Hidde L. Ploegh

Publications

• Cholera Toxin Activates Nonconventional Adjuvant Pathways That Induce Protective CD8 T-cell Responses After Epicutaneous Vaccination
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012  |   Pubmed ID: 22308317
• Accessory Molecules for Toll-like Receptors and Their Function
  Nature Reviews. Immunology. Feb, 2012  |   Pubmed ID: 22301850
• Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes
  PloS One. 2012  |   Pubmed ID: 22299025
• Protein Quality Control in the ER: Balancing the Ubiquitin Checkbook
  Trends in Cell Biology. Jan, 2012  |   Pubmed ID: 22055166
• BAT3 Guides Misfolded Glycoproteins out of the Endoplasmic Reticulum
  PloS One. 2011  |   Pubmed ID: 22174835
• Identification of Host Cell Factors Required for Intoxication Through Use of Modified Cholera Toxin
  The Journal of Cell Biology. Nov, 2011  |   Pubmed ID: 22123862
• Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum
  Science (New York, N.Y.). Nov, 2011  |   Pubmed ID: 22116878
• Determinants of GBP Recruitment to Toxoplasma Gondii Vacuoles and the Parasitic Factors That Control It
  PloS One. 2011  |   Pubmed ID: 21931713
• CD8α(+) Dendritic Cells Are the Critical Source of Interleukin-12 That Controls Acute Infection by Toxoplasma Gondii Tachyzoites
  Immunity. Aug, 2011  |   Pubmed ID: 21867928
• Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control
  The Journal of Biological Chemistry. Oct, 2011  |   Pubmed ID: 21857022
• Fungal Recognition is Mediated by the Association of Dectin-1 and Galectin-3 in Macrophages
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011  |   Pubmed ID: 21825168
• Competition by Inhibitory Oligonucleotides Prevents Binding of CpG to C-terminal TLR9
  European Journal of Immunology. Oct, 2011  |   Pubmed ID: 21766476
• Global Gene Disruption in Human Cells to Assign Genes to Phenotypes by Deep Sequencing
  Nature Biotechnology. Jun, 2011  |   Pubmed ID: 21623355
• Helicobacter Pylori Cytotoxin-associated Gene A (CagA) Subverts the Apoptosis-stimulating Protein of P53 (ASPP2) Tumor Suppressor Pathway of the Host
  Proceedings of the National Academy of Sciences of the United States of America. May, 2011  |   Pubmed ID: 21562218
• Making and Breaking Peptide Bonds: Protein Engineering Using Sortase
  Angewandte Chemie (International Ed. in English). May, 2011  |   Pubmed ID: 21538739
• Ubiquitin-dependent Control of Class II MHC Localization is Dispensable for Antigen Presentation and Antibody Production
  PloS One. 2011  |   Pubmed ID: 21533087
• Sortase A As a Tool for High-yield Histatin Cyclization
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2011  |   Pubmed ID: 21525488
• Granulin is a Soluble Cofactor for Toll-like Receptor 9 Signaling
  Immunity. Apr, 2011  |   Pubmed ID: 21497117
• Enzymatic Blockade of the Ubiquitin-proteasome Pathway
  PLoS Biology. Mar, 2011  |   Pubmed ID: 21468303
• Sortase-catalyzed Transformations That Improve the Properties of Cytokines
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011  |   Pubmed ID: 21297034
• Derlin-2-deficient Mice Reveal an Essential Role for Protein Dislocation in Chondrocytes
  Molecular and Cellular Biology. Mar, 2011  |   Pubmed ID: 21220515
• Role of the Ubiquitin-like Protein Urm1 As a Noncanonical Lysine-directed Protein Modifier
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011  |   Pubmed ID: 21209336
• The Tetraspanin CD82 is Specifically Recruited to Fungal and Bacterial Phagosomes Prior to Acidification
  Infection and Immunity. Mar, 2011  |   Pubmed ID: 21149584
• The HCMV Membrane Glycoprotein US10 Selectively Targets HLA-G for Degradation
  The Journal of Experimental Medicine. Aug, 2010  |   Pubmed ID: 20713594
• Quality and Quantity Control at the Endoplasmic Reticulum
  Current Opinion in Cell Biology. Aug, 2010  |   Pubmed ID: 20570125
• The Transmembrane Segment of a Tail-anchored Protein Determines Its Degradative Fate Through Dislocation from the Endoplasmic Reticulum
