Jifeng Zhang Department of Internal Medicine, Frankel Cardiovascular Center University of Michigan, Ann Arbor Biography Publications Institution JoVE Articles Jifeng Zhang has not added a biography. If you are Jifeng Zhang and would like to personalize this page please email our Author Liaison for assistance. Publications Novel Gene Regulatory Networks Identified in Response to Nitro-conjugated Linoleic Acid in Human Endothelial Cells Physiological Genomics. Jun, 2019 | Pubmed ID: 31074702 Genomic and Transcriptomic Analysis of Hypercholesterolemic Rabbits: Progress and Perspectives International Journal of Molecular Sciences. Nov, 2018 | Pubmed ID: 30413026 Inhibition of Peptidylarginine Deiminase Alleviates LPS-induced Pulmonary Dysfunction and Improves Survival in a Mouse Model of Lethal Endotoxemia European Journal of Pharmacology. Aug, 2018 | Pubmed ID: 29981294 Dietary Obesity-induced Egr-1 in Adipocytes Facilitates Energy Storage Via Suppression of FOXC2 Scientific Reports. 2013 | Pubmed ID: 23502673 MCPIP1 Negatively Regulates Toll-like Receptor 4 Signaling and Protects Mice from LPS-induced Septic Shock Cellular Signalling. May, 2013 | Pubmed ID: 23422584 KLF11 Mediates PPARγ Cerebrovascular Protection in Ischaemic Stroke Brain : a Journal of Neurology. Apr, 2013 | Pubmed ID: 23408111 Zc3h12c Inhibits Vascular Inflammation by Repressing NF-κB Activation and Pro-inflammatory Gene Expression in Endothelial Cells The Biochemical Journal. Apr, 2013 | Pubmed ID: 23360436 Electrophilic Nitro-fatty Acids Inhibit Vascular Inflammation by Disrupting LPS-dependent TLR4 Signalling in Lipid Rafts Cardiovascular Research. Apr, 2013 | Pubmed ID: 23334216 Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β) Protein Attenuates Vascular Lesion Formation by Inhibition of Chromatin Loading of Minichromosome Maintenance Complex in Smooth Muscle Cells The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23264620 Perturbation of Thermal Unfolding and Aggregation of Human IgG1 Fc Fragment by Hofmeister Anions Molecular Pharmaceutics. Feb, 2013 | Pubmed ID: 23256580 Human Apolipoprotein A-II Protects Against Diet-induced Atherosclerosis in Transgenic Rabbits Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2013 | Pubmed ID: 23241412 Molecular Mechanisms and Function Prediction of Long Noncoding RNA TheScientificWorldJournal. 2012 | Pubmed ID: 23319885 Krüppel-like Factor-11, a Transcription Factor Involved in Diabetes Mellitus, Suppresses Endothelial Cell Activation Via the Nuclear Factor-κB Signaling Pathway Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2012 | Pubmed ID: 23042817 Loss of Perivascular Adipose Tissue on Peroxisome Proliferator-activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis Circulation. Aug, 2012 | Pubmed ID: 22855570 Specific Ion-protein Interactions Dictate Solubility Behavior of a Monoclonal Antibody at Low Salt Concentrations Molecular Pharmaceutics. Sep, 2012 | Pubmed ID: 22835004 Recombinant Rabbit Leukemia Inhibitory Factor and Rabbit Embryonic Fibroblasts Support the Derivation and Maintenance of Rabbit Embryonic Stem Cells Cellular Reprogramming. Aug, 2012 | Pubmed ID: 22775411 Characterization of Two Distinct Modes of Endophilin in Clathrin-mediated Endocytosis Cellular Signalling. Nov, 2012 | Pubmed ID: 22750032 Identification and Quantification of Fc Fusion Peptibody Degradations by Limited Proteolysis Method Analytical Biochemistry. Sep, 2012 | Pubmed ID: 22727819 Vascular Endothelial Cell-specific MicroRNA-15a Inhibits Angiogenesis in Hindlimb Ischemia The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22692216 CD62L- Memory T Cells Enhance T-cell Regeneration After Allogeneic Stem Cell Transplantation by Eliminating Host Resistance in Mice Blood. Jun, 2012 | Pubmed ID: 22596261 Yap1 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22411986 Endothelial Lipase Mediates HDL Levels in Normal and Hyperlipidemic Rabbits Journal of Atherosclerosis and Thrombosis. 