Leonardo Sacconi European Laboratory for Non-Linear Spectroscopy Biography Publications Institution JoVE Articles Leonardo Sacconi has not added a biography. If you are Leonardo Sacconi and would like to personalize this page please email our Author Liaison for assistance. Publications Fast Optical Investigation of Cardiac Electrophysiology by Parallel Detection in Multiwell Plates Frontiers in Physiology. 2021 | Pubmed ID: 34539428 Optical Clearing in Cardiac Imaging: A Comparative Study Progress in Biophysics and Molecular Biology. Aug, 2021 | Pubmed ID: 34358555 Drift and Termination of Spiral Waves in Optogenetically Modified Cardiac Tissue at Sub-threshold Illumination ELife. Jan, 2021 | Pubmed ID: 33502313 Arrhythmogenic Potential of Myocardial Disarray in Hypertrophic Cardiomyopathy: Genetic Basis, Functional Consequences and Relation to Sudden Cardiac Death Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 07, 2021 | Pubmed ID: 33447843 Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange Circulation Research. 01, 2021 | Pubmed ID: 33228470 3D Imaging and Morphometry of the Heart Capillary System in Spontaneously Hypertensive Rats and Normotensive Controls Scientific Reports. 08, 2020 | Pubmed ID: 32868776 Novel Optics-based Approaches for Cardiac Electrophysiology Progress in Biophysics and Molecular Biology. 08, 2020 | Pubmed ID: 32407749 Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks After Stroke Cell Reports. Sep, 2019 | Pubmed ID: 31553915 Publisher Correction: Whole-Brain Vasculature Reconstruction at the Single Capillary Level Scientific Reports. Jun, 2019 | Pubmed ID: 31201354 A Software Architecture to Mimic a Ventricular Tachycardia in Intact Murine Hearts by Means of an All-Optical Platform Methods and Protocols. Jan, 2019 | Pubmed ID: 31164591 Cardiac Sympathetic Innervation Network Shapes the Myocardium by Locally Controlling Cardiomyocyte Size Through the Cellular Proteolytic Machinery The Journal of Physiology. 07, 2019 | Pubmed ID: 31116413 Corrigendum: Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy Frontiers in Cellular Neuroscience. 2019 | Pubmed ID: 30853897 Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction Circulation Research. 04, 2019 | Pubmed ID: 30732554 High-Fidelity Imaging in Brain-Wide Structural Studies Using Light-Sheet Microscopy ENeuro. Nov-Dec, 2018 | Pubmed ID: 30627630 Interplay Between Sub-Cellular Alterations of Calcium Release and T-Tubular Defects in Cardiac Diseases Frontiers in Physiology. 2018 | Pubmed ID: 30410446 Axial Tubule Junctions Activate Atrial Ca Release Across Species Frontiers in Physiology. 2018 | Pubmed ID: 30349482 Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy Frontiers in Cellular Neuroscience. 2018 | Pubmed ID: 30294262 Whole-Brain Vasculature Reconstruction at the Single Capillary Level Scientific Reports. 08, 2018 | Pubmed ID: 30135559 Confocal Multispot Microscope for Fast and Deep Imaging in Semicleared Tissues Journal of Biomedical Optics. 02, 2018 | Pubmed ID: 29460510 Reply to Entcheva: The Impact of T-tubules on Action Potential Propagation in Cardiac Tissue Proceedings of the National Academy of Sciences of the United States of America. 01, 2018 | Pubmed ID: 29305385 Liquid Crystalline Networks Toward Regenerative Medicine and Tissue Repair Small (Weinheim an Der Bergstrasse, Germany). 12, 2017 | Pubmed ID: 29045016 Quantitative Assessment of Passive Electrical Properties of the Cardiac T-tubular System by FRAP Microscopy Proceedings of the National Academy of Sciences of the United States of America. 05, 2017 | Pubmed ID: 28507142 Optogenetics Gets to the Heart: A Guiding Light Beyond Defibrillation Progress in Biophysics and Molecular Biology. 11, 2017 | Pubmed ID: 28506694 Electrical Defects of the Transverse-axial Tubular System in Cardiac Diseases The Journal of Physiology. 