Joan S. Brugge Department of Cell Biology Harvard Medical School Biography Publications Institution JoVE Articles Joan S. Brugge has not added a biography. If you are Joan S. Brugge and would like to personalize this page please email our Author Liaison for assistance. Publications Outgrowth of Single Oncogene-expressing Cells from Suppressive Epithelial Environments Nature. Feb, 2012 | Pubmed ID: 22318515 Ovarian Cancer Spheroids Use Myosin-generated Force to Clear the Mesothelium Cancer Discovery. Jul, 2011 | Pubmed ID: 22303516 Intersection of FOXO- and RUNX1-mediated Gene Expression Programs in Single Breast Epithelial Cells During Morphogenesis and Tumor Progression Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21873240 Erk Regulation of Pyruvate Dehydrogenase Flux Through PDK4 Modulates Cell Proliferation Genes & Development. Aug, 2011 | Pubmed ID: 21852536 Phosphoglycerate Dehydrogenase Diverts Glycolytic Flux and Contributes to Oncogenesis Nature Genetics. Sep, 2011 | Pubmed ID: 21804546 The Myosin-II-responsive Focal Adhesion Proteome: a Tour De Force? Nature Cell Biology. Apr, 2011 | Pubmed ID: 21460805 The Myosin-II-responsive Focal Adhesion Proteome: a Tour De Force? Nature Cell Biology. Mar, 2011 | Pubmed ID: 21423174 Psidin, a Conserved Protein That Regulates Protrusion Dynamics and Cell Migration Genes & Development. Apr, 2011 | Pubmed ID: 21406550 Uncovering a Tumor Suppressor for Triple-negative Breast Cancers Cell. Mar, 2011 | Pubmed ID: 21376226 A Non-genetic Route to Aneuploidy in Human Cancers Nature Cell Biology. Mar, 2011 | Pubmed ID: 21336303 ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression Via Erk and Sprouty2 in Extracellular Matrix-detached Cells The Journal of Biological Chemistry. Jan, 2011 | Pubmed ID: 20956544 Mechanistic Biology in the Next Quarter Century Molecular Biology of the Cell. Nov, 2010 | Pubmed ID: 21079017 Profiling Y561-dependent and -independent Substrates of CSF-1R in Epithelial Cells PloS One. 2010 | Pubmed ID: 21049007 PTK6 Regulates IGF-1-induced Anchorage-independent Survival PloS One. 2010 | Pubmed ID: 20668531 Unregulated ARF6 Activation in Epithelial Cysts Generates Hyperactive Signaling Endosomes and Disrupts Morphogenesis Molecular Biology of the Cell. Jul, 2010 | Pubmed ID: 20462959 Identifying Single-cell Molecular Programs by Stochastic Profiling Nature Methods. Apr, 2010 | Pubmed ID: 20228812 Dose-dependent Induction of Distinct Phenotypic Responses to Notch Pathway Activation in Mammary Epithelial Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20194747 MYC Regulation of a "poor-prognosis" Metastatic Cancer Cell State Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133671 Mutant P53 Drives Invasion by Promoting Integrin Recycling Cell. Dec, 2009 | Pubmed ID: 20064378 Tumor Self-seeding: Bidirectional Flow of Tumor Cells Cell. Dec, 2009 | Pubmed ID: 20064369 A Stiff Blow from the Stroma: Collagen Crosslinking Drives Tumor Progression Cancer Cell. Dec, 2009 | Pubmed ID: 19962663 Transcriptional Regulation of Metastatic [Id]entity by KLF17 Genome Biology. 