Karen K. Hirschi Department of Cell Biology University of Virginia School of Medicine Biography Publications Institution JoVE Articles Karen K. Hirschi has not added a biography. If you are Karen K. Hirschi and would like to personalize this page please email our Author Liaison for assistance. Publications Understanding Neural Stem Cell Regulation and Applying the Insights to Cell Therapy for Strokes Regenerative Medicine. 09, 2021 | Pubmed ID: 34498495 The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation Journal of the American Heart Association. 07, 2021 | Pubmed ID: 34155901 Vascular Endothelial Cell Specification in Health and Disease Angiogenesis. 05, 2021 | Pubmed ID: 33844116 Regulation of Hemogenic Endothelial Cell Development and Function Annual Review of Physiology. 02, 2021 | Pubmed ID: 33035429 Isolation of Highly Purified and Viable Retinal Endothelial Cells Journal of Vascular Research. 2021 | Pubmed ID: 33022674 Tissue-Resident Macrophage Development and Function Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 33490082 The N-glycome Regulates the Endothelial-to-hematopoietic Transition Science (New York, N.Y.). 12, 2020 | Pubmed ID: 33273096 Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification Cell Reports. Dec, 2020 | Pubmed ID: 33264627 Single Cell Analysis in Vascular Biology Frontiers in Cardiovascular Medicine. 2020 | Pubmed ID: 32296715 Tet2-mediated Clonal Hematopoiesis in Nonconditioned Mice Accelerates Age-associated Cardiac Dysfunction JCI Insight. 03, 2020 | Pubmed ID: 32154790 Specification and Function of Hemogenic Endothelium During Embryogenesis Cellular and Molecular Life Sciences : CMLS. Apr, 2016 | Pubmed ID: 26849156 Bioactive Poly(ethylene Glycol) Hydrogels to Recapitulate the HSC Niche and Facilitate HSC Expansion in Culture Biotechnology and Bioengineering. Apr, 2016 | Pubmed ID: 26497172 Corrigendum: Ionizing Particle Radiation As a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers Frontiers in Oncology. 2015 | Pubmed ID: 26636037 Ionizing Particle Radiation As a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers Frontiers in Oncology. 2015 | Pubmed ID: 26528440 Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells Cell Reports. Oct, 2014 | Pubmed ID: 25310984 The Magic Touch: Endothelial Cells Muscle-up Adipose Circulation Research. Oct, 2014 | Pubmed ID: 25301822 Induced Pluripotent Stem Cells for Regenerative Medicine Annual Review of Biomedical Engineering. Jul, 2014 | Pubmed ID: 24905879 Hemogenic Endothelial Cell Specification Requires C-Kit, Notch Signaling, and P27-mediated Cell-cycle Control Developmental Cell. Dec, 2013 | Pubmed ID: 24331925 Regulation of Endothelial Cell Differentiation and Specification Circulation Research. Apr, 2013 | Pubmed ID: 23620236 A Computational Approach to Detect Gap Junction Plaques and Associate Them with Cells in Fluorescent Images The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Apr, 2013 | Pubmed ID: 23324867 Connexin45 Regulates Endothelial-induced Mesenchymal Cell Differentiation Toward a Mural Cell Phenotype Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2013 | Pubmed ID: 23220276 Studying Vascular Progenitor Cells in a Neonatal Mouse Model Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22890936 Vascular Progenitor Cell Mobilization Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22890930 Partial Characterization of the Sox2+ Cell Population in an Adult Murine Model of Digit Amputation Tissue Engineering. Part A. Jul, 2012 | Pubmed ID: 22530556 Hemogenic Endothelium During Development and Beyond Blood. May, 2012 | Pubmed ID: 22415753 Cardiovascular Regenerative Biology Cells, Tissues, Organs. 2012 | Pubmed ID: 22179179 Stem Cell-derived Vascular Endothelial Cells and Their Potential Application in Regenerative Medicine Cells, Tissues, Organs. 