06, 2017 | Pubmed ID: 27981580 Optogenetics Design of Mechanistically-based Stimulation Patterns for Cardiac Defibrillation Scientific Reports. 10, 2016 | Pubmed ID: 27748433 T-Tubular Electrical Defects Contribute to Blunted β-Adrenergic Response in Heart Failure International Journal of Molecular Sciences. Sep, 2016 | Pubmed ID: 27598150 Clearing of Fixed Tissue: a Review from a Microscopist's Perspective Journal of Biomedical Optics. Aug, 2016 | Pubmed ID: 27020691 Novel Insights on the Relationship Between T-tubular Defects and Contractile Dysfunction in a Mouse Model of Hypertrophic Cardiomyopathy Journal of Molecular and Cellular Cardiology. Feb, 2016 | Pubmed ID: 26714042 Multi-Modal Optical Imaging of the Cerebellum in Animals Cerebellum (London, England). Feb, 2016 | Pubmed ID: 26476852 Label-free Near-infrared Reflectance Microscopy As a Complimentary Tool for Two-photon Fluorescence Brain Imaging Biomedical Optics Express. Nov, 2015 | Pubmed ID: 26601011 Comprehensive Optical and Data Management Infrastructure for High-throughput Light-sheet Microscopy of Whole Mouse Brains Neurophotonics. Oct, 2015 | Pubmed ID: 26158018 A Versatile Clearing Agent for Multi-modal Brain Imaging Scientific Reports. May, 2015 | Pubmed ID: 25950610 Towards a Comprehensive Understanding of Brain Machinery by Correlative Microscopy Journal of Biomedical Optics. Jun, 2015 | Pubmed ID: 25749101 Functional Cardiac Imaging by Random Access Microscopy Frontiers in Physiology. 2014 | Pubmed ID: 25368580 Defects in T-tubular Electrical Activity Underlie Local Alterations of Calcium Release in Heart Failure Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25288764 Impact of Detubulation on Force and Kinetics of Cardiac Muscle Contraction The Journal of General Physiology. Jun, 2014 | Pubmed ID: 24863933 The Connectomics Challenge Functional Neurology. Jul-Sep, 2013 | Pubmed ID: 24139653 Correlative Two-photon and Light Sheet Microscopy Methods (San Diego, Calif.). Jun, 2013 | Pubmed ID: 23806642 In Vivo Single Branch Axotomy Induces GAP-43-dependent Sprouting and Synaptic Remodeling in Cerebellar Cortex Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23754371 Two-photon Microscopy Imaging of Thy1GFP-M Transgenic Mice: a Novel Animal Model to Investigate Brain Dendritic Cell Subsets in Vivo PloS One. 2013 | Pubmed ID: 23409142 Palette of Fluorinated Voltage-sensitive Hemicyanine Dyes Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23169660 Protein Conformation and Molecular Order Probed by Second-harmonic-generation Microscopy Journal of Biomedical Optics. Jun, 2012 | Pubmed ID: 22734730 Action Potential Propagation in Transverse-axial Tubular System is Impaired in Heart Failure Proceedings of the National Academy of Sciences of the United States of America. Apr, 2012 | Pubmed ID: 22451916 Multi-photon Nanosurgery in Live Brain Frontiers in Neuroenergetics. 2010 | Pubmed ID: 20725602 Optical Recording of Electrical Activity in Intact Neuronal Networks with Random Access Second-harmonic Generation Microscopy Optics Express. Sep, 2008 | Pubmed ID: 18795028 In Vivo Multiphoton Nanosurgery on Cortical Neurons Journal of Biomedical Optics. Sep-Oct, 2007 | Pubmed ID: 17994859 Cell Imaging and Manipulation by Nonlinear Optical Microscopy Cell Biochemistry and Biophysics. 2006 | Pubmed ID: 16845175 Lac Repressor Hinge Flexibility and DNA Looping: Single Molecule Kinetics by Tethered Particle Motion Nucleic Acids Research. 