Job Dekker Department of Systems Biology University of Massachusetts Medical School Biography Publications Institution JoVE Articles Job Dekker has not added a biography. If you are Job Dekker and would like to personalize this page please email our Author Liaison for assistance. Publications Multiscale Reorganization of the Genome Following DNA Damage Facilitates Chromosome Translocations Via Nuclear Actin Polymerization Nature Structural & Molecular Biology. Jan, 2023 | Pubmed ID: 36564591 Diverse Silent Chromatin States Modulate Genome Compartmentalization and Loop Extrusion Barriers Nature Structural & Molecular Biology. Jan, 2023 | Pubmed ID: 36550219 A Cohesin Traffic Pattern Genetically Linked to Gene Regulation Nature Structural & Molecular Biology. Dec, 2022 | Pubmed ID: 36482254 Regulation of the Mitotic Chromosome Folding Machines The Biochemical Journal. Oct, 2022 | Pubmed ID: 36268993 CTCF-CTCF Loops and Intra-TAD Interactions Show Differential Dependence on Cohesin Ring Integrity Nature Cell Biology. Oct, 2022 | Pubmed ID: 36202971 Nutritional Control Regulates Symbiont Proliferation and Life History in Coral-dinoflagellate Symbiosis BMC Biology. May, 2022 | Pubmed ID: 35549698 Author Correction: Expanded Encyclopaedias of DNA Elements in the Human and Mouse Genomes Nature. May, 2022 | Pubmed ID: 35474001 Loops, Topologically Associating Domains, Compartments, and Territories Are Elastic and Robust to Dramatic Nuclear Volume Swelling Scientific Reports. Mar, 2022 | Pubmed ID: 35304523 Spatial Organization of Transcribed Eukaryotic Genes Nature Cell Biology. Mar, 2022 | Pubmed ID: 35177821 Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions Cold Spring Harbor Perspectives in Biology. Jul, 2022 | Pubmed ID: 34518339 Inner Nuclear Protein Matrin-3 Coordinates Cell Differentiation by Stabilizing Chromatin Architecture Nature Communications. Oct, 2021 | Pubmed ID: 34716321 Symbiodinium Microadriaticum (coral Microalgal Endosymbiont) Trends in Genetics : TIG. Nov, 2021 | Pubmed ID: 34518054 Systematic Evaluation of Chromosome Conformation Capture Assays Nature Methods. Sep, 2021 | Pubmed ID: 34480151 Linker Histone H1.8 Inhibits Chromatin Binding of Condensins and DNA Topoisomerase II to Tune Chromosome Length and Individualization ELife. Aug, 2021 | Pubmed ID: 34406118 Hi-C 3.0: Improved Protocol for Genome-Wide Chromosome Conformation Capture Current Protocols. Jul, 2021 | Pubmed ID: 34286910 Chromosome-Level Assembly of the Atlantic Silverside Genome Reveals Extreme Levels of Sequence Diversity and Structural Genetic Variation Genome Biology and Evolution. Jun, 2021 | Pubmed ID: 33964136 Genetic and Spatial Organization of the Unusual Chromosomes of the Dinoflagellate Symbiodinium Microadriaticum Nature Genetics. May, 2021 | Pubmed ID: 33927399 Liquid Chromatin Hi-C Characterizes Compartment-dependent Chromatin Interaction Dynamics Nature Genetics. Mar, 2021 | Pubmed ID: 33574602 Cohesin Mutations Alter DNA Damage Repair and Chromatin Structure and Create Therapeutic Vulnerabilities in MDS/AML JCI Insight. Feb, 2021 | Pubmed ID: 33351783 Is Involved in Corneal Stroma Development by Regulating Neural Crest Migration International Journal of Molecular Sciences. Oct, 2020 | Pubmed ID: 33096935 Detecting Chromatin Interactions Between and Along Sister Chromatids with SisterC Nature Methods. Oct, 2020 | Pubmed ID: 32968250 Clustering of Strong Replicators Associated with Active Promoters is Sufficient to Establish an Early-replicating Domain The EMBO Journal. Nov, 2020 | Pubmed ID: 32935369 Multi-contact 3C Reveals That the Human Genome During Interphase is Largely Not Entangled Nature Structural & Molecular Biology. Dec, 2020 | Pubmed ID: 32929283 Large Domains of Heterochromatin Direct the Formation of Short Mitotic Chromosome Loops ELife. Sep, 2020 | Pubmed ID: 32915140 Expanded Encyclopaedias of DNA Elements in the Human and Mouse Genomes Nature. Jul, 2020 | Pubmed ID: 32728249 Mechanisms and Functions of Chromosome Compartmentalization Trends in Biochemical Sciences. May, 2020 | Pubmed ID: 32311333 Ultrastructural Details of Mammalian Chromosome Architecture Molecular Cell. May, 2020 | Pubmed ID: 32213324 SPEN Integrates Transcriptional and Epigenetic Control of X-inactivation Nature. 