Joel Gottesfeld Department of Molecular Biology The Scripps Research Institute Biography Publications Institution JoVE Articles Joel Gottesfeld has not added a biography. If you are Joel Gottesfeld and would like to personalize this page please email our Author Liaison for assistance. Publications A Gene Expression Phenotype in Lymphocytes from Friedreich Ataxia Patients Annals of Neurology. Nov, 2011 | Pubmed ID: 22162061 Evaluation of Histone Deacetylase Inhibitors As Therapeutics for Neurodegenerative Diseases Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21913121 Introduction to the Thematic Minireview Series on Epigenetics The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21454488 Prolonged Treatment with Pimelic O-aminobenzamide HDAC Inhibitors Ameliorates the Disease Phenotype of a Friedreich Ataxia Mouse Model Neurobiology of Disease. Jun, 2011 | Pubmed ID: 21397024 Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and IPSCs During Reprogramming and Time in Culture Cell Stem Cell. Jan, 2011 | Pubmed ID: 21211785 Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAAâ‹…TTC Triplet Repeat Instability Cell Stem Cell. Nov, 2010 | Pubmed ID: 21040903 Chemical Biology Meets Biological Chemistry Minireview Series The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20147295 Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model PloS One. 2010 | Pubmed ID: 20098685 Reduced Histone Deacetylase 7 Activity Restores Function to Misfolded CFTR in Cystic Fibrosis Nature Chemical Biology. Jan, 2010 | Pubmed ID: 19966789 Potent Activity Against K562 Cells by Polyamide-seco-CBI Conjugates Targeting Histone H4 Genes Bioorganic & Medicinal Chemistry. Jan, 2010 | Pubmed ID: 19962902 Development of Histone Deacetylase Inhibitors As Therapeutics for Neurological Disease Future Neurology. Nov, 2009 | Pubmed ID: 20177429 Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing Chemistry & Biology. Sep, 2009 | Pubmed ID: 19778726 Design and Synthesis of Novel Hybrid Benzamide-peptide Histone Deacetylase Inhibitors Bioorganic & Medicinal Chemistry Letters. Jul, 2009 | Pubmed ID: 19362838 Growth Arrest of BCR-ABL Positive Cells with a Sequence-specific Polyamide-chlorambucil Conjugate PloS One. 2008 | Pubmed ID: 18974832 Pimelic Diphenylamide 106 is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18953021 The HDAC Inhibitor 4b Ameliorates the Disease Phenotype and Transcriptional Abnormalities in Huntington's Disease Transgenic Mice Proceedings of the National Academy of Sciences of the United States of America. Oct, 2008 | Pubmed ID: 18829438 Targeting Specific Gene by Alkylating Pyrrole-imidazole Polyamides Nucleic Acids Symposium Series (2004). 2008 | Pubmed ID: 18776404 HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model PloS One. 2008 | Pubmed ID: 18463734 Small Molecules Targeting Histone H4 As Potential Therapeutics for Chronic Myelogenous Leukemia Molecular Cancer Therapeutics. Apr, 2008 | Pubmed ID: 18413791 Small Molecules Affecting Transcription in Friedreich Ataxia Pharmacology & Therapeutics. Nov, 2007 | Pubmed ID: 17826840 Unanticipated Differences Between Alpha- and Gamma-diaminobutyric Acid-linked Hairpin Polyamide-alkylator Conjugates Nucleic Acids Research. 2007 | Pubmed ID: 17170006 Histone Deacetylase Inhibitors Reverse Gene Silencing in Friedreich's Ataxia Nature Chemical Biology. Oct, 2006 | Pubmed ID: 16921367 A Two-hit Mechanism for Pre-mitotic Arrest of Cancer Cell Proliferation by a Polyamide-alkylator Conjugate Cell Cycle (Georgetown, Tex.). Jul, 2006 | Pubmed ID: 16861886 DNA Sequence-specific Polyamides Alleviate Transcription Inhibition Associated with Long GAA.TTC Repeats in Friedreich's Ataxia Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16857735 Alkylation of Duplex DNA in Nucleosome Core Particles by Duocarmycin SA and Yatakemycin Nature Chemical Biology. Feb, 2006 | Pubmed ID: 16415862 Induced Fit and "lock and Key" Recognition of 5S RNA by Zinc Fingers of Transcription Factor IIIA Journal of Molecular Biology. Mar, 2006 | Pubmed ID: 16405997 Inhibition of DNA Binding by Human Estrogen-related Receptor 2 and Estrogen Receptor Alpha with Minor Groove Binding Polyamides Biochemistry. Mar, 2005 | Pubmed ID: 15766247 Role of DNA Sequence in the Binding Specificity of Synthetic Basic-helix-loop-helix Domains Chembiochem : a European Journal of Chemical Biology. Jan, 2005 | Pubmed ID: 15593070 Nucleosomes in Solution Exist As a Mixture of Twist-defect States Journal of Molecular Biology. Jan, 2005 | Pubmed ID: 15567414 Arresting Cancer Proliferation by Small-molecule Gene Regulation Chemistry & Biology. Nov, 2004 | Pubmed ID: 15556009 Regulation of Gene Expression with Pyrrole-imidazole Polyamides Journal of Biotechnology. Aug, 2004 | Pubmed ID: 15288953 Molecular Recognition of the Nucleosomal "supergroove" Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15100411 Accessibility of Nuclear Chromatin by DNA Binding Polyamides Chemistry & Biology. Sep, 2003 | Pubmed ID: 14522056 RNA As a Transcriptional Activator Chemistry & Biology. Jul, 2003 | Pubmed ID: 12890529 Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands Journal of Molecular Biology. Feb, 2003 | Pubmed ID: 12559907 Blocking Transcription Through a Nucleosome with Synthetic DNA Ligands Journal of Molecular Biology. Aug, 2002 | Pubmed ID: 12144782 Cyclin L is an RS Domain Protein Involved in Pre-mRNA Splicing The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 11980906 Promoter Scanning for Transcription Inhibition with DNA-binding Polyamides Molecular and Cellular Biology. Mar, 2002 | Pubmed ID: 11865052 Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts Urszula Polak1,2, Calley Hirsch1, Sherman Ku3, Joel Gottesfeld3, Sharon Y.R. Dent1, Marek Napierala1 1Department of Molecular Carcinogenesis and Center for Cancer Epigenetics, University of Texas M.D. Anderson Cancer Center, 2Department of Cell Biology, Poznan University of Medical Sciences, 3Department of Molecular Biology, The Scripps Research Institute JoVE 3416 Biology
Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts Urszula Polak1,2, Calley Hirsch1, Sherman Ku3, Joel Gottesfeld3, Sharon Y.R. Dent1, Marek Napierala1 1Department of Molecular Carcinogenesis and Center for Cancer Epigenetics, University of Texas M.D. Anderson Cancer Center, 2Department of Cell Biology, Poznan University of Medical Sciences, 3Department of Molecular Biology, The Scripps Research Institute JoVE 3416 Biology