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In JoVE (1)
Other Publications (2)
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Articles by Judy Coleman in JoVE
Dissection של בלוטות הרוק midgut ו מ AE. aegypti יתושים
Judy Coleman1, Jennifer Juhn1, Anthony A. James2
1Department of Molecular Biology and Biochemistry, University of California, Irvine (UCI), 2Department of Molecular Biology and Biochemistry, Department of Microbiology and Molecular Genetics, University of California, Irvine (UCI)
Midgut יתושים בלוטות הרוק הם מפתח כניסה ויציאה עבור וקטור פתוגנים כמו Plasmodium falciparum ואת וירוס דנגה. וידאו זה מדגים את הטכניקות לנתיחה עבור הסרת בלוטות הרוק midgut ו מ Aedes aegypti יתושים.
Other articles by Judy Coleman on PubMed
Genetic Control of Malaria Parasite Transmission: Threshold Levels for Infection in an Avian Model System
The American Journal of Tropical Medicine and Hygiene. Jun, 2007 | Pubmed ID: 17556613
Genetic strategies for controlling malaria transmission based on engineering pathogen resistance in Anopheles mosquitoes are being tested in a number of animal models. A key component is the effector molecule and the efficiency with which it reduces parasite transmission. Single-chain antibodies (scFvs) that bind the circumsporozoite protein of the avian parasite, Plasmodium gallinaceum, can reduce mean intensities of sporozoite infection of salivary glands by two to four orders of magnitude in transgenic Aedes aegypti. Significantly, mosquitoes with as few as 20 sporozoites in their salivary glands are infectious for a vertebrate host, Gallus gallus. Although scFvs hold promise as effector molecules, they will have to reduce mean intensities of infection to zero to prevent parasite transmission and disease. We conclude that similar endpoints must be reached with human pathogens if we are to expect an effect on disease transmission.
Spatial Mapping of Gene Expression in the Salivary Glands of the Dengue Vector Mosquito, Aedes Aegypti
Parasites & Vectors. 2011 | Pubmed ID: 21205315
Aedes aegypti mosquitoes are the main vectors of dengue viruses to humans. Understanding their biology and interactions with the pathogen are prerequisites for development of dengue transmission control strategies. Mosquito salivary glands are organs involved directly in pathogen transmission to vertebrate hosts. Information on the spatial distribution of gene expression in these organs is expected to assist in the development of novel disease control strategies, including those that entail the release of transgenic mosquitoes with impaired vector competence.