2012 | Pubmed ID: 22005724 Vascular Precursor Cells Genes & Cancer. Dec, 2011 | Pubmed ID: 22866199 The Role of Quaking in Mammalian Embryonic Development Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 21189687 Establishment and Regulation of the HSC Niche: Roles of Osteoblastic and Vascular Compartments Birth Defects Research. Part C, Embryo Today : Reviews. Dec, 2010 | Pubmed ID: 21181885 Mdm2 is Required for Survival of Hematopoietic Stem Cells/progenitors Via Dampening of ROS-induced P53 Activity Cell Stem Cell. Nov, 2010 | Pubmed ID: 21040902 Endothelial Cell Migration During Murine Yolk Sac Vascular Remodeling Occurs by Means of a Rac1 and FAK Activation Pathway in Vivo Developmental Dynamics : an Official Publication of the American Association of Anatomists. Oct, 2010 | Pubmed ID: 20737513 Quiescence and Activation of Stem and Precursor Cell Populations in the Subependymal Zone of the Mammalian Brain Are Associated with Distinct Cellular and Extracellular Matrix Signals The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2010 | Pubmed ID: 20660259 Characterization of Bacterial Artificial Chromosome Transgenic Mice Expressing MCherry Fluorescent Protein Substituted for the Murine Smooth Muscle Alpha-actin Gene Genesis (New York, N.Y. : 2000). Jul, 2010 | Pubmed ID: 20506352 Vascular Potential of Human Pluripotent Stem Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2010 | Pubmed ID: 20453170 Vascular Precursors: Origin, Regulation and Function Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2010 | Pubmed ID: 20453165 Hemato-vascular Origins of Endothelial Progenitor Cells? Microvascular Research. May, 2010 | Pubmed ID: 20149806 Epimorphic Regeneration Approach to Tissue Replacement in Adult Mammals Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 19966310 Diverse Roles of the Vasculature Within the Neural Stem Cell Niche Regenerative Medicine. Nov, 2009 | Pubmed ID: 19903006 A Mouse Chromosome 4 Balancer ENU-mutagenesis Screen Isolates Eleven Lethal Lines BMC Genetics. 2009 | Pubmed ID: 19267930 Signaling Hierarchy Regulating Human Endothelial Cell Development Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2009 | Pubmed ID: 19213939 Embryonic Vasculogenesis and Hematopoietic Specification Organogenesis. Oct, 2008 | Pubmed ID: 19337406 Cell Signaling Directing the Formation and Function of Hemogenic Endothelium During Murine Embryogenesis Blood. Oct, 2008 | Pubmed ID: 18684862 Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2008 | Pubmed ID: 18669889 Injury Mechanism Dictates Contribution of Bone Marrow-derived Cells to Murine Hepatic Vascular Regeneration Pediatric Research. Feb, 2008 | Pubmed ID: 18043513 Murine Neonatal Intravascular Injections: Modeling Newborn Disease Journal of the American Association for Laboratory Animal Science : JAALAS. Nov, 2007 | Pubmed ID: 17994673 Coregulation of Vascular Tube Stabilization by Endothelial Cell TIMP-2 and Pericyte TIMP-3 The Journal of Cell Biology. Oct, 2006 | Pubmed ID: 17030988 Visceral Endoderm Function is Regulated by Quaking and Required for Vascular Development Genesis (New York, N.Y. : 2000). Feb, 2006 | Pubmed ID: 16470614 Understanding Abnormalities in Vascular Specification and Remodeling Pediatrics. Jul, 2005 | Pubmed ID: 15995057 Red Light, Green Light: Signals That Control Endothelial Cell Proliferation During Embryonic Vascular Development Cell Cycle (Georgetown, Tex.). Dec, 2004 | Pubmed ID: 15611620 Retinoic Acid Slows Progression and Promotes Apoptosis of Spontaneous Prostate Cancer The Prostate. Oct, 2004 | Pubmed ID: 15305337 Nutrient Regulation of Cell Cycle Progression Annual Review of Nutrition. 2004 | Pubmed ID: 15189127 Signaling Hierarchy Downstream of Retinoic Acid That Independently Regulates Vascular Remodeling and Endothelial Cell Proliferation Genes & Development. Jun, 2004 | Pubmed ID: 15175265 Smooth Muscle Stem Cells The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology. Jan, 2004 | Pubmed ID: 14699631 Primitive Adult Hematopoietic Stem Cells Can Function As Osteoblast Precursors Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14673088 Ouabain- and Marinobufagenin-induced Proliferation of Human Umbilical Vein Smooth Muscle Cells and a Rat Vascular Smooth Muscle Cell Line, A7r5 Circulation. Dec, 2003 | Pubmed ID: 14638550 Retinoic Acid Regulates Endothelial Cell Proliferation During Vasculogenesis Development (Cambridge, England). Dec, 2003 | Pubmed ID: 14627725 Altered Phenotype and Reduced Function of Muscle-derived Hematopoietic Stem Cells Experimental Hematology. Sep, 2003 | Pubmed ID: 12962727 Gap Junction Communication Mediates Transforming Growth