched Outcome Comparison of Two Subcutaneous Interferon Beta 1a Dosages for Multiple Sclerosis PloS One. 2013 | Pubmed ID: 23704913 The Australian Multiple Sclerosis (MS) Immunotherapy Study: a Prospective, Multicentre Study of Drug Utilisation Using the MSBase Platform PloS One. 2013 | Pubmed ID: 23527252 EphA4 Receptor Tyrosine Kinase is a Modulator of Onset and Disease Severity of Experimental Autoimmune Encephalomyelitis (EAE) PloS One. 2013 | Pubmed ID: 23390555 Microstructural Abnormalities in the Trigeminal Nerves of Patients with Trigeminal Neuralgia Revealed by Multiple Diffusion Metrics European Journal of Radiology. May, 2013 | Pubmed ID: 23265178 Commentary on "Possible Induction of Acute Disseminated Encephalomyelitis (ADEM)-like Demyelinating Illness by Intrathecal Mesenchymal Stem Cell Injection" Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Feb, 2013 | Pubmed ID: 23149272 Optic Nerve Magnetisation Transfer Ratio After Acute Optic Neuritis Predicts Axonal and Visual Outcomes PloS One. 2012 | Pubmed ID: 23272235 What Do Effective Treatments for Multiple Sclerosis Tell Us About the Molecular Mechanisms Involved in Pathogenesis? International Journal of Molecular Sciences. 2012 | Pubmed ID: 23202920 Altered Topological Organization of White Matter Structural Networks in Patients with Neuromyelitis Optica PloS One. 2012 | Pubmed ID: 23144994 Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis PloS One. 2012 | Pubmed ID: 23133550 Leukemia Inhibitory Factor Protects Axons in Experimental Autoimmune Encephalomyelitis Via an Oligodendrocyte-independent Mechanism PloS One. 2012 | Pubmed ID: 23077604 Baseline Brain Activity Changes in Patients with Clinically Isolated Syndrome Revealed by Resting-state Functional MRI Acta Radiologica (Stockholm, Sweden : 1987). Nov, 2012 | Pubmed ID: 23002142 Country, Sex, EDSS Change and Therapy Choice Independently Predict Treatment Discontinuation in Multiple Sclerosis and Clinically Isolated Syndrome PloS One. 2012 | Pubmed ID: 22768046 A Double-blind, Randomized, Controlled Study of Botulinum Toxin Type A in MS-related Tremor Neurology. Jul, 2012 | Pubmed ID: 22753445 Increasing Age at Disability Milestones Among MS Patients in the MSBase Registry Journal of the Neurological Sciences. Jul, 2012 | Pubmed ID: 22507751 Diffusion Tensor Imaging Correlates of Visual Impairment in Multiple Sclerosis and Chronic Optic Neuritis Investigative Ophthalmology & Visual Science. Feb, 2012 | Pubmed ID: 22247457 The Kurtzke EDSS Rank Stability Increases 4 Years After the Onset of Multiple Sclerosis: Results from the MSBase Registry Journal of Neurology, Neurosurgery, and Psychiatry. Mar, 2012 | Pubmed ID: 22205675 Diffusion Tensor Imaging of the Optic Radiations After Optic Neuritis Human Brain Mapping. Sep, 2012 | Pubmed ID: 21915943 Neurodegeneration in MS and NMO: The Eye and the Blood Multiple Sclerosis International. 2011 | Pubmed ID: 22203903 Genome-wide Meta-analysis Identifies Novel Multiple Sclerosis Susceptibility Loci Annals of Neurology. Dec, 2011 | Pubmed ID: 22190364 A Tract-based Diffusion Study of Cerebral White Matter in Neuromyelitis Optica Reveals Widespread Pathological Alterations Multiple Sclerosis (Houndmills, Basingstoke, England). Dec, 2011 | Pubmed ID: 22183932 Neurofilament Proteins As Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis Multiple Sclerosis International. 2011 | Pubmed ID: 22096635 Genetic Risk and a Primary Role for Cell-mediated Immune Mechanisms in Multiple Sclerosis Nature. Aug, 2011 | Pubmed ID: 21833088 Clinical Isolated Syndrome: a 3-year Follow-up Study in China Clinical Neurology and Neurosurgery. Oct, 2011 | Pubmed ID: 21680087 Vaginally Administered PEGylated LIF Antagonist Blocked Embryo Implantation and Eliminated Non-target Effects on Bone in Mice PloS One. 2011 | Pubmed ID: 21611124 Brain Plasticity in Relapsing-remitting Multiple Sclerosis: Evidence from Resting-state FMRI Journal of the Neurological Sciences. May, 2011 | Pubmed ID: 21349545 Galanin in Glia: Expression and Potential Roles in the CNS EXS. 2010 | Pubmed ID: 21299062 A Polymorphism in the HLA-DPB1 Gene is Associated with Susceptibility to Multiple Sclerosis PloS One. 2010 | Pubmed ID: 21049023 Common Variation in the MOG Gene Influences Transcript Splicing in Humans Journal of Neuroimmunology. Dec, 2010 | Pubmed ID: 20800907 Multiple Sclerosis