02, 2020 | Pubmed ID: 32025035 Transcriptional Silencers in Drosophila Serve a Dual Role As Transcriptional Enhancers in Alternate Cellular Contexts Molecular Cell. Jan, 2020 | Pubmed ID: 31704182 A Chromosome Folding Intermediate at the Condensin-to-cohesin Transition During Telophase Nature Cell Biology. Nov, 2019 | Pubmed ID: 31685986 Highly Structured Homolog Pairing Reflects Functional Organization of the Drosophila Genome Nature Communications. Oct, 2019 | Pubmed ID: 31582763 The Genome-wide Multi-layered Architecture of Chromosome Pairing in Early Drosophila Embryos Nature Communications. Oct, 2019 | Pubmed ID: 31582744 Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation Cell Stem Cell. Nov, 2019 | Pubmed ID: 31495782 Publisher Correction: Heterochromatin Drives Compartmentalization of Inverted and Conventional Nuclei Nature. Aug, 2019 | Pubmed ID: 31375785 Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance Between Replication Timing and Chromatin Compartment Stem Cell Reports. Jul, 2019 | Pubmed ID: 31231024 Heterochromatin Drives Compartmentalization of Inverted and Conventional Nuclei Nature. Jun, 2019 | Pubmed ID: 31168090 Measuring the Reproducibility and Quality of Hi-C Data Genome Biology. Mar, 2019 | Pubmed ID: 30890172 Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization Cell. Mar, 2019 | Pubmed ID: 30799036 CTCF Sites Display Cell Cycle-dependent Dynamics in Factor Binding and Nucleosome Positioning Genome Research. Feb, 2019 | Pubmed ID: 30655336 The Non-canonical SMC Protein SmcHD1 Antagonises TAD Formation and Compartmentalisation on the Inactive X Chromosome Nature Communications. Jan, 2019 | Pubmed ID: 30604745 Higher-Order Organization Principles of Pre-translational MRNPs Molecular Cell. Nov, 2018 | Pubmed ID: 30415953 Single-allele Chromatin Interactions Identify Regulatory Hubs in Dynamic Compartmentalized Domains Nature Genetics. Dec, 2018 | Pubmed ID: 30374068 Integrative Detection and Analysis of Structural Variation in Cancer Genomes Nature Genetics. Oct, 2018 | Pubmed ID: 30202056 CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia Cell. Jun, 2018 | Pubmed ID: 29958106 C-BERST: Defining Subnuclear Proteomic Landscapes at Genomic Elements with DCas9-APEX2 Nature Methods. Jun, 2018 | Pubmed ID: 29735996 A Pathway for Mitotic Chromosome Formation Science (New York, N.Y.). Feb, 2018 | Pubmed ID: 29348367 The Cluster is a Dynamic and Resilient TAD Boundary Controlling the Segregation of Antagonistic Regulatory Landscapes Genes & Development. Nov, 2017 | Pubmed ID: 29273679 The 4D Nucleome Project Nature. 09, 2017 | Pubmed ID: 28905911 SMC Complexes Differentially Compact Mitotic Chromosomes According to Genomic Context Nature Cell Biology. Sep, 2017 | Pubmed ID: 28825700 Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization Cell. May, 2017 | Pubmed ID: 28525758 Shelterin Components Mediate Genome Reorganization in Response to Replication Stress Proceedings of the National Academy of Sciences of the United States of America. May, 2017 | Pubmed ID: 28490498 Hi-C 2.0: An Optimized Hi-C Procedure for High-resolution Genome-wide Mapping of Chromosome Conformation Methods (San Diego, Calif.). Jul, 2017 | Pubmed ID: 28435001 Epigenetic Characteristics of the Mitotic Chromosome in 1D and 3D Critical Reviews in Biochemistry and Molecular Biology. Apr, 2017 | Pubmed ID: 28228067 Polycomb Repressive Complex 1 Generates Discrete Compacted Domains That Change During Differentiation Molecular Cell. Feb, 2017 | Pubmed ID: 28157505 CTCF-mediated Topological Boundaries During Development Foster Appropriate Gene Regulation Genes & Development. 