  The Journal of Biological Chemistry. Jul, 2010  |   Pubmed ID: 20435896
• Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma Gondii Obtained Via SCNT
  Science (New York, N.Y.). Apr, 2010  |   Pubmed ID: 20378817
• Differential Regulation of Effector- and Central-memory Responses to Toxoplasma Gondii Infection by IL-12 Revealed by Tracking of Tgd057-specific CD8+ T Cells
  PLoS Pathogens. Mar, 2010  |   Pubmed ID: 20333242
• The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc
  Cell. Mar, 2010  |   Pubmed ID: 20211139
• Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase UCHL3
  The Journal of Biological Chemistry. Feb, 2010  |   Pubmed ID: 20042598
• A Structural Element Within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities
  The Journal of Biological Chemistry. Feb, 2010  |   Pubmed ID: 20007713
• Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens
  Science (New York, N.Y.). Nov, 2009  |   Pubmed ID: 19965467
• The Otubain YOD1 is a Deubiquitinating Enzyme That Associates with P97 to Facilitate Protein Dislocation from the ER
  Molecular Cell. Oct, 2009  |   Pubmed ID: 19818707
• Subtilase Cytotoxin Cleaves Newly Synthesized BiP and Blocks Antibody Secretion in B Lymphocytes
  The Journal of Experimental Medicine. Oct, 2009  |   Pubmed ID: 19808260
• XBP-1-deficient Plasmablasts Show Normal Protein Folding but Altered Glycosylation and Lipid Synthesis
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2009  |   Pubmed ID: 19710472
• A Gammaherpesvirus Ubiquitin-specific Protease is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection
  Journal of Virology. Oct, 2009  |   Pubmed ID: 19706716
• Site-specific N- and C-terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity
  Journal of the American Chemical Society. Aug, 2009  |   Pubmed ID: 19610623
• Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009  |   Pubmed ID: 19553543
• Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection
  Cell Host & Microbe. Jun, 2009  |   Pubmed ID: 19527883
• XBP-1 Regulates Signal Transduction, Transcription Factors and Bone Marrow Colonization in B Cells
  The EMBO Journal. Jun, 2009  |   Pubmed ID: 19407814
• Site-specific Protein Labeling Via Sortase-mediated Transpeptidation
  Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [et Al.]. Apr, 2009  |   Pubmed ID: 19365788
• A Straight Path to Circular Proteins
  The Journal of Biological Chemistry. Jun, 2009  |   Pubmed ID: 19359246
• Ubiquitin C-terminal Electrophiles Are Activity-based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery
  ACS Chemical Biology. Apr, 2009  |   Pubmed ID: 19256548
• Substrate Filtering by the Active Site Crossover Loop in UCHL3 Revealed by Sortagging and Gain-of-function Mutations
  The Journal of Biological Chemistry. Feb, 2009  |   Pubmed ID: 19047059
• A Functional Proteomics Approach Links the Ubiquitin-related Modifier Urm1 to a TRNA Modification Pathway
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008  |   Pubmed ID: 19017811
• Profiling Antibody Responses by Multiparametric Analysis of Primary B Cells
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008  |   Pubmed ID: 19004776
• Lipid Modification of Proteins Through Sortase-catalyzed Transpeptidation
  Journal of the American Chemical Society. Dec, 2008  |   Pubmed ID: 18989959
• Proteolytic Cleavage in an Endolysosomal Compartment is Required for Activation of Toll-like Receptor 9
  Nature Immunology. Dec, 2008  |   Pubmed ID: 18931679
• The CD8 T-cell Response Against Murine Gammaherpesvirus 68 is Directed Toward a Broad Repertoire of Epitopes from Both Early and Late Antigens
  Journal of Virology. Dec, 2008  |   Pubmed ID: 18922872
• Parasite Stage-specific Recognition of Endogenous Toxoplasma Gondii-derived CD8+ T Cell Epitopes
  The Journal of Infectious Diseases. Dec, 2008  |   Pubmed ID: 18922097
• SEL1L Nucleates a Protein Complex Required for Dislocation of Misfolded Glycoproteins
