Joan S. Brugge

Publications

• Outgrowth of Single Oncogene-expressing Cells from Suppressive Epithelial Environments
  Nature. Feb, 2012  |   Pubmed ID: 22318515
• Ovarian Cancer Spheroids Use Myosin-generated Force to Clear the Mesothelium
  Cancer Discovery. Jul, 2011  |   Pubmed ID: 22303516
• Intersection of FOXO- and RUNX1-mediated Gene Expression Programs in Single Breast Epithelial Cells During Morphogenesis and Tumor Progression
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011  |   Pubmed ID: 21873240
• Erk Regulation of Pyruvate Dehydrogenase Flux Through PDK4 Modulates Cell Proliferation
  Genes & Development. Aug, 2011  |   Pubmed ID: 21852536
• Phosphoglycerate Dehydrogenase Diverts Glycolytic Flux and Contributes to Oncogenesis
  Nature Genetics. Sep, 2011  |   Pubmed ID: 21804546
• The Myosin-II-responsive Focal Adhesion Proteome: a Tour De Force?
  Nature Cell Biology. Apr, 2011  |   Pubmed ID: 21460805
• The Myosin-II-responsive Focal Adhesion Proteome: a Tour De Force?
  Nature Cell Biology. Mar, 2011  |   Pubmed ID: 21423174
• Psidin, a Conserved Protein That Regulates Protrusion Dynamics and Cell Migration
  Genes & Development. Apr, 2011  |   Pubmed ID: 21406550
• Uncovering a Tumor Suppressor for Triple-negative Breast Cancers
  Cell. Mar, 2011  |   Pubmed ID: 21376226
• A Non-genetic Route to Aneuploidy in Human Cancers
  Nature Cell Biology. Mar, 2011  |   Pubmed ID: 21336303
• ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression Via Erk and Sprouty2 in Extracellular Matrix-detached Cells
  The Journal of Biological Chemistry. Jan, 2011  |   Pubmed ID: 20956544
• Mechanistic Biology in the Next Quarter Century
  Molecular Biology of the Cell. Nov, 2010  |   Pubmed ID: 21079017
• Profiling Y561-dependent and -independent Substrates of CSF-1R in Epithelial Cells
  PloS One. 2010  |   Pubmed ID: 21049007
• PTK6 Regulates IGF-1-induced Anchorage-independent Survival
  PloS One. 2010  |   Pubmed ID: 20668531
• Unregulated ARF6 Activation in Epithelial Cysts Generates Hyperactive Signaling Endosomes and Disrupts Morphogenesis
  Molecular Biology of the Cell. Jul, 2010  |   Pubmed ID: 20462959
• Identifying Single-cell Molecular Programs by Stochastic Profiling
  Nature Methods. Apr, 2010  |   Pubmed ID: 20228812
• Dose-dependent Induction of Distinct Phenotypic Responses to Notch Pathway Activation in Mammary Epithelial Cells
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010  |   Pubmed ID: 20194747
• MYC Regulation of a "poor-prognosis" Metastatic Cancer Cell State
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010  |   Pubmed ID: 20133671
• Mutant P53 Drives Invasion by Promoting Integrin Recycling
  Cell. Dec, 2009  |   Pubmed ID: 20064378
• Tumor Self-seeding: Bidirectional Flow of Tumor Cells
  Cell. Dec, 2009  |   Pubmed ID: 20064369
• A Stiff Blow from the Stroma: Collagen Crosslinking Drives Tumor Progression
  Cancer Cell. Dec, 2009  |   Pubmed ID: 19962663
• Transcriptional Regulation of Metastatic [Id]entity by KLF17
  Genome Biology. 2009  |   Pubmed ID: 19951400
• YAP-dependent Induction of Amphiregulin Identifies a Non-cell-autonomous Component of the Hippo Pathway
  Nature Cell Biology. Dec, 2009  |   Pubmed ID: 19935651
• Antioxidant and Oncogene Rescue of Metabolic Defects Caused by Loss of Matrix Attachment
  Nature. Sep, 2009  |   Pubmed ID: 19693011
• YB-1 Translational Control of Epithelial-mesenchyme Transition
  Cancer Cell. May, 2009  |   Pubmed ID: 19411064
• Fibroblast Growth Factor Receptor 1-transformed Mammary Epithelial Cells Are Dependent on RSK Activity for Growth and Survival
