Jeffrey R. Capadona Department of Biomedical Engineering Case Western Reserve University Biography Publications Institution JoVE Articles Jeffrey R. Capadona has not added a biography. If you are Jeffrey R. Capadona and would like to personalize this page please email our Author Liaison for assistance. Publications Neuroinflammatory Gene Expression Analysis Reveals Pathways of Interest As Potential Targets to Improve the Recording Performance of Intracortical Microelectrodes Cells. Jul, 2022 | Pubmed ID: 35954192 Characterization of Active Electrode Yield for Intracortical Arrays: Awake Versus Anesthesia Micromachines. Mar, 2022 | Pubmed ID: 35334770 Investigation of the Feasibility of Ventricular Delivery of Resveratrol to the Microelectrode Tissue Interface Micromachines. Nov, 2021 | Pubmed ID: 34945296 Intracortical Microelectrode Array Unit Yield Under Chronic Conditions: A Comparative Evaluation Micromachines. Aug, 2021 | Pubmed ID: 34442594 Investigating the Association Between Motor Function, Neuroinflammation, and Recording Metrics in the Performance of Intracortical Microelectrode Implanted in Motor Cortex Micromachines. Sep, 2020 | Pubmed ID: 32899336 Second Harmonic Generation Imaging of Collagen in Chronically Implantable Electrodes in Brain Tissue Frontiers in Neuroscience. 2020 | Pubmed ID: 32733179 Editorial: Bridging the Gap in Neuroelectronic Interfaces Frontiers in Neuroscience. 2020 | Pubmed ID: 32581667 Mechanically Adaptive Implants Fabricated with Poly(2-hydroxyethyl Methacrylate)-based Negative Photoresists Journal of Materials Chemistry. B. 08, 2020 | Pubmed ID: 32555874 Toward Standardization of Electrophysiology and Computational Tissue Strain in Rodent Intracortical Microelectrode Models Frontiers in Bioengineering and Biotechnology. 2020 | Pubmed ID: 32457888 Differential Expression of Genes Involved in the Acute Innate Immune Response to Intracortical Microelectrodes Acta Biomaterialia. 01, 2020 | Pubmed ID: 31733330 Sonic Hedgehog is Expressed by Hilar Mossy Cells and Regulates Cellular Survival and Neurogenesis in the Adult Hippocampus Scientific Reports. 11, 2019 | Pubmed ID: 31758070 Neuron-like Neural Probes Nature Materials. 05, 2019 | Pubmed ID: 30804508 A Graphical User Interface to Assess the Neuroinflammatory Response to Intracortical Microelectrodes Journal of Neuroscience Methods. 04, 2019 | Pubmed ID: 30664915 Anti-inflammatory Approaches to Mitigate the Neuroinflammatory Response to Brain-Dwelling Intracortical Microelectrodes Journal of Immunological Sciences. 2018 | Pubmed ID: 30854523 Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes Critical Reviews in Biomedical Engineering. 2018 | Pubmed ID: 30806249 Understanding the Effects of Both CD14-Mediated Innate Immunity and Device/Tissue Mechanical Mismatch in the Neuroinflammatory Response to Intracortical Microelectrodes Frontiers in Neuroscience. 2018 | Pubmed ID: 30429766 Characterization of the Neuroinflammatory Response to Thiol-ene Shape Memory Polymer Coated Intracortical Microelectrodes Micromachines. Sep, 2018 | Pubmed ID: 30424419 The Role of Toll-Like Receptor 2 and 4 Innate Immunity Pathways in Intracortical Microelectrode-Induced Neuroinflammation Frontiers in Bioengineering and Biotechnology. 2018 | Pubmed ID: 30159311 Evaluation of an in Vivo Model for Ventricular Shunt Infection: a Pilot Study Using a Novel Antimicrobial-loaded Polymer Journal of Neurosurgery. 08, 2018 | Pubmed ID: 30074457 Implantation of Neural Probes in the Brain Elicits Oxidative Stress Frontiers in Bioengineering and Biotechnology. 2018 | Pubmed ID: 29487848 Targeting CD14 on Blood Derived Cells Improves Intracortical Microelectrode Performance Biomaterials. May, 2018 | Pubmed ID: 29471127 A Mosquito Inspired Strategy to Implant Microprobes into the Brain Scientific Reports. Jan, 2018 | Pubmed ID: 29317748 Inhibition of the Cluster of Differentiation 14 Innate Immunity Pathway with IAXO-101 Improves Chronic Microelectrode Performance Journal of Neural Engineering. Apr, 2018 | Pubmed ID: 29219114 Potential for Thermal Damage to the Blood-brain Barrier During Craniotomy: Implications for Intracortical Recording Microelectrodes Journal of Neural Engineering. Jun, 2018 | Pubmed ID: 29205169 Microelectrode Implantation in Motor Cortex Causes Fine Motor Deficit: Implications on Potential Considerations to Brain Computer Interfacing and Human Augmentation Scientific Reports. Nov, 2017 | Pubmed ID: 29127346 Status Epilepticus Due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats Veterinary Medicine International. 