2006 | Pubmed ID: 16835309 Optical Recording of Fast Neuronal Membrane Potential Transients in Acute Mammalian Brain Slices by Second-harmonic Generation Microscopy Journal of Neurophysiology. Nov, 2005 | Pubmed ID: 16093337 Nuclear and Division-plane Positioning Revealed by Optical Micromanipulation Current Biology : CB. Jul, 2005 | Pubmed ID: 16005294 Combined Intracellular Three-dimensional Imaging and Selective Nanosurgery by a Nonlinear Microscope Journal of Biomedical Optics. Jan-Feb, 2005 | Pubmed ID: 15847583 Optical Micromanipulations Inside Yeast Cells Applied Optics. Apr, 2005 | Pubmed ID: 15835347 Positioning and Elongation of the Fission Yeast Spindle by Microtubule-based Pushing Current Biology : CB. Jul, 2004 | Pubmed ID: 15242615 Mesoscopic Optical Imaging of Whole Mouse Heart Francesco Giardini*1, Erica Lazzeri*1, Camilla Olianti*1, Giada Beconi1, Irene Costantini1,2, Ludovico Silvestri1,3,4, Elisabetta Cerbai1,5, Francesco S. Pavone1,3,4, Leonardo Sacconi1,3,6 1European Laboratory for Non-Linear Spectroscopy, 2Department of Biology, University of Florence, 3National Institute of Optics, National Research Council, 4Department of Physics and Astronomy, University of Florence, 5Department of Neurosciences, Psychology, Drugs and Child Health, University of Florence, 6Institute for Experimental Cardiovascular Medicine, Faculty of Medicine, University of Freiburg JoVE 62795 Biology Laser Nanosurgery of Cerebellar Axons In Vivo Anna L. Allegra Mascaro1, Leonardo Sacconi1,2, Francesco Saverio Pavone1,2,3,4 1European Laboratory for Non-Linear Spectroscopy, University of Florence, 2National Institute of Optics, National Research Council, 3Department of Physics and Astronomy, University of Florence, 4International Center for Computational Neurophotonics (ICON Foundation) JoVE 51371 Neuroscience Micron-scale Resolution Optical Tomography of Entire Mouse Brains with Confocal Light Sheet Microscopy Ludovico Silvestri1, Alessandro Bria2,3, Irene Costantini1, Leonardo Sacconi1,4, Hanchuan Peng5, Giulio Iannello2, Francesco Saverio Pavone1,4,6,7 1European Laboratory for Non-linear Spectroscopy (LENS), 2Integrated Research Centre, University Campus Bio-medico of Rome, 3DAEMI, University of Cassino, 4National Institute of Optics (CNR-INO), 5Allen Institute for Brain Science, 6Department of Physics, University of Florence, 7ICON Foundation, Sesto Fiorentino, Italy JoVE 50696 Neuroscience
Mesoscopic Optical Imaging of Whole Mouse Heart Francesco Giardini*1, Erica Lazzeri*1, Camilla Olianti*1, Giada Beconi1, Irene Costantini1,2, Ludovico Silvestri1,3,4, Elisabetta Cerbai1,5, Francesco S. Pavone1,3,4, Leonardo Sacconi1,3,6 1European Laboratory for Non-Linear Spectroscopy, 2Department of Biology, University of Florence, 3National Institute of Optics, National Research Council, 4Department of Physics and Astronomy, University of Florence, 5Department of Neurosciences, Psychology, Drugs and Child Health, University of Florence, 6Institute for Experimental Cardiovascular Medicine, Faculty of Medicine, University of Freiburg JoVE 62795 Biology
Laser Nanosurgery of Cerebellar Axons In Vivo Anna L. Allegra Mascaro1, Leonardo Sacconi1,2, Francesco Saverio Pavone1,2,3,4 1European Laboratory for Non-Linear Spectroscopy, University of Florence, 2National Institute of Optics, National Research Council, 3Department of Physics and Astronomy, University of Florence, 4International Center for Computational Neurophotonics (ICON Foundation) JoVE 51371 Neuroscience
Micron-scale Resolution Optical Tomography of Entire Mouse Brains with Confocal Light Sheet Microscopy Ludovico Silvestri1, Alessandro Bria2,3, Irene Costantini1, Leonardo Sacconi1,4, Hanchuan Peng5, Giulio Iannello2, Francesco Saverio Pavone1,4,6,7 1European Laboratory for Non-linear Spectroscopy (LENS), 2Integrated Research Centre, University Campus Bio-medico of Rome, 3DAEMI, University of Cassino, 4National Institute of Optics (CNR-INO), 5Allen Institute for Brain Science, 6Department of Physics, University of Florence, 7ICON Foundation, Sesto Fiorentino, Italy JoVE 50696 Neuroscience