12, 2016 | Pubmed ID: 28087711 Mapping the 3D Genome: Aiming for Consilience Nature Reviews. Molecular Cell Biology. Nov, 2016 | Pubmed ID: 27869158 Crystal Structure of the DNA Binding Domain of the Transcription Factor T-bet Suggests Simultaneous Recognition of Distant Genome Sites Proceedings of the National Academy of Sciences of the United States of America. Oct, 2016 | Pubmed ID: 27791029 RUNX1 Contributes to Higher-order Chromatin Organization and Gene Regulation in Breast Cancer Cells Biochimica Et Biophysica Acta. Nov, 2016 | Pubmed ID: 27514584 Structural Organization of the Inactive X Chromosome in the Mouse Nature. Jul, 2016 | Pubmed ID: 27437574 SMARCA4 Regulates Gene Expression and Higher-order Chromatin Structure in Proliferating Mammary Epithelial Cells Genome Research. Sep, 2016 | Pubmed ID: 27435934 Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma American Journal of Respiratory and Critical Care Medicine. Dec, 2016 | Pubmed ID: 27367781 Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State During Somatic Cell Reprogramming Cell Stem Cell. May, 2016 | Pubmed ID: 27152443 TAD Disruption As Oncogenic Driver Current Opinion in Genetics & Development. Feb, 2016 | Pubmed ID: 27111891 The 3D Genome As Moderator of Chromosomal Communication Cell. Mar, 2016 | Pubmed ID: 26967279 Activation of Proto-oncogenes by Disruption of Chromosome Neighborhoods Science (New York, N.Y.). Mar, 2016 | Pubmed ID: 26940867 Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire Cell Reports. Feb, 2016 | Pubmed ID: 26804913 Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions Between Promoters and Distal Elements Around the CFTR Locus American Journal of Human Genetics. Jan, 2016 | Pubmed ID: 26748519 The Conformation of Yeast Chromosome III Is Mating Type Dependent and Controlled by the Recombination Enhancer Cell Reports. Dec, 2015 | Pubmed ID: 26655901 HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing Genome Biology. 2015 | Pubmed ID: 26619908 High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex Across the X Chromosome in Drosophila Molecular Cell. Oct, 2015 | Pubmed ID: 26431028 Long-Range Chromatin Interactions Cold Spring Harbor Perspectives in Biology. Oct, 2015 | Pubmed ID: 26430217 Chromatin Interaction Analysis Reveals Changes in Small Chromosome and Telomere Clustering Between Epithelial and Breast Cancer Cells Genome Biology. Sep, 2015 | Pubmed ID: 26415882 Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells Cell. Sep, 2015 | Pubmed ID: 26365489 Structural and Functional Diversity of Topologically Associating Domains FEBS Letters. Oct, 2015 | Pubmed ID: 26348399 Condensin Promotes the Juxtaposition of DNA Flanking Its Loading Site in Bacillus Subtilis Genes & Development. Aug, 2015 | Pubmed ID: 26253537 The Yeast Genome Undergoes Significant Topological Reorganization in Quiescence Nucleic Acids Research. Sep, 2015 | Pubmed ID: 26202961 Measuring Chromatin Structure in Budding Yeast Cold Spring Harbor Protocols. Jul, 2015 | Pubmed ID: 26134912 Hi-C in Budding Yeast Cold Spring Harbor Protocols. Jul, 2015 | Pubmed ID: 26134906 Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C Cell. Jul, 2015 | Pubmed ID: 26119342 Chromosome Conformation Capture Carbon Copy (5C) in Budding Yeast Cold Spring Harbor Protocols. Jun, 2015 | Pubmed ID: 26034306 Randomized Ligation Control for Chromosome Conformation Capture Cold Spring Harbor Protocols. Jun, 2015 | Pubmed ID: 26034305 Chromosome Conformation Capture (3C) in Budding Yeast Cold Spring Harbor Protocols. Jun, 2015 | Pubmed ID: 26034304 Condensin-driven Remodelling of X Chromosome Topology During Dosage Compensation Nature. Jul, 2015 | Pubmed ID: 26030525 Spatial Enhancer Clustering and Regulation of Enhancer-proximal Genes by Cohesin Genome Research. Apr, 2015 | Pubmed ID: 25677180 The Hitchhiker's Guide to Hi-C Analysis: Practical Guidelines Methods (San Diego, Calif.). Jan, 2015 | Pubmed ID: 25448293 Two Ways to Fold the Genome During the Cell Cycle: Insights Obtained with Chromosome Conformation Capture Epigenetics & Chromatin. 