Susceptibility-associated SNPs Do Not Influence Disease Severity Measures in a Cohort of Australian MS Patients PloS One. 2010 | Pubmed ID: 20368992 Neuroprotection in Multiple Sclerosis: a Therapeutic Challenge for the Next Decade Pharmacology & Therapeutics. Apr, 2010 | Pubmed ID: 20122960 A Role for Galanin in Human and Experimental Inflammatory Demyelination Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19717462 Fine Mapping of Multiple Sclerosis Susceptibility Genes Provides Evidence of Allelic Heterogeneity at the IL2RA Locus Journal of Neuroimmunology. Jun, 2009 | Pubmed ID: 19375175 Optic Nerve Diffusion Changes and Atrophy Jointly Predict Visual Dysfunction After Optic Neuritis NeuroImage. Apr, 2009 | Pubmed ID: 19162205 Validation of a Novel Biomarker for Acute Axonal Injury in Experimental Autoimmune Encephalomyelitis Journal of Neuroscience Research. Dec, 2008 | Pubmed ID: 18709652 Gas6 Deficiency Increases Oligodendrocyte Loss and Microglial Activation in Response to Cuprizone-induced Demyelination The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2008 | Pubmed ID: 18480276 Leukemia Inhibitory Factor Signaling Modulates Both Central Nervous System Demyelination and Myelin Repair Glia. Apr, 2008 | Pubmed ID: 18293407 Prolonged Interval Between Sentinel Pseudotumoral Demyelination and Development of Primary CNS Lymphoma Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Nov, 2007 | Pubmed ID: 17890092 MR Diffusion Changes Correlate with Ultra-structurally Defined Axonal Degeneration in Murine Optic Nerve NeuroImage. Oct, 2007 | Pubmed ID: 17689104 Analysis of Extended HLA Haplotypes in Multiple Sclerosis and Narcolepsy Families Confirms a Predisposing Effect for the Class I Region in Tasmanian MS Patients Immunogenetics. Mar, 2007 | Pubmed ID: 17256150 Dopamine Agonist-induced Pathological Gambling in Restless Legs Syndrome Due to Multiple Sclerosis Movement Disorders : Official Journal of the Movement Disorder Society. Mar, 2007 | Pubmed ID: 17230484 Suppressor of Cytokine Signaling 3 Limits Protection of Leukemia Inhibitory Factor Receptor Signaling Against Central Demyelination Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16682639 Endogenous Leukemia Inhibitory Factor Production Limits Autoimmune Demyelination and Oligodendrocyte Loss Glia. May, 2006 | Pubmed ID: 16498619 On the Utility of Data from the International HapMap Project for Australian Association Studies Human Genetics. Mar, 2006 | Pubmed ID: 16404587 Multiple Sclerosis: a Haplotype Association Study Novartis Foundation Symposium. 2005 | Pubmed ID: 15999799 Neuroglial Responses to CNS Injury: Prospects for Novel Therapeutics Expert Review of Neurotherapeutics. Sep, 2004 | Pubmed ID: 15853513 Extended Haplotype Analysis in the HLA Complex Reveals an Increased Frequency of the HFE-C282Y Mutation in Individuals with Multiple Sclerosis Human Genetics. May, 2004 | Pubmed ID: 15014978 Schwann Cell Apoptosis in the Postnatal Axotomized Sciatic Nerve is Mediated Via NGF Through the Low-affinity Neurotrophin Receptor Journal of Neuropathology and Experimental Neurology. Apr, 2003 | Pubmed ID: 12722832 Prospects for Stem Cell Transplantation in Multiple Sclerosis Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Jul, 2002 | Pubmed ID: 12217663 LIF Receptor Signaling Limits Immune-mediated Demyelination by Enhancing Oligodendrocyte Survival Nature Medicine. Jun, 2002 | Pubmed ID: 12042813 Genetic Dissection of the Human Leukocyte Antigen Region by Use of Haplotypes of Tasmanians with Multiple Sclerosis American Journal of Human Genetics. May, 2002 | Pubmed ID: 11923913 A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data Tim Spelman1,2, Orla Gray3, Robyn Lucas4, Helmut Butzkueven1,2 1Department of Neurology, Royal Melbourne Hospital, 2Department of Medicine (RMH), The University of Melbourne, 3Department of Neurology, Ulster Hospital, 4National Centre for Epidemiology and Population Health, Australian National University JoVE 53169 Medicine
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data Tim Spelman1,2, Orla Gray3, Robyn Lucas4, Helmut Butzkueven1,2 1Department of Neurology, Royal Melbourne Hospital, 2Department of Medicine (RMH), The University of Melbourne, 3Department of Neurology, Ulster Hospital, 4National Centre for Epidemiology and Population Health, Australian National University JoVE 53169 Medicine
