Articles by Hidemi Suzuki in JoVE

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

JoVE 3947 7/10/2012

Hidemi Suzuki^1,2, Lin Fan^1,2, David S. Wilkes^1,2

¹Departments of Medicine, Microbiology and Immunology, Indiana University School of Medicine, ²Center for Immunobiology, Indiana University School of Medicine

Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust preclinical model precludes examining obliterative bronchiolitis immunopathogenesis. Unlike other solid organ transplants, vascularized mouse lung transplantation has only recently been developed. Here we show our independently developed obliterative bronchiolitis model after murine orthotopic single-lung transplantation.