2012 | Pubmed ID: 22240910 Antibody Solubility Behavior in Monovalent Salt Solutions Reveals Specific Anion Effects at Low Ionic Strength Journal of Pharmaceutical Sciences. Mar, 2012 | Pubmed ID: 22113783 Identification and Mechanism of 10-carbon Fatty Acid As Modulating Ligand of Peroxisome Proliferator-activated Receptors The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22039047 MicroRNA and Vascular Smooth Muscle Cells Vitamins and Hormones. 2011 | Pubmed ID: 22127249 Follicular Oocytes Better Support Development in Rabbit Cloning Than Oviductal Oocytes Cellular Reprogramming. Dec, 2011 | Pubmed ID: 22029417 Inhibition of Gluconeogenic Genes by Calcium-regulated Heat-stable Protein 1 Via Repression of Peroxisome Proliferator-activated Receptor α The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21990353 Smooth Muscle Cell Differentiation in Vitro: Models and Underlying Molecular Mechanisms Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2011 | Pubmed ID: 21677291 Opalescence of an IgG2 Monoclonal Antibody Solution As It Relates to Liquid-liquid Phase Separation Journal of Pharmaceutical Sciences. Nov, 2011 | Pubmed ID: 21638285 Platelet-derived Growth Factor Induces Rad Expression Through Egr-1 in Vascular Smooth Muscle Cells PloS One. 2011 | Pubmed ID: 21559360 Rad GTPase Induces Cardiomyocyte Apoptosis Through the Activation of P38 Mitogen-activated Protein Kinase Biochemical and Biophysical Research Communications. May, 2011 | Pubmed ID: 21549102 Generation of PPARγ Mono-allelic Knockout Pigs Via Zinc-finger Nucleases and Nuclear Transfer Cloning Cell Research. Jun, 2011 | Pubmed ID: 21502977 Three-dimensional Growth of IPS Cell-derived Smooth Muscle Cells on Nanofibrous Scaffolds Biomaterials. Jul, 2011 | Pubmed ID: 21439638 Rad GTPase Inhibits Cardiac Fibrosis Through Connective Tissue Growth Factor Cardiovascular Research. Jul, 2011 | Pubmed ID: 21382976 Vascular PPARδ Protects Against Stroke-induced Brain Injury Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2011 | Pubmed ID: 21205987 Vascular Smooth Muscle Cell Peroxisome Proliferator-activated Receptor-γ Mediates Pioglitazone-reduced Vascular Lesion Formation Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2011 | Pubmed ID: 21088248 MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-like Factor 4 Stem Cells and Development. Feb, 2011 | Pubmed ID: 20799856 Liquid-liquid Phase Separation of a Monoclonal Antibody and Nonmonotonic Influence of Hofmeister Anions Biophysical Journal. Dec, 2010 | Pubmed ID: 21112304 Vascular Smooth Muscle Cell Peroxisome Proliferator-activated Receptor-γ Deletion Promotes Abdominal Aortic Aneurysms Journal of Vascular Surgery. Oct, 2010 | Pubmed ID: 20630681 Nitro-oleic Acid Inhibits Angiotensin II-induced Hypertension Circulation Research. Aug, 2010 | Pubmed ID: 20558825 Involvement of Inducible 6-phosphofructo-2-kinase in the Anti-diabetic Effect of Peroxisome Proliferator-activated Receptor Gamma Activation in Mice The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20498376 Nitroalkenes Induce Rat Aortic Smooth Muscle Cell Apoptosis Via Activation of Caspase-dependent Pathways Biochemical and Biophysical Research Communications. Jun, 2010 | Pubmed ID: 20493166 Peroxisome Proliferator-activated Receptor Delta Regulation of MiR-15a in Ischemia-induced Cerebral Vascular Endothelial Injury The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20445066 Smooth and Cardiac Muscle-selective Knock-out of Kruppel-like Factor 4 Causes Postnatal Death and Growth Retardation The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20439457 Acceptance of Embryonic Stem Cells by a Wide Developmental Range of Mouse Tetraploid Embryos Biology of Reproduction. Aug, 2010 | Pubmed ID: 20410454 MiR-10a Contributes to Retinoid Acid-induced Smooth Muscle Cell Differentiation The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20118242 Covalent Peroxisome Proliferator-activated Receptor Gamma Adduction by Nitro-fatty Acids: Selective Ligand Activity and Anti-diabetic Signaling Actions The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20097754 MiR-497 Regulates Neuronal Death in Mouse Brain After Transient Focal Cerebral Ischemia Neurobiology