  Cancer Research. Mar, 2009  |   Pubmed ID: 19258500
• Identification of Genes That Regulate Epithelial Cell Migration Using an SiRNA Screening Approach
  Nature Cell Biology. Sep, 2008  |   Pubmed ID: 19160483
• The Cell Biology of Cell-in-cell Structures
  Nature Reviews. Molecular Cell Biology. Oct, 2008  |   Pubmed ID: 18784728
• Regulation of Cell Adhesion and Collective Cell Migration by Hindsight and Its Human Homolog RREB1
  Current Biology : CB. Apr, 2008  |   Pubmed ID: 18394891
• [Entosis, a Cell Death Process Related to Cell Cannibalism Between Tumor Cells]
  Médecine Sciences : M/S. Mar, 2008  |   Pubmed ID: 18334170
• Lumen Formation During Mammary Epithelial Morphogenesis: Insights from in Vitro and in Vivo Models
  Cell Cycle (Georgetown, Tex.). Jan, 2008  |   Pubmed ID: 18196964
• Circulating Colony Stimulating Factor-1 and Breast Cancer Risk
  Cancer Research. Jan, 2008  |   Pubmed ID: 18172291
• IL-6 Involvement in Epithelial Cancers
  The Journal of Clinical Investigation. Dec, 2007  |   Pubmed ID: 18060028
• A Nonapoptotic Cell Death Process, Entosis, That Occurs by Cell-in-cell Invasion
  Cell. Nov, 2007  |   Pubmed ID: 18045538
• Engineering Tumors with 3D Scaffolds
  Nature Methods. Oct, 2007  |   Pubmed ID: 17767164
• Tensins: a New Switch in Cell Migration
  Developmental Cell. Sep, 2007  |   Pubmed ID: 17765673
• Common Effector Processing Mediates Cell-specific Responses to Stimuli
  Nature. Aug, 2007  |   Pubmed ID: 17637676
• Functional Role and Oncogene-regulated Expression of the BH3-only Factor Bmf in Mammary Epithelial Anoikis and Morphogenesis
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007  |   Pubmed ID: 17360431
• P63, Cell Adhesion and Survival
  Cell Cycle (Georgetown, Tex.). Feb, 2007  |   Pubmed ID: 17297292
• BIM Regulates Apoptosis During Mammary Ductal Morphogenesis, and Its Absence Reveals Alternative Cell Death Mechanisms
  Developmental Cell. Feb, 2007  |   Pubmed ID: 17276340
• SePARating Polarity and Proliferation in ErbB2 Oncogenesis
  Nature Cell Biology. Nov, 2006  |   Pubmed ID: 17077856
• Transforming Properties of YAP, a Candidate Oncogene on the Chromosome 11q22 Amplicon
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006  |   Pubmed ID: 16894141
• P63 Regulates an Adhesion Programme and Cell Survival in Epithelial Cells
  Nature Cell Biology. Jun, 2006  |   Pubmed ID: 16715076
• An Active Form of Vav1 Induces Migration of Mammary Epithelial Cells by Stimulating Secretion of an Epidermal Growth Factor Receptor Ligand
  Cell Communication and Signaling : CCS. 2006  |   Pubmed ID: 16709244
• Requirements for Vav Guanine Nucleotide Exchange Factors and Rho GTPases in FcgammaR- and Complement-mediated Phagocytosis
  Immunity. Mar, 2006  |   Pubmed ID: 16546099
• Functional Proteomics Approach to Investigate the Biological Activities of CDNAs Implicated in Breast Cancer
  Journal of Proteome Research. Mar, 2006  |   Pubmed ID: 16512675
• Distinct Roles of Akt1 and Akt2 in Regulating Cell Migration and Epithelial-mesenchymal Transition
  The Journal of Cell Biology. Dec, 2005  |   Pubmed ID: 16365168
• Novel Role for PDEF in Epithelial Cell Migration and Invasion
  Cancer Research. Dec, 2005  |   Pubmed ID: 16357167
• Breast Cancer-associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells
  Cancer Research. Dec, 2005  |   Pubmed ID: 16322248
• Modelling Glandular Epithelial Cancers in Three-dimensional Cultures
  Nature Reviews. Cancer. Sep, 2005  |   Pubmed ID: 16148884
• Activation of NF-kappaB Following Detachment Delays Apoptosis in Intestinal Epithelial Cells