2017 | Pubmed ID: 28785508 High-throughput in Vitro Assay to Evaluate the Cytotoxicity of Liberated Platinum Compounds for Stimulating Neural Electrodes Journal of Neuroscience Methods. Nov, 2016 | Pubmed ID: 27485087 Engineering and Commercialization of Human-device Interfaces, from Bone to Brain Biomaterials. Jul, 2016 | Pubmed ID: 27108404 Influence of Resveratrol Release on the Tissue Response to Mechanically Adaptive Cortical Implants Acta Biomaterialia. Jan, 2016 | Pubmed ID: 26553391 Reducing the "Stress": Antioxidative Therapeutic and Material Approaches May Prevent Intracortical Microelectrode Failure ACS Macro Letters. Mar, 2015 | Pubmed ID: 35596335 Implications of Chronic Daily Anti-oxidant Administration on the Inflammatory Response to Intracortical Microelectrodes Journal of Neural Engineering. Aug, 2015 | Pubmed ID: 26015427 Compliant Intracortical Implants Reduce Strains and Strain Rates in Brain Tissue in Vivo Journal of Neural Engineering. Jun, 2015 | Pubmed ID: 25834105 Progress Towards Biocompatible Intracortical Microelectrodes for Neural Interfacing Applications Journal of Neural Engineering. Feb, 2015 | Pubmed ID: 25460808 Development of Superoxide Dismutase Mimetic Surfaces to Reduce Accumulation of Reactive Oxygen Species for Neural Interfacing Applications Journal of Materials Chemistry. B. Apr, 2014 | Pubmed ID: 25132966 Mechanically-compliant Intracortical Implants Reduce the Neuroinflammatory Response Journal of Neural Engineering. Oct, 2014 | Pubmed ID: 25125443 The Roles of Blood-derived Macrophages and Resident Microglia in the Neuroinflammatory Response to Implanted Intracortical Microelectrodes Biomaterials. Sep, 2014 | Pubmed ID: 24973296 The Effect of Residual Endotoxin Contamination on the Neuroinflammatory Response to Sterilized Intracortical Microelectrodes Journal of Materials Chemistry. B. May, 2014 | Pubmed ID: 24778808 A Comparison of Neuroinflammation to Implanted Microelectrodes in Rat and Mouse Models Biomaterials. Jul, 2014 | Pubmed ID: 24755527 Curcumin-releasing Mechanically Adaptive Intracortical Implants Improve the Proximal Neuronal Density and Blood-brain Barrier Stability Acta Biomaterialia. May, 2014 | Pubmed ID: 24468582 The Effect of Resveratrol on Neurodegeneration and Blood Brain Barrier Stability Surrounding Intracortical Microelectrodes Biomaterials. Sep, 2013 | Pubmed ID: 23791503 Bioinspired Water-Enhanced Mechanical Gradient Nanocomposite Films That Mimic the Architecture and Properties of the Squid Beak Journal of the American Chemical Society. Mar, 2013 | Pubmed ID: 23530595 An Organotypic Spinal Cord Slice Culture Model to Quantify Neurodegeneration Journal of Neuroscience Methods. Nov, 2012 | Pubmed ID: 22975474 Stab Injury and Device Implantation Within the Brain Results in Inversely Multiphasic Neuroinflammatory and Neurodegenerative Responses Journal of Neural Engineering. Aug, 2012 | Pubmed ID: 22832283 Reduction of Autofluorescence at the Microelectrode-cortical Tissue Interface Improves Antibody Detection Journal of Neuroscience Methods. Jan, 2012 | Pubmed ID: 21978484 Stimuli-responsive Mechanically Adaptive Polymer Nanocomposites ACS Applied Materials & Interfaces. Jan, 2010 | Pubmed ID: 20305827 Polymer Brushes and Self-assembled Monolayers: Versatile Platforms to Control Cell Adhesion to Biomaterials (Review) Biointerphases. Jun, 2009 | Pubmed ID: 20408714 Polymer Nanocomposites with Nanowhiskers Isolated from Microcrystalline Cellulose Biomacromolecules. Apr, 2009 | Pubmed ID: 19256493 Stimuli-responsive Polymer Nanocomposites Inspired by the Sea Cucumber Dermis Science (New York, N.Y.). Mar, 2008 | Pubmed ID: 18323449 A Versatile Approach for the Processing of Polymer Nanocomposites with Self-assembled Nanofibre Templates Nature Nanotechnology. Dec, 2007 | Pubmed ID: 18654428 Preparation of Homogeneous Dispersions of Tunicate Cellulose Whiskers in