2014 | Pubmed ID: 25435919 Cohesin-dependent Globules and Heterochromatin Shape 3D Genome Architecture in S. Pombe Nature. Dec, 2014 | Pubmed ID: 25307058 Reply to Brunet and Doolittle: Both Selected Effect and Causal Role Elements Can Influence Human Biology and Disease Proceedings of the National Academy of Sciences of the United States of America. Aug, 2014 | Pubmed ID: 25275169 Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription Cell. May, 2014 | Pubmed ID: 24813616 Defining Functional DNA Elements in the Human Genome Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24753594 High-throughput Genome Scaffolding from in Vivo DNA Interaction Frequency Nature Biotechnology. Dec, 2013 | Pubmed ID: 24270850 Flexible Ordering of Antibody Class Switch and V(D)J Joining During B-cell Ontogeny Genes & Development. Nov, 2013 | Pubmed ID: 24240234 Organization of the Mitotic Chromosome Science (New York, N.Y.). Nov, 2013 | Pubmed ID: 24200812 Cohesin-based Chromatin Interactions Enable Regulated Gene Expression Within Preexisting Architectural Compartments Genome Research. Dec, 2013 | Pubmed ID: 24002784 Architectural Protein Subclasses Shape 3D Organization of Genomes During Lineage Commitment Cell. Jun, 2013 | Pubmed ID: 23706625 Exploring the Three-dimensional Organization of Genomes: Interpreting Chromatin Interaction Data Nature Reviews. Genetics. Jun, 2013 | Pubmed ID: 23657480 Nuclear Biology: What's Been Most Surprising? Cell. Mar, 2013 | Pubmed ID: 23616995 The Hierarchy of the 3D Genome Molecular Cell. Mar, 2013 | Pubmed ID: 23473598 Correlated Alterations in Genome Organization, Histone Methylation, and DNA-lamin A/C Interactions in Hutchinson-Gilford Progeria Syndrome Genome Research. Feb, 2013 | Pubmed ID: 23152449 3C-based Technologies to Study the Shape of the Genome Methods (San Diego, Calif.). Nov, 2012 | Pubmed ID: 23199640 From Cells to Chromatin: Capturing Snapshots of Genome Organization with 5C Technology Methods (San Diego, Calif.). Nov, 2012 | Pubmed ID: 23137922 The Long-range Interaction Landscape of Gene Promoters Nature. Sep, 2012 | Pubmed ID: 22955621 The Accessible Chromatin Landscape of the Human Genome Nature. Sep, 2012 | Pubmed ID: 22955617 Iterative Correction of Hi-C Data Reveals Hallmarks of Chromosome Organization Nature Methods. Oct, 2012 | Pubmed ID: 22941365 HiTC: Exploration of High-throughput 'C' Experiments Bioinformatics (Oxford, England). Nov, 2012 | Pubmed ID: 22923296 Analysis of Long-range Chromatin Interactions Using Chromosome Conformation Capture Methods (San Diego, Calif.). Nov, 2012 | Pubmed ID: 22903059 An Encyclopedia of Mouse DNA Elements (Mouse ENCODE) Genome Biology. Aug, 2012 | Pubmed ID: 22889292 Hi-C: a Comprehensive Technique to Capture the Conformation of Genomes Methods (San Diego, Calif.). Nov, 2012 | Pubmed ID: 22652625 CTCF and Cohesin Help Neurons Raise Their Self-awareness Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012 | Pubmed ID: 22615386 MORC Family ATPases Required for Heterochromatin Condensation and Gene Silencing Science (New York, N.Y.). Jun, 2012 | Pubmed ID: 22555433 The Context of Gene Expression Regulation F1000 Biology Reports. 