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008  |   Pubmed ID: 18711132
• Live Imaging of Cysteine-cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth
  PloS One. 2008  |   Pubmed ID: 18698347
• Concurrent Detection of Secreted Products from Human Lymphocytes by Microengraving: Cytokines and Antigen-reactive Antibodies
  Clinical Immunology (Orlando, Fla.). Oct, 2008  |   Pubmed ID: 18675591
• The Known Unknowns of Antigen Processing and Presentation
  Nature Reviews. Immunology. Aug, 2008  |   Pubmed ID: 18641646
• UNC93B1 Delivers Nucleotide-sensing Toll-like Receptors to Endolysosomes
  Nature. Mar, 2008  |   Pubmed ID: 18305481
• Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain Degradation
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2008  |   Pubmed ID: 18292509
• Discovery of CD8+ T Cell Epitopes in Chlamydia Trachomatis Infection Through Use of Caged Class I MHC Tetramers
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008  |   Pubmed ID: 18245382
• N-linked Glycosylation Does Not Impair Proteasomal Degradation but Affects Class I Major Histocompatibility Complex Presentation
  The Journal of Biological Chemistry. Jan, 2008  |   Pubmed ID: 17951257
• Bridging B Cell and T Cell Recognition of Antigen
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2007  |   Pubmed ID: 18025158
• Mechanisms, Biology and Inhibitors of Deubiquitinating Enzymes
  Nature Chemical Biology. Nov, 2007  |   Pubmed ID: 17948018
• Sortagging: a Versatile Method for Protein Labeling
  Nature Chemical Biology. Nov, 2007  |   Pubmed ID: 17891153
• The Peptide Cargo of Class I Molecules: Not Just Passive Passengers
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007  |   Pubmed ID: 17878322
• Differential Priming of CD8 and CD4 T-cells in Animal Models of Autoimmune Hepatitis and Cholangitis
  Hepatology (Baltimore, Md.). Oct, 2007  |   Pubmed ID: 17657820
• Screen for ISG15-crossreactive Deubiquitinases
  PloS One. 2007  |   Pubmed ID: 17653289
• A Lipid-based Model for the Creation of an Escape Hatch from the Endoplasmic Reticulum
  Nature. Jul, 2007  |   Pubmed ID: 17653186
• A Functional Ubiquitin-specific Protease Embedded in the Large Tegument Protein (ORF64) of Murine Gammaherpesvirus 68 is Active During the Course of Infection
  Journal of Virology. Oct, 2007  |   Pubmed ID: 17634221
• Sequence and Structure Evolved Separately in a Ribosomal Ubiquitin Variant
  The EMBO Journal. Jul, 2007  |   Pubmed ID: 17599068
• TLRs Bent into Shape
  Nature Immunology. Jul, 2007  |   Pubmed ID: 17579642
• Empty Class II Major Histocompatibility Complex Created by Peptide Photolysis Establishes the Role of DM in Peptide Association
  The Journal of Biological Chemistry. Jul, 2007  |   Pubmed ID: 17525157
• Tubulation of Class II MHC Compartments is Microtubule Dependent and Involves Multiple Endolysosomal Membrane Proteins in Primary Dendritic Cells
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2007  |   Pubmed ID: 17513769
• The Mouse Polyubiquitin Gene UbC is Essential for Fetal Liver Development, Cell-cycle Progression and Stress Tolerance
  The EMBO Journal. Jun, 2007  |   Pubmed ID: 17491588
• The Interaction Between the ER Membrane Protein UNC93B and TLR3, 7, and 9 is Crucial for TLR Signaling
  The Journal of Cell Biology. Apr, 2007  |   Pubmed ID: 17452530
• ElaD, a Deubiquitinating Protease Expressed by E. Coli
  PloS One. 2007  |   Pubmed ID: 17440617
• Structure of a Herpesvirus-encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
  Molecular Cell. Mar, 2007  |   Pubmed ID: 17349955
• Chemical Probes for the Rapid Detection of Fatty-acylated Proteins in Mammalian Cells
  Journal of the American Chemical Society. Mar, 2007  |   Pubmed ID: 17305342
• AID-/-mus-/- Mice Are Agammaglobulinemic and Fail to Maintain B220-CD138+ Plasma Cells
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2007  |   Pubmed ID: 17277124
• Mechanism-based Probe for the Analysis of Cathepsin Cysteine Proteases in Living Cells