Organic Solvents Biomacromolecules. Apr, 2007 | Pubmed ID: 17343361 Integrin Specificity and Enhanced Cellular Activities Associated with Surfaces Presenting a Recombinant Fibronectin Fragment Compared to RGD Supports Biomaterials. Nov, 2006 | Pubmed ID: 16846640 Assessment of Thermal Damage from Robot-Drilled Craniotomy for Cranial Window Surgery in Mice George F. Hoeferlin*1,2, Dhariyat M. Menendez*1,2, Olivia K. Krebs1,2, Jeffrey R. Capadona1,2, Andrew J. Shoffstall1,2 1Department of Biomedical Engineering, Case Western Reserve University, 2Advanced Platform Technology Center, Louis Stokes Cleveland VA Medical Center JoVE 64188 Neuroscience Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes Olivia K. Krebs1,2, Gaurav Mittal1,2, Shreya Ramani1,2, Jichu Zhang1,2, Andrew J. Shoffstall1,2, Stuart F. Cogan3, Joseph J. Pancrazio3, Jeffrey R. Capadona1,2 1Department of Biomedical Engineering, Case Western Reserve University, 2Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 3Department of Bioengineering, The University of Texas at Dallas JoVE 63500 Bioengineering A Novel Single Animal Motor Function Tracking System Using Simple, Readily Available Software Keith R. Dona1,2, Monika Goss-Varley1,2, Andrew J. Shoffstall1,2, Jeffrey R. Capadona1,2 1Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 2Department of Biomedical Engineering, Case Western Reserve University JoVE 57917 Behavior Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex Monika Goss-Varley1,2, Andrew J. Shoffstall1,2, Keith R. Dona1,2, Justin A. McMahon1,2, Sydney C. Lindner1,2, Evon S. Ereifej1,2, Jeffrey R. Capadona1,2 1Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 2Department of Biomedical Engineering, Case Western Reserve University JoVE 57829 Bioengineering Environmentally-controlled Microtensile Testing of Mechanically-adaptive Polymer Nanocomposites for ex vivo Characterization Allison E. Hess1, Kelsey A. Potter1,2, Dustin J. Tyler1,2, Christian A. Zorman1,3, Jeffrey R. Capadona1,2 1Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 2Department of Biomedical Engineering, Case Western Reserve University, 3Department of Electrical Engineering and Computer Science, Case Western Reserve University JoVE 50078 Bioengineering
Assessment of Thermal Damage from Robot-Drilled Craniotomy for Cranial Window Surgery in Mice George F. Hoeferlin*1,2, Dhariyat M. Menendez*1,2, Olivia K. Krebs1,2, Jeffrey R. Capadona1,2, Andrew J. Shoffstall1,2 1Department of Biomedical Engineering, Case Western Reserve University, 2Advanced Platform Technology Center, Louis Stokes Cleveland VA Medical Center JoVE 64188 Neuroscience
Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes Olivia K. Krebs1,2, Gaurav Mittal1,2, Shreya Ramani1,2, Jichu Zhang1,2, Andrew J. Shoffstall1,2, Stuart F. Cogan3, Joseph J. Pancrazio3, Jeffrey R. Capadona1,2 1Department of Biomedical Engineering, Case Western Reserve University, 2Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 3Department of Bioengineering, The University of Texas at Dallas JoVE 63500 Bioengineering
A Novel Single Animal Motor Function Tracking System Using Simple, Readily Available Software Keith R. Dona1,2, Monika Goss-Varley1,2, Andrew J. Shoffstall1,2, Jeffrey R. Capadona1,2 1Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 2Department of Biomedical Engineering, Case Western Reserve University JoVE 57917 Behavior
Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex Monika Goss-Varley1,2, Andrew J. Shoffstall1,2, Keith R. Dona1,2, Justin A. McMahon1,2, Sydney C. Lindner1,2, Evon S. Ereifej1,2, Jeffrey R. Capadona1,2 1Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 2Department of Biomedical Engineering, Case Western Reserve University JoVE 57829 Bioengineering
Environmentally-controlled Microtensile Testing of Mechanically-adaptive Polymer Nanocomposites for ex vivo Characterization Allison E. Hess1, Kelsey A. Potter1,2, Dustin J. Tyler1,2, Christian A. Zorman1,3, Jeffrey R. Capadona1,2 1Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 2Department of Biomedical Engineering, Case Western Reserve University, 3Department of Electrical Engineering and Computer Science, Case Western Reserve University JoVE 50078 Bioengineering