2012 | Pubmed ID: 22500194 Spatial Partitioning of the Regulatory Landscape of the X-inactivation Centre Nature. May, 2012 | Pubmed ID: 22495304 Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations Cell. Mar, 2012 | Pubmed ID: 22341456 Evidence for Transcript Networks Composed of Chimeric RNAs in Human Cells PloS One. 2012 | Pubmed ID: 22238572 THE STRUCTURE AND FUNCTION OF CHROMATIN AND CHROMOSOMES Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2012 | Pubmed ID: 22174298 Enhanced Yeast One-hybrid Assays for High-throughput Gene-centered Regulatory Network Mapping Nature Methods. Dec, 2011 | Pubmed ID: 22037705 Yeast One-hybrid Assays for Gene-centered Human Gene Regulatory Network Mapping Nature Methods. Dec, 2011 | Pubmed ID: 22037702 The Three-dimensional Architecture of a Bacterial Genome and Its Alteration by Genetic Perturbation Molecular Cell. Oct, 2011 | Pubmed ID: 22017872 Translocation Mapping Exposes the Risky Lifestyle of B Cells Cell. Sep, 2011 | Pubmed ID: 21962501 Chromatin Globules: a Common Motif of Higher Order Chromosome Structure? Current Opinion in Cell Biology. Jun, 2011 | Pubmed ID: 21489772 A Long Noncoding RNA Maintains Active Chromatin to Coordinate Homeotic Gene Expression Nature. Apr, 2011 | Pubmed ID: 21423168 The Three-dimensional Folding of the α-globin Gene Domain Reveals Formation of Chromatin Globules Nature Structural & Molecular Biology. Jan, 2011 | Pubmed ID: 21131981 Sister Cohesion and Structural Axis Components Mediate Homolog Bias of Meiotic Recombination Cell. Dec, 2010 | Pubmed ID: 21145459 Genomics Tools for Unraveling Chromosome Architecture Nature Biotechnology. Oct, 2010 | Pubmed ID: 20944601 Mediator and Cohesin Connect Gene Expression and Chromatin Architecture Nature. Sep, 2010 | Pubmed ID: 20720539 Chemical Genetic Strategy Identifies Histone Deacetylase 1 (HDAC1) and HDAC2 As Therapeutic Targets in Sickle Cell Disease Proceedings of the National Academy of Sciences of the United States of America. Jul, 2010 | Pubmed ID: 20616024 Integrating One-dimensional and Three-dimensional Maps of Genomes Journal of Cell Science. Jun, 2010 | Pubmed ID: 20519580 Cell-type-specific Long-range Looping Interactions Identify Distant Regulatory Elements of the CFTR Gene Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20360044 Comprehensive Mapping of Long-range Interactions Reveals Folding Principles of the Human Genome Science (New York, N.Y.). Oct, 2009 | Pubmed ID: 19815776 My5C: Web Tools for Chromosome Conformation Capture Studies Nature Methods. Oct, 2009 | Pubmed ID: 19789528 Determining Spatial Chromatin Organization of Large Genomic Regions Using 5C Technology Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19588094 Disease-causing 7.4 Kb Cis-regulatory Deletion Disrupting Conserved Non-coding Sequences and Their Interaction with the FOXL2 Promotor: Implications for Mutation Screening PLoS Genetics. Jun, 2009 | Pubmed ID: 19543368 Gene Dates, Parties and Galas. Symposium on Chromatin Dynamics and Higher Order Organization EMBO Reports. Jul, 2009 | Pubmed ID: 19525922 Yeast Silent Mating Type Loci Form Heterochromatic Clusters Through Silencer Protein-dependent Long-range Interactions PLoS Genetics. May, 2009 | Pubmed ID: 19424429 Mechanisms That Regulate Localization of a DNA Double-strand Break to the Nuclear Periphery Genes & Development. Apr, 2009 | Pubmed ID: 19390086 Mapping Cis- and Trans- Chromatin Interaction Networks Using Chromosome Conformation Capture (3C) Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 18951182 Long-range Chromosomal Interactions and Gene Regulation Molecular BioSystems. Nov, 2008 | Pubmed ID: 18931780 Mapping in Vivo Chromatin Interactions in Yeast Suggests an Extended Chromatin Fiber with Regional Variation in Compaction The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18930918 Gene Regulation in the Third Dimension Science (New York, N.Y.). Mar, 2008 | Pubmed ID: 18369139 A Mechanism for Ikaros Regulation of Human Globin Gene Switching British Journal of Haematology. May, 2008 | Pubmed ID: 18318763 Chromosome Conformation Capture Carbon Copy Technology Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [et Al.]