  ACS Chemical Biology. Dec, 2006  |   Pubmed ID: 17184136
• Antigen Presentation and the Ubiquitin-proteasome System in Host-pathogen Interactions
  Advances in Immunology. 2006  |   Pubmed ID: 17145306
• Viral Interference with B7-1 Costimulation: a New Role for Murine Cytomegalovirus Fc Receptor-1
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2006  |   Pubmed ID: 17142739
• Recruitment of CD63 to Cryptococcus Neoformans Phagosomes Requires Acidification
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006  |   Pubmed ID: 17043215
• SEL1L, the Homologue of Yeast Hrd3p, is Involved in Protein Dislocation from the Mammalian ER
  The Journal of Cell Biology. Oct, 2006  |   Pubmed ID: 17043138
• Identification by Functional Proteomics of a Deubiquitinating/deNeddylating Enzyme in Plasmodium Falciparum
  Molecular Microbiology. Sep, 2006  |   Pubmed ID: 16925553
• Murine Polyomavirus Requires the Endoplasmic Reticulum Protein Derlin-2 to Initiate Infection
  Journal of Virology. Sep, 2006  |   Pubmed ID: 16912321
• Immune-privileged Embryonic Swiss Mouse STO and STO Cell-derived Progenitor Cells: Major Histocompatibility Complex and Cell Differentiation Antigen Expression Patterns Resemble Those of Human Embryonic Stem Cell Lines
  Immunology. Sep, 2006  |   Pubmed ID: 16836618
• Chlamydia Trachomatis-derived Deubiquitinating Enzymes in Mammalian Cells During Infection
  Molecular Microbiology. Jul, 2006  |   Pubmed ID: 16824101
• Development of Intravital Intermittent Confocal Imaging System for Studying Langerhans Cell Turnover
  The Journal of Investigative Dermatology. Nov, 2006  |   Pubmed ID: 16794586
• Signal Peptide Peptidase is Required for Dislocation from the Endoplasmic Reticulum
  Nature. Jun, 2006  |   Pubmed ID: 16738546
• High-molecular-weight Protein (pUL48) of Human Cytomegalovirus is a Competent Deubiquitinating Protease: Mutant Viruses Altered in Its Active-site Cysteine or Histidine Are Viable
  Journal of Virology. Jun, 2006  |   Pubmed ID: 16731939
• A Microengraving Method for Rapid Selection of Single Cells Producing Antigen-specific Antibodies
  Nature Biotechnology. Jun, 2006  |   Pubmed ID: 16699501
• Regulation of Monoubiquitinated PCNA by DUB Autocleavage
  Nature Cell Biology. Apr, 2006  |   Pubmed ID: 16531995
• Crystal Structure of the Boronic Acid-based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome
  Structure (London, England : 1993). Mar, 2006  |   Pubmed ID: 16531229
• Monovalent Ligation of the B Cell Receptor Induces Receptor Activation but Fails to Promote Antigen Presentation
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006  |   Pubmed ID: 16492756
• Behavioral Responses of Epidermal Langerhans Cells in Situ to Local Pathological Stimuli
  The Journal of Investigative Dermatology. Apr, 2006  |   Pubmed ID: 16439974
• Rapid Turnover of Unspliced Xbp-1 As a Factor That Modulates the Unfolded Protein Response
  The Journal of Biological Chemistry. Mar, 2006  |   Pubmed ID: 16332684
• Mechanism-based Proteomics Tools Based on Ubiquitin and Ubiquitin-like Proteins: Synthesis of Active Site-directed Probes
  Methods in Enzymology. 2005  |   Pubmed ID: 16338376
• Mechanism-based Proteomics Tools Based on Ubiquitin and Ubiquitin-like Proteins: Crystallography, Activity Profiling, and Protease Identification
  Methods in Enzymology. 2005  |   Pubmed ID: 16338352
• A Deubiquitinating Activity is Conserved in the Large Tegument Protein of the Herpesviridae
  Journal of Virology. Dec, 2005  |   Pubmed ID: 16306630
• Loss of Usp14 Results in Reduced Levels of Ubiquitin in Ataxia Mice
  Journal of Neurochemistry. Nov, 2005  |   Pubmed ID: 16190881
• Multiprotein Complexes That Link Dislocation, Ubiquitination, and Extraction of Misfolded Proteins from the Endoplasmic Reticulum Membrane
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005  |   Pubmed ID: 16186509
• Ubiquitin--conserved Protein or Selfish Gene?
