Lee M. Nadler Medical Oncology Dana Farber Cancer Institute Biography Publications Institution JoVE Articles Lee M. Nadler has not added a biography. If you are Lee M. Nadler and would like to personalize this page please email our Author Liaison for assistance. Publications Ex Vivo Expansion of Human CD8 T Cells Using Autologous CD4 T Cell Help PloS One. 2012 | Pubmed ID: 22279573 IL-21 Can Supplement Suboptimal Lck-Independent MAPK Activation in a STAT-3-Dependent Manner in Human CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2012 | Pubmed ID: 22238455 Induction of HLA-DP4-restricted Anti-survivin Th1 and Th2 Responses Using an Artificial Antigen-presenting Cell Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011 | Pubmed ID: 21705450 Aberrant Expression of Functional BAFF-system Receptors by Malignant B-cell Precursors Impacts Leukemia Cell Survival PloS One. 2011 | Pubmed ID: 21687682 Establishment of Antitumor Memory in Humans Using in Vitro-educated CD8+ T Cells Science Translational Medicine. Apr, 2011 | Pubmed ID: 21525398 Targeting of Active MTOR Inhibits Primary Leukemia T Cells and Synergizes with Cytotoxic Drugs and Signaling Inhibitors Experimental Hematology. Apr, 2011 | Pubmed ID: 21277936 A Phase III Study of Anti-B4-blocked Ricin As Adjuvant Therapy Post-autologous Bone Marrow Transplant: CALGB 9254 Leukemia & Lymphoma. Apr, 2011 | Pubmed ID: 21275630 A Panel of Human Cell-based Artificial APC Enables the Expansion of Long-lived Antigen-specific CD4+ T Cells Restricted by Prevalent HLA-DR Alleles International Immunology. Nov, 2010 | Pubmed ID: 21059769 Combining CD19 Redirection and Alloanergization to Generate Tumor-specific Human T Cells for Allogeneic Cell Therapy of B-cell Malignancies Cancer Research. May, 2010 | Pubmed ID: 20424114 Expansion of Allospecific Regulatory T Cells After Anergized, Mismatched Bone Marrow Transplantation Science Translational Medicine. Oct, 2009 | Pubmed ID: 20368155 Cyclin D1-specific Cytotoxic T Lymphocytes Are Present in the Repertoire of Cancer Patients: Implications for Cancer Immunotherapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2008 | Pubmed ID: 18927298 Dissociation of Its Opposing Immunologic Effects is Critical for the Optimization of Antitumor CD8+ T-cell Responses Induced by Interleukin 21 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2008 | Pubmed ID: 18829491 Induction of Alloanergy in Human Donor T Cells Without Loss of Pathogen or Tumor Immunity Transplantation. Sep, 2008 | Pubmed ID: 18813111 CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2008 | Pubmed ID: 18765557 Identification of an Evolutionarily Conserved Transcriptional Signature of CD8 Memory Differentiation That is Shared by T and B Cells Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008 | Pubmed ID: 18641323 Outcome of Alloanergized Haploidentical Bone Marrow Transplantation After Ex Vivo Costimulatory Blockade: Results of 2 Phase 1 Studies Blood. Sep, 2008 | Pubmed ID: 18617635 Lee Marshall Nadler, MD: a Conversation with the Editor Proceedings (Baylor University. Medical Center). Oct, 2007 | Pubmed ID: 17948113 Long-term Survival After Autologous Bone Marrow Transplantation for Follicular Lymphoma in First Remission Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Sep, 2007 | Pubmed ID: 17697968 Long-lived Antitumor CD8+ Lymphocytes for Adoptive Therapy Generated Using an Artificial Antigen-presenting Cell Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2007 | Pubmed ID: 17363542 Identification of an Immunogenic CD8+ T-cell Epitope Derived from Gamma-globin, a Putative Tumor-associated Antigen for Juvenile Myelomonocytic Leukemia Blood. Oct, 2006 | Pubmed ID: 16778141 Efficient Presentation of Naturally Processed HLA Class I Peptides by Artificial Antigen-presenting Cells for the Generation of Effective Antitumor Responses Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2006 | Pubmed ID: 16707591 Leukemia-stimulated Bone Marrow Endothelium Promotes Leukemia Cell Survival Experimental Hematology. May, 2006 | Pubmed ID: 16647567 CD40-activated B Cells Express Full Lymph Node Homing Triad and Induce T-cell Chemotaxis: Potential As Cellular Adjuvants Blood. Apr, 2006 | Pubmed ID: 16357329 Engagement of CD83 Ligand Induces Prolonged Expansion of CD8+ T Cells and Preferential Enrichment for Antigen Specificity Blood. Feb, 2006 | Pubmed ID: 16239433 Proangiogenic Stimulation of Bone Marrow Endothelium Engages MTOR and is Inhibited by Simultaneous Blockade of MTOR and NF-kappaB Blood. Jan, 2006 | Pubmed ID: 16141350 Gene Expression Profiling Identifies BAX-delta As a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Cancer Research. Nov, 2005 | Pubmed ID: 16267031 Autologous and Allogeneic Stem Cell Transplantations for Poor-risk Chronic Lymphocytic Leukemia Blood. Dec, 2005 | Pubmed ID: 16131571 Phase I/II Combined Chemoimmunotherapy with Carcinoembryonic Antigen-derived HLA-A2-restricted CAP-1 Peptide and Irinotecan, 5-fluorouracil, and Leucovorin in Patients with Primary Metastatic Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2005 | Pubmed ID: 16115944 Unexpected Association Between Induction