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In JoVE (1)
Other Publications (6)
Articles by Jasneet Bhullar in JoVE
JoVE Clinical and Translational Medicine
Creation of Reversible Cholestatic Rat Model
Department of General Surgery, Providence Hospital and Medical Centers
Cholestasis is a clinical condition commonly encountered by both surgeons and gastroenterologists. Creation of a reversible cholestatic rat model can be challenging in view of the smaller size and unique hepatopancreatobiliary anatomy in rats. This video article demonstrates the creation of a reversible cholestatic model.
Other articles by Jasneet Bhullar on PubMed
Topical Gentamicin Does Not Provide Any Additional Anastomotic Strength when Combined with Fibrin Glue
We evaluated the effect of a combination of fibrin sealant and topical gentamicin on a colonic anastomosis in a rat model.
Unique Case of Tubulocystic Carcinoma of the Kidney with Sarcomatoid Features: a New Entity
Tubulocystic carcinoma of the kidney is a recently reported rare entity, with very few reports in the literature. It has always been described as a low-grade malignancy with favorable prognosis. We report the case of 33-year-old man who presented with back pain. Investigations revealed multiple bony metastases and a large, solid, cystic left renal tumor. Decompression of the spine followed by left radical nephrectomy was done. Final pathologic diagnosis was tubulocystic carcinoma of the kidney with sarcomatoid features. Unfortunately, he presented after 2 months with intestinal obstruction, and an exploratory laparotomy revealed multiple peritoneal metastases with ascites.
A Novel Nonoperative Orthotopic Colorectal Cancer Murine Model Using Electrocoagulation
Orthotopic mouse models of human colorectal cancer represent an important in vivo tool for testing chemotherapeutic agents and studying intraluminal factors that may alter the growth of cancers. Currently the orthotopic mouse models of colorectal cancer require either an operative procedure or creation of colitis to implant the cancer cells in rectum. We have developed a nonoperative, minimally invasive technique to create a true orthotopic colon cancer mouse model.
Response To: Topical Gentamicin Does Not Provide Any Additional Anastomotic Strength when Combined with Fibrin Glue
Prolonged (longer Than 3 Hours) Laparoscopic Cholecystectomy: Reasons and Results
For the experienced surgeon, the average operative time for a laparoscopic cholecystectomy is less than 1 hour. There has been no study documenting the causes and results of prolonged (longer than 3 hours) surgery. A retrospective study was done of patients who underwent cholecystectomy between January 2003 and December 2007. A total of 3126 cholecystectomies were done. After excluding patients who had a planned open cholecystectomy and patients who had additional laparoscopic surgeries, we identified 70 patients who had a planned laparoscopic cholecystectomy with operative time exceeding 3 hours. Multivariate stepwise logistic regression was performed analyzing the various factors leading to prolonged surgery. Of the 70 patients, ranging in age from 21 to 92 years (mean, 57 years), most (n = 53) were female. Operative time ranged from 3 hours to 6 hours 40 minutes (mean, 3 hours 37 minutes). Emergency:elective admission ratio was 9:5 and acute cholecystitis (n = 40) was the most common indication. Common characteristics were obesity (n = 44, P = 0.031), intra-abdominal adhesions (n = 43, P = 0.004), and previous abdominal surgeries (n = 40, P = 0.002). Intraoperative complications included spillage of stones (n = 6), bile duct injury (n = 3), and bleeding (n = 3). The possibility of prolonged laparoscopic cholecystectomy should be anticipated in patients with obesity and previous abdominal operations. Prolonged surgery increases the risk of complications (bile duct injury, bleeding) and prolongs the postoperative hospital stay.
Receptor Changes in Metachronous Breast Tumors-our Experience of 10 Years
INTRODUCTION: Patients with primary breast cancer (PBC) are at 2 to 6 times higher risk for developing synchronous and metachronous breast cancer (MBC). The pathology and behavior of MBC still remains unclear. METHODS: We reviewed the charts of 108 women with MBC at our hospital over the past 10 years. Profile patterns of the estrogen receptor (ER), the progesterone receptor (PR), and Her2/neu receptors were explored. RESULTS: Of 33 patients with ER(+)/PR(+) in the primary tumor, 23 (70%) retained the status in MBC. Forty-five (92%) of 49 patients with ER(-)/PR(-) in the primary tumor remained the same in MBC. Most Her2(-) tumors (22/31, 71%) remained negative, but 50% (8/16) of Her2(+) tumors became negative. CONCLUSIONS: Most MBC retained the ER/PR expression patterns irrespective of the treatment for the primary tumor, thus suggesting a common origin. Because MBCs tend to be triple negative and thus more aggressive, early detection and close surveillance techniques must be devised.