  Trends in Biochemical Sciences. Nov, 2005  |   Pubmed ID: 16185873
• Cathepsin L is Essential for Onset of Autoimmune Diabetes in NOD Mice
  The Journal of Clinical Investigation. Oct, 2005  |   Pubmed ID: 16184198
• Viral Modulation of Antigen Presentation: Manipulation of Cellular Targets in the ER and Beyond
  Immunological Reviews. Oct, 2005  |   Pubmed ID: 16181332
• Effects of PS-341 on the Activity and Composition of Proteasomes in Multiple Myeloma Cells
  Cancer Research. Sep, 2005  |   Pubmed ID: 16140960
• A Deubiquitinating Enzyme Encoded by HSV-1 Belongs to a Family of Cysteine Proteases That is Conserved Across the Family Herpesviridae
  Molecular Cell. Aug, 2005  |   Pubmed ID: 16109378
• XBP-1 Specifically Promotes IgM Synthesis and Secretion, but is Dispensable for Degradation of Glycoproteins in Primary B Cells
  The Journal of Experimental Medicine. Aug, 2005  |   Pubmed ID: 16103408
• A Molecule's Right to Choose: How Diabetogenic Class II MHC Products Bind Peptides
  The Journal of Clinical Investigation. Aug, 2005  |   Pubmed ID: 16075053
• Cellular Internalization of Cytolethal Distending Toxin: a New End to a Known Pathway
  Cellular Microbiology. Jul, 2005  |   Pubmed ID: 15953025
• Asparagine Endopeptidase is Not Essential for Class II MHC Antigen Presentation but is Required for Processing of Cathepsin L in Mice
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2005  |   Pubmed ID: 15905550
• Activity Probe for in Vivo Profiling of the Specificity of Proteasome Inhibitor Bortezomib
  Nature Methods. May, 2005  |   Pubmed ID: 15846363
• Human Cytomegalovirus Protein US11 Provokes an Unfolded Protein Response That May Facilitate the Degradation of Class I Major Histocompatibility Complex Products
  Journal of Virology. Mar, 2005  |   Pubmed ID: 15708995
• CX3CR1-mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
  Science (New York, N.Y.). Jan, 2005  |   Pubmed ID: 15653504
• Small-molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-like-specific Proteases
  Chembiochem : a European Journal of Chemical Biology. Feb, 2005  |   Pubmed ID: 15651044
• Cotranslational Endoplasmic Reticulum Assembly of FcepsilonRI Controls the Formation of Functional IgE-binding Receptors
  The Journal of Experimental Medicine. Jan, 2005  |   Pubmed ID: 15642744
• Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate
  The Journal of Biological Chemistry. Jan, 2005  |   Pubmed ID: 15531586
• Using a Small Molecule Inhibitor of Peptide: N-glycanase to Probe Its Role in Glycoprotein Turnover
  Chemistry & Biology. Dec, 2004  |   Pubmed ID: 15610852
• Identification of Proteins Associated with Murine Cytomegalovirus Virions
  Journal of Virology. Oct, 2004  |   Pubmed ID: 15452238
• Mice Deficient in Invariant-chain and MHC Class II Exhibit a Normal Mature B2 Cell Compartment
  European Journal of Immunology. Aug, 2004  |   Pubmed ID: 15259020
• Preferred in Vivo Ubiquitination Sites
  Bioinformatics (Oxford, England). Dec, 2004  |   Pubmed ID: 15256413
• Translating Cell Biology in Vitro to Immunity in Vivo
  Nature. Jul, 2004  |   Pubmed ID: 15241425
• A Membrane Protein Required for Dislocation of Misfolded Proteins from the ER
  Nature. Jun, 2004  |   Pubmed ID: 15215855
• Immunology. Nothing 'gainst Time's Scythe Can Make Defense
  Science (New York, N.Y.). May, 2004  |   Pubmed ID: 15166355
• Development of an Isotope-coded Activity-based Probe for the Quantitative Profiling of Cysteine Proteases
  Bioorganic & Medicinal Chemistry Letters. Jun, 2004  |   Pubmed ID: 15149659