  Oncogene. Sep, 2005  |   Pubmed ID: 16007176
• G1/S Cell Cycle Arrest Provides Anoikis Resistance Through Erk-mediated Bim Suppression
  Molecular and Cellular Biology. Jun, 2005  |   Pubmed ID: 15923641
• Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini is Targeted by Oncogenes
  Molecular and Cellular Biology. Jun, 2005  |   Pubmed ID: 15899862
• Vav Family GEFs Link Activated Ephs to Endocytosis and Axon Guidance
  Neuron. Apr, 2005  |   Pubmed ID: 15848800
• Use of Three-dimensional Basement Membrane Cultures to Model Oncogene-induced Changes in Mammary Epithelial Morphogenesis
  Journal of Mammary Gland Biology and Neoplasia. Oct, 2004  |   Pubmed ID: 15838601
• Epidermal Growth Factor Receptor-dependent Regulation of Integrin-mediated Signaling and Cell Cycle Entry in Epithelial Cells
  Molecular and Cellular Biology. Oct, 2004  |   Pubmed ID: 15367678
• Vav GEFs Are Required for Beta2 Integrin-dependent Functions of Neutrophils
  The Journal of Cell Biology. Jul, 2004  |   Pubmed ID: 15249579
• Autocrine CSF-1R Activation Promotes Src-dependent Disruption of Mammary Epithelial Architecture
  The Journal of Cell Biology. Apr, 2004  |   Pubmed ID: 15117969
• ErbB2 and TGF-beta: a Cooperative Role in Mammary Tumor Progression?
  Cell Cycle (Georgetown, Tex.). May, 2004  |   Pubmed ID: 15107620
• A Cytoskeleton-based Functional Genetic Screen Identifies Bcl-xL As an Enhancer of Metastasis, but Not Primary Tumor Growth
  Oncogene. Jun, 2004  |   Pubmed ID: 15064711
• Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) is Required for Induction of Autophagy During Lumen Formation in Vitro
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004  |   Pubmed ID: 14993595
• Cooperation of the ErbB2 Receptor and Transforming Growth Factor Beta in Induction of Migration and Invasion in Mammary Epithelial Cells
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004  |   Pubmed ID: 14739340
• Src Kinase Activation by Direct Interaction with the Integrin Beta Cytoplasmic Domain
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003  |   Pubmed ID: 14593208
• Akt Activation Disrupts Mammary Acinar Architecture and Enhances Proliferation in an MTOR-dependent Manner
  The Journal of Cell Biology. Oct, 2003  |   Pubmed ID: 14568991
• The PHD Finger of the Chromatin-associated Protein ING2 Functions As a Nuclear Phosphoinositide Receptor
  Cell. Jul, 2003  |   Pubmed ID: 12859901
• Integrins and EGFR Coordinately Regulate the Pro-apoptotic Protein Bim to Prevent Anoikis
  Nature Cell Biology. Aug, 2003  |   Pubmed ID: 12844146
• Morphogenesis and Oncogenesis of MCF-10A Mammary Epithelial Acini Grown in Three-dimensional Basement Membrane Cultures
  Methods (San Diego, Calif.). Jul, 2003  |   Pubmed ID: 12798140
• Overview of the Alliance for Cellular Signaling
  Nature. Dec, 2002  |   Pubmed ID: 12478301
• The Role of Apoptosis in Creating and Maintaining Luminal Space Within Normal and Oncogene-expressing Mammary Acini
  Cell. Oct, 2002  |   Pubmed ID: 12372298
• Direct Phosphorylation of Focal Adhesion Kinase by C-Src: Evidence Using a Modified Nucleotide Pocket Kinase and ATP Analog
  Biochemical and Biophysical Research Communications. Jun, 2002  |   Pubmed ID: 12051709
• Sensing the Environment: a Historical Perspective on Integrin Signal Transduction
  Nature Cell Biology. Apr, 2002  |   Pubmed ID: 11944041
• Coordinate Interactions of Csk, Src, and Syk Kinases with [alpha]IIb[beta]3 Initiate Integrin Signaling to the Cytoskeleton
  The Journal of Cell Biology. Apr, 2002  |   Pubmed ID: 11940607