Factor-beta Activation and Endothelial-induced Mural Cell Differentiation Circulation Research. Sep, 2003 | Pubmed ID: 12919949 Phenotype and Hematopoietic Potential of Side Population Cells Throughout Embryonic Development Blood. Oct, 2003 | Pubmed ID: 12805065 The FAKs About Blood Vessel Assembly Circulation Research. Feb, 2003 | Pubmed ID: 12595334 Distinct Progenitor Populations in Skeletal Muscle Are Bone Marrow Derived and Exhibit Different Cell Fates During Vascular Regeneration The Journal of Clinical Investigation. Jan, 2003 | Pubmed ID: 12511590 Vascular Assembly in Engineered and Natural Tissues: Breakout Session Summary Annals of the New York Academy of Sciences. Jun, 2002 | Pubmed ID: 12081911 Vascular Assembly in Natural and Engineered Tissues Annals of the New York Academy of Sciences. Jun, 2002 | Pubmed ID: 12081906 Quaking is Essential for Blood Vessel Development Genesis (New York, N.Y. : 2000). Mar, 2002 | Pubmed ID: 11892011 Transforming Growth Factor-beta Induction of Smooth Muscle Cell Phenotpye Requires Transcriptional and Post-transcriptional Control of Serum Response Factor The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11741973 Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing Nicholas W. Chavkin1,2, Shelby Cain1, Kenneth Walsh2,3,4, Karen K. Hirschi1,2,4,5 1Department of Cell Biology, University of Virginia School of Medicine, 2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, 3Department of Cardiology, University of Virginia School of Medicine, 4Hematovascular Biology Center, University of Virginia School of Medicine, 5Yale Cardiovascular Research Center, Yale University School of Medicine JoVE 63133 Developmental Biology Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells Elizabeth A. Nelson1,2, Jingyao Qiu3,4, Nicholas W. Chavkin1,2, Karen K. Hirschi1,2,3,4,5 1Department of Cell Biology, University of Virginia, 2Cardiovascular Research Center, University of Virginia, 3Department of Medicine, Yale University School of Medicine, 4Department of Genetics, Yale University School of Medicine, 5Yale Cardiovascular Research Center, Yale University School of Medicine JoVE 62391 Developmental Biology Isolation of Murine Embryonic Hemogenic Endothelial Cells Jennifer S. Fang*1, Emily C. Gritz*2, Kathrina L. Marcelo3, Karen K. Hirschi1 1Departments of Medicine, Genetics and Biomedical Engineering, Yale Cardiovascular Research Center, Vascular Biology and Therapeutics Program, Yale Stem Cell Center, Yale University School of Medicine, 2Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Yale University School of Medicine, 3Department of Molecular and Cellular Biology, Baylor College of Medicine JoVE 54150 Developmental Biology
Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing Nicholas W. Chavkin1,2, Shelby Cain1, Kenneth Walsh2,3,4, Karen K. Hirschi1,2,4,5 1Department of Cell Biology, University of Virginia School of Medicine, 2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, 3Department of Cardiology, University of Virginia School of Medicine, 4Hematovascular Biology Center, University of Virginia School of Medicine, 5Yale Cardiovascular Research Center, Yale University School of Medicine JoVE 63133 Developmental Biology
Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells Elizabeth A. Nelson1,2, Jingyao Qiu3,4, Nicholas W. Chavkin1,2, Karen K. Hirschi1,2,3,4,5 1Department of Cell Biology, University of Virginia, 2Cardiovascular Research Center, University of Virginia, 3Department of Medicine, Yale University School of Medicine, 4Department of Genetics, Yale University School of Medicine, 5Yale Cardiovascular Research Center, Yale University School of Medicine JoVE 62391 Developmental Biology
Isolation of Murine Embryonic Hemogenic Endothelial Cells Jennifer S. Fang*1, Emily C. Gritz*2, Kathrina L. Marcelo3, Karen K. Hirschi1 1Departments of Medicine, Genetics and Biomedical Engineering, Yale Cardiovascular Research Center, Vascular Biology and Therapeutics Program, Yale Stem Cell Center, Yale University School of Medicine, 2Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Yale University School of Medicine, 3Department of Molecular and Cellular Biology, Baylor College of Medicine JoVE 54150 Developmental Biology