• Chemistry-based Functional Proteomics: Mechanism-based Activity-profiling Tools for Ubiquitin and Ubiquitin-like Specific Proteases
  Journal of Proteome Research. Mar-Apr, 2004  |   Pubmed ID: 15113103
• Differential Dependence of CD4+CD25+ Regulatory and Natural Killer-like T Cells on Signals Leading to NF-kappaB Activation
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004  |   Pubmed ID: 15070758
• Activity-based Ubiquitin-specific Protease (USP) Profiling of Virus-infected and Malignant Human Cells
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004  |   Pubmed ID: 14982996
• Control of Cross-presentation During Dendritic Cell Maturation
  European Journal of Immunology. Feb, 2004  |   Pubmed ID: 14768044
• Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin
  Molecular Biology of the Cell. Apr, 2004  |   Pubmed ID: 14767067
• A Glycosylated Type I Membrane Protein Becomes Cytosolic when Peptide: N-glycanase is Compromised
  The EMBO Journal. Feb, 2004  |   Pubmed ID: 14749736
• Zinc-finger Protein A20, a Regulator of Inflammation and Cell Survival, Has De-ubiquitinating Activity
  The Biochemical Journal. Mar, 2004  |   Pubmed ID: 14748687
• Yeast N-glycanase Distinguishes Between Native and Non-native Glycoproteins
  EMBO Reports. Feb, 2004  |   Pubmed ID: 14726951
• Thymic Selection and Peripheral Activation of CD8 T Cells by the Same Class I MHC/peptide Complex
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2004  |   Pubmed ID: 14688383
• Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-like Proteins
  Molecular and Cellular Biology. Jan, 2004  |   Pubmed ID: 14673145
• The ER-lumenal Domain of the HHV-7 Immunoevasin U21 Directs Class I MHC Molecules to Lysosomes
  Traffic (Copenhagen, Denmark). Dec, 2003  |   Pubmed ID: 14617346
• Elimination in Vivo of Developing T Cells by Natural Killer Cells
  The Journal of Experimental Medicine. Oct, 2003  |   Pubmed ID: 14568980
• A Single Protease, Apg4B, is Specific for the Autophagy-related Ubiquitin-like Proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L
  The Journal of Biological Chemistry. Dec, 2003  |   Pubmed ID: 14530254
• Functional Proteomics of the Active Cysteine Protease Content in Drosophila S2 Cells
  Molecular & Cellular Proteomics : MCP. Nov, 2003  |   Pubmed ID: 13130081
• Dislocation of a Type I Membrane Protein Requires Interactions Between Membrane-spanning Segments Within the Lipid Bilayer
  Molecular Biology of the Cell. Sep, 2003  |   Pubmed ID: 12972557
• Chemistry in Living Cells: Detection of Active Proteasomes by a Two-step Labeling Strategy
  Angewandte Chemie (International Ed. in English). Aug, 2003  |   Pubmed ID: 12916032
• Ubiquitinylation of the Cytosolic Domain of a Type I Membrane Protein is Not Required to Initiate Its Dislocation from the Endoplasmic Reticulum
  The Journal of Biological Chemistry. Sep, 2003  |   Pubmed ID: 12832421
• The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites
  The Journal of Biological Chemistry. Sep, 2003  |   Pubmed ID: 12815064
• A Role for N-glycanase in the Cytosolic Turnover of Glycoproteins
  The EMBO Journal. Mar, 2003  |   Pubmed ID: 12606569
• Protein Unfolding is Not a Prerequisite for Endoplasmic Reticulum-to-cytosol Dislocation
  The Journal of Biological Chemistry. Feb, 2003  |   Pubmed ID: 12482753
• Zwitterionic Polysaccharides Stimulate T Cells by MHC Class II-dependent Interactions
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2002  |   Pubmed ID: 12444118
• Mouse MHC Class I Tetramers That Are Unable to Bind to CD8 Reveal the Need for CD8 Engagement in Order to Activate Naive CD8 T Cells
