Translate this page to:
Dutch
In JoVE (1)
Other Publications (2)
Automatic Translation
This translation into Dutch was automatically generated.
English Version | Other Languages
Articles by Judy Coleman in JoVE
JoVE General
Ontleding van Midgut en speekselklieren van de Ae. aegypti Muggen
1Department of Molecular Biology and Biochemistry, University of California, Irvine (UCI), 2Department of Molecular Biology and Biochemistry, Department of Microbiology and Molecular Genetics, University of California, Irvine (UCI)
De mug middendarm en de speekselklieren zijn belangrijke in-en uitgangen voor vector ziekteverwekkers zoals Plasmodium falciparum en het dengue virus. Deze video toont de dissectie technieken voor het verwijderen van de middendarm en de speekselklieren van Aedes aegypti muggen.
Other articles by Judy Coleman on PubMed
Genetic Control of Malaria Parasite Transmission: Threshold Levels for Infection in an Avian Model System
Genetic strategies for controlling malaria transmission based on engineering pathogen resistance in Anopheles mosquitoes are being tested in a number of animal models. A key component is the effector molecule and the efficiency with which it reduces parasite transmission. Single-chain antibodies (scFvs) that bind the circumsporozoite protein of the avian parasite, Plasmodium gallinaceum, can reduce mean intensities of sporozoite infection of salivary glands by two to four orders of magnitude in transgenic Aedes aegypti. Significantly, mosquitoes with as few as 20 sporozoites in their salivary glands are infectious for a vertebrate host, Gallus gallus. Although scFvs hold promise as effector molecules, they will have to reduce mean intensities of infection to zero to prevent parasite transmission and disease. We conclude that similar endpoints must be reached with human pathogens if we are to expect an effect on disease transmission.
Spatial Mapping of Gene Expression in the Salivary Glands of the Dengue Vector Mosquito, Aedes Aegypti
Aedes aegypti mosquitoes are the main vectors of dengue viruses to humans. Understanding their biology and interactions with the pathogen are prerequisites for development of dengue transmission control strategies. Mosquito salivary glands are organs involved directly in pathogen transmission to vertebrate hosts. Information on the spatial distribution of gene expression in these organs is expected to assist in the development of novel disease control strategies, including those that entail the release of transgenic mosquitoes with impaired vector competence.