of Disease. Apr, 2010 | Pubmed ID: 20053374 Rad As a Novel Regulator of Excitation-contraction Coupling and Beta-adrenergic Signaling in Heart Circulation Research. Feb, 2010 | Pubmed ID: 19926875 Human C-reactive Protein Does Not Promote Atherosclerosis in Transgenic Rabbits Circulation. Nov, 2009 | Pubmed ID: 19901190 Nitro-fatty Acid Inhibition of Neointima Formation After Endoluminal Vessel Injury Circulation Research. Nov, 2009 | Pubmed ID: 19797175 The Role of Peroxisome Proliferator-activated Receptor Gamma in Blood Pressure Regulation Current Hypertension Reports. Aug, 2009 | Pubmed ID: 19602323 Vascular Smooth Muscle Cell-selective Peroxisome Proliferator-activated Receptor-gamma Deletion Leads to Hypotension Circulation. Apr, 2009 | Pubmed ID: 19364979 Expression Profiling of Nuclear Receptors in Human and Mouse Embryonic Stem Cells Molecular Endocrinology (Baltimore, Md.). May, 2009 | Pubmed ID: 19196830 PPARgamma and Its Ligands: Therapeutic Implications in Cardiovascular Disease Clinical Science (London, England : 1979). Feb, 2009 | Pubmed ID: 19118492 Beneficial Effect of Young Oocytes for Rabbit Somatic Cell Nuclear Transfer Cloning and Stem Cells. Mar, 2009 | Pubmed ID: 19090660 PPARs and the Cardiovascular System Antioxidants & Redox Signaling. Jun, 2009 | Pubmed ID: 19061437 A Comparison of Murine Smooth Muscle Cells Generated from Embryonic Versus Induced Pluripotent Stem Cells Stem Cells and Development. Jun, 2009 | Pubmed ID: 18795840 Subunit Stoichiometry of the Clostridium Botulinum Type A Neurotoxin Complex Determined Using Denaturing Capillary Electrophoresis The Protein Journal. Dec, 2008 | Pubmed ID: 19020965 Molecular Recognition of Nitrated Fatty Acids by PPAR Gamma Nature Structural & Molecular Biology. Aug, 2008 | Pubmed ID: 18604218 Two-stage Designs to Identify the Effects of SNP Combinations on Complex Diseases Journal of Human Genetics. 2008 | Pubmed ID: 18584117 Nitroalkenes Suppress Lipopolysaccharide-induced Signal Transducer and Activator of Transcription Signaling in Macrophages: a Critical Role of Mitogen-activated Protein Kinase Phosphatase 1 Endocrinology. Aug, 2008 | Pubmed ID: 18467446 An Entropy-based Approach for Testing Genetic Epistasis Underlying Complex Diseases Journal of Theoretical Biology. Jan, 2008 | Pubmed ID: 17996908 Rad GTPase Deficiency Leads to Cardiac Hypertrophy Circulation. Dec, 2007 | Pubmed ID: 18056528 A Highly Efficient Method to Differentiate Smooth Muscle Cells from Human Embryonic Stem Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2007 | Pubmed ID: 18029907 Interleukin-1 Beta-induced Id2 Gene Expression is Mediated by Egr-1 in Vascular Smooth Muscle Cells Cardiovascular Research. Oct, 2007 | Pubmed ID: 17631285 Nitro-linoleic Acid Inhibits Vascular Smooth Muscle Cell Proliferation Via the Keap1/Nrf2 Signaling Pathway American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2007 | Pubmed ID: 17468336 Transplantation of Human Undifferentiated Embryonic Stem Cells into a Myocardial Infarction Rat Model Stem Cells and Development. Feb, 2007 | Pubmed ID: 17348803 Association of DAOA Polymorphisms with Schizophrenia and Clinical Symptoms or Therapeutic Effects Neuroscience Letters. Apr, 2007 | Pubmed ID: 17293043 Association of G72/G30 Polymorphisms with Early-onset and Male Schizophrenia Neuroreport. Dec, 2006 | Pubmed ID: 17179866 Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators The Journal of Biological Chemistry. Nov, 2006 | Pubmed ID: 16887803 Generation of an Adult Smooth Muscle Cell-targeted Cre Recombinase Mouse Model Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2006 | Pubmed ID: 16484601 Derivation of Adipocytes from Human Embryonic Stem Cells Stem Cells and Development. Dec, 2005 | Pubmed ID: 16433622 Divergent Effects of BMP-2 on Gene Expression in Pulmonary Artery Smooth Muscle Cells from Normal Subjects and Patients with Idiopathic Pulmonary Arterial Hypertension Experimental Lung Research. Oct, 2005 | Pubmed ID: 16368652 Impaired Expression of PPAR Gamma Protein Contributes to the Exaggerated Growth of Vascular Smooth Muscle