John R. Grider Department of Physiology and Biophysics Virginia Commonwealth University Biography Publications Institution JoVE Articles John R. Grider has not added a biography. If you are John R. Grider and would like to personalize this page please email our Author Liaison for assistance. Publications Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by CAMP-Independent PKA PloS One. 2013 | Pubmed ID: 23825105 Retinaldehyde Dehydrogenase Enzymes Regulate Colon Enteric Nervous System Structure and Function Developmental Biology. Jun, 2013 | Pubmed ID: 23806210 Changes in the Expression of Smooth Muscle Contractile Proteins in TNBS- and DSS-Induced Colitis in Mice Inflammation. Jun, 2013 | Pubmed ID: 23794034 Differential Regulation of Muscarinic M2 and M3 Receptor Signaling in Gastrointestinal Smooth Muscle by Caveolin-1 American Journal of Physiology. Cell Physiology. Aug, 2013 | Pubmed ID: 23784544 Differential Expression of Multidrug-Resistance Protein 5 and Phosphodiesterase 5 and Regulation of CGMP Levels in Phasic and Tonic Smooth Muscle American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2013 | Pubmed ID: 23764893 TRPM5-dependent Amiloride- and Benzamil-insensitive NaCl Chorda Tympani Taste Nerve Response American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2013 | Pubmed ID: 23639808 Characterization of Signaling Pathways Coupled to Melatonin Receptors in Gastrointestinal Smooth Muscle Regulatory Peptides. Jun, 2013 | Pubmed ID: 23541890 Caveolae-dependent Internalization and Homologous Desensitization of VIP/PACAP Receptor, VPAC₂, in Gastrointestinal Smooth Muscle Peptides. May, 2013 | Pubmed ID: 23499767 Electrophysiological Characteristics of Enteric Neurons Isolated from the Immortomouse Digestive Diseases and Sciences. Jun, 2013 | Pubmed ID: 23371009 Activation of G Protein-coupled Bile Acid Receptor, TGR5, Induces Smooth Muscle Relaxation Via Both Epac- and PKA-mediated Inhibition of RhoA/Rho Kinase Pathway American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2013 | Pubmed ID: 23275618 The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and is Required for Normal Defecation in Mice Gastroenterology. Jan, 2013 | Pubmed ID: 23041323 Morphine Decreases Enteric Neuron Excitability Via Inhibition of Sodium Channels PloS One. 2012 | Pubmed ID: 23028881 Activation of Transmembrane Bile Acid Receptor TGR5 Stimulates Insulin Secretion in Pancreatic β Cells Biochemical and Biophysical Research Communications. Oct, 2012 | Pubmed ID: 23022524 Up-regulation of Brain-derived Neurotrophic Factor is Regulated by Extracellular Signal-regulated Protein Kinase 5 and by Nerve Growth Factor Retrograde Signaling in Colonic Afferent Neurons in Colitis Experimental Neurology. Dec, 2012 | Pubmed ID: 22921460 Up-regulation of Brain-derived Neurotrophic Factor in Primary Afferent Pathway Regulates Colon-to-bladder Cross-sensitization in Rat Journal of Neuroinflammation. 2012 | Pubmed ID: 22335898 Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-inflammatory Drug-induced Gastric Hemorrhages in Mice The Journal of Pharmacology and Experimental Therapeutics. Sep, 2011 | Pubmed ID: 21659471 Endogenous IGFBP-3 Regulates Excess Collagen Expression in Intestinal Smooth Muscle Cells of Crohn's Disease Strictures Inflammatory Bowel Diseases. Jan, 2011 | Pubmed ID: 20848532 Amelioration of Excess Collagen IαI, Fibrosis, and Smooth Muscle Growth in TNBS-induced Colitis in IGF-I(+/-) Mice Inflammatory Bowel Diseases. Mar, 2011 | Pubmed ID: 20722057 Colitis Elicits Differential Changes in the Expression Levels of Receptor Tyrosine Kinase TrkA and TrkB in Colonic Afferent Neurons: a Possible Involvement of Axonal Transport Pain. Oct, 2010 | Pubmed ID: 20638179 The Timing and Location of Glial Cell Line-derived Neurotrophic Factor Expression Determine Enteric Nervous System Structure and Function The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2010 | Pubmed ID: 20107080 Endogenous IGF-I and AlphaVbeta3 Integrin Ligands Regulate Increased Smooth Muscle Hyperplasia in Stricturing Crohn's Disease Gastroenterology. Jan, 2010 | Pubmed ID: 19751734 Modulation of Motor and Sensory Pathways of the Peristaltic Reflex by Cannabinoids American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2009 | Pubmed ID: 19589944 Colitis Induces Calcitonin Gene-related Peptide Expression and Akt Activation in Rat Primary