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In JoVE (1)
Other Publications (1)
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Articles by Joyce Hui-Yuen in JoVE
Epstein-बर्र वायरस विकास तब्दील Lymphoblastoid सेल लाइन्स की स्थापना
Joyce Hui-Yuen1,2, Shane McAllister1,2, Siva Koganti2, Erik Hill2, Sumita Bhaduri-McIntosh1,2,3,4
1Stony Brook Children's Hospital, State University of New York at Stony Brook, 2Department of Pediatrics, State University of New York at Stony Brook, 3Department of Molecular Genetics, State University of New York at Stony Brook, 4Department of Microbiology, State University of New York at Stony Brook
हम बदल बी सेल Epstein-बर्र वायरस का उपयोग लाइनों पैदा करने के लिए एक विधि का वर्णन. हम भी एक उपन्यास परख है कि बी कोशिकाओं को संक्रमण के बाद तीन दिन के रूप में में जल्दी के रूप में परिवर्तन से गुजरना करने के लिए किस्मत की पहचान कर सकते हैं वर्णन.
Other articles by Joyce Hui-Yuen on PubMed
TNF-alpha is Necessary for Induction of Coronary Artery Inflammation and Aneurysm Formation in an Animal Model of Kawasaki Disease
Journal of Immunology (Baltimore, Md. : 1950). May, 2006 | Pubmed ID: 16670341
Kawasaki disease is the most common cause of multisystem vasculitis in childhood. The resultant coronary artery lesions make Kawasaki disease the leading cause of acquired heart disease in children in the developed world. TNF-alpha is a pleiotropic inflammatory cytokine elevated during the acute phase of Kawasaki disease. In this study, we report rapid production of TNF-alpha in the peripheral immune system after disease induction in a murine model of Kawasaki disease. This immune response becomes site directed, with migration to the coronary arteries dependent on TNF-alpha-mediated events. Production of TNF-alpha in the heart is coincident with the presence of inflammatory infiltrate at the coronary arteries, which persists during development of aneurysms. More importantly, inflammation and elastin breakdown in the coronary vessels are completely eliminated in the absence of TNF-alpha effector functions. Mice treated with the TNF-alpha-blocking agent etanercept, as well as TNFRI knockout mice, are resistant to development of both coronary arteritis and coronary aneurysm formation. Taken together, TNF-alpha is necessary for the development of coronary artery lesions in an animal model of Kawasaki disease. These findings have important implications for potential new therapeutic interventions in children with Kawasaki disease.