of Immunity to the Universal Tumor Antigen CYP1B1 and Response to Next Therapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2005 | Pubmed ID: 15958627 Antigen-specific T-cell Memory is Preserved in Children Treated for Acute Lymphoblastic Leukemia Blood. Sep, 2005 | Pubmed ID: 15920008 Increasing Incidence of Late Second Malignancies After Conditioning with Cyclophosphamide and Total-body Irradiation and Autologous Bone Marrow Transplantation for Non-Hodgkin's Lymphoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2005 | Pubmed ID: 15753460 Failure to Define Window of Time for Autologous Tumor Vaccination in Patients with Newly Diagnosed or Relapsed Acute Lymphoblastic Leukemia Experimental Hematology. Mar, 2005 | Pubmed ID: 15730852 Identification of a New HLA-A*0201-restricted Cryptic Epitope from CYP1B1 International Journal of Cancer. Journal International Du Cancer. Jun, 2005 | Pubmed ID: 15688394 Presence of Anti-kinectin and Anti-PMS1 Antibodies in Japanese Aplastic Anaemia Patients British Journal of Haematology. Jan, 2005 | Pubmed ID: 15638857 Combination Immunotherapy with a CpG Oligonucleotide (1018 ISS) and Rituximab in Patients with Non-Hodgkin Lymphoma: Increased Interferon-alpha/beta-inducible Gene Expression, Without Significant Toxicity Blood. Jan, 2005 | Pubmed ID: 15358617 Common Gamma Chain-signaling Cytokines Promote Proliferation of T-cell Acute Lymphoblastic Leukemia Haematologica. Dec, 2004 | Pubmed ID: 15590396 Measuring T Cell Immunity to Influenza Vaccination in Children After Haemopoietic Stem Cell Transplantation British Journal of Haematology. Nov, 2004 | Pubmed ID: 15491293 Activation of PI3K is Indispensable for Interleukin 7-mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells The Journal of Experimental Medicine. Sep, 2004 | Pubmed ID: 15353558 PH-triggered Microparticles for Peptide Vaccination Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15294974 Correspondence Re R. Lapointe Et Al., CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells. Cancer Res 2003;63:2836-43 Cancer Research. Jun, 2004 | Pubmed ID: 15173021 Autologous Bone Marrow Transplantation for Marginal Zone Non-Hodgkin's Lymphoma Leukemia & Lymphoma. Feb, 2004 | Pubmed ID: 15101717 Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2004 | Pubmed ID: 14871958 IL-7-dependent Human Leukemia T-cell Line As a Valuable Tool for Drug Discovery in T-ALL Blood. Mar, 2004 | Pubmed ID: 14615384 Autoantibodies Frequently Detected in Patients with Aplastic Anemia Blood. Dec, 2003 | Pubmed ID: 12947009 Differential Localization and Function of ADP-ribosylation Factor-6 in Anergic Human T Cells: a Potential Marker for Their Identification Journal of Immunology (Baltimore, Md. : 1950). Aug, 2003 | Pubmed ID: 12902467 The Shared Tumor-associated Antigen Cytochrome P450 1B1 is Recognized by Specific Cytotoxic T Cells Blood. Nov, 2003 | Pubmed ID: 12869499 Viral Antigen-specific CD8+ T-cell Responses Are Impaired in Multiple Myeloma British Journal of Haematology. Jun, 2003 | Pubmed ID: 12786794 MUC1-like Tandem Repeat Proteins Are Broadly Immunogenic in Cancer Patients Cancer Immunity : a Journal of the Academy of Cancer Immunology. Mar, 2003 | Pubmed ID: 12747745 CAMP Inhibits Both Ras and Rap1 Activation in Primary Human T Lymphocytes, but Only Ras Inhibition Correlates with Blockade of Cell Cycle Progression Blood. Feb, 2003 | Pubmed ID: 12393539 From Genomics to Cancer Vaccines: Patient-tailored or Universal Vaccines? Current Opinion in Molecular Therapeutics. Dec, 2002 | Pubmed ID: 12596359 HER-2/neu and HTERT Cryptic Epitopes As Novel Targets for Broad Spectrum Tumor Immunotherapy Journal of Immunology (Baltimore, Md. : 1950). Jun, 2002 | Pubmed ID: 12023395 Human Primary and Memory Cytotoxic T Lymphocyte Responses Are Efficiently Induced by Means of CD40-activated B Cells As Antigen-presenting Cells: Potential for Clinical Application Blood. May, 2002 | Pubmed ID: 11964299 CD28 Costimulation Mediates Down-regulation of P27kip1 and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells Journal of Immunology (Baltimore, Md. : 1950). Mar, 2002 | Pubmed ID: 11884439 Blockade of B7/CD28 in Mixed Lymphocyte Reaction Cultures Results in the Generation of Alternatively Activated Macrophages, Which Suppress T-cell Responses Blood. Feb, 2002 | Pubmed ID: 11830501 Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade Jeff K. Davies1,2, Christine M. Barbon1, Annie R. Voskertchian1, Lee M. Nadler1,2, Eva C. Guinan3,4 1Medical Oncology, Dana Farber Cancer Institute, 2Department of Medicine, Brigham and Womens Hospital, 3Pediatric Oncology, Dana Farber Cancer Institute, 4Division of Hematology/Oncology, Children’s Hospital Boston JoVE 2673 Immunology and Infection
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade Jeff K. Davies1,2, Christine M. Barbon1, Annie R. Voskertchian1, Lee M. Nadler1,2, Eva C. Guinan3,4 1Medical Oncology, Dana Farber Cancer Institute, 2Department of Medicine, Brigham and Womens Hospital, 3Pediatric Oncology, Dana Farber Cancer Institute, 4Division of Hematology/Oncology, Children’s Hospital Boston JoVE 2673 Immunology and Infection