Afferent Pathways Experimental Neurology. Sep, 2009 | Pubmed ID: 19422825 Endogenous IGF-I and Alpha V Beta3 Integrin Ligands Regulate Increased Smooth Muscle Growth in TNBS-induced Colitis American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2009 | Pubmed ID: 19359426 Alterations to Enteric Neural Signaling Underlie Secretory Abnormalities of the Ileum in Experimental Colitis in the Guinea Pig American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2009 | Pubmed ID: 19221017 Autoinhibition of Endothelial Nitric Oxide Synthase (eNOS) in Gut Smooth Muscle by Nitric Oxide Regulatory Peptides. Nov, 2008 | Pubmed ID: 18926858 Up-regulation of Calcitonin Gene-related Peptide and Receptor Tyrosine Kinase TrkB in Rat Bladder Afferent Neurons Following TNBS Colitis Experimental Neurology. Apr, 2007 | Pubmed ID: 17303123 Cross-regulation of VPAC(2) Receptor Desensitization by M(3) Receptors Via PKC-mediated Phosphorylation of RKIP and Inhibition of GRK2 American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2007 | Pubmed ID: 17170028 Brain-derived Neurotrophic Factor Augments Peristalsis by Augmenting 5-HT and Calcitonin Gene-related Peptide Release Gastroenterology. Mar, 2006 | Pubmed ID: 16530518 Desensitization of the Peristaltic Reflex Induced by Mucosal Stimulation with the Selective 5-HT4 Agonist Tegaserod American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2006 | Pubmed ID: 16223945 Differential Expression of Y Receptors and Signaling Pathways in Intestinal Circular and Longitudinal Smooth Muscle Regulatory Peptides. Feb, 2005 | Pubmed ID: 15582728 Gq/G13 Signaling by ET-1 in Smooth Muscle: MYPT1 Phosphorylation Via ETA and CPI-17 Dephosphorylation Via ETB American Journal of Physiology. Cell Physiology. Nov, 2004 | Pubmed ID: 15475516 Coexpression of Y1, Y2, and Y4 Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways The Journal of Pharmacology and Experimental Therapeutics. Dec, 2004 | Pubmed ID: 15308651 Gastrin-releasing Peptide is a Modulatory Neurotransmitter of the Descending Phase of the Peristaltic Reflex American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2004 | Pubmed ID: 15297260 Neurotransmitters Mediating the Intestinal Peristaltic Reflex in the Mouse The Journal of Pharmacology and Experimental Therapeutics. Nov, 2003 | Pubmed ID: 12966154 Physiological Role of Neuropeptide Y in the Regulation of the Ascending Phase of the Peristaltic Reflex American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2003 | Pubmed ID: 12919938 Inhibition of Sustained Smooth Muscle Contraction by PKA and PKG Preferentially Mediated by Phosphorylation of RhoA American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2003 | Pubmed ID: 12736149 Differential Signalling by Muscarinic Receptors in Smooth Muscle: M2-mediated Inactivation of Myosin Light Chain Kinase Via Gi3, Cdc42/Rac1 and P21-activated Kinase 1 Pathway, and M3-mediated MLC20 (20 KDa Regulatory Light Chain of Myosin II) Phosphorylation Via Rho-associated Kinase/myosin Phosphatase Targeting Subunit 1 and Protein Kinase C/CPI-17 Pathway The Biochemical Journal. Aug, 2003 | Pubmed ID: 12733988 GDNF Availability Determines Enteric Neuron Number by Controlling Precursor Proliferation Development (Cambridge, England). May, 2003 | Pubmed ID: 12668632 Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines Derek M. Kendig1,2, Norm R. Hurst1, John R. Grider1 1Department of Physiology and Biophysics, Virginia Commonwealth University, 2Department of Biology, Loyola University Maryland JoVE 53263 Biology An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse Tricia H. Smith1, Joy Ngwainmbi1, John R. Grider2, William L. Dewey1, Hamid I. Akbarali1 1Pharmacology and Toxicology, Virginia Commonwealth University, 2Physiology and Biophyics, Virginia Commonwealth University JoVE 50688 Neuroscience
Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines Derek M. Kendig1,2, Norm R. Hurst1, John R. Grider1 1Department of Physiology and Biophysics, Virginia Commonwealth University, 2Department of Biology, Loyola University Maryland JoVE 53263 Biology
An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse Tricia H. Smith1, Joy Ngwainmbi1, John R. Grider2, William L. Dewey1, Hamid I. Akbarali1 1Pharmacology and Toxicology, Virginia Commonwealth University, 2Physiology and Biophyics, Virginia Commonwealth University JoVE 50688 Neuroscience