  European Journal of Immunology. Dec, 2002  |   Pubmed ID: 12432573
• Invariant Chain Controls the Activity of Extracellular Cathepsin L
  The Journal of Experimental Medicine. Nov, 2002  |   Pubmed ID: 12417635
• The Ubiquitin-proteasome Pathway in Thymocyte Apoptosis: Caspase-dependent Processing of the Deubiquitinating Enzyme USP7 (HAUSP)
  Molecular Immunology. Nov, 2002  |   Pubmed ID: 12413694
• Chemistry-based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family
  Chemistry & Biology. Oct, 2002  |   Pubmed ID: 12401499
• The Human Cytomegalovirus US10 Gene Product Delays Trafficking of Major Histocompatibility Complex Class I Molecules
  Journal of Virology. Nov, 2002  |   Pubmed ID: 12388737
• Class I Negative CD8 T Cells Reveal the Confounding Role of Peptide-transfer Onto CD8 T Cells Stimulated with Soluble H2-Kb Molecules
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002  |   Pubmed ID: 12374858
• Lessons from Viral Manipulation of Protein Disposal Pathways
  The Journal of Clinical Investigation. Oct, 2002  |   Pubmed ID: 12370262
• MHC Class I Antigen Processing Regulated by Cytosolic Proteolysis-short Cuts That Alter Peptide Generation
  Molecular Immunology. Oct, 2002  |   Pubmed ID: 12200049
• T-cell Engagement of Dendritic Cells Rapidly Rearranges MHC Class II Transport
  Nature. Aug, 2002  |   Pubmed ID: 12198548
• Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation
  The Journal of Experimental Medicine. Aug, 2002  |   Pubmed ID: 12186844
• Proteolysis and Antigen Presentation by MHC Class II Molecules
  Advances in Immunology. 2002  |   Pubmed ID: 12078484
• The Human Cytomegalovirus US8 Glycoprotein Binds to Major Histocompatibility Complex Class I Products
  Journal of Virology. Jul, 2002  |   Pubmed ID: 12050396
• Neuronal Loss and Brain Atrophy in Mice Lacking Cathepsins B and L
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002  |   Pubmed ID: 12048238
• Kaposi's Sarcoma-associated Herpesvirus K3 Utilizes the Ubiquitin-proteasome System in Routing Class Major Histocompatibility Complexes to Late Endocytic Compartments
  Journal of Virology. Jun, 2002  |   Pubmed ID: 11991980
• Human Cytomegalovirus Gene Products US2 and US11 Differ in Their Ability to Attack Major Histocompatibility Class I Heavy Chains in Dendritic Cells
  Journal of Virology. May, 2002  |   Pubmed ID: 11967320
• Visualization of the ER-to-cytosol Dislocation Reaction of a Type I Membrane Protein
  The EMBO Journal. Mar, 2002  |   Pubmed ID: 11867532
• Don Craig Wiley (1944-2001)
  Nature. Jan, 2002  |   Pubmed ID: 11823846
• Uncoating ATPase Hsc70 is Recruited by Invariant Chain and Controls the Size of Endocytic Compartments
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002  |   Pubmed ID: 11818572
• Specific Role for Cathepsin S in the Generation of Antigenic Peptides in Vivo
  European Journal of Immunology. Feb, 2002  |   Pubmed ID: 11813165
• US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide
  The Journal of Biological Chemistry. Mar, 2002  |   Pubmed ID: 11790769
• A Closer Look at Proteolysis and MHC-class-II-restricted Antigen Presentation
  Current Opinion in Immunology. Feb, 2002  |   Pubmed ID: 11790528
• The Cell Biology of Antigen Presentation
  Experimental Cell Research. Jan, 2002  |   Pubmed ID: 11740859
• Membrane-specific, Host-derived Factors Are Required for US2- and US11-mediated Degradation of Major Histocompatibility Complex Class I Molecules
  The Journal of Biological Chemistry. Feb, 2002  |   Pubmed ID: 11717308