. Oct, 2007 | Pubmed ID: 18265398 Polycomb Response Elements Mediate the Formation of Chromosome Higher-order Structures in the Bithorax Complex Nature Cell Biology. Oct, 2007 | Pubmed ID: 17828248 Quantitative Analysis of Chromosome Conformation Capture Assays (3C-qPCR) Nature Protocols. 2007 | Pubmed ID: 17641637 GC- and AT-rich Chromatin Domains Differ in Conformation and Histone Modification Status and Are Differentially Modulated by Rpd3p Genome Biology. 2007 | Pubmed ID: 17577398 Identification and Analysis of Functional Elements in 1% of the Human Genome by the ENCODE Pilot Project Nature. Jun, 2007 | Pubmed ID: 17571346 Mapping Networks of Physical Interactions Between Genomic Elements Using 5C Technology Nature Protocols. 2007 | Pubmed ID: 17446898 Mapping Chromatin Interactions by Chromosome Conformation Capture Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [et Al.]. May, 2006 | Pubmed ID: 18265379 Chromosome Conformation Capture Carbon Copy (5C): a Massively Parallel Solution for Mapping Interactions Between Genomic Elements Genome Research. Oct, 2006 | Pubmed ID: 16954542 The Active FMR1 Promoter is Associated with a Large Domain of Altered Chromatin Conformation with Embedded Local Histone Modifications Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16891414 The Three 'C' S of Chromosome Conformation Capture: Controls, Controls, Controls Nature Methods. Jan, 2006 | Pubmed ID: 16369547 Proximity Among Distant Regulatory Elements at the Beta-globin Locus Requires GATA-1 and FOG-1 Molecular Cell. Feb, 2005 | Pubmed ID: 15694345 A Mechanical Basis for Chromosome Function Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15299144 A Closer Look at Long-range Chromosomal Interactions Trends in Biochemical Sciences. Jun, 2003 | Pubmed ID: 12826398 Capturing Chromosome Conformation Science (New York, N.Y.). Feb, 2002 | Pubmed ID: 11847345 Chromosoomconformatie vastleggen over lengteschalen Liyan Yang1, Betul Akgol Oksuz1, Job Dekker1,2, Johan Harmen Gibcus1 1Department of Systems Biology, University of Massachusetts Medical School, 2Howard Hughes Medical Institute JoVE 64001 Genetics Hi-C: een methode om de driedimensionale architectuur van genoom-onderzoek. Nynke L. van Berkum*1, Erez Lieberman-Aiden*2,3,4,5, Louise Williams*2, Maxim Imakaev6, Andreas Gnirke2, Leonid A. Mirny3,6, Job Dekker1, Eric S. Lander2,7,8 1Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 2Broad Institute of Harvard and Massachusetts Institute of Technology, 3Division of Health Sciences and Technology, Massachusetts Institute of Technology, 4Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, 5Department of Applied Mathematics, Harvard University, 6Department of Physics, Massachusetts Institute of Technology, 7Department of Systems Biology, Harvard Medical School, 8Department of Biology, Massachusetts Institute of Technology JoVE 1869 Biology
Chromosoomconformatie vastleggen over lengteschalen Liyan Yang1, Betul Akgol Oksuz1, Job Dekker1,2, Johan Harmen Gibcus1 1Department of Systems Biology, University of Massachusetts Medical School, 2Howard Hughes Medical Institute JoVE 64001 Genetics
Hi-C: een methode om de driedimensionale architectuur van genoom-onderzoek. Nynke L. van Berkum*1, Erez Lieberman-Aiden*2,3,4,5, Louise Williams*2, Maxim Imakaev6, Andreas Gnirke2, Leonid A. Mirny3,6, Job Dekker1, Eric S. Lander2,7,8 1Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 2Broad Institute of Harvard and Massachusetts Institute of Technology, 3Division of Health Sciences and Technology, Massachusetts Institute of Technology, 4Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, 5Department of Applied Mathematics, Harvard University, 6Department of Physics, Massachusetts Institute of Technology, 7Department of Systems Biology, Harvard Medical School, 8Department of Biology, Massachusetts Institute of Technology JoVE 1869 Biology