Cells in Spontaneously Hypertensive Rats Life Sciences. Oct, 2005 | Pubmed ID: 15970297 [Accumulation of La(NO3)3 in Mice Liver and Its Genetic Toxicity] Ying Yong Sheng Tai Xue Bao = The Journal of Applied Ecology / Zhongguo Sheng Tai Xue Xue Hui, Zhongguo Ke Xue Yuan Shenyang Ying Yong Sheng Tai Yan Jiu Suo Zhu Ban. Jan, 2005 | Pubmed ID: 15852973 Rad GTPase Attenuates Vascular Lesion Formation by Inhibition of Vascular Smooth Muscle Cell Migration Circulation. Mar, 2005 | Pubmed ID: 15710763 Nitrolinoleic Acid: an Endogenous Peroxisome Proliferator-activated Receptor Gamma Ligand Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15701701 Selective Disruption of PPARgamma 2 Impairs the Development of Adipose Tissue and Insulin Sensitivity Proceedings of the National Academy of Sciences of the United States of America. Jul, 2004 | Pubmed ID: 15249658 Interferon Regulatory Factor-1 Mediates PPARgamma-induced Apoptosis in Vascular Smooth Muscle Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2004 | Pubmed ID: 14656743 Egr-1 Target Genes in Human Endothelial Cells Identified by Microarray Analysis Gene. Oct, 2003 | Pubmed ID: 14557062 Peroxisome Proliferator-activated Receptors and the Cardiovascular System Vitamins and Hormones. 2003 | Pubmed ID: 12852255 Early Stimulation and Late Inhibition of Peroxisome Proliferator-activated Receptor Gamma (PPAR Gamma) Gene Expression by Transforming Growth Factor Beta in Human Aortic Smooth Muscle Cells: Role of Early Growth-response Factor-1 (Egr-1), Activator Protein 1 (AP1) and Smads The Biochemical Journal. Mar, 2003 | Pubmed ID: 12457461 15-Deoxy-prostaglandin J(2) Inhibits PDGF-A and -B Chain Expression in Human Vascular Endothelial Cells Independent of PPAR Gamma Biochemical and Biophysical Research Communications. Oct, 2002 | Pubmed ID: 12379230 PDGF Induces Osteoprotegerin Expression in Vascular Smooth Muscle Cells by Multiple Signal Pathways FEBS Letters. Jun, 2002 | Pubmed ID: 12067713 Activation of Peroxisome Proliferator-activated Receptor Gamma Inhibits Osteoprotegerin Gene Expression in Human Aortic Smooth Muscle Cells Biochemical and Biophysical Research Communications. Jun, 2002 | Pubmed ID: 12056809 Early Growth Response Factor-1 is a Critical Transcriptional Mediator of Peroxisome Proliferator-activated Receptor-gamma 1 Gene Expression in Human Aortic Smooth Muscle Cells The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 12011097 Peroxisome Proliferator-activated Receptor Delta is Up-regulated During Vascular Lesion Formation and Promotes Post-confluent Cell Proliferation in Vascular Smooth Muscle Cells The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11809753 Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase Chao Xue1, Guizhen Zhao1, Yang Zhao1, Y Eugene Chen1, Jifeng Zhang1 1Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor JoVE 63608 Biology CRISPR/Cas9 Ribonucleoprotein-mediated Precise Gene Editing by Tube Electroporation Linyuan Ma*1, Lydia Jang*1, Jian Chen2, Jun Song1, Dongshan Yang1, Jifeng Zhang1, Y. Eugene Chen1, Jie Xu1 1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Celetrix LLC JoVE 59512 Genetics Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases Dongshan Yang1, Jifeng Zhang1, Jie Xu1, Tianqing Zhu1, Yanbo Fan1, Jianglin Fan2, Y. Eugene Chen1 1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi JoVE 50957 Medicine
Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase Chao Xue1, Guizhen Zhao1, Yang Zhao1, Y Eugene Chen1, Jifeng Zhang1 1Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor JoVE 63608 Biology
CRISPR/Cas9 Ribonucleoprotein-mediated Precise Gene Editing by Tube Electroporation Linyuan Ma*1, Lydia Jang*1, Jian Chen2, Jun Song1, Dongshan Yang1, Jifeng Zhang1, Y. Eugene Chen1, Jie Xu1 1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Celetrix LLC JoVE 59512 Genetics
Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases Dongshan Yang1, Jifeng Zhang1, Jie Xu1, Tianqing Zhu1, Yanbo Fan1, Jianglin Fan2, Y. Eugene Chen1 1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi JoVE 50957 Medicine