2009 | Pubmed ID: 19951400 YAP-dependent Induction of Amphiregulin Identifies a Non-cell-autonomous Component of the Hippo Pathway Nature Cell Biology. Dec, 2009 | Pubmed ID: 19935651 Antioxidant and Oncogene Rescue of Metabolic Defects Caused by Loss of Matrix Attachment Nature. Sep, 2009 | Pubmed ID: 19693011 YB-1 Translational Control of Epithelial-mesenchyme Transition Cancer Cell. May, 2009 | Pubmed ID: 19411064 Fibroblast Growth Factor Receptor 1-transformed Mammary Epithelial Cells Are Dependent on RSK Activity for Growth and Survival Cancer Research. Mar, 2009 | Pubmed ID: 19258500 Identification of Genes That Regulate Epithelial Cell Migration Using an SiRNA Screening Approach Nature Cell Biology. Sep, 2008 | Pubmed ID: 19160483 The Cell Biology of Cell-in-cell Structures Nature Reviews. Molecular Cell Biology. Oct, 2008 | Pubmed ID: 18784728 Regulation of Cell Adhesion and Collective Cell Migration by Hindsight and Its Human Homolog RREB1 Current Biology : CB. Apr, 2008 | Pubmed ID: 18394891 [Entosis, a Cell Death Process Related to Cell Cannibalism Between Tumor Cells] Médecine Sciences : M/S. Mar, 2008 | Pubmed ID: 18334170 Lumen Formation During Mammary Epithelial Morphogenesis: Insights from in Vitro and in Vivo Models Cell Cycle (Georgetown, Tex.). Jan, 2008 | Pubmed ID: 18196964 Circulating Colony Stimulating Factor-1 and Breast Cancer Risk Cancer Research. Jan, 2008 | Pubmed ID: 18172291 IL-6 Involvement in Epithelial Cancers The Journal of Clinical Investigation. Dec, 2007 | Pubmed ID: 18060028 A Nonapoptotic Cell Death Process, Entosis, That Occurs by Cell-in-cell Invasion Cell. Nov, 2007 | Pubmed ID: 18045538 Engineering Tumors with 3D Scaffolds Nature Methods. Oct, 2007 | Pubmed ID: 17767164 Tensins: a New Switch in Cell Migration Developmental Cell. Sep, 2007 | Pubmed ID: 17765673 Common Effector Processing Mediates Cell-specific Responses to Stimuli Nature. Aug, 2007 | Pubmed ID: 17637676 Functional Role and Oncogene-regulated Expression of the BH3-only Factor Bmf in Mammary Epithelial Anoikis and Morphogenesis Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360431 P63, Cell Adhesion and Survival Cell Cycle (Georgetown, Tex.). Feb, 2007 | Pubmed ID: 17297292 BIM Regulates Apoptosis During Mammary Ductal Morphogenesis, and Its Absence Reveals Alternative Cell Death Mechanisms Developmental Cell. Feb, 2007 | Pubmed ID: 17276340 SePARating Polarity and Proliferation in ErbB2 Oncogenesis Nature Cell Biology. Nov, 2006 | Pubmed ID: 17077856 Transforming Properties of YAP, a Candidate Oncogene on the Chromosome 11q22 Amplicon Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16894141 P63 Regulates an Adhesion Programme and Cell Survival in Epithelial Cells Nature Cell Biology. Jun, 2006 | Pubmed ID: 16715076 An Active Form of Vav1 Induces Migration of Mammary Epithelial Cells by Stimulating Secretion of an Epidermal Growth Factor Receptor Ligand Cell Communication and Signaling : CCS. 2006 | Pubmed ID: 16709244 Requirements for Vav Guanine Nucleotide Exchange Factors and Rho GTPases in FcgammaR- and Complement-mediated Phagocytosis Immunity. Mar, 2006 | Pubmed ID: 16546099 Functional Proteomics Approach to Investigate the Biological Activities of CDNAs Implicated in Breast Cancer Journal of Proteome Research. Mar, 2006 | Pubmed ID: 16512675 Distinct Roles of Akt1 and Akt2 in Regulating Cell Migration and Epithelial-mesenchymal Transition The Journal of Cell Biology. Dec, 2005 | Pubmed ID: 16365168 Novel Role for PDEF in Epithelial Cell Migration and Invasion Cancer Research. Dec, 2005 | Pubmed ID: 16357167 Breast Cancer-associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells Cancer Research. Dec, 2005 | Pubmed ID: 16322248 Modelling Glandular Epithelial Cancers in Three-dimensional Cultures Nature Reviews. Cancer. Sep, 2005 | Pubmed ID: 16148884 Activation of NF-kappaB Following Detachment Delays Apoptosis in Intestinal Epithelial Cells Oncogene. Sep, 2005 | Pubmed ID: 16007176 G1/S Cell Cycle Arrest Provides Anoikis Resistance Through Erk-mediated Bim Suppression Molecular and Cellular Biology. Jun, 2005 | Pubmed ID: 15923641 Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini is Targeted by Oncogenes Molecular and Cellular Biology. Jun, 2005 | Pubmed ID: 15899862 Vav Family GEFs Link Activated Ephs to Endocytosis and Axon Guidance Neuron. Apr, 2005 | Pubmed ID: 15848800 Use of Three-dimensional Basement Membrane Cultures to Model Oncogene-induced Changes in Mammary Epithelial Morphogenesis Journal of Mammary Gland Biology and Neoplasia. Oct, 2004 | Pubmed ID: 15838601 Epidermal Growth Factor Receptor-dependent Regulation of Integrin-mediated Signaling and Cell Cycle Entry in Epithelial Cells Molecular and Cellular Biology. Oct, 2004 | Pubmed ID: 15367678 Vav GEFs Are Required for Beta2 Integrin-dependent Functions of Neutrophils The Journal of Cell Biology. Jul, 2004 | Pubmed ID: 15249579 Autocrine CSF-1R Activation Promotes Src-dependent Disruption of Mammary Epithelial Architecture The Journal of Cell Biology. Apr, 2004 | Pubmed ID: 15117969 ErbB2 and TGF-beta: a Cooperative Role in Mammary Tumor Progression? Cell Cycle (Georgetown, Tex.). May, 2004 | Pubmed ID: 15107620 A Cytoskeleton-based Functional Genetic Screen Identifies Bcl-xL As an Enhancer of Metastasis, but Not Primary Tumor Growth Oncogene. Jun, 2004 | Pubmed ID: 15064711 Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) is Required for Induction of Autophagy During Lumen Formation in Vitro Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14993595 Cooperation of the ErbB2 Receptor and Transforming Growth Factor Beta in Induction of Migration and Invasion in Mammary Epithelial Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14739340 Src Kinase Activation by Direct Interaction with the Integrin Beta Cytoplasmic Domain Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14593208 Akt Activation Disrupts Mammary Acinar Architecture and Enhances Proliferation in an MTOR-dependent Manner The Journal of Cell Biology. Oct, 2003 | Pubmed ID: 14568991 The PHD Finger of the Chromatin-associated Protein ING2 Functions As a Nuclear Phosphoinositide Receptor Cell. Jul, 2003 | Pubmed ID: 12859901 Integrins and EGFR Coordinately Regulate the Pro-apoptotic Protein Bim to Prevent Anoikis Nature Cell Biology. Aug, 2003 | Pubmed ID: 12844146 Morphogenesis and Oncogenesis of MCF-10A Mammary Epithelial Acini Grown in Three-dimensional Basement Membrane Cultures Methods (San Diego, Calif.). Jul, 2003 | Pubmed ID: 12798140 Overview of the Alliance for Cellular Signaling Nature. Dec, 2002 | Pubmed ID: 12478301 The Role of Apoptosis in Creating and Maintaining Luminal Space Within Normal and Oncogene-expressing Mammary Acini Cell. Oct, 2002 | Pubmed ID: 12372298 Direct Phosphorylation of Focal Adhesion Kinase by C-Src: Evidence Using a Modified Nucleotide Pocket Kinase and ATP Analog Biochemical and Biophysical Research Communications. Jun, 2002 | Pubmed ID: 12051709 Sensing the Environment: a Historical Perspective on Integrin Signal Transduction Nature Cell Biology. Apr, 2002 | Pubmed ID: 11944041 Coordinate Interactions of Csk, Src, and Syk Kinases with [alpha]IIb[beta]3 Initiate Integrin Signaling to the Cytoskeleton The Journal of Cell Biology. Apr, 2002 | Pubmed ID: 11940607 In vitro Mezotelyal Gümrükleme Assay o Yumurtalık Kanseri Metastaz Erken Adımlar modeller Rachel A. Davidowitz1, Marcin P. Iwanicki1, Joan S. Brugge1 1Department of Cell Biology, Harvard Medical School JoVE 3888 Medicine
In vitro Mezotelyal Gümrükleme Assay o Yumurtalık Kanseri Metastaz Erken Adımlar modeller Rachel A. Davidowitz1, Marcin P. Iwanicki1, Joan S. Brugge1 1Department of Cell Biology, Harvard Medical School JoVE 3888 Medicine